Clinical trials
Encephalopathy clinical trials
Below are recruiting encephalopathy clinical trials, each written for real people, not researchers. We’re tracking 114 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06747260RecruitingEarly Phase 1
Breast milk through the nose for HIE
This trial tests whether giving fresh breast milk through the nose is safe and possible for newborns with HIE (a brain injury from oxygen loss at birth) who are already receiving cooling therapy. It may help protect the brain and reduce injury.
BudapestAges Up to 2 days - NCT07264166Enrolling by invitation
Gene therapy trial for cerebral palsy and HIE
This trial tests a gene therapy given as a nose spray for people with cerebral palsy or HIE. It aims to see if the treatment is safe and helps improve movement over two years.
Monterrey, Nuevo LeónAges 2–65 - NCT05514340RecruitingPhase 2
Test drug for brain injury after low oxygen at birth
This Phase 2 study tests whether sovateltide can improve safety and outcomes for babies whose brains may have been injured by low oxygen around birth. It focuses on babies who show signs of moderate to severe injury soon after delivery, and who receive standard supportive care.
Mangalore, KarnatakaAges Any age - NCT05971446Recruiting
Healthy Little Eyes study for newborn vision and brain health
This study looks at eye and vision outcomes in babies who have had lack of oxygen around birth (HIE) and also compares them with healthy “well babies.” It may help doctors better understand how HIE affects the eyes and what to watch for over time.
Madison, WisconsinAges Up to 3 years - NCT07683936RecruitingEarly Phase 1
Fecal transplant for brain issues after liver procedure
This trial tests if transferring healthy bacteria into your gut (fecal microbiota transplant) can help people who still get confusion episodes (hepatic encephalopathy) even after a TIPS procedure and while on standard medications like lactulose and rifaximin.
Xi'anAges 18–75 - NCT06746532RecruitingEarly Phase 1
Breast milk nose drops for brain injury in newborns
This trial tests whether giving fresh breast milk as nose drops can help newborns with brain injury from lack of oxygen. It aims to see if this simple treatment can improve brain recovery.
BudapestAges Up to 2 days - NCT06762795Recruiting
Gene study for newborns with HIE on cooling therapy
This study uses whole genome sequencing to look at the genes of newborns with HIE (brain injury from lack of oxygen) who are receiving cooling treatment. The goal is to learn more about how genes may affect recovery and outcomes.
Houston, TexasAges birth–1 year - NCT07165938Recruiting
Genetics of newborn brain injury study
This study looks for genes that may cause or increase the risk of brain injury in newborns. It may help researchers understand why some babies develop encephalopathy and could lead to better treatments in the future.
Boston, MassachusettsAges Any age - NCT07770035Enrolling by invitation
School-age outcomes after newborn brain injury
This study looks at how children who had a brain injury around birth (called hypoxic-ischaemic encephalopathy, or HIE) are doing in school and daily life, compared to children without that history. It aims to understand the long-term effects and support needs.
Cork, CorkAges 5–12 - NCT06908226Enrolling by invitationPhase 3
LP352 for children and adults with DEE
This trial tests a medication called LP352 for children and adults with certain types of epilepsy (Dravet syndrome, Lennox-Gastaut syndrome, or other developmental and epileptic encephalopathies). It's for people who already completed a previous study of LP352 and may benefit from continued treatment.
Little Rock, ArkansasAges 2–66 - NCT07227857RecruitingPhase 1/Phase 2
Study of a new medicine for children with KCNT1-related epilepsy
This study tests a new medicine (S230815) given by lumbar puncture (spinal tap) to see if it helps reduce seizures in children with a specific genetic cause of epilepsy. It is for children aged 2 to 12 who have not responded well to other treatments.
Orange, CaliforniaAges 2–12 - NCT02881970RecruitingPhase 1/Phase 2
Cord blood stem cell treatment for newborn brain injury
This early-phase study tests whether using a baby’s own cord blood stem cells is safe and feasible for newborns with brain injury from lack of oxygen around birth. It may help researchers find new ways to treat hypoxic-ischemic encephalopathy (brain injury due to oxygen deprivation) in addition to standard care like cooling.
MarseilleAges 1 day–3 days - NCT01694953Recruiting
Study of how MNGIE changes over time
This study follows people with MNGIE (a rare mitochondrial disease) to better understand what happens over time and how lab markers relate to health. It does not test a new drug as part of the study.
New York, New YorkAges 5 years+ - NCT02544100Recruiting
Study for newborns with brain or nervous system problems
This study enrolls newborns (within the first 28 days of life) who have specific brain or nervous system conditions. It tests how these conditions are tracked and studied, which may help improve care and understanding over time.
Shanghai, Shanghai MunicipalityAges Up to 4 weeks - NCT07393620Recruiting
Predicting brain outcomes in newborns with mild oxygen loss
This study uses brain monitoring and oxygen measurements in newborns who had a mild lack of oxygen at birth to see if these tests can predict how the baby will develop. The goal is to find early signs that might help guide care.
BursaAges birth–6 hours - NCT07527104Recruiting
Bone marrow cells and rehabilitation for cerebral palsy in young children
This trial tests whether transplanting cells from a child's own bone marrow, combined with rehabilitation therapy, can improve movement and function in young children with cerebral palsy caused by birth-related brain injury or bleeding. The goal is to see if this approach helps children move better and become more independent.
Hanoi, HanoiAges 6 months–18 years - NCT05648812RecruitingPhase 3
Ultrasound tests for baby brains using special imaging
This Phase 3 study tests whether detailed ultrasound scans (with contrast and stiffness measurements) can help doctors assess a baby’s brain. It may help by improving how early brain changes are detected in newborn care settings.
Turku, Southwestern FinlandAges 1 minute–6 months - NCT06522581RecruitingPhase 1
Citicoline for brain injury in newborns
This trial tests if citicoline, a brain-protecting supplement, can help newborns with moderate to severe brain injury from lack of oxygen. It is for babies who have not gotten cooling treatment.
RawalpindiAges 1 day–4 weeks - NCT06380192Recruiting
Genetic Epilepsy and Development: A Natural History Study
This study looks at how a specific type of epilepsy with developmental challenges progresses over time. By reusing medical records, the researchers hope to learn more without extra hospital visits.
AmiensAges Any age - NCT07019922RecruitingPhase 3
A study of elsunersen for children with SCN2A-related epilepsy
This trial tests an experimental drug called elsunersen in children with a specific type of epilepsy caused by changes in the SCN2A gene. It aims to see if the drug can reduce seizures and be safe for children.
San Diego, CaliforniaAges 1 day–18 years - NCT07046429Recruiting
Melatonin for sleep and brain health in cirrhosis
This study tests whether melatonin (a natural sleep hormone) can improve sleep and thinking abilities in people with cirrhosis and liver-related brain fog. It aims to see if better sleep leads to clearer thinking.
New York, New YorkAges 18 years+ - NCT01238250Recruiting
Online autism genetics study for families with certain genetic changes
This study asks people with specific genetic changes linked to autism and their family members to complete online tasks and questionnaires. It may help researchers better understand how these genetic differences relate to autism traits.
Boston, MassachusettsAges Any age - NCT07628829Recruiting
Video AI to Monitor Newborn Brain Health
This study uses artificial intelligence to watch and analyze videos of newborns in the hospital nursery or NICU to help doctors spot neurological problems early. The goal is to see if this video AI tool can safely and accurately help care for newborns during their hospital stay.
New York, New YorkAges Any age - NCT03470467Recruiting
ICU study of a reversible brain swelling condition
This trial looks at Posterior Reversible Encephalopathy Syndrome (PRES) in adults in the ICU. It may help doctors better understand and manage a condition that can cause seizures, confusion, headaches, and vision problems, and that typically shows specific changes on brain scans.
Le ChesnayAges 18 years+
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Common questions
- Are there clinical trials for encephalopathy?
- Yes. Clin2 currently lists 114 recruiting encephalopathy studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a encephalopathy trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a encephalopathy trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.