Clinical trials
Functionality clinical trials
Below are recruiting functionality clinical trials, each written for real people, not researchers. We’re tracking 2,474 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT03541135Enrolling by invitation
Study of heart health, diet, and activity in older adults
This study looks at heart health, food, and physical functioning in people age 65 and older living in Madrid. It may help researchers understand how lifestyle affects aging and cardiovascular wellbeing.
MadridAges 65–95 - NCT03407833Enrolling by invitation
Study changes in the body after weight, gut, or liver treatment
This study looks at how the body’s insulin-sensitivity (how well your body uses sugar/insulin) and organ function change after certain medical procedures. It may help researchers understand why some people improve after surgery or liver transplant and guide future care.
Nashville, TennesseeAges 18 years+ - NCT03458429Enrolling by invitationPhase 1/Phase 2
Plasma from healthy donors for frailty and immune health
This Phase 1/2 study tests whether transfusions of donated plasma can improve frailty and immune function in older adults. It mainly checks safety first, and also looks for signs that the immune system and overall strength may improve.
Boynton Beach, FloridaAges 55–95 - NCT03442465Recruiting
Study of healing and function after bone reconstruction surgery
This study looks at how well people heal and how well they can move and use the repaired bone after reconstructive surgery for bone tumors. It may help doctors understand what recovery looks like and what could improve function over time.
Basking Ridge, New JerseyAges 4 years+ - NCT03475173Recruiting
Non-invasive eye scans for healthy and specific retinal problems
This study tests new, non-invasive ways to measure how the retina (the light-sensing part of the eye) is structured and how well it works. It may help researchers better understand certain vision disorders and how to track them, without surgery or injections.
Iowa City, IowaAges 18–99 - NCT03369353Enrolling by invitation
Personalized immune testing study for bowel and transplant patients
This study looks at whether a precise lab test can help understand inflammatory bowel disease, functional gut disorders, and immune changes after stem cell transplant or cell therapy. It may help doctors choose better monitoring and treatments based on your immune and gut test results.
Boston, MassachusettsAges Any age - NCT03067181RecruitingPhase 3
Active surveillance and chemotherapy for germ cell tumors
This study looks at how to manage germ cell tumors in children and young adults using careful monitoring for some patients and chemotherapy for others. It aims to see whether these approaches can control the cancer while avoiding unnecessary treatment when possible.
Birmingham, AlabamaAges Any age - NCT03288220Recruiting
Brain stimulation trial to improve arm movement
This trial studies whether a specific kind of non-painful brain stimulation (TMS) can improve arm and hand movement. It tests this in healthy volunteers and in people recovering from stroke.
Bethesda, MarylandAges 18–120 - NCT03142152Recruiting
Mitral valve implant for heart failure with leaky mitral valve
This trial tests whether a device called the Carillon Mitral Contour System can help people with heart failure caused by a mild-to-moderate leaky mitral valve. You’d be compared against a control group, and the goal is to improve heart failure symptoms and outcomes.
Gilbert, ArizonaAges 18 years+ - NCT03054792Enrolling by invitationPhase 1
MRI test to map low-oxygen areas in childhood sarcomas
This Phase 1 study uses special MRI scans to look at “low-oxygen” parts of a childhood sarcoma. It aims to help doctors better understand the tumor before standard treatment that may include chemotherapy and sometimes radiation.
Toronto, OntarioAges 6–18 - NCT03228290Recruiting
Liver transplant care study using patient function check
This study looks at how people with liver disease function day to day, especially around liver transplant care. It may help improve how doctors assess readiness and recovery needs.
Little Rock, ArkansasAges 18 years+ - NCT03137095Recruiting
Study how chemotherapy affects brain function in breast cancer
This study looks at changes in thinking and brain function in people with early to locally advanced breast cancer before and during chemotherapy. You may also be offered a brain MRI in a separate optional part of the research to learn more about brain changes.
Rochester, New YorkAges 21 years+ - NCT03232463Enrolling by invitation
Testing an advanced MRI scan in everyday clinic care
This study checks whether a more advanced MRI scan can be safely used in regular clinical practice. If you need an MRI for a health problem, the study may help your care team use the newer scan approach.
Santa Monica, CaliforniaAges 18–65 - NCT02825654Enrolling by invitation
Deployed Veterans Study of Service and Health
This study looks at how military service and deployment experiences relate to health and wellbeing in veterans who served after 9/11. It may help researchers understand which factors affect long-term health.
San Diego, CaliforniaAges Any age - NCT02896348Recruiting
Home therapy training for hand function after stroke
This trial tests a physio-and-neuro “platform” to help retrain hand movement at home in people who are at least 6 months out from a stroke. It may help improve hand function and confidence doing daily tasks using an at-home retraining program.
Boston, MassachusettsAges 21–80 - NCT02818400Recruiting
Face transplant evaluation for severe facial tissue loss
This trial studies face tissue transplantation for people who have lost facial tissue that cannot be fixed with standard surgical methods. It focuses on how the face looks and works after surgery, and it may help restore function and appearance when other options aren’t enough.
AmiensAges 18–50 - NCT02914951Enrolling by invitation
Therapy to reduce irritability in children with autism
This trial studies whether cognitive-behavioral therapy (a structured talk therapy) can reduce irritability and anger outbursts in children with autism. It may help improve day-to-day behavior by teaching coping skills and reducing problem reactions.
New Haven, ConnecticutAges 8–16 - NCT02754544Recruiting
Brain mapping during tumor surgery while you are awake
This study uses special recording sensors during brain tumor surgery to map the brain areas that control movement and speech. It may help the surgical team protect these key functions while removing the tumor.
Houston, TexasAges 18 years+ - NCT02725060Enrolling by invitation
Study of autoimmune changes in postural tachycardia syndrome
This trial studies whether an autoimmune (immune system–related) process is involved in postural tachycardia syndrome (POTS), a condition where your heart rate rises when you stand. The study may help researchers understand what causes POTS and how it could be treated or monitored.
Oklahoma City, OklahomaAges 18–50 - NCT02966665RecruitingPhase 1
Testing blood vessel function in people of different health conditions
This early study measures how well your blood vessels work using tests that may include MRI. It compares healthy people with people who have conditions like COPD, pulmonary arterial hypertension, heart failure, or high blood pressure, to better understand “vascular function” in health and disease.
Salt Lake City, UtahAges 18 years+ - NCT02629107Recruiting
Sleep and brain scan study with sound cues
This study checks how your brain responds while you sleep using an MRI scanner and gentle sound signals. It may help researchers better understand sleep and brain function.
Bethesda, MarylandAges 18–34 - NCT02617966Recruiting
Test of how rod and cone vision work in eye disease
This study measures how your eyes use two types of light-sensing cells (rods for dim light and cones for clearer detail). It may help researchers better understand retinal (retina) diseases and how well vision is functioning.
Bethesda, MarylandAges 5–100 - NCT02610855Enrolling by invitation
Study of activity and muscle function in children with scoliosis
This study looks at how children’s activity levels and muscle performance change in different scoliosis treatments (surgery, bracing, or healthy peers). It uses motion sensors and an ultrasound-based test to better understand what treatments may do to the body’s muscles.
Rochester, MinnesotaAges 9–16 - NCT02301182Enrolling by invitation
Compare two hip implant types for younger hip arthritis
This trial compares two different hip implant designs in people ages 40–65 with primary hip osteoarthritis. It looks at how well the hip works afterward—especially function and everyday results.
AarhusAges 40–65
Hear when a new Functionality trial opens
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Common questions
- Are there clinical trials for functionality?
- Yes. Clin2 currently lists 2,474 recruiting functionality studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a functionality trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a functionality trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.