Clinical trials
Head and Neck Cancer Squamous Cell Carcinoma clinical trials
Below are recruiting head and neck cancer squamous cell carcinoma clinical trials, each written for real people, not researchers. We’re tracking 449 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07578571RecruitingPhase 1
Testing a New Cancer Treatment Called IM-1617
This is an early-stage study testing a new drug (IM-1617) for advanced solid cancers that have not responded to standard treatments. The drug combines an antibody with a cancer-killing agent and may help people whose cancer has progressed despite prior therapy.
Sarasota, FloridaAges 18 years+ - NCT06692556RecruitingPhase 3
Radiation vs monitoring for high-risk skin cancer
This trial compares two strategies after surgery for a type of skin cancer (cutaneous squamous cell carcinoma) that has a high chance of coming back. One strategy gives radiation therapy to the area, while the other just watches and checks for any signs of recurrence. The goal is to see if radiation can prevent the cancer from returning.
Le Puy-en-Velay, Auvergne-Rhône-AlpesAges 18 years+ - NCT04842162RecruitingPhase 2
Near-infrared dye imaging to help remove all mouth/throat cancer
This Phase 2 study tests a special camera and dye during surgery to help surgeons confirm they removed all cancer at the edge of the removed tissue. If it works, it may lower the chance of cancer being left behind after oral cavity or oropharynx squamous cell cancer surgery.
AnderlechtAges 18 years+ - NCT05758389RecruitingPhase 2
Immunotherapy plus chemo for locally advanced head and neck cancer
This Phase 2 study tests whether tislelizumab (an immunotherapy) combined with chemotherapy works better for locally advanced head and neck squamous cell cancer. It aims to improve cancer control when the tumor is large and has not spread to distant organs.
Nanjing, JiangsuAges 18–75 - NCT07565740RecruitingPhase 1
Vaccine plus immunotherapy for newly diagnosed HPV-positive throat cancer
This trial tests a new nasal vaccine combined with an immunotherapy drug (tislelizumab) given before surgery for people with HPV-positive oropharyngeal cancer. The goal is to help the immune system fight the cancer and potentially improve outcomes after surgery.
Chengdu, SichuanAges 18 years+ - NCT04892173RecruitingPhase 3
Radiation plus a tumor injection, with or without cetuximab
This trial studies whether adding a special drug given directly into a head-and-neck tumor during radiation can improve outcomes. It also looks at whether cetuximab (an antibody medicine) should be added for people who cannot or should not have certain standard chemotherapy.
Birmingham, AlabamaAges 60 years+ - NCT05125055RecruitingPhase 2/Phase 3
Test new throat cancer treatment before surgery
This trial tests giving anti–PD-1 immunotherapy plus a drug called TP before surgery for oral squamous cell carcinoma (mouth/throat cancer). The goal is to see whether this pre-surgery treatment improves how much the tumor responds under the microscope.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT02128906RecruitingPhase 2
Radiation plus chemo choices for throat cancer, using a tumor marker
This trial compares two treatment combinations given with radiation for certain cancers of the throat. It also uses a lab test on the tumor (ERCC1) to help choose and study which treatment works better.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT07227350RecruitingPhase 2
L19IL2 and L19TNF for advanced basal cell carcinoma
This trial tests a combination of two drugs, L19IL2 and L19TNF, injected directly into advanced basal cell carcinoma tumors that cannot be treated with surgery or radiation. The goal is to see if these drugs can shrink the tumors.
Tampa, FloridaAges 18 years+ - NCT05379712RecruitingPhase 2
Nutrition supplements during radiation for head and neck cancer
This trial studies whether a nutritional supplement helps people with head and neck squamous cell cancer when they are receiving radiation (with or without chemotherapy). You must be able to eat by mouth and have specific cancer types and recent CT imaging.
Edmonton, AlbertaAges 18 years+ - NCT05777824RecruitingPhase 2
Testing treatment after head and neck cancer response to chemo-immunotherapy
This Phase 2 study looks at what treatment is best after you first receive chemotherapy plus immunotherapy, then have surgery for head and neck squamous cell cancer. It tries to use how your tumor responds (shown in lab tissue after treatment) to guide the next steps, which may improve outcomes.
Beijin, Beijing MunicipalityAges 18–75 - NCT06345287RecruitingPhase 2
Adaptive radiotherapy after immunotherapy for head and neck cancer
This trial tests a personalized radiotherapy approach after a few rounds of chemo-immunotherapy for people with HPV-negative head and neck cancer. It aims to adjust the radiation dose based on how the tumor responds, possibly reducing side effects while still controlling the cancer.
BeijingAges 18–75 - NCT07546045Recruiting
Robotic Surgery and Swallowing Recovery for Head and Neck Cancer
This trial tests a specialized robotic surgical approach for head and neck cancers, combined with personalized speech and swallowing rehabilitation. The goal is to remove tumors while preserving organ function and improving your ability to swallow and speak after surgery.
LausanneAges 18 years+ - NCT06161779Recruiting
Reconstructing the hypopharynx after cancer removal
This trial tests a surgical technique using a flap from under your chin to rebuild the hypopharynx after removing cancer. It may help people with hypopharyngeal cancer that has not spread far and who have not had radiation before.
Guangzhou, GuangdongAges 18–80 - NCT06354712RecruitingPhase 2
Can N-acetylcysteine prevent mouth sores during radiation?
This study tests whether a medicine called N-acetylcysteine (NAC) can prevent mouth sores caused by radiation therapy for head and neck cancer. If you are starting radiation, this trial may help protect your mouth from painful side effects.
Al MansurahAges 18–80 - NCT06549946RecruitingPhase 1/Phase 2
Ixovex-1 injection alone or with another drug for advanced solid tumors
This trial tests an experimental injection called Ixovex-1, either alone or with another drug (pembrolizumab), for people with advanced solid tumors that can be injected. It is for those who have run out of standard options and have tumors that are not too deep inside the body.
LondonAges 18 years+ - NCT06579248RecruitingEarly Phase 1
Cooling device to protect taste during radiation
This trial tests a special mouthpiece that cools the tongue during radiation therapy for advanced larynx cancer. It may help prevent taste loss caused by treatment.
Detroit, MichiganAges 18 years+ - NCT06666881Recruiting
Exercise training for head and neck cancer patients
This trial studies if exercise training can improve outcomes for people with head and neck squamous cell cancer who need chemotherapy and radiation. It uses body scans to see if muscle changes from exercise are linked to better prognosis.
New Taipei CityAges 20–80 - NCT07027280Recruiting
Measuring Tumor Differences in Head and Neck Cancer
This study uses scans and tissue samples to look at differences within your tumor (called heterogeneity). It may help doctors understand your cancer better and choose the best treatment approach.
ChongqingAges 15–89 - NCT07447570RecruitingPhase 2
Iparomlimab and Tuvonralimab plus radiation and chemo for head and neck cancer
This trial tests a combination of two immunotherapy drugs (Iparomlimab and Tuvonralimab) with low-dose radiation and chemotherapy for advanced head and neck cancer. It aims to see if this approach can help patients who have not had prior treatment for their cancer.
Hangzhou, ZhejiangAges 18–75 - NCT07528495RecruitingPhase 2/Phase 3
Skipping neck radiation for oral cancer after surgery
This trial tests whether patients with early-stage oral cancer who have surgery and lymph-node removal can skip radiation to the neck if certain favorable conditions are met. The goal is to reduce side effects like difficulty swallowing while keeping cancer control strong.
Jhajjar, HaryanaAges 18–70 - NCT04767048RecruitingPhase 2
Robot or laser tongue scraping plus tonsil removal to assess lymph nodes
This trial looks at whether a more precise procedure—removing a small area of tongue lining using a robot or laser, along with tonsil removal—can find the likely source of stubborn swollen neck lymph nodes. It’s designed for people with signs of head-and-neck cancer in lymph nodes, but no clear primary tumor found yet.
CaenAges 18 years+ - NCT05491512RecruitingPhase 2
Reduced radiation with chemo for HPV throat cancer
This trial tests whether giving less radiation (while using standard chemotherapy) can treat HPV-related throat cancer effectively. It may help reduce radiation exposure while still controlling the cancer.
Basking Ridge, New JerseyAges 18 years+ - NCT04470024RecruitingPhase 1
Testing a vaccine plus immunotherapy for recurrent head and neck cancer
This early-phase (Phase 1b) study tests a vaccine designed to train the immune system to fight head and neck squamous cell carcinoma, plus standard immunotherapy. It may help some people by boosting the body’s anti-cancer immune response, but it mainly focuses on safety and finding the best approach.
Portland, OregonAges 18 years+
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Common questions
- Are there clinical trials for head and neck cancer squamous cell carcinoma?
- Yes. Clin2 currently lists 449 recruiting head and neck cancer squamous cell carcinoma studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a head and neck cancer squamous cell carcinoma trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a head and neck cancer squamous cell carcinoma trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Squamous Cell Carcinoma Head and Neck Cancer (HNSCC)
- Head and Neck Squamous Cell Carcinoma
- Recurrent Head and Neck Squamous Cell Carcinoma
- Metastatic Head and Neck Squamous Cell Carcinoma
- Locally Advanced Head and Neck Squamous Cell Carcinoma
- Head and Neck Squamous Cell Cancer
- Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma
- Resectable Head and Neck Squamous Cell Carcinoma
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.