Clinical trials
Head and Neck clinical trials
Below are recruiting head and neck clinical trials, each written for real people, not researchers. We’re tracking 691 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06194656RecruitingPhase 2
Trial of SIBP-03 for advanced head and neck cancer
This trial tests a new drug called SIBP-03 for people with head and neck squamous cell carcinoma that has come back or spread. It is for those whose cancer has worsened after prior immunotherapy and platinum chemotherapy, and who have no option for curative local treatment.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT05837221Recruiting
Study of the mouth microbiome in oral cancer
This study looks at the types of bacteria in the mouth (the microbiome) in people with oral squamous cell cancer and compares them to people without this cancer. It may help researchers understand what’s different in oral cancer and what could be useful for diagnosis or treatment planning.
Aurora, ColoradoAges 18–100 - NCT05710679Recruiting
Blood test predicts leftover cancer after intensified head and neck radiation
This study uses a blood test to see whether cancer DNA is still detectable after a stronger combination of radiation and chemotherapy for locally advanced head and neck cancer. The goal is to predict who may have “residual” (remaining) disease and help guide future care.
Clermont-Ferrand, Puy-de-DômeAges 18–80 - NCT05328024Recruiting
Testing who benefits from anti–PD-1 immunotherapy in head cancer
This study looks for signs in your tumor that can predict how well anti–PD-1 immunotherapy will work for certain head and neck cancers. You may benefit by helping doctors match the right treatment to the right patients.
Strasbourg, FranceAges 18 years+ - NCT05187091RecruitingPhase 3
Radiation plan that tries to protect swallowing organs
This Phase 3 study compares a standard radiation approach versus a modified approach designed to spare key swallowing and aspiration (choking) related areas and one salivary gland. It may help reduce treatment side effects that affect swallowing and quality of life for certain head and neck cancer patients.
Jhajjar, HaryanaAges 18–70 - NCT05183048RecruitingEarly Phase 1
Test a new PET scan to find head and neck cancer
This early-phase study compares a special imaging marker with a standard PET scan to help identify head and neck squamous cell carcinoma before surgery. It may help doctors see where cancer is (especially if lymph nodes look negative) so surgery planning can be more accurate.
Birmingham, AlabamaAges 18 years+ - NCT05031910Recruiting
Virtual 3D guidance for head and neck cancer surgery
This study tests whether a virtual reality (3D computer) model of surgery can help surgeons improve how head and neck cancer operations are planned and done. You may benefit from more personalized surgical planning, if you’re eligible for standard surgery.
Philadelphia, PennsylvaniaAges 18 years+ - NCT04915183RecruitingPhase 2
Atorvastatin to help prevent cisplatin-related hearing loss
This Phase 2 trial tests whether a cholesterol medicine called atorvastatin can protect hearing in people with head and neck cancer receiving cisplatin plus radiation. If it works, it may reduce the chance or severity of treatment-related hearing damage.
Atlanta, GeorgiaAges 18–100 - NCT04099290Recruiting
Blood DNA test in newly diagnosed head and neck cancer
This study looks at “circulating tumor DNA” (tumor DNA found in blood) in people with newly diagnosed, locally advanced head and neck squamous cell cancer. Researchers want to see how the blood DNA levels relate to the cancer and how it may guide treatment after surgery.
Chapel Hill, North CarolinaAges 18 years+ - NCT06444776Recruiting
Taste and saliva changes during radiotherapy for head & neck cancer
This study looks at how radiation therapy for head and neck cancer changes your sense of taste and saliva. It aims to better understand and manage these side effects.
Aarau, Canton of AargauAges 18 years+ - NCT07573956RecruitingPhase 2/Phase 3
Fast versus standard radiation after head and neck cancer surgery
This trial compares two different radiation schedules after surgery for head and neck cancer. One schedule delivers radiation faster over fewer weeks, while the other uses the standard approach. The study tests whether the faster schedule works just as well while potentially reducing side effects.
Jhajjar, HaryanaAges 18–80 - NCT03396718Recruiting
De-escalating radiation after HPV head and neck cancer surgery
This study looks at whether some people with HPV-positive throat/oropharynx cancer can safely receive a less intense form of radiation (and sometimes chemo) after surgery. It aims to reduce treatment burden while keeping the cancer under control, based on how high-risk the pathology looks.
Tübingen, Baden-WurttembergAges 18 years+ - NCT06163534Recruiting
Biomarker profiling study for advanced head and neck cancer patients
This study collects blood and tumor tissue samples to analyze biological markers in patients with advanced head and neck squamous cell carcinoma before starting immunotherapy. The goal is to better understand how these markers relate to treatment response.
Duarte, CaliforniaAges 18 years+ - NCT01985984Recruiting
Predicting outcomes after head and neck radiotherapy
This study looks at how outcomes may be predicted for people with head and neck cancer who receive radiotherapy. It may help doctors better estimate results and tailor follow-up care.
MaastrichtAges 18 years+ - NCT03632200Recruiting
Nutrition care plan after head and neck cancer surgery
This study tests a structured nutrition care plan for people after head and neck cancer surgery. It may help you maintain weight and nutrition during recovery so you can heal better.
AmiensAges 18–80 - NCT04729543RecruitingPhase 1/Phase 2
TCR cell therapy for melanoma and head and neck cancer
This early-phase study tests a lab-made T-cell treatment that targets a specific tumor marker (MC2) in melanoma and head and neck cancers. It aims to see if the treatment can safely shrink tumors and control cancer after standard options have run out.
RotterdamAges 18 years+ - NCT07807163RecruitingPhase 2
Study of ficerafusp alfa with pembrolizumab for head and neck cancer
This study tests a new drug called ficerafusp alfa combined with pembrolizumab (an immunotherapy) in people with head and neck cancer that has returned or spread. The drug targets a protein that may help the immune system fight the cancer. The study is comparing two different schedules of giving the drug to see which is better.
Fort Myers, FloridaAges 18 years+ - NCT07694726Recruiting
Vein repair during neck surgery to prevent lymphedema
This study tests whether repairing veins during head and neck cancer surgery helps prevent lymphedema (painful swelling) after treatment. It may help patients who are having lymph node removal and will receive radiation afterward.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT07492914RecruitingPhase 2
Study of pre-surgery drugs for head and neck cancer
This trial tests two medications given before surgery for head and neck cancer. The goal is to see if shrinking the tumor beforehand improves outcomes. If you have operable head and neck squamous cell cancer and are generally healthy, you may be eligible.
Chengdu, SichuanAges 18 years+ - NCT06773039Recruiting
Comparing treatment approaches for head and neck cancer after radiation
This study looks back at different treatment approaches for people with head and neck cancer who received radiation therapy at the S. Orsola Polyclinic. It aims to understand which strategies worked best, and may help improve future care.
BolognaAges 18 years+ - NCT06776900Recruiting
Breathing tube placement: side vs. back in children
This study compares two ways of placing a breathing tube (fiberoptic intubation) in children during surgery: lying on their side versus lying on their back. It aims to see which position is easier and safer for kids having non-head-and-neck surgeries.
CairoAges 2–10 - NCT07293013Recruiting
Olive oil mouthwash for mouth sores during cancer treatment
This study tests whether using an olive oil mouthwash can help prevent or reduce mouth sores caused by radiation and chemotherapy for head and neck cancer. If you are starting treatment, you may be able to join and receive the mouthwash to see if it helps keep your mouth healthier.
Chiayi City, Chia-Yi CityAges 20 years+ - NCT07189897RecruitingPhase 4
Apixaban vs. Enoxaparin for Blood Clot Prevention After Head and Neck Cancer Surgery
This study compares two blood-thinning medicines (apixaban pills vs. enoxaparin injections) to see which works better at preventing blood clots after head and neck cancer surgery. It may help you avoid dangerous clots without increasing bleeding risk.
Syracuse, New YorkAges 18–89 - NCT07190755Recruiting
Symptom tracking with a smartphone app for head and neck cancer
This trial uses a smartphone app to track your symptoms during radiation treatment for head and neck cancer. It aims to help your care team catch problems early and improve your quality of life.
RouenAges 18–75
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Common questions
- Are there clinical trials for head and neck?
- Yes. Clin2 currently lists 691 recruiting head and neck studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a head and neck trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a head and neck trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.