Clinical trials · Ohio
Heart failure clinical trials in Ohio
We’re tracking 66 recruiting heart failure studies with a site in Ohio — including Phase 2, Phase 2/Phase 3, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies in Ohio
- NCT06024746RecruitingPhase 3
Finerenone plus SGLT2i for hospitalized heart failure
This trial tests whether adding two heart medicines together (finerenone and an SGLT2 inhibitor) helps people who are in the hospital for heart failure recover better. It may be an option for you if you are currently hospitalized and your heart stress markers are high.
Centerville, OhioAges 18 years+ - NCT06935370RecruitingPhase 3
Testing vicadrostat with empagliflozin for heart failure with weak pump
This trial tests a new drug called vicadrostat combined with another drug, empagliflozin, for people with heart failure and a weak heart pump. It aims to see if this combination helps improve symptoms and outcomes.
Cleveland, OhioAges 18 years+ - NCT02901184RecruitingPhase 3
Spironolactone start study for heart failure with preserved pumping
This trial tests whether starting spironolactone helps people with heart failure symptoms when the heart pumps “preserved” (not severely reduced). Participants are assigned to start spironolactone or usual care so researchers can see if it improves outcomes.
Cincinnati, OhioAges 50–99 - NCT07436299Recruiting
New ultrasound method for heart pressure in atrial fibrillation
This study tests a new way to use ultrasound (echocardiogram) to measure heart pressure in people who have both heart failure and atrial fibrillation (irregular heartbeat). Participants will have an ultrasound and a heart catheterization to see if the new ultrasound method can accurately detect elevated pressures.
Cleveland, OhioAges 18 years+ - NCT06307652RecruitingPhase 3
Testing a new heart failure and kidney treatment combo
This study tests a new combination of two medicines (balcinrenone and dapagliflozin) for people with heart failure and reduced kidney function. The goal is to see if this combination helps improve heart and kidney health better than current treatments.
Cincinnati, OhioAges 18–130 - NCT07761117RecruitingPhase 3
Heart failure treatment study for people with preserved pumping function
This study tests an investigational medication called elecoglipron to see if it can improve heart and blood vessel outcomes in people with heart failure with preserved or mildly reduced ejection fraction. If you join, you will receive either the study drug or a placebo, and your heart health will be monitored over time.
Dayton, OhioAges 18 years+ - NCT05996328Recruiting
Healthy meals for veterans with heart failure
This study tests whether providing healthy meals to veterans recently hospitalized for heart failure can improve their health and reduce the chance of going back to the hospital. Participants will receive meals at home for a period of time.
Cleveland, OhioAges 60 years+ - NCT06174103Recruiting
BiVACOR total artificial heart early feasibility study
This study tests a new total artificial heart called BiVACOR for people with severe heart failure that cannot be helped by standard pumps. It is designed to keep you alive while you wait for a heart transplant.
Cincinnati, OhioAges 18–70 - NCT07795814RecruitingPhase 2
Study of a new medicine for heart failure with preserved pumping function
This study tests an investigational medicine called EDG-15400 for people with a type of heart failure where the heart muscle is stiff and doesn't relax properly, even though the pumping function is normal. The goal is to see if the medicine improves symptoms and daily functioning.
Cincinnati, OhioAges 30–84 - NCT07184541Recruiting
Nurse-led weight monitoring for heart failure quality of life
This study tests a nurse-led program where you weigh yourself daily at home to help manage your heart failure. It aims to improve your quality of life and your ability to care for yourself.
Avon, OhioAges 55 years+ - NCT07192952RecruitingPhase 3
Long-term safety of finerenone for children with heart failure
This trial tests a medicine called finerenone to see if it is safe for children and young adults with heart failure when taken for a long time. It may help improve heart function and manage symptoms.
Cincinnati, OhioAges Up to 18 years - NCT07188805RecruitingPhase 3
Finerenone for children with heart failure
This study tests a medicine called finerenone in children with heart failure. It looks at whether finerenone helps the heart work better and is safe compared to a placebo (a dummy pill), when taken with the usual heart-failure medicines.
Cincinnati, OhioAges 6 months–17 years - NCT06677060RecruitingPhase 3
Study of baxdrostat plus dapagliflozin for heart risk in type 2 diabetes
This study tests whether a new drug called baxdrostat, when added to the diabetes medicine dapagliflozin (Farxiga), can prevent heart failure and heart-related death in people with type 2 diabetes, high blood pressure, and existing heart or blood vessel disease. You may be able to join if you have type 2 diabetes, heart or blood vessel disease, high blood pressure, and at least one extra risk factor for heart failure.
Canton, OhioAges 40 years+ - NCT05714085RecruitingPhase 2/Phase 3
Vericiguat study for children with heart failure
This trial tests whether vericiguat helps children with chronic heart failure caused by weaker left heart pumping. It also checks safety and how the medicine behaves in the body (dose and processing).
Cincinnati, OhioAges 4 weeks–17 years - NCT07081711Recruiting
Testing new heart MRI technology in volunteers
This study is testing a new way to take pictures of the heart using MRI. It is looking for healthy volunteers to help make sure the technology works correctly.
Cleveland, OhioAges 18 years+ - NCT05654272Recruiting
Testing CIRC imaging technology for people with heart problems
This study is developing and testing CIRC technologies using heart imaging. You may be able to join if you’re an adult with cardiovascular (heart) disease and can safely have the MRI scans.
Cleveland, OhioAges 18 years+ - NCT06678841Recruiting
Pacing therapy for heart failure with preserved pumping ability
This study tests a new pacing approach for people with a specific type of heart failure (HFpEF) to see if it can improve symptoms and quality of life. It involves a pacemaker-like device that adjusts heart rate based on your needs.
Columbus, OhioAges 40 years+ - NCT06898515Recruiting
Fluid removal study for acute heart failure patients
This trial tests a device designed to safely remove extra fluid from patients hospitalized with worsening heart failure. It may help those who are not responding well to standard water pills (diuretics).
Cincinnati, OhioAges 22 years+ - NCT06033950RecruitingPhase 3
A study of finerenone for heart failure patients who can't take standard MRA drugs
This study tests whether finerenone, a new type of drug, can help people with heart failure who cannot take standard steroid-based MRAs (a kind of heart medication) because of side effects or other reasons. It aims to see if it improves symptoms and is safe for you.
Akron, OhioAges 18 years+ - NCT05919342Recruiting
Screening for early heart failure in primary care or at home
This trial tests whether simple screening using a blood test (natriuretic peptides) plus an ultrasound of the heart (echocardiogram) can find early heart failure sooner. Finding it earlier may help doctors start the right management to prevent it from getting worse.
Cleveland, OhioAges 40 years+ - NCT06217302RecruitingPhase 3
Sotagliflozin for kidney protection in type 1 diabetes
This study tests whether sotagliflozin (a pill that helps control blood sugar and protects the kidneys) can slow down kidney function decline in people with type 1 diabetes and diabetic kidney disease. You may qualify if you have had type 1 diabetes for at least 8 years, have moderate kidney damage, and are on standard treatments.
Cleveland, OhioAges 18–75 - NCT07131631Recruiting
MitraClip for leaky heart valve in heart failure patients
This trial tests if the MitraClip device helps people with heart failure and a leaky mitral valve. It uses a special MRI to check how the heart responds to treatment.
Cincinnati, OhioAges 18 years+ - NCT04191681RecruitingPhase 4
Testing ARNI in people with implanted LVAD devices
This trial studies whether a heart medicine called ARNI (sacubitril-valsartan) is safe and works well for people who have a durable LVAD and moderate-to-severe heart pumping weakness. It may help improve symptoms and outcomes, while carefully checking side effects in this higher-risk group.
Cleveland, OhioAges 18 years+ - NCT03523416Recruiting
Shunt device for heart failure with reduced pumping function
This trial studies a small device placed in the heart to create a passage that may help relieve pressure and improve symptoms in people with heart failure and a weak pumping function. It aims to see if the device is safe and helpful for daily life.
Cincinnati, OhioAges 18 years+
Heart failure trials by city in Ohio
Where these studies are running in Ohio
Institutions with a site for the recruiting heart failure studies listed above.
- Cleveland Clinic · 5 studies
- Research Site · 3 studies
- Cincinnati Children's Hospital Medical Center · 2 studies
- Cleveland Clinic Children's · 2 studies
- Nationwide Children's Hospital · 2 studies
- The Christ Hospital · 2 studies
- The Ohio State University Wexner Medical Center · 2 studies
- Cardiovascular Innovation Research Center
What taking part in a heart failure study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Heart failure trials in other states
Common questions
- Are there heart failure clinical trials in Ohio?
- Yes. We're currently tracking 66 recruiting heart failure studies with a site in Ohio, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a heart failure study in Ohio?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Ohio to take part?
- Not necessarily. These studies have a site in Ohio, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a heart failure trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New heart failure studies open in Ohio regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.