Clinical trials · Cleveland, OH
Heart failure clinical trials in Cleveland
We’re tracking 42 recruiting heart failure studies with a site in or near Cleveland — including Phase 1, Phase 2/Phase 3, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies near Cleveland
- NCT05180773RecruitingPhase 4
Bromocriptine for new postpartum heart weakness
This trial studies whether bromocriptine improves health outcomes in people recently diagnosed with peripartum cardiomyopathy (a weakened heart during late pregnancy or soon after delivery). You may be asked about timing after childbirth, heart strength tests, and whether you plan to keep breastfeeding.
Cleveland, OhioAges 18 years+ - NCT05627440Recruiting
Protein diet program to improve muscle strength in heart failure
This trial tests whether adding dietary protein can help skeletal muscles recover and function better in people living with heart failure. It may help with strength, muscle wasting, and overall ability to do daily activities.
Cleveland, OhioAges 18–100 - NCT06736574RecruitingPhase 3
Study of omecamtiv mecarbil for chronic heart failure with very weak heart pump
This study tests an investigational medicine (omecamtiv mecarbil) for people with chronic heart failure and very low pumping strength. It looks at whether the drug can help prevent heart failure events or the need for stronger treatments.
Cleveland, OhioAges 18–85 - NCT06310031Recruiting
Testing BrioVAD heart pump for severe heart failure
This trial tests a new left-ventricular assist device (LVAD) called BrioVAD for people with advanced heart failure who are not getting enough benefit from medicines. If you qualify, the device is implanted to help your heart pump blood.
Cleveland, OhioAges 18–100 - NCT07219511RecruitingPhase 1
Safety study of VS-041 for heart failure with preserved pumping strength
This trial tests an investigational drug called VS-041 to see if it's safe and helps people with a type of heart failure where the heart pumps well but doesn't relax properly (HFpEF). It may be an option if you are 50 or older and have stable heart failure symptoms.
Cleveland, OhioAges 50 years+ - NCT05427370Recruiting
Compare bypass or stent treatment in weak heart patients
This study compares two ways to restore blood flow to the heart—bypass surgery (CABG) or stent procedure (PCI)—in people with a weak pumping heart. It looks at which approach works best when the heart muscle is not pumping well and there are multiple blocked heart arteries.
Cleveland, OhioAges 18 years+ - NCT07214376Recruiting
Nerve ablation for pulmonary hypertension from left heart disease
This trial tests a device that uses a catheter to deliver energy to nerves around the pulmonary arteries, aiming to reduce high blood pressure in the lungs caused by left heart failure. It is for people with ongoing heart failure symptoms despite optimal medications.
Cleveland, OhioAges 18–85 - NCT05919342Recruiting
Screening for early heart failure in primary care or at home
This trial tests whether simple screening using a blood test (natriuretic peptides) plus an ultrasound of the heart (echocardiogram) can find early heart failure sooner. Finding it earlier may help doctors start the right management to prevent it from getting worse.
Cleveland, OhioAges 40 years+ - NCT06378632Recruiting
Heart failure monitoring app study
This study tests a smartphone app that listens to your voice to detect early signs of heart failure worsening. It aims to help you avoid hospital stays by catching problems sooner.
Cleveland, OhioAges 22 years+ - NCT05714085RecruitingPhase 2/Phase 3
Vericiguat study for children with heart failure
This trial tests whether vericiguat helps children with chronic heart failure caused by weaker left heart pumping. It also checks safety and how the medicine behaves in the body (dose and processing).
Cleveland, OhioAges 4 weeks–17 years - NCT06849752Recruiting
Early heart failure screening for high-risk patients
This trial checks for early signs of heart failure in people who have multiple risk factors. It will use blood tests, a wearable device, and a handheld ultrasound to find any changes early, so treatment can start quickly.
Cleveland, OhioAges 40 years+ - NCT05650307Recruiting
Heart and metabolic scan study of weight and rehabilitation
This study uses detailed heart scans and information about metabolism (how your body uses energy) to understand how metabolic treatments and heart rehabilitation may affect your health. You may qualify either as someone undergoing bariatric (weight-loss) care or as part of a heart rehabilitation group—or as a healthy comparison group.
Cleveland, OhioAges 18 years+ - NCT07207811RecruitingPhase 3
Coramitug for heart failure caused by ATTR amyloidosis
This trial tests a new medicine called Coramitug for people with heart failure due to ATTR amyloidosis, a condition where abnormal proteins build up in the heart. The study aims to see if Coramitug can improve heart function and quality of life.
Cleveland, OhioAges 18 years+ - NCT04191681RecruitingPhase 4
Testing ARNI in people with implanted LVAD devices
This trial studies whether a heart medicine called ARNI (sacubitril-valsartan) is safe and works well for people who have a durable LVAD and moderate-to-severe heart pumping weakness. It may help improve symptoms and outcomes, while carefully checking side effects in this higher-risk group.
Cleveland, OhioAges 18 years+ - NCT06898515Recruiting
Fluid removal study for acute heart failure patients
This trial tests a device designed to safely remove extra fluid from patients hospitalized with worsening heart failure. It may help those who are not responding well to standard water pills (diuretics).
Cleveland, OhioAges 22 years+ - NCT06526195Recruiting
A study of CardioMEMS and HeartMate 3 for advanced heart failure
This trial tests if a combination of a tiny lung-artery pressure sensor (CardioMEMS) and a mechanical heart pump (HeartMate 3) is safe and effective for people with advanced heart failure. If you qualify, you'll either get the heart pump plus standard medical therapy, or continue with standard therapy alone and have your pressure monitored remotely.
Cleveland, OhioAges 18 years+ - NCT07098858Recruiting
Registry for WiSE heart device patients
This registry collects safety and performance data for the WiSE System, a device to pace the heart from inside a chamber. If you or your doctor plan to use the WiSE System, this study may help track how well it works in real patients.
Cleveland, OhioAges 22 years+ - NCT07131631Recruiting
MitraClip for leaky heart valve in heart failure patients
This trial tests if the MitraClip device helps people with heart failure and a leaky mitral valve. It uses a special MRI to check how the heart responds to treatment.
Cleveland, OhioAges 18 years+ - NCT07081711Recruiting
Testing new heart MRI technology in volunteers
This study is testing a new way to take pictures of the heart using MRI. It is looking for healthy volunteers to help make sure the technology works correctly.
Cleveland, OhioAges 18 years+ - NCT07188805RecruitingPhase 3
Finerenone for children with heart failure
This study tests a medicine called finerenone in children with heart failure. It looks at whether finerenone helps the heart work better and is safe compared to a placebo (a dummy pill), when taken with the usual heart-failure medicines.
Cleveland, OhioAges 6 months–17 years - NCT06812533Recruiting
Testing a new approach for heart failure with weak pump
This study tests a new device or procedure to help people with heart failure and a weak heart pump. If you have a low ejection fraction and are on standard medications, you may be able to join.
Cleveland, OhioAges 18 years+ - NCT00271180Recruiting
Tracks long-term performance of Medtronic heart devices
This study follows how well certain Medtronic heart devices work over the long term. You may be included if you have a qualifying Medtronic implant and the research team can reliably get your implant and follow-up information.
Cleveland, OhioAges Any age - NCT07567001RecruitingPhase 3
Testing NNC0487-0111 for Heart Failure and Obesity
This study tests whether a new medication called NNC0487-0111 can help people with heart failure who also have obesity. Researchers will compare it to a placebo (inactive pill) to see if it improves heart function and overall health.
Cleveland, OhioAges 18 years+ - NCT05650658Recruiting
Compare two heart pacing options in people with weak heart function
This trial compares two types of “left-side” heart pacing to see which one works better in people with weak heart pumping. It may help guide the best pacing choice for improving heart function and symptoms.
Cleveland, OhioAges 18 years+
Hear when a new Heart failure trial opens near Cleveland, OH
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Heart failure trials in other cities
Where these studies are running near Cleveland
Institutions with a site for the recruiting heart failure studies listed above.
- Cleveland Clinic · 14 studies
- University Hospitals Cleveland Medical Center · 3 studies
- Cleveland Clinic Foundation · 2 studies
- Cardiovascular Innovation Research Center
- Cleveland Clinic - Taussig Cancer Institute
- Cleveland Clinic Children's
- Cleveland Clinic-Cleveland Clinic Chidren's ( Site 0022)
- Louis Stokes Clvlnd VA Med Ctr
What taking part in a heart failure study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Looking wider? See all recruiting heart failure studies in Ohio.
Common questions
- Are there heart failure clinical trials near Cleveland?
- Yes. We're currently tracking 42 recruiting heart failure studies with a site near Cleveland, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a heart failure study near Cleveland?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Cleveland to take part?
- Not necessarily. These studies have a site near Cleveland, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a heart failure trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New heart failure studies open near Cleveland regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.