Clinical trials · Pennsylvania
Heart failure clinical trials in Pennsylvania
We’re tracking 56 recruiting heart failure studies with a site in Pennsylvania — including Phase 3 studies, each written for real people, not researchers.
Recruiting studies in Pennsylvania
- NCT07214376Recruiting
Nerve ablation for pulmonary hypertension from left heart disease
This trial tests a device that uses a catheter to deliver energy to nerves around the pulmonary arteries, aiming to reduce high blood pressure in the lungs caused by left heart failure. It is for people with ongoing heart failure symptoms despite optimal medications.
Mechanicsburg, PennsylvaniaAges 18–85 - NCT06736574RecruitingPhase 3
Study of omecamtiv mecarbil for chronic heart failure with very weak heart pump
This study tests an investigational medicine (omecamtiv mecarbil) for people with chronic heart failure and very low pumping strength. It looks at whether the drug can help prevent heart failure events or the need for stronger treatments.
Camp Hill, PennsylvaniaAges 18–85 - NCT07251894Enrolling by invitation
Meals after heart failure hospitalization
This study provides medically tailored meals to people recently hospitalized with heart failure to see if they help recovery. It is testing whether having healthy meals delivered can improve how patients feel and reduce the chance of being readmitted to the hospital.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06310031Recruiting
Testing BrioVAD heart pump for severe heart failure
This trial tests a new left-ventricular assist device (LVAD) called BrioVAD for people with advanced heart failure who are not getting enough benefit from medicines. If you qualify, the device is implanted to help your heart pump blood.
Philadelphia, PennsylvaniaAges 18–100 - NCT07574593Recruiting
Heart Failure Sensor Implant Study
This study tests a small sensor placed in a vein to help monitor and manage heart failure. The sensor tracks fluid buildup in your heart and may help doctors adjust your treatment to keep you feeling better and out of the hospital.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07069738Recruiting
New pacemaker vs standard cardiac therapy for heart failure
This study tests a newer type of pacemaker that paces the heart's left bundle branch area, compared to the usual cardiac resynchronization therapy. It is for people with heart failure who need a combined pacemaker-defibrillator (CRT-D) and have a specific heart rhythm pattern (left bundle branch block) with reduced pumping strength.
Philadelphia, PennsylvaniaAges 18 years+ - NCT05677100Recruiting
Aortix device for acute heart failure
This trial is testing a small pump placed in the aorta to help the kidneys remove extra fluid when standard IV diuretics aren't working well enough for severe heart failure. It may help you if you're hospitalized and still very congested (swollen, fluid buildup) despite strong water pills.
Abington, PennsylvaniaAges 21 years+ - NCT06552637Recruiting
Diaphragm stimulation for heart failure
This trial tests a device that stimulates your diaphragm (the muscle that helps you breathe) while you have heart failure. It may help improve your breathing and heart function. The study is for people with moderate heart failure symptoms whose heart pumps less blood than normal.
Philadelphia, PennsylvaniaAges 18 years+ - NCT05064709Recruiting
Test device for heart failure symptoms in some patients
This study tests whether a heart-related device called CCM can improve symptoms and daily function in people with heart failure and a moderately reduced pumping strength. It may help if you’ve had recent heart-failure-related hospital care or urgent treatment and your heart and overall health fit the study limits.
Bryn Mawr, PennsylvaniaAges 18 years+ - NCT05650658Recruiting
Compare two heart pacing options in people with weak heart function
This trial compares two types of “left-side” heart pacing to see which one works better in people with weak heart pumping. It may help guide the best pacing choice for improving heart function and symptoms.
Lancaster, PennsylvaniaAges 18 years+ - NCT05873634Recruiting
Using health records and testing to study heart failure types
This study combines electronic health record data and detailed heart testing to better understand different heart failure types and what treatments may work best for each. It mainly enrolls people with known heart failure, and also some people without heart failure for comparison.
Philadelphia, PennsylvaniaAges 30 years+ - NCT05934487Recruiting
Monitoring device trial for stable heart failure symptoms
This trial tests whether a wearable home monitoring system (myCordella™) can help people with moderate heart failure (NYHA class II or III) by tracking heart pressure and supporting follow-up care. It may help detect changes earlier so clinicians can adjust treatment sooner.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT06517186Recruiting
Heart failure study with preserved pumping function
This study looks at how the heart muscle works in people with a type of heart failure where the heart pumps normally but doesn't fill properly. It aims to understand the cause better, which could lead to new treatments.
Philadelphia, PennsylvaniaAges 30 years+ - NCT06526195Recruiting
A study of CardioMEMS and HeartMate 3 for advanced heart failure
This trial tests if a combination of a tiny lung-artery pressure sensor (CardioMEMS) and a mechanical heart pump (HeartMate 3) is safe and effective for people with advanced heart failure. If you qualify, you'll either get the heart pump plus standard medical therapy, or continue with standard therapy alone and have your pressure monitored remotely.
Hershey, PennsylvaniaAges 18 years+ - NCT06008197RecruitingPhase 3
A study of finerenone for hospitalized heart failure patients
This trial tests a medication called finerenone to see if it helps people hospitalized for heart failure live longer and have fewer heart-related problems. It may be an option for those with a certain type of heart failure where the heart's pumping strength is mildly reduced or normal.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07037459RecruitingPhase 3
A study of a new drug for heart failure with obesity
This trial tests a medication called maridebart cafraglutide for people with heart failure (where the heart doesn't pump as well as it should) and obesity. The goal is to see if it can help improve symptoms and outcomes.
Horsham, PennsylvaniaAges 18–99 - NCT03142152Recruiting
Mitral valve implant for heart failure with leaky mitral valve
This trial tests whether a device called the Carillon Mitral Contour System can help people with heart failure caused by a mild-to-moderate leaky mitral valve. You’d be compared against a control group, and the goal is to improve heart failure symptoms and outcomes.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT05610787Enrolling by invitation
Testing a device that helps move an EXCOR pediatric heart pump
This trial studies an “active driving” system that controls the EXCOR pediatric heart pump. It’s meant for children who need a heart pump as a bridge to heart transplantation, to help the pump work more safely and effectively.
Philadelphia, PennsylvaniaAges Up to 21 years - NCT06222099Recruiting
Heartfelt study for chronic heart failure with swelling and adherence challenges
This trial tests a program to help people with chronic heart failure who have swelling in their feet and legs and struggle to follow their care plan. It aims to reduce hospital visits by improving daily monitoring and medication use.
Bala-Cynwyd, PennsylvaniaAges 22 years+ - NCT07166965Enrolling by invitation
Supplement for Heart Failure: Ketones and Hawthorn
This trial tests whether adding a supplement containing ketones and hawthorn extract can help people with heart failure feel better and improve their heart function. You will take the supplement daily and have imaging scans and exercise tests to monitor your progress.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07009132Recruiting
Liver function test for adults with Fontan or heart failure
This study tests a simple liver function test (called dual cholate clearance) to see how well it works in adults with a Fontan circulation or right heart failure. It aims to help doctors better detect liver problems in these heart conditions.
Philadelphia, PennsylvaniaAges 18 years+ - NCT04141605Enrolling by invitation
Heart transplant candidates matched for better heart preservation
This study creates a worldwide registry and information database to help improve how donor hearts are preserved for transplant. If you are a heart transplant candidate, your details may be recorded to see what matching and preservation approaches work best.
State College, PennsylvaniaAges Any age - NCT07567001RecruitingPhase 3
Testing NNC0487-0111 for Heart Failure and Obesity
This study tests whether a new medication called NNC0487-0111 can help people with heart failure who also have obesity. Researchers will compare it to a placebo (inactive pill) to see if it improves heart function and overall health.
Camp Hill, PennsylvaniaAges 18 years+ - NCT06935370RecruitingPhase 3
Testing vicadrostat with empagliflozin for heart failure with weak pump
This trial tests a new drug called vicadrostat combined with another drug, empagliflozin, for people with heart failure and a weak heart pump. It aims to see if this combination helps improve symptoms and outcomes.
Yardley, PennsylvaniaAges 18 years+
Heart failure trials by city in Pennsylvania
Where these studies are running in Pennsylvania
Institutions with a site for the recruiting heart failure studies listed above.
- University of Pennsylvania · 11 studies
- Thomas Jefferson University Hospital · 7 studies
- University of Pittsburgh Medical Center · 4 studies
- Penn Medicine Lancaster General Health · 3 studies
- Penn Presbyterian Medical Center · 3 studies
- Allegheny General Hospital · 2 studies
- Allegheny Health Network · 2 studies
- Penn State Milton S Hershey Medical Center · 2 studies
What taking part in a heart failure study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Heart failure trials in other states
Common questions
- Are there heart failure clinical trials in Pennsylvania?
- Yes. We're currently tracking 56 recruiting heart failure studies with a site in Pennsylvania, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a heart failure study in Pennsylvania?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Pennsylvania to take part?
- Not necessarily. These studies have a site in Pennsylvania, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a heart failure trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New heart failure studies open in Pennsylvania regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.