Clinical trials
Heart failure clinical trials
A condition where the heart can’t pump blood as well as it should. We’re tracking 949 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07237451Recruiting
Heart and kidney study of SGLT2 inhibitors
This study looks at whether a type of diabetes medicine called SGLT2 inhibitors (also known as flozins) can help protect the heart and kidneys in people with both heart failure with preserved pumping function and moderate chronic kidney disease, with or without diabetes.
IașiAges 18 years+ - NCT07223242RecruitingPhase 2/Phase 3
Tailored exercise training for heart failure with preserved pumping strength
This trial tests a personalized exercise program to help people with a type of heart failure called HFpEF. You may qualify if your heart still pumps well but you have trouble being active, and you are willing to use a phone app and exercise regularly.
Dallas, TexasAges 18 years+ - NCT01757730Recruiting
MRI test to measure soft tissue stiffness
This trial uses a special type of MRI to estimate how stiff certain soft tissues are in the body. You may benefit by helping doctors better measure tissue stiffness, which can relate to different health problems.
Columbus, OhioAges 18 years+ - NCT04680442RecruitingPhase 2
Keeping HER2 therapy when your heart function is weaker
This trial studies whether it’s safe to continue HER2-targeted breast cancer treatment (like trastuzumab, pertuzumab, or T-DM1) even when heart function (left ventricle) is reduced. It may help people avoid stopping a helpful cancer medicine because of heart concerns.
Porto Alegre, Rio Grande do SulAges Any age - NCT07215715Recruiting
Heart ultrasound study for older adults with heart failure
This study uses a special ultrasound to measure heart stiffness in people 60 and older who have heart failure with preserved or mildly reduced pumping function, with or without a condition called ATTR amyloidosis (a protein buildup in the heart). It also includes healthy controls.
Boston, MassachusettsAges 60 years+ - NCT07217392Recruiting
Study on pacing the left bundle branch area of the heart
This study tests a new way to place a pacemaker lead in the left bundle branch area of the heart. It may help people who need a pacemaker to see if this approach is safe and works well.
Rio de Janeiro, Rio de JaneiroAges 18 years+ - NCT07210606RecruitingPhase 4
Sleep apnea treatment study for veterans with heart failure
This study looks at how well a medicine called trazodone might help treat central sleep apnea in veterans who also have heart failure. It aims to improve sleep and breathing, which may help you feel better.
Detroit, MichiganAges 18 years+ - NCT07207811RecruitingPhase 3
Coramitug for heart failure caused by ATTR amyloidosis
This trial tests a new medicine called Coramitug for people with heart failure due to ATTR amyloidosis, a condition where abnormal proteins build up in the heart. The study aims to see if Coramitug can improve heart function and quality of life.
Phoenix, ArizonaAges 18 years+ - NCT07206602Recruiting
AI-guided left bundle branch pacing
This trial tests a new way to place a pacemaker lead in the heart's left bundle branch area, guided by artificial intelligence. It aims to improve heart function in people with heart failure who need pacing.
Rochester, MinnesotaAges 18 years+ - NCT07191730Recruiting
Heart risk prediction for cancer patients on certain chemotherapies
This trial uses a special scoring system (ML Score) to predict if you might develop heart problems while receiving anthracycline chemotherapy or HER2-targeted therapies. It helps doctors decide on the best heart monitoring plan before starting treatment.
CaenAges 18 years+ - NCT07180368Recruiting
Managing multiple medications in older adults
This study looks at how to better manage multiple medications in older adults with long-term health conditions. It aims to improve safety and reduce drug-related problems.
Xi'an, ShaanxiAges 65 years+ - NCT07173348Recruiting
Hypnosis for managing severe breathlessness
This study tests whether hypnosis sessions can help you feel more in control of your breathlessness. If you have a chronic lung or heart condition and struggle with shortness of breath, you may be able to join a series of 3 hypnosis visits to see if it improves your daily life.
Geneva, Canton of GenevaAges 18 years+ - NCT07159269Recruiting
Cardiac ultrasound training for emergency department providers
This study teaches nurse practitioners and physician assistants in the emergency department how to use a special type of heart ultrasound (called cardiac point-of-care ultrasound). The goal is to help these providers quickly and accurately check the heart at the bedside.
Durham, North CarolinaAges 18 years+ - NCT07158450Enrolling by invitation
Heart health check for cancer patients
This trial tests a new device that monitors heart health during cancer treatment. It uses a simple on-body sensor alongside your regular echocardiogram to see if it can detect heart changes early.
Golden, ColoradoAges 18 years+ - NCT07145138Recruiting
Multi-ethnic dilated cardiomyopathy registry
This study is a registry for people with dilated cardiomyopathy (DCM)—a condition where the heart's main pumping chamber becomes enlarged and weak. It aims to learn more about DCM, especially in people from different ethnic backgrounds, by collecting health information over time.
Chicago, IllinoisAges 18 years+ - NCT07147114RecruitingPhase 4
Combined macitentan and dapagliflozin for heart failure with lung high blood pressure
This trial tests whether adding two medications—macitentan and dapagliflozin—together is safe and effective for people with heart failure and a certain type of high blood pressure in the lungs. It might help improve your symptoms and daily function.
BusanAges 19 years+ - NCT07118488Recruiting
New ablation approach for persistent atrial fibrillation with heart issues
This study tests a new way to treat long-lasting atrial fibrillation using focused energy (pulse field ablation) guided by special heart mapping. It may help people who have not improved with medications or have other heart problems like heart failure.
Madrid, MadridAges 18–80 - NCT07112924Recruiting
CCM Heart Device Registry Study
This registry study follows patients who have or will get a CCM device to see how well it works and how safe it is over time. It helps doctors learn more about improving heart function in people with heart failure.
Mesa, ArizonaAges 18 years+ - NCT07111585Recruiting
Personal health coaching for heart failure patients
This study tests whether personalized health coaching helps people who are frail and have been hospitalized for heart failure. If you are 40 or older, recently in the hospital for heart failure, and feeling weak or vulnerable, this program may support your recovery.
IncheonAges 40 years+ - NCT07105007Recruiting
Heart health program for older adults living with HIV
This study tests a special program to help people living with HIV improve their heart health through activity and healthy habits. If you have early signs of heart trouble and are not currently very active, this support may help you feel better and reduce your risk.
Seattle, WashingtonAges 40 years+ - NCT07096544Recruiting
Using a lung artery sensor to guide LVAD care
This study tests whether a small sensor (CardioMEMS) implanted in the lung artery can help doctors better manage LVAD settings and reduce hospital visits. It is for people who already have a HeartMate 3 heart pump and are stable enough to go home.
Plano, TexasAges 21–85 - NCT07098858Recruiting
Registry for WiSE heart device patients
This registry collects safety and performance data for the WiSE System, a device to pace the heart from inside a chamber. If you or your doctor plan to use the WiSE System, this study may help track how well it works in real patients.
Mesa, ArizonaAges 22 years+ - NCT07094919Recruiting
Corheart 6 heart pump long-term study
This study follows people who have already received the Corheart 6 heart pump to see how well it works over time. You may qualify if you have severe heart failure that doesn't improve with standard treatments and you got the pump after October 1, 2021.
Shenzhen, GuangdongAges 18 years+ - NCT07087613Recruiting
Detecting heart and lung pressure problems with a smart stethoscope
This study tests if a digital stethoscope and a simple 3-lead ECG (heart rhythm test) can detect two heart conditions: high blood pressure in the lungs (pulmonary hypertension) and low pumping strength of the heart (low ejection fraction). It's intended for adults who recently had a heart ultrasound or a heart catheterization.
O'Fallon, IllinoisAges 18 years+
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Common questions
- Are there clinical trials for heart failure?
- Yes. Clin2 currently lists 949 recruiting heart failure studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a heart failure trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a heart failure trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.