Clinical trials
HIE clinical trials
Below are recruiting hie clinical trials, each written for real people, not researchers. We’re tracking 22 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06747260RecruitingEarly Phase 1
Breast milk through the nose for HIE
This trial tests whether giving fresh breast milk through the nose is safe and possible for newborns with HIE (a brain injury from oxygen loss at birth) who are already receiving cooling therapy. It may help protect the brain and reduce injury.
BudapestAges Up to 2 days - NCT06762795Recruiting
Gene study for newborns with HIE on cooling therapy
This study uses whole genome sequencing to look at the genes of newborns with HIE (brain injury from lack of oxygen) who are receiving cooling treatment. The goal is to learn more about how genes may affect recovery and outcomes.
Houston, TexasAges birth–1 year - NCT07264166Enrolling by invitation
Gene therapy trial for cerebral palsy and HIE
This trial tests a gene therapy given as a nose spray for people with cerebral palsy or HIE. It aims to see if the treatment is safe and helps improve movement over two years.
Monterrey, Nuevo LeónAges 2–65 - NCT05443321Enrolling by invitation
Health information sharing during hospital transfers
This trial studies whether sharing patients’ health information between hospitals during transfers can improve outcomes. You may be included if you are moved from a specific partner hospital to Brigham and Women’s Hospital and admitted to certain hospital units.
Boston, MassachusettsAges 18 years+ - NCT07262983RecruitingPhase 1
Baricitinib for Job syndrome with lupus or eczema
This study tests if baricitinib, a pill that changes how your immune system works, is safe and tolerable for people with Job syndrome who also have lupus-like disease or severe eczema. It might offer a new treatment option for these skin and immune problems.
Bethesda, MarylandAges 12–120 - NCT04621279Recruiting
Cooling treatment study for babies with mild brain injury
This study compares different approaches to “cooling” treatment in newborns with mild hypoxic-ischemic encephalopathy (mild brain injury from not enough oxygen around birth). The goal is to see which approach works best and is safest for babies like yours.
Dallas, TexasAges 8 months+ - NCT06195345Recruiting
Brain oxygen study for children having an MRI
This study looks at oxygen levels in the brains of children and young adults (birth to 18 years) during a standard MRI. The goal is to learn more about how the brain works, and it only adds a few minutes to your child's regular MRI scan.
Los Angeles, CaliforniaAges 1 minute–18 years - NCT06563687Recruiting
Continuous glucose monitoring for HIE newborns
This study tests a continuous glucose monitor (CGM) in newborns with hypoxic-ischemic encephalopathy (HIE) — a type of brain injury from lack of oxygen around birth. The CGM tracks sugar levels to help doctors manage care better.
AvellinoAges Up to 6 hours - NCT06643598Recruiting
Virtual and lived-experience support for newborns with brain challenges
This study tests whether a program that combines virtual support and a peer who has been through it can help parents of newborns with certain brain conditions. It is designed for families living in rural areas and aims to improve children's recovery.
Madison, WisconsinAges Up to 5 years - NCT06746532RecruitingEarly Phase 1
Breast milk nose drops for brain injury in newborns
This trial tests whether giving fresh breast milk as nose drops can help newborns with brain injury from lack of oxygen. It aims to see if this simple treatment can improve brain recovery.
BudapestAges Up to 2 days - NCT06855108RecruitingPhase 3
Caffeine for newborn brain injury after oxygen loss
This trial tests if giving caffeine to newborns who had low oxygen at birth can help protect their brains. It compares caffeine plus standard care to placebo plus standard care for moderate to severe hypoxic ischemic encephalopathy (HIE).
SaidpurAges Up to 6 hours - NCT06857539Recruiting
Assessing thinking and movement in high-risk infants
This study looks at how high-risk infants (especially those born early or with brain concerns) develop their thinking and movement skills over time, comparing them to healthy babies. The goal is to better understand and support their development.
CorkAges birth–4 months - NCT07136636Recruiting
Speech development in kids treated for brain injury at birth
This study looks at how children who had a brain injury around birth (HIE) and received cooling therapy are developing speech. It may help families understand language outcomes after this treatment.
BudapestAges birth–7 years - NCT07165938Recruiting
Genetics of newborn brain injury study
This study looks for genes that may cause or increase the risk of brain injury in newborns. It may help researchers understand why some babies develop encephalopathy and could lead to better treatments in the future.
Boston, MassachusettsAges Any age - NCT07275021Recruiting
Brain Injury & Vision Screening in Newborns
This study looks for early signs of vision problems in babies who had brain injuries around the time of birth. It aims to help doctors better identify and predict these issues.
Boston, MassachusettsAges 7 months–10 months - NCT00006150Recruiting
Understanding Hyper-IgE Syndrome: Natural History and Genetics
This study follows people with or suspected Hyper-IgE syndrome (a rare immune disorder causing repeated infections and skin problems) to understand how the condition develops, how best to manage it, and which genes are involved. Researchers also welcome healthy relatives of patients to help identify genetic patterns.
Bethesda, MarylandAges 1 month–120 years - NCT02664831Recruiting
Study of inflammation after cardiac arrest in ICU patients
This trial looks at how the body’s inflammation response behaves after someone has a cardiac arrest and was treated in the ICU. It may help doctors understand which patients could benefit from treatments that target harmful inflammation after resuscitation.
Portland, MaineAges 18 years+ - NCT02621944RecruitingEarly Phase 1
Melatonin for newborns with brain injury after oxygen problems
This early study tests whether giving melatonin to newborns with hypoxic-ischemic encephalopathy (brain injury from not enough oxygen around birth) can help protect the brain while they are cooled (therapeutic hypothermia). It may be most relevant if your baby shows early brain-injury signs and meets specific blood test and birth-history timing criteria.
Gainesville, FloridaAges Up to 6 hours - NCT07413900Recruiting
Brain injury study for babies and toddlers
This study looks at biomarkers (biological signs) in infants who had a brain injury around birth or were born very early, and compares them with healthy babies. The goal is to learn more about brain injuries and recovery.
Madison, WisconsinAges 3 months–2 years - NCT07493096Recruiting
Intensive therapy program for children with brain-based conditions
This trial tests an intensive therapy program designed to help children with brain-based conditions like cerebral palsy or autism improve their skills in movement, thinking, and daily activities. The program runs for 2 weeks with daily sessions, and researchers will check for changes in your child's abilities.
The Woodlands, TexasAges 4–12 - NCT07555652Recruiting
Cooling treatment for newborns with birth-related brain injury
This trial studies whether cooling a newborn's body after a difficult birth helps prevent brain damage. Researchers will track babies treated with this cooling therapy and use brain imaging to see how well it works.
Ha Nội, HanoiAges birth–6 hours - NCT06429007Enrolling by invitationPhase 1
Metformin for infants after brain injury from HIE
This trial tests whether metformin, a common diabetes medicine, can help heal brain injury in infants who had HIE (lack of oxygen at birth) and were treated with cooling. It aims to see if the drug is safe and possible to give to babies between 3 and 6 months old.
Boston, MassachusettsAges 3 months–6 months
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Common questions
- Are there clinical trials for hie?
- Yes. Clin2 currently lists 22 recruiting hie studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a hie trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a hie trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.