Clinical trials
High Risk clinical trials
Below are recruiting high risk clinical trials, each written for real people, not researchers. We’re tracking 941 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04169737RecruitingPhase 2
Acalabrutinib and venetoclax for high-risk CLL or SLL
This trial tests whether acalabrutinib and venetoclax (with or without early obinutuzumab) can control chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). It is mainly for people whose disease is high-risk, has come back, or did not respond to earlier treatment.
Houston, TexasAges 18 years+ - NCT06257394RecruitingPhase 2
Treating high-risk childhood leukemia in Korea
This trial tests a new treatment plan for children with very high-risk acute lymphoblastic leukemia. It aims to improve outcomes for patients whose leukemia has specific genetic markers or has not responded well to initial treatment.
DaeguAges 1–19 - NCT05727761RecruitingPhase 2
Pioglitazone plus metformin for high-risk mouth lesions
This trial studies whether a two-medicine diabetes drug combination can reduce or control risky early changes in certain mouth and throat lesions. You may be asked for small tissue samples (biopsies) before and after 12 weeks to see how the lesions respond.
Minneapolis, MinnesotaAges 18 years+ - NCT06057948RecruitingPhase 2
Vaccine with beta-glucan for high-risk neuroblastoma
This trial tests a vaccine combined with a substance called beta-glucan to help the immune system recognize and fight neuroblastoma cells. It is for children who have already completed treatment for high-risk neuroblastoma and are now in remission.
Basking Ridge, New JerseyAges Any age - NCT07613294RecruitingPhase 3
Testing lepodisiran to reduce heart plaque buildup
This study tests whether a new medicine called lepodisiran can shrink plaque in heart arteries for adults with high Lp(a) (a type of cholesterol linked to heart disease) who have had a heart event or are at serious risk. The trial uses CT scans to monitor changes in your arteries.
La Jolla, CaliforniaAges 45–80 - NCT06987058Enrolling by invitationPhase 2
Continued RVU120 treatment study for current participants
This trial is for people who are already in a RVU120 study and have been receiving the drug for at least 5 cycles. It allows you to keep getting RVU120 if you are benefiting from it and don't have other treatment options.
GdanskAges 18 years+ - NCT07249840RecruitingPhase 1
Testing ropeginterferon for high-risk JAK2 mutation carriers
This trial tests whether the drug ropeginterferon can help people with a JAK2 gene mutation who have additional risk factors but do not yet have a blood cancer. The goal is to see if treatment can prevent blood clots, high blood counts, or other complications.
Boston, MassachusettsAges 18 years+ - NCT07725887Recruiting
Structured physical therapy for high-risk heart bypass patients
This trial tests a structured physical therapy program for patients at high risk who are getting heart bypass surgery. The therapy is done in the hospital before and after surgery to help you recover better.
Istanbul, EyupsultanAges 18–90 - NCT07285668Recruiting
Special donor immune cells after stem cell transplant for high-risk blood cancers
This study tests whether giving specially treated donor immune cells after a stem cell transplant can help prevent relapse in patients with high-risk blood cancers. You would get a stem cell transplant from a relative, followed by an infusion of donor cells that have been processed to reduce the risk of graft-versus-host disease.
Madison, WisconsinAges 18–80 - NCT07281599Recruiting
Using a pad to screen for cervical precancer
This trial tests whether a special pad you wear during your period can detect signs of cervical precancer. If you are already scheduled for a colposcopy due to an abnormal Pap or HPV test, you might be able to participate.
New Haven, ConnecticutAges 25 years+ - NCT07217899RecruitingPhase 2
Calcium to reduce bleeding after C-section
This trial tests if giving calcium through an IV before a C-section can help reduce blood loss in women at higher risk for heavy bleeding due to the uterus not contracting well.
Ann Arbor, MichiganAges 18 years+ - NCT07711314RecruitingPhase 2
Rezvilutamide after prostate removal for high-risk cancer
This trial tests if a daily pill called Rezvilutamide can prevent prostate cancer from returning in men who had their prostate removed and are at high risk of recurrence. It is for men who cannot or choose not to have radiation therapy.
Nanjing, JiangsuAges 18–75 - NCT05861050RecruitingPhase 1/Phase 2
Study of 4-drug treatment for newly diagnosed high-risk mantle cell lymphoma
This trial tests a combination of medicines to treat newly diagnosed high-risk mantle cell lymphoma (MCL). It may help shrink the lymphoma and improve outcomes, especially for people whose disease has higher-risk features.
Duarte, CaliforniaAges 18–80 - NCT06528496RecruitingPhase 2
Less chemo plus antibody therapy for high-risk neuroblastoma in children
This study tests whether giving fewer chemotherapy drugs along with other targeted therapies (monoclonal antibodies) works well for children with high-risk neuroblastoma. It aims to reduce side effects while still treating the cancer effectively.
New York, New YorkAges 1.5 years–19 years - NCT06344819RecruitingPhase 2
Acupuncture for People at High Risk of Sepsis
This study tests whether acupuncture can help people at high risk for sepsis, a serious infection that can lead to organ failure. If you’re 18 or older, have had a sepsis order set put in within the last two days, and are not yet in the ICU, you may be able to join.
Irvine, CaliforniaAges 18 years+ - NCT07207824RecruitingPhase 3
Study of a new drug for high-risk bladder cancer
This trial tests a combination of a drug (DV) and BCG immunotherapy for people with high-risk, early-stage bladder cancer that has not spread into the muscle. The cancer must show a specific protein called HER2 on its cells.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT05890716Recruiting
AI analyzes your ECG to help in high-risk heart rhythm cases
This trial uses an AI program to review ECG heart-tracing data collected from short-term monitoring devices. It aims to see whether the AI can better detect concerning heart rhythm patterns in people who are high risk for heart rhythm or heart problems.
Groningen, Provincie GroningenAges 4 years+ - NCT07250646RecruitingPhase 1
Rebecsinib for secondary AML or high-risk myelofibrosis
This trial tests a new drug called rebecsinib for people with a certain type of leukemia (secondary acute myeloid leukemia) or a high-risk bone marrow disorder (myelofibrosis) that has come back or not responded to other treatments. The goal is to see if it works and is safe.
Duarte, CaliforniaAges 18 years+ - NCT07168993Recruiting
Testing a new sputum test for lung cancer in high-risk adults
This study tests a new, non-invasive sputum test (FlowPath Lung) to see if it can accurately detect lung cancer in people at high risk who have a lung nodule. If you are between 50 and 80, have a smoking history, and have a lung nodule, this test may help decide if further steps are needed.
Palo Alto, CaliforniaAges 50–80 - NCT07363161Recruiting
Drug-coated balloon vs. stent for high-risk heart disease
This trial compares two treatments for people with complex coronary artery disease who have high-risk conditions or complicated blockages: a drug-coated balloon (DCB) versus a drug-eluting stent (DES). Both are ways to open up narrowed arteries and keep them open without surgery.
HomburgAges 18 years+ - NCT03959085RecruitingPhase 3
Inotuzumab plus chemotherapy for high-risk childhood leukemia
This Phase 3 trial tests whether adding inotuzumab to standard post-induction chemotherapy improves outcomes for children and young teens with high-risk B-ALL, mixed phenotype acute leukemia (MPAL), or certain high-risk B-LLy. It may help by targeting leukemia cells more directly, but participation depends on specific age, lab results, and medical history rules.
Birmingham, AlabamaAges 12 months–25 years - NCT05958082Recruiting
Genetic testing education for Black men with prostate cancer
This study tests whether educational support helps Black men with high-risk prostate cancer complete genetic testing. It may make it easier to get genetic results that can guide care for you and your family.
Detroit, MichiganAges 18 years+ - NCT05996107RecruitingPhase 1
Ribociclib with radiation for high-risk HR+ breast cancer
This trial tests whether adding the targeted therapy ribociclib (Kisqali) to radiation after surgery reduces the risk of breast cancer returning in patients with high-risk, hormone-positive breast cancer.
Ann Arbor, MichiganAges 18 years+ - NCT07372131Recruiting
Shorter antibiotics for high-risk fever with low white blood cells
This study looks at how long antibiotics should be given to cancer patients with fever and very low white blood cell counts after finding a certain type of bacteria (Gram-negative) in their blood. The goal is to find the best treatment duration to help patients recover without complications.
Rozzano, MilanAges 18 years+
Hear when a new High Risk trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for high risk?
- Yes. Clin2 currently lists 941 recruiting high risk studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a high risk trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a high risk trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.