Clinical trials · Raleigh–Durham, NC
High blood pressure clinical trials in Raleigh–Durham
We’re tracking 38 recruiting high blood pressure studies with a site in or near Raleigh–Durham — including Phase 2, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies near Raleigh–Durham
- NCT07064473RecruitingPhase 3
Testing vicadrostat plus empagliflozin for diabetes, high blood pressure, and heart disease
This study tests a new pill called vicadrostat taken with another medicine (empagliflozin) to see if it helps people with type 2 diabetes, high blood pressure, and heart disease. It may reduce the risk of heart problems, but you must not have had heart failure or use certain other heart medications.
Cary, North CarolinaAges 18 years+ - NCT06059638Recruiting
Pacemaker pacing for blood pressure control
This study tests whether adjusting the timing of a pacemaker can help lower blood pressure in people who already have or need a pacemaker. It could be an option for those whose blood pressure is not well controlled with medication.
Raleigh, North CarolinaAges 18 years+ - NCT06742723RecruitingPhase 3
Study of baxdrostat and dapagliflozin for kidney disease and high blood pressure
This trial tests if combining baxdrostat with dapagliflozin helps protect kidney function and reduce heart risks in people with chronic kidney disease and high blood pressure. It's for adults who are already taking standard blood pressure medications.
Raleigh, North CarolinaAges 18 years+ - NCT06559891Recruiting
Ultrasound treatment for high blood pressure
This trial tests an ultrasound device that targets nerves around the kidney to lower blood pressure. It may help people whose blood pressure is not well controlled with medication.
Raleigh, North CarolinaAges 22–75 - NCT06388421Recruiting
PH-ILD patient registry: tracking real-world outcomes
This study tracks people with both lung scarring and high blood pressure in the lungs (Group 3 PH-ILD) to better understand the disease and how treatments like Tyvaso work in real life. It may help you and your doctor make more informed decisions about your care.
Raleigh, North CarolinaAges 18 years+ - NCT07147075Enrolling by invitation
Improving blood pressure care through better doctor-patient talks
This study tests a training program for doctors to help them communicate better with patients who have high blood pressure. If you have high blood pressure and see a doctor at certain Duke Primary Care clinics, you may be able to join.
Durham, North CarolinaAges 18 years+ - NCT04454203RecruitingPhase 4
Local anesthetic catheter to reduce tourniquet-related blood pressure spikes
This Phase 4 trial tests whether a local anesthetic catheter placed near a nerve and artery can prevent high blood pressure caused by a tourniquet during total ankle replacement surgery. If it works, it may make recovery safer and more comfortable for some patients.
Durham, North CarolinaAges 18–75 - NCT07288398RecruitingPhase 3
Levosimendan for exercise limitation in PH-HFpEF
This trial tests if the drug levosimendan can help people with a specific type of pulmonary hypertension (PH-HFpEF) feel less tired and breathless during daily activities, and improve their exercise ability.
Durham, North CarolinaAges 18–85 - NCT06297291Recruiting
Long-term safety study for a kidney nerve treatment
This study tests a device that uses ultrasound to calm overactive kidney nerves, which may help lower blood pressure. It is for people with high blood pressure that is hard to control with medication.
Durham, North CarolinaAges 18 years+ - NCT04991454RecruitingPhase 2
Xenon mri to image lung blood flow in pulmonary hypertension
This trial uses a special MRI scan with xenon gas to take detailed images of how blood moves through your lungs. It aims to see if this imaging can help doctors better understand and manage pulmonary hypertension, which is high blood pressure in the lungs.
Durham, North CarolinaAges 18–75 - NCT07534501Recruiting
Getting Fresh Produce to Manage Your Health
This study tests whether giving people prescriptions for fresh fruits and vegetables helps them manage high blood pressure, diabetes, or weight—and improves their overall health. You'll get produce and support to eat better.
Durham, North CarolinaAges 18 years+ - NCT07181109RecruitingPhase 3
Study of zilebesiran for high-risk hypertension patients
This trial tests a new medicine called zilebesiran for people with high blood pressure that isn't well controlled. It may be an option if you have heart or blood vessel disease, or are at high risk for it.
Durham, North CarolinaAges 18 years+ - NCT03683186Enrolling by invitationPhase 3
Long-term study of ralinepag for pulmonary hypertension
This study follows people with pulmonary arterial hypertension (PAH) to see how safe and effective ralinepag is over the long term. It may help your care team understand what to expect from continued treatment and monitoring.
Durham, North CarolinaAges 18 years+ - NCT04071327Recruiting
Pulmonary hypertension registry for patient experiences
This trial is a registry that collects health information from people with pulmonary hypertension to better understand the disease and improve care. You may be asked to share details about your diagnosis and visits, especially soon after you start seeing a specialized PH care center.
Durham, North CarolinaAges birth+ - NCT04669548Recruiting
Accuryn monitoring study for people having heart surgery
This registry collects information from patients who are monitored with the Accuryn system during heart surgery and their ICU stay. It helps researchers learn from the system’s signals to better understand patient care around cardiac procedures.
Durham, North CarolinaAges 18 years+ - NCT05129345Recruiting
HIV care program for heart health goals in the Southeast US
This trial tests an approach to help people living with HIV reach heart- and metabolism-related health goals, such as blood pressure, cholesterol, and blood sugar. It involves clinics and community partners and may offer education, support, and care coordination to remove barriers to treatment.
Durham, North CarolinaAges 18 years+ - NCT04278404Recruiting
Drug safety study for children already on certain medicines
This study measures how certain medicines move through the body and checks their safety in children. It may help doctors better understand dosing and side effects in kids who are already receiving these treatments, or in some kids who recently tested positive for COVID-19.
Durham, North CarolinaAges birth–20 years - NCT04930289Enrolling by invitation
Lung transplant registry for better donor lung preservation
This study builds a worldwide database to track and improve how donor lungs are preserved before transplant. Your information may help doctors choose and manage donor lungs more effectively.
Durham, North CarolinaAges Any age - NCT04778046RecruitingPhase 2
Study lung pressure treatment for people waiting for transplant
This Phase 2 trial is for adults with pulmonary hypertension who are on the lung transplant waiting list at Duke. It aims to test whether the study treatment can improve lung pressure and related health outcomes, while using things like MRI to monitor changes.
Durham, North CarolinaAges 18 years+ - NCT05760898Recruiting
Helping control blood pressure in people with rheumatoid arthritis
This study aims to improve blood pressure control in adults who have both uncontrolled high blood pressure and rheumatoid arthritis. It may help by testing ways to better coordinate care between primary care and rheumatology.
Durham, North CarolinaAges 18 years+ - NCT06038630RecruitingPhase 2
Xenon gas MRI study for lung and heart health
This study uses a special MRI scan (Xenon gas imaging) to look at how well your lungs and heart are working. It is for people with certain lung conditions, those getting blood transfusions or phlebotomy, or healthy volunteers.
Durham, North CarolinaAges 18 years+ - NCT07136623Recruiting
Can a smart stethoscope detect pulmonary hypertension?
This study is testing if a special digital stethoscope (CORE 500) can help detect a heart condition called pulmonary hypertension. You may join if you are 18 or older, not currently hospitalized, and will have a heart ultrasound or right heart catheterization around the time of your visit.
Durham, North CarolinaAges 18 years+ - NCT07218029RecruitingPhase 3
Long-term study of sotatercept for PAH
This study is for people who have already taken part in a clinical trial of sotatercept for pulmonary arterial hypertension and done well enough to continue. It tests the long-term safety and effectiveness of staying on sotatercept, an investigational treatment that helps lower blood pressure in the lungs.
Durham, North CarolinaAges 18 years+ - NCT06052072Enrolling by invitation
Heart failure trial testing nerve treatment for lung pressure
This trial tests a new treatment that uses a device to calm overactive nerves in the lung's blood vessels. It is for heart failure patients who also have high blood pressure in their lungs, to see if it can help them breathe easier and feel better.
Durham, North CarolinaAges 22–85
Hear when a new High blood pressure trial opens near Raleigh–Durham, NC
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High blood pressure trials in other cities
Where these studies are running near Raleigh–Durham
Institutions with a site for the recruiting high blood pressure studies listed above.
- Duke University Medical Center · 10 studies
- University of North Carolina at Chapel Hill · 4 studies
- Duke University · 2 studies
- Duke University Health System · 2 studies
- WakeMed Health & Hospitals · 2 studies
- Cary Cardiology
- Clinical Trial Site
- Duke Lung Transplant Clinic
What taking part in a high blood pressure study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Looking wider? See all recruiting high blood pressure studies in North Carolina.
Common questions
- Are there high blood pressure clinical trials near Raleigh–Durham?
- Yes. We're currently tracking 38 recruiting high blood pressure studies with a site near Raleigh–Durham, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a high blood pressure study near Raleigh–Durham?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Raleigh–Durham to take part?
- Not necessarily. These studies have a site near Raleigh–Durham, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a high blood pressure trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New high blood pressure studies open near Raleigh–Durham regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.