Clinical trials · North Carolina
High blood pressure clinical trials in North Carolina
We’re tracking 53 recruiting high blood pressure studies with a site in North Carolina — including Phase 2, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies in North Carolina
- NCT04071327Recruiting
Pulmonary hypertension registry for patient experiences
This trial is a registry that collects health information from people with pulmonary hypertension to better understand the disease and improve care. You may be asked to share details about your diagnosis and visits, especially soon after you start seeing a specialized PH care center.
Chapel Hill, North CarolinaAges birth+ - NCT03683186Enrolling by invitationPhase 3
Long-term study of ralinepag for pulmonary hypertension
This study follows people with pulmonary arterial hypertension (PAH) to see how safe and effective ralinepag is over the long term. It may help your care team understand what to expect from continued treatment and monitoring.
Durham, North CarolinaAges 18 years+ - NCT06104228RecruitingPhase 2
Xenon MRI to detect and track pulmonary hypertension
This trial uses a special MRI scan (using xenon gas) to see how well the lungs are working in people with pulmonary arterial hypertension (PAH). It aims to improve diagnosis and monitoring of PAH from connective tissue disease or unknown cause.
Durham, North CarolinaAges 18–75 - NCT07090161RecruitingPhase 2
Study of iloperidone for uncontrolled high blood pressure
This trial tests if iloperidone can lower blood pressure in people whose high blood pressure is not controlled by current medications. You may qualify if your blood pressure is still high after weeks of treatment.
Kinston, North CarolinaAges 18–65 - NCT06527794Recruiting
Remote blood pressure management for Black patients
This study tests a remote program to help Black patients manage high blood pressure from home. You would use a blood pressure monitor and have phone or video visits with your care team.
Winston-Salem, North CarolinaAges 21–85 - NCT06468202RecruitingPhase 4
Aspirin dose study to prevent high blood pressure in pregnancy
This trial compares two doses of aspirin to see which is better at preventing conditions like preeclampsia (a serious form of high blood pressure during pregnancy). You may qualify if you are in early pregnancy and have certain risk factors.
Chapel Hill, North CarolinaAges 14–35 - NCT06388421Recruiting
PH-ILD patient registry: tracking real-world outcomes
This study tracks people with both lung scarring and high blood pressure in the lungs (Group 3 PH-ILD) to better understand the disease and how treatments like Tyvaso work in real life. It may help you and your doctor make more informed decisions about your care.
Greensboro, North CarolinaAges 18 years+ - NCT06059638Recruiting
Pacemaker pacing for blood pressure control
This study tests whether adjusting the timing of a pacemaker can help lower blood pressure in people who already have or need a pacemaker. It could be an option for those whose blood pressure is not well controlled with medication.
Asheville, North CarolinaAges 18 years+ - NCT04752293Recruiting
Study of a kidney blood-pressure system in kids
This study looks at how a kidney-related blood-pressure system works in children and teenagers, comparing those with newly diagnosed primary (no known cause) high blood pressure to those with normal blood pressure. It may help doctors better understand childhood blood-pressure changes and guide future care.
Winston-Salem, North CarolinaAges 7–18 - NCT04991454RecruitingPhase 2
Xenon mri to image lung blood flow in pulmonary hypertension
This trial uses a special MRI scan with xenon gas to take detailed images of how blood moves through your lungs. It aims to see if this imaging can help doctors better understand and manage pulmonary hypertension, which is high blood pressure in the lungs.
Durham, North CarolinaAges 18–75 - NCT04454203RecruitingPhase 4
Local anesthetic catheter to reduce tourniquet-related blood pressure spikes
This Phase 4 trial tests whether a local anesthetic catheter placed near a nerve and artery can prevent high blood pressure caused by a tourniquet during total ankle replacement surgery. If it works, it may make recovery safer and more comfortable for some patients.
Durham, North CarolinaAges 18–75 - NCT07181109RecruitingPhase 3
Study of zilebesiran for high-risk hypertension patients
This trial tests a new medicine called zilebesiran for people with high blood pressure that isn't well controlled. It may be an option if you have heart or blood vessel disease, or are at high risk for it.
Durham, North CarolinaAges 18 years+ - NCT07583940Recruiting
Energy Intake and Blood Pressure in College Athletes
This study looks at whether not eating enough calories affects blood pressure in Division I college athletes. Researchers want to understand if improving nutrition can help prevent high blood pressure in young athletes.
Greensboro, North CarolinaAges 18–26 - NCT07543120RecruitingPhase 2
Extended Safety Study of QCZ484 Blood Pressure Medication
This is a continuation study for people who completed a previous QCZ484 trial and tolerated it well. Researchers will monitor how safe and effective the medication remains with longer-term use for managing high blood pressure.
Monroe, North CarolinaAges 18 years+ - NCT07365332RecruitingPhase 3
IKT-001 for pulmonary arterial hypertension
This study tests a new medicine called IKT-001 for people with pulmonary arterial hypertension (PAH). It aims to see if IKT-001 helps improve exercise ability and other symptoms when added to current PAH therapies.
Durham, North CarolinaAges 18–75 - NCT07356518Recruiting
Telehealth and Remote Blood Pressure for Pregnancy
This study tests if using telehealth and remote blood pressure monitoring can help manage high blood pressure during pregnancy. It may be a good fit if you already had high blood pressure before pregnancy and want to monitor it from home.
Winston-Salem, North CarolinaAges 18–45 - NCT07191873RecruitingPhase 4
Tirzepatide for treating high pressure in the brain
This trial tests if tirzepatide can help lower the pressure inside your skull caused by a condition called Idiopathic Intracranial Hypertension. It's designed for people with a BMI of 30 or higher who have swelling of the optic nerve.
Durham, North CarolinaAges 18–60 - NCT07179380RecruitingPhase 3
Inhaled treprostinil for pulmonary hypertension related to interstitial lung disease
This study tests an inhaled powder medication called TPIP (treprostinil palmitil inhalation powder) to see if it can improve symptoms and exercise ability in people who have both interstitial lung disease and pulmonary hypertension. The study will compare TPIP against a placebo (a dummy treatment without the active drug) to understand how well it works and if it is safe.
Chapel Hill, North CarolinaAges 18 years+ - NCT07147075Enrolling by invitation
Improving blood pressure care through better doctor-patient talks
This study tests a training program for doctors to help them communicate better with patients who have high blood pressure. If you have high blood pressure and see a doctor at certain Duke Primary Care clinics, you may be able to join.
Durham, North CarolinaAges 18 years+ - NCT07142356RecruitingPhase 2
New oral medication for high blood pressure not controlled by current pills
This study tests a new medication, RTN-001, for people whose blood pressure remains high even when taking multiple blood pressure medications. The goal is to see if this drug can lower blood pressure more effectively.
Asheboro, North CarolinaAges 18–75 - NCT07136623Recruiting
Can a smart stethoscope detect pulmonary hypertension?
This study is testing if a special digital stethoscope (CORE 500) can help detect a heart condition called pulmonary hypertension. You may join if you are 18 or older, not currently hospitalized, and will have a heart ultrasound or right heart catheterization around the time of your visit.
Durham, North CarolinaAges 18 years+ - NCT06911632Recruiting
AI-assisted check for pulmonary hypertension in interstitial lung disease
This study uses an AI tool to help doctors decide if you should be tested for pulmonary hypertension (high blood pressure in the lungs), which can be a complication of interstitial lung disease. If the tool suggests you might have it, you may get an echocardiogram (an ultrasound of the heart) and a right heart catheterization (a test to measure pressure in the heart) to find out for sure.
Winston-Salem, North CarolinaAges 18 years+ - NCT06559891Recruiting
Ultrasound treatment for high blood pressure
This trial tests an ultrasound device that targets nerves around the kidney to lower blood pressure. It may help people whose blood pressure is not well controlled with medication.
Raleigh, North CarolinaAges 22–75 - NCT06343298RecruitingPhase 2
Study of manp for hard-to-control high blood pressure
This study tests a new investigational drug called MANP to see if it can lower blood pressure in people whose blood pressure stays high even when they are already taking several medications. If it works, this drug might offer a new option for people with difficult-to-control hypertension.
Monroe, North CarolinaAges 18–80
High blood pressure trials by city in North Carolina
Where these studies are running in North Carolina
Institutions with a site for the recruiting high blood pressure studies listed above.
- Duke University Medical Center · 8 studies
- Monroe Biomedical Research · 2 studies
- University of North Carolina at Chapel Hill · 2 studies
- Wake Forest University Health Sciences · 2 studies
- Asheville Cardiology Associates
- Atrium Health Sanger Heart
- Clinical Trial Site
- Duke Primary Care South Durham
What taking part in a high blood pressure study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
High blood pressure trials in other states
Common questions
- Are there high blood pressure clinical trials in North Carolina?
- Yes. We're currently tracking 53 recruiting high blood pressure studies with a site in North Carolina, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a high blood pressure study in North Carolina?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in North Carolina to take part?
- Not necessarily. These studies have a site in North Carolina, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a high blood pressure trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New high blood pressure studies open in North Carolina regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.