Clinical trials
Intraoperative clinical trials
Below are recruiting intraoperative clinical trials, each written for real people, not researchers. We’re tracking 272 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05576974RecruitingPhase 2
Test a dye used during surgery to find head and neck cancer
This trial tests whether a single dose of an imaging dye (given during surgery) can help doctors find the unknown origin of head and neck cancer and check safety. It may help guide surgery and biopsies when the primary cancer location hasn’t been identified.
Dallas, TexasAges 18–99 - NCT05830812Recruiting
Improve accuracy of lung cancer invasiveness diagnosis during surgery
This trial looks to improve how doctors judge how “invasive” a small lung adenocarcinoma is while you’re having surgery. Better accuracy may help guide treatment decisions for people with early-stage, operable lung cancer.
Wuhan, HubeiAges 20–80 - NCT05893888RecruitingPhase 2/Phase 3
Testing three investigational drugs for mouth and lung cancers
This trial tests whether PRV111, PRV211, and PRV131 are safe and work better than expected for certain mouth (lip/oral cavity) cancers and lung cancers. It may help by trying a new approach given directly to the tumor and then monitoring how well it shrinks and how safe it is.
Duarte, CaliforniaAges 18–100 - NCT05901545RecruitingPhase 1
Test an iodine-labeled drug to map neck lymph nodes
This Phase 1 study tests a labelling of panitumumab with iodine (111In) to see how well it can identify lymph nodes in head and neck cancer before surgery. The goal is to improve lymph node staging (which can help guide treatment), with the main focus on safety and early performance.
Nashville, TennesseeAges 19 years+ - NCT05966519Recruiting
Study testing flexible planning for knee replacement with ROSA
This study looks at how flexible pre-op planning can be when you get a total knee replacement using the ROSA system. It may help doctors fine-tune surgery planning while keeping outcomes safe and effective.
Fukuoka, FukuokaAges 20 years+ - NCT06002984Recruiting
Nerve monitoring during thyroid surgery to protect your voice
This study tests a device that monitors a nerve near your voice box during thyroid surgery. The goal is to help protect your voice by giving the surgeon live feedback on the nerve's location and function.
SeoulAges 19–79 - NCT06031181RecruitingPhase 3
Sublobar resection for early lung cancer found during surgery
This trial tests if a smaller surgery (sublobar resection) works well for patients with very early-stage lung cancer (adenocarcinoma in situ or minimally invasive adenocarcinoma) that is found during the operation. It may help avoid removing more lung tissue than necessary.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT06039085Recruiting
Electrical sensing for real-time cancer margin check during prostate surgery
This study tests a new device that uses tiny electrical sensors to help surgeons check if all the cancer has been removed during prostate cancer surgery. It could give real-time feedback so the surgeon can remove leftover cancer right away.
Lebanon, New HampshireAges 18 years+ - NCT06059859Recruiting
Augmented reality during robot-assisted prostate removal
This study tests whether using augmented reality (a computer overlay) during robot-assisted surgery for prostate cancer can help the surgeon remove the cancer more precisely. It may be an option for people with low or intermediate risk prostate cancer who have good erectile function.
MilanAges 18–70 - NCT06101511Recruiting
Breathing tube pressure for safer abdominal surgery
This trial is testing if using less air pressure from the breathing machine during abdominal surgery can help prevent lung complications. If you are at higher risk for breathing problems after surgery, this study may help find a safer way to manage your breathing during the operation.
Amsterdam, NoordhollandAges 18–100 - NCT06133842Recruiting
Brain blood flow and confusion after surgery study
This trial looks at how well the brain controls its own blood flow during non-cardiac surgeries. It aims to see if problems with this regulation are linked to confusion after surgery (delirium).
Boston, MassachusettsAges 60 years+ - NCT06140927RecruitingPhase 3
Ketamine's effect on spinal monitoring during back surgery
This study tests if giving ketamine during certain back surgeries affects how well doctors can monitor your spinal nerves during the operation. It's for adults having a posterior spinal fusion.
San Francisco, CaliforniaAges 18–100 - NCT06202638Recruiting
Predicting low blood pressure during lung surgery
This study tests a new tool that warns doctors when your blood pressure might drop during lung surgery. If it works well, it could help prevent complications and keep you safer during the operation.
AthensAges 18 years+ - NCT06205160Recruiting
Flexible brain electrodes for epilepsy surgery
This trial is testing new flexible brain electrodes during epilepsy surgery. These electrodes may help doctors map brain activity better than standard rigid ones. If you are having surgery for epilepsy caused by a brain lesion, you might be able to join.
UtrechtAges 18 years+ - NCT06227338Recruiting
Testing a dye to see breast cancer during surgery
This trial uses a special dye called ICG that makes cancer glow under a special camera during breast cancer surgery. Doctors want to find the best time to give the dye so they can see the cancer clearly and remove all of it in one operation.
BrusselsAges 18 years+ - NCT06229483RecruitingPhase 3
Does tranexamic acid reduce bleeding during brain tumor surgery?
This study tests whether a medication called tranexamic acid (TXA) given during brain tumor surgery can reduce bleeding. If you are having a standard craniotomy for a tumor and don’t have certain health risks, you may be eligible.
Halifax, Nova ScotiaAges 18–80 - NCT06235125RecruitingPhase 1
Using Cytalux during lung surgery in children and teens
This study tests whether a dye called Cytalux, injected before lung surgery, can help surgeons see and remove cancer spots in children and teens with certain cancers. It may help make sure all visible cancer is removed during the operation.
Chicago, IllinoisAges 6–17 - NCT06254859Recruiting
Nerve monitoring during thyroid surgery and voice outcomes
This study tests whether using nerve monitoring during thyroid surgery helps protect the nerves that control your voice. It includes adults having one side of their thyroid removed and tracks voice changes before and after surgery.
Fuzhou, FujianAges Any age - NCT06263075Recruiting
Monitoring during craniosynostosis surgery: comparing newer vs. traditional monitors
This study compares two types of monitors that track your baby's heart and blood flow during surgery to fix craniosynostosis. The goal is to see if a newer monitor works as well as the traditional one.
Bologna, BOAges 3 months–8 months - NCT06273176Recruiting
Surgery with or without brain mapping for recurrent glioblastoma
This study is testing whether using a special brain-mapping technique during surgery helps people with recurrent glioblastoma. It compares standard surgery to surgery with mapping to see if it leads to better outcomes for tumors near important brain areas.
San Francisco, CaliforniaAges Up to 90 years - NCT06281223Recruiting
Brain and spinal cord connection study in spasticity
This study looks at how the brain and spinal cord connect in children with spasticity (muscle stiffness). It will help doctors understand more about this condition by studying patients who are already scheduled for surgery to reduce stiffness.
NiceAges 3–17 - NCT06284174Recruiting
Comparing two antiseptics for spinal surgery wound soaking
This trial compares two common antiseptics (povidone-iodine and chlorhexidine gluconate) to see which better reduces germs in spinal surgery wounds during the operation. If you are having lumbar spine surgery, this study may help determine the best way to prevent infections.
Tainan, TaiwanAges 18 years+ - NCT06291389Recruiting
Airway pressure changes during tummy tuck surgery
This trial tests how changes in airway pressure during tummy tuck surgery affect breathing after the operation. It is for healthy adults having a tummy tuck with muscle tightening.
Tanta, EgyptAges 20–50 - NCT06307548RecruitingPhase 1/Phase 2
Image-guided surgery and light therapy for colorectal cancer
This trial tests a special dye that helps surgeons see tumors more clearly during surgery, followed by a light therapy to destroy any remaining cancer cells. It is for people with advanced or returning colorectal cancer who are already scheduled for surgery.
Buffalo, New YorkAges 18 years+
Hear when a new Intraoperative trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for intraoperative?
- Yes. Clin2 currently lists 272 recruiting intraoperative studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a intraoperative trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a intraoperative trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.