Clinical trials
Knee clinical trials
Below are recruiting knee clinical trials, each written for real people, not researchers. We’re tracking 812 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07630896RecruitingPhase 4
Prednisone and blood sugar monitoring after knee or hip replacement
This study looks at how a common steroid medicine, prednisone, affects blood sugar after knee or hip replacement surgery. It aims to find the best way to manage blood sugar for a smoother recovery.
New York, New YorkAges 18 years+ - NCT05672784Recruiting
Knee numbing injections during knee replacement surgery
This trial compares two ways of numbing a knee area during planned knee replacement surgery: a nerve block alone versus a nerve block plus additional numbing medicine near the back of the knee. It may help doctors find which approach improves pain control and recovery while keeping side effects low.
ZagazigAges 21–60 - NCT06632639Recruiting
Wedged insoles with ankle straps for knee pain and bow legs
This trial tests whether special shoe inserts (wedged insoles) combined with ankle straps can reduce pain and improve knee alignment in people with mild bow legs and inner knee pain. It aims to help those who have not had knee surgery and can walk without help.
GizaAges 20–60 - NCT07613502Recruiting
Bio Leg: Advancing Mobility (BAM)
This study tests a new prosthetic leg designed to help people with above-knee amputations walk better. It may be a good fit if you already use a C-leg and can walk with a single point cane.
Jacksonville, FloridaAges 40–70 - NCT07618403Recruiting
Physical Therapy for Knee Arthritis
This study tests whether a structured physical therapy program helps knee arthritis pain and function. Researchers will also look at how your expectations about treatment affect your results.
Ankara, YenimahalleAges 50 years+ - NCT06683222Recruiting
How muscle and bone talk to each other in healthy women
This study looks at how signals from muscles affect bone health in women of different ages. It aims to understand why bone density changes over time.
MontpellierAges 20–89 - NCT07611526Recruiting
How Your Body Responds to Special Exercise After Knee Surgery
This study looks at how tired your leg muscles get during a new type of exercise training (called blood flow restriction training) after knee replacement surgery. The goal is to understand how this training affects your recovery and strength.
Bonn, North Rhine-WestphaliaAges 18–85 - NCT07607249Enrolling by invitation
Floating Needle Treatment for Stomach Issues After Knee Surgery
This trial tests whether a traditional Chinese acupuncture technique called 'floating needle' can help with stomach and bowel problems that sometimes happen after knee surgery under general anesthesia. You would receive this treatment along with standard post-surgery care to see if it reduces nausea, constipation, or other digestive issues.
Guangzhou, GuangdongAges 18 years+ - NCT07592325Recruiting
Testing a New Flexible Prosthetic Socket for Below-Knee Amputees
This trial compares a new flexible prosthetic socket design to the rigid socket you currently wear. The goal is to see if the new socket is more comfortable, easier to put on, and improves how well your prosthetic leg works for daily activities.
ClamartAges 18 years+ - NCT07592871Recruiting
Knee Injury and Arthritis Long-Term Health Study
This study follows patients with knee injuries or wear-and-tear arthritis over time to understand how these conditions develop and change. Your health information helps doctors learn what treatments work best and how to prevent problems.
Ningbo, ZhejiangAges 18–90 - NCT07580157Enrolling by invitation
Shockwave therapy for knee pain after ACL surgery
This study tests whether focused shockwave treatment can reduce knee pain in people who have had ACL (anterior cruciate ligament) reconstruction surgery. Shockwave therapy uses sound waves to reduce pain and inflammation.
Rochester, MinnesotaAges 18 years+ - NCT07574762Recruiting
Knee Replacement: Computer Navigation vs. Robotic Surgery
This study compares two advanced surgical techniques for knee replacement in patients with knee arthritis. Researchers want to see if robotic-assisted surgery offers any advantages over computer-guided navigation surgery for placing the artificial knee.
Paris, ParisAges 18 years+ - NCT06479161RecruitingPhase 2
Oral tranexamic acid study for knee replacement patients
This trial tests if taking tranexamic acid (TXA) as a pill can reduce bleeding after total knee replacement surgery. It may help you if you have knee osteoarthritis and are scheduled for a first-time knee replacement.
Hartford, ConnecticutAges 18–89 - NCT07562425Recruiting
Knee Strengthening Exercises for Patellofemoral Pain
This study compares three types of thigh muscle exercises to help reduce knee pain in people with patellofemoral pain syndrome (pain around the kneecap). Researchers want to see which exercise style—holding steady, moving through motion, or lowering slowly—works best for your pain.
Elâzığ, MErkezAges 18–50 - NCT06734221Recruiting
Testing a paclitaxel-coated balloon for leg artery disease
This trial tests a special balloon coated with a drug (paclitaxel) to open blocked leg arteries, aiming to improve blood flow and reduce symptoms like leg pain when walking. It is for people with moderate to severe leg artery disease who have not had prior stents or bypass in the treated area.
Chrzanów, MalopolskaAges 18 years+ - NCT07548567Recruiting
Nerve Block to Reduce Pain During Below-Knee Fracture Surgery
This study tests a nerve-blocking injection (numbing medicine around the femoral artery nerve in your groin area) to help reduce pain and blood pressure changes during below-knee fracture surgery when a tourniquet (pressure cuff) is used. The goal is to see if this approach makes surgery more comfortable and safer.
AthensAges 18 years+ - NCT07542184Recruiting
Nanochon Chondrograft Knee Cartilage Repair Study
This early-stage study tests a new implant designed to repair damaged knee cartilage. Researchers will evaluate whether this treatment is safe and feasible for people with knee cartilage damage.
Panama City, Provincia de PanamáAges 22–60 - NCT07538570RecruitingPhase 4
Pain Management After Knee Replacement Surgery
This study tests different pain treatments for patients undergoing total knee replacement surgery. The goal is to find the most effective way to manage pain after this common procedure.
Bellaire, TexasAges 18–80 - NCT07532070Recruiting
Exercise and Therapy for Chronic Pain and Sleep Problems
This study tests whether exercise, talk therapy for sleep problems, or both together can help people with long-term back, hip, or knee pain who also struggle with sleep. You'll attend video appointments and try one of these approaches for several weeks.
San Antonio, NevadaAges 18 years+ - NCT07523854Recruiting
Knee Strength Recovery After ACL Surgery: Comparing Graft Types
This study compares how well the knee recovers its strength after ACL (anterior cruciate ligament) reconstruction surgery using two different graft options. By tracking your progress over time, researchers hope to understand which graft type helps you regain the most strength.
AnkaraAges 13–45 - NCT07514013Recruiting
Olive Oil Extract for Knee Comfort and Function
This study tests whether a daily olive oil extract capsule can help improve knee comfort and function in adults with ongoing knee discomfort. Participants will track their symptoms and wear an activity monitor while taking the supplement.
San Francisco, CaliforniaAges 40–75 - NCT07491367RecruitingPhase 4
Platelet-rich plasma for knee osteoarthritis
This study tests two different ways of preparing platelet-rich plasma (a treatment made from your own blood) to see which one works better for knee osteoarthritis. You'll also do physical therapy as part of the study.
San Francisco, CaliforniaAges 18 years+ - NCT06759116Recruiting
Comparing two pain medicines for knee surgery recovery
This trial tests whether adding fentanyl or dexmedetomidine to a standard numbing medicine (bupivacaine) provides better pain relief after knee surgery. It may help find the best option for patients undergoing knee procedures like total knee replacement or ACL repair.
El SharkiaAges 21–85 - NCT06709963Recruiting
Brain stimulation for older adults with chronic back or knee pain
This study tests a type of brain stimulation called intermittent theta burst stimulation to see if it can reduce pain and improve thinking in older adults with long-term back or knee pain. The treatment involves a non-invasive procedure that uses magnetic pulses to stimulate the brain.
Hong KongAges 60–85
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Common questions
- Are there clinical trials for knee?
- Yes. Clin2 currently lists 812 recruiting knee studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a knee trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a knee trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.