Clinical trials
Knee clinical trials
Below are recruiting knee clinical trials, each written for real people, not researchers. We’re tracking 816 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06863610Recruiting
Knee extension loss after ACL reconstruction
This study looks at why some people still have trouble fully straightening their knee after ACL reconstruction. It compares people who have full extension to those who don't, to find out what might be limiting recovery. The goal is to help improve rehab after ACL surgery.
AnkaraAges 18–45 - NCT06863636RecruitingPhase 3
Combination painkiller vs celecoxib for osteoarthritis flare-ups
This study tests whether a combination of two pain relievers (celecoxib and acetaminophen) works better than celecoxib alone for sudden, severe osteoarthritis pain in the knee or hip.
Mexico CityAges 40 years+ - NCT06878417Recruiting
Cannabinoids for osteoarthritis knee or hip pain
This study tests if cannabinoid medications can reduce pain interference in daily life for people with hip or knee osteoarthritis. It may be a new option for moderate to severe pain.
Toronto, OntarioAges 40–80 - NCT06920186Recruiting
Extra nerve blocks for knee replacement pain
This study compares two ways to manage pain after knee replacement surgery: one uses a nerve block around the knee (adductor canal block), and the other adds an extra shot or nerve block. The goal is to see which approach works better for controlling pain and helping you recover.
Quincy-sous-SénartAges 18 years+ - NCT07001761Recruiting
Ultrasound study for knee osteoarthritis
This study uses ultrasound imaging to evaluate knee osteoarthritis in people over 30 with painful knees. It aims to better understand how the condition appears on imaging.
SohagAges 30 years+ - NCT07003113Recruiting
Blood flow therapy for knee and back pain
This study tests a treatment called ischemic preconditioning, which uses a blood pressure cuff to temporarily restrict blood flow to your leg. It may help reduce pain from osteoarthritis in the knee or chronic back pain.
Chicago, IllinoisAges 50 years+ - NCT07006883Recruiting
Yoga program for knee osteoarthritis
This trial tests whether a yoga program can improve daily function in people with knee osteoarthritis. It may help reduce pain and stiffness while improving mobility.
São PauloAges 40–80 - NCT07016672Recruiting
PRP vs. hyaluronic acid for advanced knee arthritis
This study compares two treatments—platelet-rich plasma (PRP) and hyaluronic acid (a lubricating injection)—for people with severe knee arthritis seen on MRI. The goal is to see which better reduces pain.
Toulon, VarAges 18 years+ - NCT07047300Recruiting
How a heel lift insole affects walking for healthy adults
This study tests whether wearing a heel lift insole changes how your legs and lower back move while walking. It may help understand if such insoles can benefit people with certain conditions, but right now it only includes healthy volunteers.
Giza, Giza GovernorateAges 18–25 - NCT07055113Recruiting
Home rehab program for hip or knee arthritis
This study tests a home-based rehab program for people with hip or knee arthritis who do not need joint replacement yet. It aims to help improve function and reduce pain through online sessions.
Edmonton, AlbertaAges Any age - NCT07075198Recruiting
Testing the Caesar running foot for people with below-knee amputations
This trial tests a new running foot called Caesar for people with below-knee amputations who want to run but don't have a running blade yet. You'll try the foot at home and give feedback on how it works.
Austin, TexasAges 18 years+ - NCT07079254Recruiting
Meniscus repair vs. partial removal for bucket-handle tears
This trial compares two surgeries for a specific type of meniscus tear that blocks knee straightening: repairing the torn meniscus versus removing the damaged part. The goal is to see which leads to better recovery.
Hässleholm, Skåne CountyAges 15 years+ - NCT07090928RecruitingPhase 4
Numbing medicine for less pain after knee scope surgery
This study tests whether giving bupivacaine (a numbing medicine) around the time of knee arthroscopy can reduce pain at the surgery sites and help you move your knee better after the operation.
Peshawar, KPKAges 18–70 - NCT07094100Recruiting
Repairing knee cartilage with lab-grown tissue
This study tests whether lab-made cartilage can safely and effectively repair knee joint damage in adults. It may be an option if you have a cartilage defect from an injury or other cause and haven't had recent knee surgery.
Xinxiang, HenanAges 18–65 - NCT07134244Recruiting
Predicting cartilage damage and pain after knee injury or early arthritis
This study uses computer models and MRI scans to predict how knee cartilage and pain may change over time in people with early osteoarthritis or a recent ACL tear. It aims to find better ways to manage these conditions and prevent long-term damage.
Aalborg, North DenmarkAges 18–70 - NCT07174219Recruiting
Return to sports after MCL knee surgery
This study tracks people who had surgery to reattach the medial collateral ligament (MCL) in the knee, alone or with other repairs. It measures how well and how safely they return to sports. If you had this surgery, you may help improve future care.
Bologna, BolognaAges 12–65 - NCT07179016Recruiting
Acupressure for chronic pain in rural areas
This trial tests if a self-managed acupressure program can help people living in rural areas manage long-term muscle or joint pain, like neck, back, or knee pain. You would learn to press small seeds on your ear to ease pain.
Columbia, South CarolinaAges 18–85 - NCT07191067Recruiting
Study of NOVABLOC system for knee replacement pain
This trial tests a new device called the NOVABLOC system to see if it helps control pain during and after knee replacement surgery. It is for people with osteoarthritis who are having their first knee replacement on one knee.
Daphne, AlabamaAges 21 years+ - NCT07215572Recruiting
Group physical therapy for veterans with knee osteoarthritis
This trial studies whether a group physical therapy program can help veterans with knee osteoarthritis. It aims to see if this approach is practical and effective for improving knee pain and function.
Durham, North CarolinaAges Any age - NCT07231471Recruiting
Platelet-rich plasma for muscle and joint pain
This study tests whether an injection of your own platelet-rich plasma (PRP) can help heal muscle, tendon, or joint problems that haven't gotten better with other treatments like physical therapy or medications.
Salt Lake City, UtahAges 18 years+ - NCT07241572Recruiting
Heart injury risk during below-knee surgery
This trial checks for heart muscle injury during surgery on the lower leg (below the knee). It helps doctors understand how to better protect patients having this type of operation.
AnkaraAges 18 years+ - NCT07670728Enrolling by invitation
Comparing two types of leg exercises for stroke patients with knee hyperextension
This trial tests whether open-chain (moving one part freely) or closed-chain (keeping foot on ground) exercises better improve knee hyperextension in stroke survivors. It may help you if you have leg weakness and walk with your knee locked back.
Karachi, SindhAges 7 months–1.2 years - NCT07256548Recruiting
Predicting spinal anesthesia duration with machine learning
This trial uses a computer program to predict how long spinal anesthesia will last for patients having knee replacement surgery. It may help doctors plan better care.
Kocaeli, İzmitAges 18 years+ - NCT07271849RecruitingPhase 4
Timing of Nalbuphine for Pain and Blood Pressure in Older Knee Surgery Patients
This study tests whether giving the pain medicine nalbuphine at different times during knee replacement surgery affects blood pressure and pain control in older adults. It may help find the best timing to reduce pain and keep vital signs stable.
Jinan, ShandongAges 65–90
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Common questions
- Are there clinical trials for knee?
- Yes. Clin2 currently lists 816 recruiting knee studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a knee trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a knee trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.