Clinical trials
Knee clinical trials
Below are recruiting knee clinical trials, each written for real people, not researchers. We’re tracking 814 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06581965RecruitingPhase 4
Personalized blood clot prevention for hip or knee replacement
This trial compares a personalized approach to preventing blood clots after hip or knee replacement surgery with the standard one-size-fits-all method. The goal is to see if tailoring prevention to each patient works better and is safer.
Apeldoorn, GelderlandAges 18 years+ - NCT06563531Recruiting
Do compression stockings help after hip or knee replacement?
This trial looks at whether compression stockings are still needed for people who have a new hip or knee joint and are following a modern "fast-track" recovery program. It aims to find out if these stockings are necessary to prevent blood clots when people are up and moving quickly after surgery.
BrestAges 18 years+ - NCT06541756Recruiting
Fibrin clot repair for torn knee cartilage
This trial tests whether adding a fibrin clot to standard meniscus repair helps heal a torn knee cartilage better. You'd get surgery, then an MRI one year later to check healing.
AnkaraAges 18–50 - NCT06532851Recruiting
Exercise therapy for knee cartilage health
This study tests whether specific exercises can improve your knee cartilage health and daily function. It is for people with a meniscus tear who are at risk for knee arthritis but don't have arthritis yet.
Ar RamthaAges 35–55 - NCT06529692Recruiting
Split-belt treadmill training after ACL reconstruction
This study tests whether walking on a special split-belt treadmill (where each belt moves at a different speed) can help improve how your knee moves and feels after ACL reconstruction. The goal is to see if this training leads to better long-term knee health.
Ann Arbor, MichiganAges 14–45 - NCT06522152Recruiting
Long-term outcomes after meniscal transplant
This study looks at how well patients' knees are doing 10 years or more after a meniscal transplant (a surgery to replace torn knee cartilage). It aims to understand the long-term benefits and any changes in knee function.
BolognaAges 18–65 - NCT06507241Recruiting
Knee meniscus root tear repair using ligament suture
This trial tests a surgical technique to fix a certain type of meniscus tear (called a root tear) by stitching it to the knee's posterior cruciate ligament. The goal is to see if this approach helps patients recover better.
BolognaAges 18–50 - NCT06469177Enrolling by invitation
Pain management app study for joint replacement recovery
This study tests a smartphone tool to help manage pain after hip, knee, or shoulder replacement. It aims to see if using the tool improves your recovery compared to standard care.
Dartmouth, Nova ScotiaAges 19 years+ - NCT06462040Recruiting
Dissolving Screws for Loose Knee Cartilage
This study follows patients who have a loose piece of bone and cartilage in their knee and are having it fixed with special screws that dissolve over time. The goal is to see how well the knee heals and works after surgery.
Bologna, BolognaAges 12–35 - NCT06474182Recruiting
Apixaban for blood clots in myeloma patients
This study looks at how Apixaban (a blood thinner) works in people with newly diagnosed multiple myeloma. It compares them to people having knee replacement surgery. The goal is to see if the drug prevents clots effectively in both groups.
Saint-EtienneAges 18 years+ - NCT06466850Recruiting
Stem cell exosomes for knee osteoarthritis
This trial studies whether a natural substance called exosomes, derived from stem cells, can help reduce pain and improve function in people with knee osteoarthritis. It may be an option if other treatments have not worked well for you.
IsfahanAges 45–75 - NCT06452186Recruiting
Study of a new leg prosthetic controller for improved balance
This study tests a new prosthetic leg controller that helps people with below-knee amputations walk more steadily and with better balance. You may be eligible if you have used a prosthetic leg for at least a year and are comfortable walking in the community.
Raleigh, North CarolinaAges 18–99 - NCT06423378Enrolling by invitationPhase 2
Kneebar implant for knee pain and bone marrow lesion
This trial tests a new type of implant (a fiber-reinforced kneebar) for people with knee pain caused by a bone marrow lesion (BML) and osteoarthritis. The goal is to see if it helps relieve pain and improve knee function.
Nashville, TennesseeAges 18–75 - NCT06407427Recruiting
Mobile app for recovery after hip, knee, or spine surgery
This study tests whether a mobile app can help with physical therapy after common bone or joint surgeries. You may qualify if you recently had a hip fracture, hip or knee replacement, or spine surgery without paralysis. The app guides your exercises at home.
New Haven, ConnecticutAges 18 years+ - NCT06368700Recruiting
Testing a new knee cartilage implant (HYALEX)
This study is testing a new implant called HYALEX to repair cartilage damage in the knee. It may help people with painful knee cartilage defects that haven't gotten better with other treatments like physical therapy or injections.
La Mesa, CaliforniaAges 22–70 - NCT06337123Recruiting
Testing a new knee replacement implant for total knee replacement
This study tests a specific knee replacement implant (the Physica TT Tibial Plate) in people needing a total knee replacement. The goal is to see how well it works and how safe it is.
Forte dei Marmi, LuccaAges 18 years+ - NCT06328062Recruiting
Comparing two pain medicines for knee replacement
This study compares two medicines, mirogabalin and pregabalin, to see which works better for pain after total knee replacement. It may help you find more effective pain relief after surgery.
Khlong Luang, Changwat Pathum ThaniAges 50–85 - NCT06309433Recruiting
Bone density after different knee replacement designs
This study looks at how bone density around a new knee replacement changes over time, comparing two different types of knee implants. It may help your surgeon choose the best option for you.
Bologna, ItaliaAges 45 years+ - NCT06311513RecruitingPhase 4
Concentrated bone marrow injection during repeat ACL surgery
This study tests whether adding a concentrated bone marrow injection during repeat ACL surgery helps healing and recovery better than surgery alone. If you have had a previous ACL reconstruction that failed, you may be eligible.
Atlanta, GeorgiaAges 18–55 - NCT05863741Recruiting
Knee surgery planning using a 3D next-step guidance system
This trial studies whether a NextAR system’s planning and gait (walking) analysis can improve how knee replacement surgery is done and how you walk afterward. It’s for adults with severe knee osteoarthritis who are eligible for total knee replacement.
FremantleAges 18 years+ - NCT05459948Recruiting
Follow-up study for a primary knee replacement
This study tracks outcomes after a standard (first-time) total knee replacement using the GMK SpheriKA implant. It mainly looks at how well the knee works in everyday life, including activity and self-checks over time.
MérignacAges 18–80 - NCT06267482Recruiting
Robotic knee replacement for better outcomes
This study tests a robot-assisted tool for knee replacement surgery. It aims to make surgery more precise and improve recovery and comfort for people with knee osteoarthritis.
London, OntarioAges 21–80 - NCT06231758RecruitingPhase 3
Metformin for knee osteoarthritis: a phase 3 trial
This study tests whether metformin, a common diabetes medication, can help reduce pain and improve knee function in people with knee osteoarthritis. It may offer a new treatment option for those with moderate knee OA.
Damietta, New DamiettaAges 30–60 - NCT06208267Recruiting
Tranexamic acid for pain and bleeding after hip or knee replacement
This study tests whether a medicine called tranexamic acid (TXA) can reduce pain, improve movement, and lessen bleeding after hip or knee replacement surgery. It is for adults having their first joint replacement at St. Mary's Hospital.
Montreal, QuebecAges 18 years+
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Common questions
- Are there clinical trials for knee?
- Yes. Clin2 currently lists 814 recruiting knee studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a knee trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a knee trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.