Clinical trials
Knee clinical trials
Below are recruiting knee clinical trials, each written for real people, not researchers. We’re tracking 814 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06216756Recruiting
Frozen cartilage transplant for knee cartilage defects
This trial tests a frozen cartilage transplant (called an osteochondral allograft) for people with painful knee cartilage defects. It aims to see if this procedure can help relieve pain and improve knee function.
Phoenix, ArizonaAges 12–60 - NCT06145516Recruiting
Sleep program to ease pain after joint replacement
This study tests whether a sleep program can help with pain after knee or hip replacement. If you have insomnia and arthritis pain, you may be able to join before your surgery.
Uppsala, UpplandAges 18–100 - NCT06138548Enrolling by invitation
Study of a reinforced knee implant for bone weakness
This trial tests a new, reinforced knee implant for people with a specific type of knee bone weakness. It's for those who already need a knee scope procedure for problems like a meniscal tear or loose cartilage.
Stanford, CaliforniaAges 18 years+ - NCT02844751RecruitingPhase 2
Regenerative knee cell therapy for arthritis pain and swelling
This Phase 2 study tests a patient’s own (autologous) regenerative cell treatment to reduce knee pain and inflammation from osteoarthritis. It mainly looks at whether the treatment is safe and whether it can improve symptoms over time.
Grove City, PennsylvaniaAges 18–90 - NCT06071429Recruiting
Dissolvable medicine stent for leg artery disease
This trial tests a new dissolvable stent that slowly releases medicine to keep your lower-leg artery open. It is for people with severe leg pain or small wounds due to poor blood flow, and who are not eligible for other stents.
New York, New YorkAges 18 years+ - NCT06073106Recruiting
Frailty prevention study for older Asian adults
This trial tests a program to prevent frailty in people aged 50 and older of Asian descent who have recently been diagnosed with a stroke, traumatic brain injury, knee osteoarthritis, or breast cancer. The goal is to help you stay strong and healthy as you recover.
Singapore, SingaporeAges 50 years+ - NCT06058169Recruiting
Home vibration therapy for arthritis knee pain
This study tests if doing whole-body vibration exercises at home can help reduce knee pain from arthritis. You stand on a gently vibrating platform for short periods over several weeks.
Augusta, GeorgiaAges 40–75 - NCT06080152Recruiting
Wheeled device use after knee replacement
This study observes how people use wheeled devices (like walkers) after a total knee replacement. It helps doctors understand what patients need during recovery.
Redwood City, CaliforniaAges 18–99 - NCT05986292RecruitingPhase 2
Study of new pain treatments for chronic pain
This study tests new treatments for people with chronic pain that has lasted at least 12 weeks. It aims to find better ways to reduce pain and improve quality of life.
Birmingham, AlabamaAges 18 years+ - NCT05992038Recruiting
Bone putty as gap filler in knee realignment surgery
This trial tests a new bone putty used to fill the small gap created during realignment surgery for knee osteoarthritis. It aims to see if the putty helps the bone heal better and reduces pain.
Utrecht, UtrechtAges 18 years+ - NCT05985785Recruiting
Bone Marrow vs Steroid Injection for Knee Arthritis
This study compares two different knee injections—one using your own concentrated bone marrow cells (BMAC) and the other using a steroid (cortisone)—to see which works better for long-term knee pain from osteoarthritis.
Chicago, IllinoisAges 18–70 - NCT05955976Recruiting
Fat tissue study in knee osteoarthritis patients
This study looks at fat tissue around the knee and inside the thigh muscle in people having knee replacement surgery for osteoarthritis. It may help researchers understand how fat tissue affects the knee joint.
NiceAges 40–85 - NCT05946044Recruiting
Preventing Knee Arthritis in People at Higher Risk
This study looks at ways to help prevent knee osteoarthritis before it starts. It is designed for women with higher body weight who currently have no arthritis signs on scans and do not have much knee pain.
Boston, MassachusettsAges 50 years+ - NCT05792189Recruiting
Knee fracture surgery: plates vs knee replacement for older adults
This trial compares two ways to treat certain lower-thigh (distal femur) fractures near the knee: using plates/screws or doing a knee replacement. It aims to see which option works better for recovery and long-term outcomes.
Gainesville, FloridaAges 55–100 - NCT05785884Recruiting
Diet program to help knee osteoarthritis pain
This trial studies whether different diet approaches can reduce knee pain in people with knee osteoarthritis who have certain eating patterns. It may help by changing diet-related factors that can affect inflammation and pain.
Birmingham, AlabamaAges 40–75 - NCT05788016Recruiting
Help planning an opioid taper before knee or hip surgery
This study looks at a plan to safely reduce (taper) opioid pain medicines before total knee or hip replacement surgery. It may help people who are already taking opioids and are preparing for surgery in the next 1 to 2 months.
Birmingham, AlabamaAges 18 years+ - NCT05761015RecruitingPhase 4
Test of an NSAID to help osteoarthritis pain when walking
This trial studies whether taking an anti-inflammatory pain medicine (an NSAID) can reduce hip or knee osteoarthritis pain during walking. It may help people who have had walking pain for at least 3 months and don’t already take NSAIDs.
Clermont-FerrandAges 50–70 - NCT05754632Recruiting
Blood flow restriction exercises after ACL surgery in teens
This trial tests whether a special type of exercise that uses a cuff (blood flow restriction training, or BFRT) can help teens recover after ACL reconstruction. It’s designed to see if adding BFRT to standard rehab improves strength and return to sport.
Farmington, ConnecticutAges 12–18 - NCT03383081RecruitingPhase 2
Stem cell injection for moderate knee osteoarthritis pain
This Phase 2 study tests whether injected umbilical-cord stem cells can improve safety and reduce symptoms in people with moderate knee osteoarthritis. It focuses on people with significant knee pain who have not gotten enough relief from standard, non-procedure treatments.
Changsha, HunanAges Up to 70 years - NCT05675618Recruiting
Returning to Golf After Joint Replacement Surgery
This study focuses on helping people get back to golfing after common orthopedic (bone/joint) surgeries like hip or knee or shoulder replacement. You may be asked to complete follow-up questionnaires to track recovery and return-to-golf progress.
New York, New YorkAges 18 years+ - NCT05658796Recruiting
Program to reduce opioid use after hip or knee replacement
This trial tests a support program called RXWell to help people use less opioid pain medicine after elective hip or knee replacement surgery. It may help by addressing anxiety and depression symptoms that can affect pain and recovery.
Monroeville, PennsylvaniaAges 18–100 - NCT05644522Recruiting
At-home brace study for leg support and walking
This study tests an at-home wearable activity monitor and brace-related walking support for people who already use a knee-ankle-foot brace. It may help researchers understand how brace use and day-to-day movement relate to walking ability.
Chicago, IllinoisAges 18–89 - NCT05527548RecruitingPhase 4
Alendronate for knee recovery after ACL surgery
This trial tests whether alendronate, a drug commonly used for bone health, can improve knee function and recovery after ACL surgery. It is for people having their first ACL repair.
ShatinAges 14 years+ - NCT05514405Recruiting
Testing two anesthesia medicines to prevent confusion after surgery
This trial tests whether using remimazolam or propofol during hip or knee replacement surgery can lower the risk of postoperative delirium, a sudden, short-term confusion that can happen after anesthesia. It may help people who are at higher risk of postoperative confusion by finding the safer anesthesia approach.
SeoulAges 65–100
Hear when a new Knee trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for knee?
- Yes. Clin2 currently lists 814 recruiting knee studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a knee trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a knee trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.