Clinical trials
Knee clinical trials
Below are recruiting knee clinical trials, each written for real people, not researchers. We’re tracking 816 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06581965RecruitingPhase 4
Personalized blood clot prevention for hip or knee replacement
This trial compares a personalized approach to preventing blood clots after hip or knee replacement surgery with the standard one-size-fits-all method. The goal is to see if tailoring prevention to each patient works better and is safer.
Apeldoorn, GelderlandAges 18 years+ - NCT06586840Recruiting
Adding an extra nerve block to knee replacement
This trial tests if adding a special nerve block behind the knee (IPACK) to a standard thigh block helps control pain better after total knee replacement. It may lead to less pain and faster recovery.
AydinAges 18–85 - NCT06600815Recruiting
Step-by-step numbing shots for pain relief in knee replacement
This study tests whether a special step-by-step numbing injection given before knee replacement surgery can provide better pain relief during and after the procedure. It may help you have less pain and use fewer painkillers after surgery.
Fuzhou, FujianAges 18 years+ - NCT06603662RecruitingPhase 4
Steroids for sudden osteoarthritis pain in the emergency room
This trial tests if a short course of oral steroids (glucocorticoids) can relieve sudden osteoarthritis pain in the knee, hip, or shoulder for people who come to the emergency department and are well enough to go home.
York, PennsylvaniaAges 18 years+ - NCT06608394Recruiting
Exercise habits and knee recovery after ACL surgery
This study looks at how your exercise habits before surgery might affect your knee function and the chance of re-injury after anterior cruciate ligament (ACL) reconstruction. It aims to help doctors give better advice on post-surgery rehabilitation.
Beijing, Beijing MunicipalityAges 18–45 - NCT06608992RecruitingPhase 4
Studying a powder to reduce bleeding in knee replacement
This trial tests a powder called SURGICEL® that may help control bleeding during knee replacement surgery. People with severe knee arthritis who are having their first knee replacement may be able to join.
Beijing, Beijing MunicipalityAges Any age - NCT06630975Recruiting
Knee alignment surgery comparison for children
This trial compares two surgical methods to correct knee alignment in children whose bones are still growing. It will help doctors know which approach works better and is safer.
AsyutAges 2–18 - NCT06632639Recruiting
Wedged insoles with ankle straps for knee pain and bow legs
This trial tests whether special shoe inserts (wedged insoles) combined with ankle straps can reduce pain and improve knee alignment in people with mild bow legs and inner knee pain. It aims to help those who have not had knee surgery and can walk without help.
GizaAges 20–60 - NCT06637709Recruiting
Pain after osteoarthritis treatment: a 24-month study
This study looks at why some people still have pain after knee surgery or other treatments for osteoarthritis. It tests a marker in the blood to see if it relates to ongoing pain. You would be followed for 24 months.
Roma, RomaAges 18–99 - NCT06648421Recruiting
Knee strength test for healthy Brazilian adults
This study is measuring normal knee strength in healthy Brazilian adults aged 18 to 80. By participating, you will help doctors understand what typical knee strength looks like, which can improve care for people with knee problems.
Londrina, ParanáAges 18–80 - NCT06665438RecruitingPhase 3
Pain relief after knee arthroscopy: numbing injection with added medication
This trial tests whether adding dexmedetomidine to a numbing injection (bupivacaine) inside the knee joint provides better pain relief after arthroscopic ACL reconstruction. It aims to help patients recover more comfortably after surgery.
AsyutAges 18–65 - NCT06687109Recruiting
Joint replacement surgery registry study
This study collects information from people having joint replacement surgery to track how they do over time and improve care.
Spokane, WashingtonAges 18 years+ - NCT06684587Recruiting
Telehealth exercise and mindfulness for knee osteoarthritis pain
This study tests whether a telehealth program combining exercise and mindfulness can help reduce knee pain from osteoarthritis. It is designed for people who have had knee pain for at least 3 months and can attend sessions remotely.
Boston, MassachusettsAges 50 years+ - NCT07464860Recruiting
Breathwork for older adults after knee surgery
This study tests a breathing exercise program to help older adults recover after knee replacement surgery. Participants practice controlled breathing at home using a smartphone or computer.
Tucson, ArizonaAges 65 years+ - NCT06734221Recruiting
Testing a paclitaxel-coated balloon for leg artery disease
This trial tests a special balloon coated with a drug (paclitaxel) to open blocked leg arteries, aiming to improve blood flow and reduce symptoms like leg pain when walking. It is for people with moderate to severe leg artery disease who have not had prior stents or bypass in the treated area.
Chrzanów, MalopolskaAges 18 years+ - NCT06747494Recruiting
Comparing general vs spinal anesthesia for hip or knee replacement
This study compares two types of anesthesia (general and spinal) for people having a total hip or knee replacement. The goal is to see which approach is better for recovery and overall outcomes.
Miami, FloridaAges 18 years+ - NCT06759116Recruiting
Comparing two pain medicines for knee surgery recovery
This trial tests whether adding fentanyl or dexmedetomidine to a standard numbing medicine (bupivacaine) provides better pain relief after knee surgery. It may help find the best option for patients undergoing knee procedures like total knee replacement or ACL repair.
El SharkiaAges 21–85 - NCT06776094Recruiting
Exercise and insulin sensitivity study in healthy men
This trial looks at how physical activity affects how your body responds to insulin in healthy men aged 22-35. If you are a non-smoking man with a BMI between 28 and 35 and a certain fitness level, you may be eligible.
CopenhagenAges 22–35 - NCT06784882RecruitingPhase 4
Continuous vs. single-injection nerve block for outpatient knee replacement
This trial compares two types of nerve blocks for pain control after total knee replacement. You will receive either a one-time injection or a continuous block that delivers medication through a small tube. The goal is to see which method provides better pain relief while allowing you to go home the same day.
La Jolla, CaliforniaAges 18 years+ - NCT06787417RecruitingPhase 4
Knee alignment study for total knee replacement
This study compares two different surgical techniques for total knee replacement to see which one leads to better knee movement and function. If you need a knee replacement due to arthritis, this trial may help find the best approach for your surgery.
Hamilton, OntarioAges 18 years+ - NCT06823440Recruiting
Preventing nerve damage from chemo with compressive therapy
This trial tests if wearing compressive therapy (like special sleeves or stockings) during weekly paclitaxel chemotherapy can prevent nerve damage (peripheral neuropathy) in breast cancer patients. It is for people who have not yet had nerve issues or diabetes.
BrnoAges 18–70 - NCT06832852Recruiting
Comparing cost-effective care for muscle and joint pain
This study compares different models of care to find the most cost-effective way to treat common muscle and joint problems (like back, neck, knee, or shoulder pain). It looks at which approach works best for patients with persistent pain to guide future treatment decisions.
Québec, QuebecAges 18–65 - NCT06833749RecruitingPhase 2
Testing KBP-336 for knee osteoarthritis with obesity
This study tests an experimental medicine called KBP-336 for people with both obesity and knee osteoarthritis who still have significant knee pain despite standard treatments. It aims to see if KBP-336 can reduce pain and improve function.
BrnoAges 45 years+ - NCT06850818Recruiting
Hip and knee implant registry study
This study is creating a registry of patients who have hip or knee replacement surgery or revision surgery at a specific hospital. The goal is to track outcomes and improve care for future patients.
Heidelberg, Baden-WurttembergAges 18 years+
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Common questions
- Are there clinical trials for knee?
- Yes. Clin2 currently lists 816 recruiting knee studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a knee trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a knee trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.