Clinical trials
Knee clinical trials
Below are recruiting knee clinical trials, each written for real people, not researchers. We’re tracking 814 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06910150Enrolling by invitation
Pain relief after knee surgery: electric stimulation study
This trial tests two types of mild electric stimulation (one with tiny needles, one without) applied to the thigh muscle to reduce pain in people who had ACL knee surgery in the last six weeks. The goal is to see if this can help you feel better and recover quicker.
Madrid, MadridAges 18–55 - NCT06896240Recruiting
A smoothie supplement before and after knee revision surgery
This study tests whether drinking a special smoothie each day for 2 weeks before and after your knee revision surgery helps reduce inflammation and improve recovery. It is for people who have health conditions that cause inflammation, like diabetes or heart disease, and who are getting a knee replacement.
New York, New YorkAges 40–80 - NCT06885372Enrolling by invitation
Long-term follow-up of ACL tear patients without surgery
This trial is for people with a torn ACL who are young (up to 25) and have certain risk factors for knee instability. It will follow them long-term to see how their knee does without surgery, focusing on those who are active in pivoting sports, have a loose knee joint, or have naturally loose joints.
Banff, AlbertaAges 14–25 - NCT06878794Enrolling by invitation
Bio glue for fixing knee meniscus tears
This trial tests a medical bio glue to repair a torn meniscus in the knee. It may be a good option if you have a single tear and are otherwise healthy.
Ningbo, ZhejiangAges 18–60 - NCT06878417Recruiting
Cannabinoids for osteoarthritis knee or hip pain
This study tests if cannabinoid medications can reduce pain interference in daily life for people with hip or knee osteoarthritis. It may be a new option for moderate to severe pain.
Toronto, OntarioAges 40–80 - NCT04511247Recruiting
Drug-coated balloon for artery disease below the knee
This trial tests a drug-coated balloon to open narrowed or blocked arteries in the lower leg (below the knee) and help them stay open. It’s meant for people with significant symptoms, to reduce re-narrowing after treatment.
SingaporeAges 21 years+ - NCT06850818Recruiting
Hip and knee implant registry study
This study is creating a registry of patients who have hip or knee replacement surgery or revision surgery at a specific hospital. The goal is to track outcomes and improve care for future patients.
Heidelberg, Baden-WurttembergAges 18 years+ - NCT06823440Recruiting
Preventing nerve damage from chemo with compressive therapy
This trial tests if wearing compressive therapy (like special sleeves or stockings) during weekly paclitaxel chemotherapy can prevent nerve damage (peripheral neuropathy) in breast cancer patients. It is for people who have not yet had nerve issues or diabetes.
BrnoAges 18–70 - NCT06808386Enrolling by invitation
How often should you train for knee pain relief?
This study looks at how different training frequencies affect knee pain recovery. It may help active adults who have had front knee pain for at least three months.
São Paulo, São PauloAges 18–40 - NCT06776094Recruiting
Exercise and insulin sensitivity study in healthy men
This trial looks at how physical activity affects how your body responds to insulin in healthy men aged 22-35. If you are a non-smoking man with a BMI between 28 and 35 and a certain fitness level, you may be eligible.
CopenhagenAges 22–35 - NCT06781021Enrolling by invitation
ACL surgery: Clearer view with medication or tourniquet?
This study compares two ways to control bleeding during ACL knee surgery: a medication called tranexamic acid (TXA) versus a tourniquet. The goal is to see which method gives surgeons a clearer view inside the knee, which may help them do a better job.
Kingston, JamaicaAges 18 years+ - NCT05580315Recruiting
Study of treatment for a painful discoid meniscus in children
This trial is for children who have a painful discoid meniscus (a cartilage in the knee) confirmed by an orthopedic exam and MRI. It tests whether a specific study approach can help symptoms in children, while avoiding people who may need different knee treatments.
LeuvenAges 1–18 - NCT06368544Recruiting
Early walking training after ACL knee surgery
This trial studies whether starting walking exercises earlier after ACL reconstruction can help protect the knee cartilage from wearing down. It may be a good fit if you are having your first ACL surgery at Peking University Third Hospital and your knee has already healed from the initial injury.
BeijingAges 18–40 - NCT06771050RecruitingPhase 4
Antibiotics and surgery for hip and knee joint infections
This trial tests different antibiotic types and durations, plus surgical approaches, for people with a current joint infection in a hip or knee. It aims to find the best way to treat the infection and prevent it from coming back.
Garran, Australian Capital TerritoryAges 18 years+ - NCT06747494Recruiting
Comparing general vs spinal anesthesia for hip or knee replacement
This study compares two types of anesthesia (general and spinal) for people having a total hip or knee replacement. The goal is to see which approach is better for recovery and overall outcomes.
Miami, FloridaAges 18 years+ - NCT06737770Recruiting
Bone-anchored leg implant study
This study tests a bone-anchored implant (directly attached to the thighbone) for people with a single leg amputation above the knee. It aims to see if this implant helps with pain, movement, and skin issues caused by a traditional socket prosthetic.
BolognaAges 18–65 - NCT04433572RecruitingPhase 3
Temsirolimus treatment to improve below-knee artery procedures
This trial studies whether delivering a medicine called temsirolimus directly into the artery during a below-knee revascularization procedure can improve blood flow and outcomes. It may help people with severe leg artery disease who have symptoms like pain while walking or threatened limb tissue loss.
Houma, LouisianaAges 18 years+ - NCT06715709Enrolling by invitationPhase 4
How many doses of dexamethasone before knee replacement?
This trial compares different numbers of doses of dexamethasone (a steroid that reduces inflammation) given around the time of knee replacement surgery. It aims to find the best balance of pain control and side effects.
Rochester, MinnesotaAges 18 years+ - NCT06687109Recruiting
Joint replacement surgery registry study
This study collects information from people having joint replacement surgery to track how they do over time and improve care.
Spokane, WashingtonAges 18 years+ - NCT06647082Recruiting
Robotic exoskeleton and game-based therapy for kids
This study tests a robotic exoskeleton (like a wearable robot) combined with fun video game activities to help kids and young adults improve their walking. It is designed for people who have certain knee problems when they walk.
Atlanta, GeorgiaAges 4–21 - NCT06636669Enrolling by invitationPhase 4
Probiotics to prevent repeat joint infection after replacement surgery
This trial tests whether taking probiotics can help prevent another infection in people who have had a hip or knee replacement that became infected. If you are scheduled for revision surgery due to an infection, this study may be a good fit.
Boston, MassachusettsAges 18–90 - NCT06603662RecruitingPhase 4
Steroids for sudden osteoarthritis pain in the emergency room
This trial tests if a short course of oral steroids (glucocorticoids) can relieve sudden osteoarthritis pain in the knee, hip, or shoulder for people who come to the emergency department and are well enough to go home.
York, PennsylvaniaAges 18 years+ - NCT06590402RecruitingPhase 4
Nerve blocks for pain relief after kids' knee surgery
This study compares two types of nerve blocks to manage pain after knee surgery in children and teens. It is for patients aged 8 to 18 having a first-time ACL or MPFL reconstruction.
New York, New YorkAges 8–18 - NCT06571240Recruiting
Turkish Activity Score Tool for ACL Surgery Patients
This study checks if a new Turkish version of an activity score (Tegner) is valid and reliable for people having ACL surgery. If you are having your first ACL repair and speak Turkish, you may be able to take part.
AnkaraAges 18 years+
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Common questions
- Are there clinical trials for knee?
- Yes. Clin2 currently lists 814 recruiting knee studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a knee trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a knee trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.