Clinical trials
Large Vessel Occlusion clinical trials
Below are recruiting large vessel occlusion clinical trials, each written for real people, not researchers. We’re tracking 54 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06472336Recruiting
Stenting for severe stroke caused by plaque buildup
This trial tests whether placing a stent (a tiny tube) in the blocked artery in the brain can improve blood flow and help people recover from a severe stroke, especially when standard clot removal has not worked.
Basel, Canton of Basel-CityAges 18 years+ - NCT06559475Recruiting
Testing a new aspiration catheter for large vessel stroke
This trial tests a new catheter (Super-Bore 8/7F) to remove blood clots in people having a major stroke caused by a blocked large artery in the brain. The goal is to see if it is safe and effective at restoring blood flow when used within 24 hours of stroke symptoms starting.
Hefei, AnhuiAges 18 years+ - NCT06633809Recruiting
Treating minor stroke with large artery blockage
This study tests whether a specific treatment (likely endovascular therapy) helps people who have a minor stroke caused by a blockage in a large brain artery. If you are eligible, you may receive this treatment within 24 hours of your stroke to try to improve your recovery.
Hangzhou, ZhejiangAges 18 years+ - NCT06658197RecruitingPhase 3
Comparing a new clot-busting drug for severe stroke
This study tests a medication called tenecteplase, given before a procedure to remove a large blood clot in the brain. It may help people who have had a severe stroke within the last 4.5 hours.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06825897Recruiting
Direct to angiography suite for stroke clot removal
This trial compares two ways to treat severe stroke patients with a large vessel blockage. One way is the standard approach of first imaging you and then deciding. The other way takes you directly to the angiography suite for immediate clot removal by the doctor. The goal is to see if this faster, direct approach helps you get better results.
Iowa City, IowaAges 18 years+ - NCT06881420Recruiting
New stroke treatment study for blocked arteries
This study tests a special technique called BASIS to treat strokes caused by a buildup of plaque in the brain's large arteries. It may help people who have had a stroke from this condition and are treated within 72 hours.
Fuzhou, FujianAges 18 years+ - NCT06940128Recruiting
Ischemic conditioning after stroke clot removal
This trial tests a method called direct ischemic conditioning, which is a gentle way to prepare your brain to better handle the return of blood flow after a stroke. It is for people who have had a large artery blockage in the front part of the brain and have already had a successful procedure to reopen the artery.
Shengyang, LiaoningAges 18 years+ - NCT07099599Recruiting
Image test for blood flow after stroke treatment
This trial uses a special imaging technique to check if blood flow has fully returned to the brain after a stroke clot is removed. It aims to improve understanding of how well the brain's tiny blood vessels are working after treatment.
Cincinnati, OhioAges 18 years+ - NCT07115511Recruiting
Surgical rescue after failed clot removal for stroke
This trial tests a surgical rescue treatment for people who have had a major stroke from a large artery blockage, but the standard clot removal procedure (thrombectomy) did not fully open the artery. The goal is to see if combining surgery with the earlier procedure can improve outcomes.
Tianjin, Tianjin MunicipalityAges 18–75 - NCT07141303RecruitingPhase 3
Steroid after stroke clot removal for anterior circulation large vessel occlusion
This trial tests if giving a steroid (methylprednisolone) directly into the brain artery after successful clot removal improves recovery. It is for people who had a large stroke in the front part of the brain and got the clot out within 24 hours.
Xi'an, ShaanxiAges 18–80 - NCT07172789Recruiting
Head down position before clot removal for large stroke
This trial tests whether a specific head-down position before a clot removal procedure improves outcomes for people with a large vessel occlusion stroke. It is for patients who have a confirmed blockage and can wait a short time before the procedure.
Shenyang, None SelectedAges 18 years+ - NCT07174505Recruiting
Study of the CONDA Stent Retriever for stroke patients
This trial tests a device called the CONDA Stent Retriever to remove blood clots in people having a severe stroke caused by a blockage in a large brain artery. It may help if you can be treated within 24 hours of symptoms starting and meet specific brain scan and health criteria.
BudapestAges 18–85 - NCT07263308RecruitingPhase 3
Albumin for large artery stroke after clot removal
This trial tests whether giving albumin, a protein naturally found in blood, can improve recovery after a large artery stroke when given along with a procedure to remove the clot. It's for people aged 18-80 who have a stroke from a blockage in the front part of the brain and can get treatment within 24 hours.
Fuyang, AnhuiAges 18–80 - NCT07356284RecruitingPhase 3
Stroke treatment study for blocked arteries with narrowing
This study tests a rescue treatment for people having a major stroke caused by a blocked artery in the brain that also has severe narrowing. If doctors can't fully open the artery with standard clot removal, this study looks at whether additional treatments can help.
Toledo, OhioAges 18–80 - NCT07375966RecruitingPhase 2
Repeated clot-busting drug for stroke with large vessel block
This trial tests if giving a second dose of the clot-busting drug tenecteplase can help people whose stroke symptoms don't improve after the first dose, when a large or medium artery in the brain is still blocked. It may be an option for patients who cannot have a mechanical clot removal procedure.
Shenyang, LiaoningAges 18–80 - NCT07550296RecruitingPhase 2
Second IV Clot-Dissolving Treatment for Major Stroke
This trial tests giving a second dose of an IV clot-dissolving medicine (prourokinase) to patients who had a stroke from a large clot but didn't improve enough after the first dose. The goal is to see if a second dose within 6 hours of stroke onset can help more patients recover.
Shenyang, None SelectedAges 18–80 - NCT07404852Recruiting
Vagus nerve stimulation for reducing inflammation after stroke
This trial tests whether a non-invasive device that stimulates the vagus nerve can reduce inflammation and brain injury after a stroke caused by a large blood clot.
St Louis, MissouriAges 18–99 - NCT07509645RecruitingPhase 3
Testing a new drug with clot removal for severe back-of-the-brain stroke
This trial checks if adding an interleukin-6 receptor inhibitor (a drug that reduces inflammation) to standard emergency clot removal can improve recovery for people with a severe stroke affecting the back part of the brain (posterior circulation). It is for patients who need urgent treatment within 24 hours of symptom onset.
Suzhou, AnhuiAges 18 years+ - NCT07516522RecruitingPhase 2
Steroid injection during stroke clot removal surgery
This trial tests whether injecting a steroid (methylprednisolone) directly into brain blood vessels after removing a stroke clot helps reduce brain swelling and improve recovery. You would be eligible if you had a large clot stroke in the front part of your brain that was successfully removed within the past 24 hours.
Xi'an, ShaanxiAges 18–80 - NCT07519044RecruitingPhase 4
GM1 drug added to clot removal for acute stroke
This study tests whether adding a medicine called GM1 to emergency clot-removal surgery helps people recover better from sudden strokes caused by blood clots in major brain arteries. GM1 may protect brain cells from damage during and after the stroke.
Beijing, Beijing MunicipalityAges 18–80 - NCT07626450Recruiting
Hyperbaric oxygen after stroke clot removal treatment
This study tests whether hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) can help recovery after emergency clot-removal surgery for large blood vessel strokes. The goal is to see if extra oxygen can reduce brain damage and improve outcomes.
Beijing, Beijing MunicipalityAges 18–80 - NCT06781385Enrolling by invitationPhase 2
Tenecteplase after clot removal for severe stroke
This trial tests if giving a clot-busting drug (tenecteplase) directly into the brain artery after a successful clot-removal procedure can improve outcomes for people with a major stroke. It is for patients who had a large vessel blockage and received endovascular thrombectomy within 24 hours of symptoms starting.
Charlotte, North CarolinaAges 18 years+ - NCT06702787Enrolling by invitation
Mechanical thrombectomy for stroke in the Middle East and North Africa
This study collects information from people who had a stroke from a blocked brain artery and were treated with mechanical thrombectomy (a procedure to remove the clot). The goal is to understand how well this treatment works in the Middle East and North Africa.
Alexandria, Alexandria GovernorateAges Any age - NCT07357987RecruitingPhase 3
Stroke treatment with tenecteplase via artery
This trial tests a clot-busting drug called tenecteplase given directly into the brain artery for people having a moderate stroke caused by a blockage in a medium-sized blood vessel. The goal is to see if it helps improve recovery when given within 24 hours of stroke symptoms starting.
Beijing, Beijing MunicipalityAges 18 years+
Hear when a new Large Vessel Occlusion trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for large vessel occlusion?
- Yes. Clin2 currently lists 54 recruiting large vessel occlusion studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a large vessel occlusion trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a large vessel occlusion trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.