Clinical trials
Large Vessel Occlusion clinical trials
Below are recruiting large vessel occlusion clinical trials, each written for real people, not researchers. We’re tracking 55 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07375966RecruitingPhase 2
Repeated clot-busting drug for stroke with large vessel block
This trial tests if giving a second dose of the clot-busting drug tenecteplase can help people whose stroke symptoms don't improve after the first dose, when a large or medium artery in the brain is still blocked. It may be an option for patients who cannot have a mechanical clot removal procedure.
Shenyang, LiaoningAges 18–80 - NCT07367633Recruiting
Head position after clot removal for stroke
This trial tests whether keeping the head of the bed flat or elevated after a mechanical clot-removal procedure affects recovery. It may help determine the best position to improve outcomes after a stroke caused by a large blockage in a brain artery.
Greater Sudbury, OntarioAges 18 years+ - NCT07356284RecruitingPhase 3
Stroke treatment study for blocked arteries with narrowing
This study tests a rescue treatment for people having a major stroke caused by a blocked artery in the brain that also has severe narrowing. If doctors can't fully open the artery with standard clot removal, this study looks at whether additional treatments can help.
Toledo, OhioAges 18–80 - NCT07263308RecruitingPhase 3
Albumin for large artery stroke after clot removal
This trial tests whether giving albumin, a protein naturally found in blood, can improve recovery after a large artery stroke when given along with a procedure to remove the clot. It's for people aged 18-80 who have a stroke from a blockage in the front part of the brain and can get treatment within 24 hours.
Anqing, AnhuiAges 18–80 - NCT07253181RecruitingPhase 3
Stroke clot-busting drug before transfer for artery clearing
This trial tests whether giving a clot-busting drug (tenecteplase) before transferring you to a hospital that can do a procedure to remove the clot improves outcomes for people who had a stroke up to 24 hours earlier. You may qualify if you have a blockage in a large artery in the front of your brain and can still get the procedure.
Beijing, Beijing MunicipalityAges 18 years+ - NCT05199662RecruitingPhase 3
IV clot-busting medicine for stroke when standard options don’t fit
This trial tests whether giving IV TNK (tenecteplase) plus standard stroke care can improve outcomes in some people who have a new stroke but cannot get alteplase (another clot-busting drug) and do not have a large blocked artery that can be treated with a procedure. It’s meant for strokes with “mismatch” findings on scans that suggest salvageable brain tissue.
Porto Alegre, Rio Grande do SulAges 18 years+ - NCT07174505Recruiting
Study of the CONDA Stent Retriever for stroke patients
This trial tests a device called the CONDA Stent Retriever to remove blood clots in people having a severe stroke caused by a blockage in a large brain artery. It may help if you can be treated within 24 hours of symptoms starting and meet specific brain scan and health criteria.
BudapestAges 18–85 - NCT07172789Recruiting
Head down position before clot removal for large stroke
This trial tests whether a specific head-down position before a clot removal procedure improves outcomes for people with a large vessel occlusion stroke. It is for patients who have a confirmed blockage and can wait a short time before the procedure.
Shenyang, None SelectedAges 18 years+ - NCT07141303RecruitingPhase 3
Steroid after stroke clot removal for anterior circulation large vessel occlusion
This trial tests if giving a steroid (methylprednisolone) directly into the brain artery after successful clot removal improves recovery. It is for people who had a large stroke in the front part of the brain and got the clot out within 24 hours.
Xi'an, ShaanxiAges 18–80 - NCT07115511Recruiting
Surgical rescue after failed clot removal for stroke
This trial tests a surgical rescue treatment for people who have had a major stroke from a large artery blockage, but the standard clot removal procedure (thrombectomy) did not fully open the artery. The goal is to see if combining surgery with the earlier procedure can improve outcomes.
Tianjin, Tianjin MunicipalityAges 18–75 - NCT07099599Recruiting
Image test for blood flow after stroke treatment
This trial uses a special imaging technique to check if blood flow has fully returned to the brain after a stroke clot is removed. It aims to improve understanding of how well the brain's tiny blood vessels are working after treatment.
Cincinnati, OhioAges 18 years+ - NCT06940128Recruiting
Ischemic conditioning after stroke clot removal
This trial tests a method called direct ischemic conditioning, which is a gentle way to prepare your brain to better handle the return of blood flow after a stroke. It is for people who have had a large artery blockage in the front part of the brain and have already had a successful procedure to reopen the artery.
Shengyang, LiaoningAges 18 years+ - NCT06904911RecruitingPhase 2
Study of tenecteplase into the artery after clot removal for stroke
This study tests a clot-dissolving drug called tenecteplase given directly into the artery after a mechanical thrombectomy (clot removal). The goal is to see if it helps improve blood flow to the small vessels in the brain after the main clot is removed.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06881420Recruiting
New stroke treatment study for blocked arteries
This study tests a special technique called BASIS to treat strokes caused by a buildup of plaque in the brain's large arteries. It may help people who have had a stroke from this condition and are treated within 72 hours.
Fuzhou, FujianAges 18 years+ - NCT06825897Recruiting
Direct to angiography suite for stroke clot removal
This trial compares two ways to treat severe stroke patients with a large vessel blockage. One way is the standard approach of first imaging you and then deciding. The other way takes you directly to the angiography suite for immediate clot removal by the doctor. The goal is to see if this faster, direct approach helps you get better results.
Iowa City, IowaAges 18 years+ - NCT06781385Enrolling by invitationPhase 2
Tenecteplase after clot removal for severe stroke
This trial tests if giving a clot-busting drug (tenecteplase) directly into the brain artery after a successful clot-removal procedure can improve outcomes for people with a major stroke. It is for patients who had a large vessel blockage and received endovascular thrombectomy within 24 hours of symptoms starting.
Charlotte, North CarolinaAges 18 years+ - NCT06702787Enrolling by invitation
Mechanical thrombectomy for stroke in the Middle East and North Africa
This study collects information from people who had a stroke from a blocked brain artery and were treated with mechanical thrombectomy (a procedure to remove the clot). The goal is to understand how well this treatment works in the Middle East and North Africa.
Alexandria, Alexandria GovernorateAges Any age - NCT06658197RecruitingPhase 3
Comparing a new clot-busting drug for severe stroke
This study tests a medication called tenecteplase, given before a procedure to remove a large blood clot in the brain. It may help people who have had a severe stroke within the last 4.5 hours.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06472336Recruiting
Stenting for severe stroke caused by plaque buildup
This trial tests whether placing a stent (a tiny tube) in the blocked artery in the brain can improve blood flow and help people recover from a severe stroke, especially when standard clot removal has not worked.
Basel, Canton of Basel-CityAges 18 years+ - NCT06383182Recruiting
Study of blood markers after stroke artery treatment
This study looks at how certain proteins in the blood change after a procedure to remove a large blockage in a brain artery. The goal is to better understand recovery after stroke treatment.
ShenyangAges 18–80 - NCT06370182Recruiting
New catheter for clot removal in disabling stroke
This trial tests a new catheter device (ANA Funnel) for removing large blood clots from the brain in people having a disabling stroke. The goal is to see if it safely removes clots better than standard treatment.
Jacksonville, FloridaAges 22–85 - NCT06143488Recruiting
Clot removal versus medication for mild stroke with large vessel blockage
This trial compares a procedure to remove the blockage (endovascular therapy) with the best medications alone for people who have a mild stroke caused by a large blocked artery in the brain. The goal is to see if the procedure can improve recovery better than medicine alone.
Wuhu, AnhuiAges 18 years+ - NCT05723926Recruiting
Carotid implants to help prevent stroke repeat in atrial fibrillation
This trial tests whether placing a carotid implant can reduce the chance of having another stroke in people with atrial fibrillation who are already taking blood thinners. It aims to prevent stroke recurrence while you continue prescribed anticoagulation.
Rockford, IllinoisAges 18 years+ - NCT07357987RecruitingPhase 3
Stroke treatment with tenecteplase via artery
This trial tests a clot-busting drug called tenecteplase given directly into the brain artery for people having a moderate stroke caused by a blockage in a medium-sized blood vessel. The goal is to see if it helps improve recovery when given within 24 hours of stroke symptoms starting.
Beijing, Beijing MunicipalityAges 18 years+
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Common questions
- Are there clinical trials for large vessel occlusion?
- Yes. Clin2 currently lists 55 recruiting large vessel occlusion studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a large vessel occlusion trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a large vessel occlusion trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.