Clinical trials
Leg Ulcer clinical trials
Below are recruiting leg ulcer clinical trials, each written for real people, not researchers. We’re tracking 56 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06939673Recruiting
Miro3D wound matrix for healing wounds and ulcers
This trial tests a special wound dressing called Miro3D that helps heal open wounds and ulcers. It may be a good option if you have a wound that is not healing, especially if it has tunnels or pockets under the skin.
Coconut Creek, FloridaAges 18 years+ - NCT07541196Recruiting
PAW-Hydrogel treatment for long-lasting wound healing
This study tests a special gel called PAW-Hydrogel to help heal chronic wounds (wounds that have not closed after 3+ months). The gel may help wounds close faster by supporting the natural healing process.
Ocoyoacac, State of MexicoAges 18 years+ - NCT06764953Recruiting
Amnion membrane graft for non-healing leg ulcers
This study tests a special amnion membrane graft to help heal chronic leg ulcers that haven't improved with standard care. The graft is placed on the wound to support healing, and results are compared with standard treatment alone.
Roanoke, VirginiaAges 18 years+ - NCT03716167Recruiting
Near-infrared laser for healing and pain in leg vein ulcers
This study tests whether a near-infrared laser can improve healing and reduce pain in chronic venous leg ulcers. If you qualify, you may receive laser treatment and will be checked over time for wound healing and pain levels.
Winston-Salem, North CarolinaAges 18 years+ - NCT04647240RecruitingPhase 2
Drug trial for stubborn leg ulcers that won’t heal
This Phase 2 trial tests MTX-001 to help heal “venous stasis ulcers,” which are open sores caused by weak leg vein circulation. It may be an option if you’ve tried standard high-compression care for weeks and your ulcer is still not healing.
Tucson, ArizonaAges 18 years+ - NCT06384183Enrolling by invitation
Real-world fish skin graft registry study
This study tracks how well a fish skin graft (Kerecis) heals wounds in real patients. It helps doctors learn more about who benefits most from this treatment.
Sarasota, FloridaAges Any age - NCT07230340Enrolling by invitationPhase 4
Placenta tissue for nonhealing leg ulcers
This study tests a special dehydrated human placenta tissue dressing for leg ulcers that won't heal. You will get either standard wound care plus this dressing, or standard care alone; later you may have the chance to receive the dressing.
Rocky Mount, North CarolinaAges 18 years+ - NCT06810726RecruitingPhase 2
Platelet-rich fibrin gel for diabetic foot ulcers
This trial tests a special gel made from your own blood (platelet-rich fibrin, or PRF) to help heal diabetic foot ulcers that are not getting better with standard care. It may be an option if you have a mild-to-moderate ulcer on the bottom of your foot with good blood flow and no infection.
Corpus Christi, TexasAges 18–80 - NCT07046767Recruiting
Amnion grafts for slow-healing leg or foot ulcers
This trial tests if a special graft made from amniotic tissue can help heal chronic leg or foot ulcers that haven't improved much in the last month. It may be an option if you have a non-healing venous leg ulcer or diabetic foot ulcer that still shows some signs of healing.
Oxnard, CaliforniaAges 18 years+ - NCT06939686Recruiting
Wound matrix study for diabetic foot ulcers
This study tests a new wound dressing made from pig tissue to help heal diabetic foot ulcers. It may help you if you have a foot sore that hasn't healed after 4 weeks of regular care.
Coconut Creek, FloridaAges 18 years+ - NCT04920253Recruiting
Testing a water-jet treatment to heal certain foot and leg wounds
This trial tests a new “micro water jet” device (Debritom+) to help heal specific hard-to-heal wounds in people who can attend frequent visits. If you qualify, you’ll be assigned to the device treatment or standard care and monitored to see how well the wound heals.
Bradenton, FloridaAges 18 years+ - NCT06236750Recruiting
Testing a human tissue wound covering for hard-to-heal ulcers
This study is testing a special wound covering made from donated human tissue (amnion/chorion membrane) to see if it helps heal stubborn diabetic foot ulcers or venous leg ulcers that haven't improved with standard care. The covering is placed on the wound to help it heal.
Kobe, HyōgoAges Any age - NCT06515093Recruiting
New skin grafts for diabetic foot and venous leg ulcers
This study tests two new skin graft products (PelloGraft for diabetic foot ulcers and SanoGraft for venous leg ulcers) to see if they heal wounds faster than standard care. If you have a hard-to-heal foot or leg ulcer, this trial may offer a new option.
Vista, CaliforniaAges 18 years+ - NCT06328010Enrolling by invitation
Real-world data registry for wound care treatments
This study collects information on various wound types and how they respond to standard care. It aims to learn what works best for wounds that haven't healed after 4 weeks of treatment.
Scottsdale, ArizonaAges 18 years+ - NCT06674980Recruiting
Testing placenta-based wound treatment for diabetic and venous leg ulcers
This trial tests if adding a special placenta-based wound covering to standard care helps heal diabetic foot ulcers and venous leg ulcers faster. It's for people with wounds that haven't healed after standard treatment for at least 4 weeks.
Metairie, LouisianaAges 18 years+ - NCT07701590Recruiting
New wound dressings for hard-to-heal leg and foot ulcers
This study tests a special amniotic membrane wound dressing compared to a synthetic wound matrix for stubborn diabetic foot ulcers or venous leg ulcers. It may help if your wound has not been healing well for over a month.
San Diego, CaliforniaAges 18 years+ - NCT05319106Recruiting
Cord blood stem cell treatment for leg venous ulcers
This trial tests human umbilical cord tissue stem cells to help heal venous leg ulcers that have lasted at least one month. It’s for adults who meet specific wound size/depth and health criteria and are willing to follow study visits.
Chongqing, Chongqing MunicipalityAges 18–70 - NCT06528873RecruitingPhase 4
COMS light therapy for chronic leg ulcers
This study tests a special light therapy called COMS to help heal chronic leg ulcers. It is for people with venous leg ulcers or mixed ulcers also involving artery disease, and aims to see if the treatment improves wound closure.
GrazAges 18 years+ - NCT07172893RecruitingPhase 4
Dermabind TL for diabetic foot ulcers
This trial tests a new wound dressing called DermaBind TL for people with diabetic foot ulcers. It aims to see if the dressing helps heal these wounds, which can be hard to treat.
DeLand, FloridaAges 18–80 - NCT06899113Recruiting
Comparing a new imaging device to standard blood flow tests
This trial tests a new camera that uses light to check blood flow in your legs. It compares the camera's results to standard tests like ABI and Doppler ultrasound to see if it works as well.
Lake Success, New YorkAges 18 years+ - NCT04737941Recruiting
Study of treatment for leg ulcers from weak leg veins
This study looks at people with a healing or healing-worsening leg ulcer caused by weak veins (venous reflux). It may help improve care for this common type of ulcer and reduce time to healing by testing an approach for venous ulcers.
HelsinkiAges 18 years+ - NCT07653165Enrolling by invitation
Wound therapy for chronic leg wounds
This trial is testing a new way to clean and treat chronic leg wounds using a special wound therapy and gentle suction. It may help wounds that have not healed for a long time.
Coconut Creek, FloridaAges Any age - NCT06383013RecruitingPhase 2
BB-101 for diabetic foot and leg ulcers
This trial tests a new medicine called BB-101 for diabetic ulcers on the lower leg or foot. The goal is to see if it helps these wounds heal faster.
TainanAges 20 years+ - NCT05422248Recruiting
Testing a new oxygen treatment for hard-to-heal leg wounds
This study tests whether a new oxygen-based wound treatment is safe and workable for people with lower-leg wounds that are slow to heal. It may help improve healing by changing the wound environment, but it’s mainly focused on feasibility (whether the approach can be used).
Dunedin, OtagoAges 16 years+
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Common questions
- Are there clinical trials for leg ulcer?
- Yes. Clin2 currently lists 56 recruiting leg ulcer studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a leg ulcer trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a leg ulcer trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.