Clinical trials
Localized Prostate Cancer clinical trials
Below are recruiting localized prostate cancer clinical trials, each written for real people, not researchers. We’re tracking 483 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07570979RecruitingPhase 1
Testing INR731 for Metastatic Prostate Cancer
This trial tests a new drug called INR731, given by mouth, for men with prostate cancer that has spread to other parts of the body. The study will check if the drug is safe and how well it works, either alone or combined with other prostate cancer medicines.
Dallas, TexasAges 18 years+ - NCT06343077RecruitingPhase 2
Hiltonol injection for prostate cancer on active surveillance
This trial tests a drug called Hiltonol (Poly-ICLC) given directly into the prostate tumor along with an injection under the skin. It is for men with low-risk prostate cancer who are on active surveillance, to see if the drug can slow or stop the cancer from growing.
New York, New YorkAges 18 years+ - NCT06877598Recruiting
Online sexual health clinic for prostate cancer patients
This study tests an online clinic (SHAReClinic) that helps prostate cancer patients and their partners with sexual health and recovery. You can join if you’re in active treatment or recently finished, have internet access, and meet a few health-related requirements.
Vancouver, British ColumbiaAges 18 years+ - NCT06879041RecruitingPhase 1
Study of a radiation drug for advanced prostate cancer
This trial tests a new drug that delivers radiation directly to cancer cells. It is for men with metastatic castration-resistant prostate cancer that has progressed after other treatments.
Palo Alto, CaliforniaAges 18 years+ - NCT07140900RecruitingPhase 1
Study of xaluritamig combined with hormone therapy for advanced prostate cancer
This trial tests a new drug, xaluritamig, given with standard hormone therapy for men with prostate cancer that has spread to other parts of the body (metastatic) and is still sensitive to hormone therapy. It aims to see if the combination is safe and works better than hormone therapy alone.
San Francisco, CaliforniaAges 18 years+ - NCT07203482Recruiting
HIFU ablation treatment for prostate cancer outcomes
This study collects data on men with early, low-risk prostate cancer who choose to have a targeted ultrasound treatment called HIFU (High-Intensity Focused Ultrasound). It looks at how well this treatment works and how men recover.
Brooklyn, New YorkAges 40–95 - NCT07344311RecruitingPhase 1
CAR-T cell therapy for advanced prostate cancer
This trial tests a new immunotherapy called A-CAR032, which uses your own immune cells to attack prostate cancer cells. It is for men with metastatic castration-resistant prostate cancer that has progressed after other treatments.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07463092Recruiting
Creatine and exercise for muscle health in prostate cancer
This study tests whether taking creatine and doing weightlifting exercises can help men with prostate cancer who have been on hormone therapy for at least 6 months to improve muscle strength and size. It lasts 12 weeks and involves supervised workouts three times per week.
São Paulo, São PauloAges 40 years+ - NCT05214937Recruiting
Help to reduce sitting time in prostate cancer survivors
This study tests an intervention to help prostate cancer survivors sit less and move more. It may help improve daily activity and reduce long periods of inactivity.
Toronto, OntarioAges 18 years+ - NCT03424850RecruitingPhase 1/Phase 2
Tested different radiation doses for early prostate cancer
This trial studies how safe and effective different high-dose radiation levels are for prostate cancer placed directly in the prostate (HDR brachytherapy). It may help by finding a dose that controls the cancer while keeping side effects acceptable.
St Louis, MissouriAges 18 years+ - NCT07661641RecruitingPhase 1
Study of new radioactive treatments for GRPR-positive tumors
This early-phase study tests two new radioactive treatments (lutetium-177 and actinium-225) together with a guided imaging agent in people with GRPR-positive solid tumors (including prostate, breast, or colorectal cancers). The goal is to see if these treatments can shrink tumors that have stopped responding to standard therapies.
Melbourne N., VictoriaAges 18 years+ - NCT05786742Recruiting
Radiation plan test for early prostate cancer with a boost
This trial tests a more concentrated radiation schedule for early-stage prostate cancer, using an extra high-dose “boost” delivered from inside the body. It may help by treating the prostate more precisely while aiming to keep side effects manageable.
QuébecAges 18–95 - NCT07001241RecruitingPhase 2
Telehealth exercise for fatigue in rural cancer survivors
This study tests a 12-week home exercise program delivered via video calls, designed to help reduce fatigue and improve physical function in people who have finished treatment for breast or prostate cancer and live in rural areas.
Aurora, ColoradoAges 18–89 - NCT06451497RecruitingPhase 1
Testing ZM008 alone and with toripalimab for advanced cancers
This trial tests a new drug called ZM008, which targets a protein on some cancer cells, first alone and then combined with another drug, toripalimab, for people with advanced solid tumors that have stopped responding to standard treatments.
Boston, MassachusettsAges 18 years+ - NCT06926075RecruitingPhase 1/Phase 2
Early trial of KESONOTIDE™ for solid tumors
This trial tests a new tablet called KESONOTIDE™ for people with solid tumors that have spread. The goal is to see if it can help when other treatments have stopped working or are not an option.
Kogarah, New South WalesAges 18 years+ - NCT07578324Recruiting
TENS to reduce pain during prostate biopsy
This study tests whether TENS (a gentle electrical stimulation applied to the skin) can help reduce pain when combined with numbing medicine during a prostate biopsy procedure. The goal is to see if this may make the biopsy more comfortable for patients.
Gdansk, Pomeranian VoivodeshipAges 40 years+ - NCT07181473RecruitingPhase 1
Safety of TJ101 for advanced solid tumors
This trial tests a new drug called TJ101 for people with advanced solid tumors who have tried standard treatments or have no standard options. It aims to see if the drug is safe and how well it works.
Orlando, FloridaAges 18 years+ - NCT05497024Recruiting
Decision aid testing for older men on prostate cancer surveillance
This trial tests an English decision aid (a patient guide) to help older men understand and feel comfortable with “active surveillance” for localized prostate cancer. It also checks how easy to use it is for patients, caregivers, and prostate cancer clinicians.
Houston, TexasAges 65 years+ - NCT07077239Recruiting
Adaptive radiation after prostate surgery to lower side effects
This trial tests a precise, short-course radiation treatment (stereotactic body radiotherapy) after prostate removal surgery that adapts to your body each day to reduce side effects. It is for people whose prostate cancer has high-risk features or a rising PSA after surgery.
Los Angeles, CaliforniaAges 18 years+ - NCT07463261Recruiting
Rectal cancer surgery: with or without a temporary stoma
This trial compares two ways of doing rectal cancer surgery: one with a temporary stoma (a bag on the belly) and one without. It aims to see if a stoma helps prevent complications after the bowel is reconnected.
MoscowAges 18–70 - NCT06991556RecruitingPhase 2
Testing JSB462 plus abiraterone for advanced prostate cancer
This trial tests a new drug called JSB462 combined with abiraterone in men with prostate cancer that has spread to other parts of the body and is still responding to hormone therapy. The goal is to see if this combination works better than current treatments.
La Jolla, CaliforniaAges 18 years+ - NCT07244341RecruitingPhase 1
Valemetostat and darolutamide for advanced prostate cancer
This trial tests a new combination of two drugs (valemetostat and darolutamide) for men with metastatic castration-resistant prostate cancer that has worsened after prior treatment. The goal is to see if the combination can slow cancer growth.
La Jolla, CaliforniaAges 18 years+ - NCT06949254Recruiting
Study of radiation and hormone therapy for high-risk prostate cancer
This study looks at combining stereotactic body radiation therapy (a precise type of radiation) with hormone therapy for men with high-risk prostate cancer that hasn't spread. The goal is to see how well this treatment works with fewer side effects.
Bergamo, BergamoAges 18 years+ - NCT05116475RecruitingPhase 3
New prostate cancer trial adding darolutamide to standard treatment
This Phase 3 trial tests whether adding darolutamide to standard hormone therapy and radiation works better than standard treatment alone for newly diagnosed prostate cancer that has spread to pelvic lymph nodes. If you qualify, you may receive darolutamide or a placebo alongside long-term hormone therapy and radiation.
Chambray-lès-ToursAges 18–120
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Common questions
- Are there clinical trials for localized prostate cancer?
- Yes. Clin2 currently lists 483 recruiting localized prostate cancer studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a localized prostate cancer trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a localized prostate cancer trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.