Clinical trials
Lower Limb clinical trials
Below are recruiting lower limb clinical trials, each written for real people, not researchers. We’re tracking 194 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07633093Recruiting
Powered Leg Exoskeleton Effects on Walking in Older Adults
This study tests whether a motorized leg device (exoskeleton) can help older adults walk better and more easily. Researchers will compare how well people walk with and without the device to understand if it improves balance, strength, and walking speed.
ChangshaAges 18–75 - NCT07445035Recruiting
Robotic leg brace to help walking while on a breathing machine
This study tests whether walking with a robotic leg brace (exoskeleton) can help people who are on a breathing machine get better faster. It is for adults in the intensive care unit who can sit, stand with help, and have no major leg or heart problems.
New Taipei CityAges 45–65 - NCT06838013Recruiting
Electrical stimulation to improve leg movement after stroke
This trial tests a new way to help people with stroke move their legs better by combining electrical stimulation on the back and leg. If you have had a stroke more than 6 months ago and can already walk with or without a cane, this treatment might help strengthen ankle muscles and make walking easier.
Hong KongAges 50–85 - NCT06851195Enrolling by invitation
Electrical stimulation for leg strength in COPD
This trial tests whether a gentle electrical stimulation applied to your leg muscles can help you feel less breathless and less tired during daily activities, and improve your confidence in exercising. It is for people with stable COPD who are already in a pulmonary rehab program.
Kaohsiung, TaiwanAges 18 years+ - NCT06685094Recruiting
Pain, movement, and quality of life study for Albanian speakers
This study is translating health questionnaires into Albanian to better understand pain, movement, mood, and quality of life. It aims to help people with muscle, joint, or back pain.
Murcia, MurciaAges 18–80 - NCT04030650Recruiting
Study of walking expectations on slopes and stairs after limb amputation
This study looks at how people with a leg amputation think about and perform walking on stairs and up/down slopes. It may help researchers understand what supports safer, more confident mobility.
DijonAges 18 years+ - NCT06082349Recruiting
LVA surgery vs sham for cancer-related lymphedema
This study tests a surgery called lymphaticovenous anastomosis (LVA) against a sham (placebo) surgery to see if it helps reduce swelling in people with lymphedema caused by cancer treatment. It is for patients with early-stage lymphedema in one arm or leg that hasn't improved with standard care.
Nijmegen, GelderlandAges 18 years+ - NCT06987019Recruiting
Testing balance in people with one-sided below-knee amputation
This study tests a new way to measure balance in people who have a below-knee amputation on one leg. It uses special sensors to see how well the legs work together during movement, which could help improve prosthetic fit and rehabilitation.
New York, New YorkAges 18 years+ - NCT06544135Recruiting
Thermal camera study for blood flow in PAD with tissue loss
This study uses a special camera that detects heat to see blood flow in your leg before and after a procedure to open blocked arteries.
Beachwood, OhioAges 18–99 - NCT07335341Recruiting
Liberant thrombectomy system case survey
This survey collects feedback from doctors who used the Liberant system to remove blood clots. The results help understand how well the device works in real-life procedures.
Washington D.C., District of ColumbiaAges 22 years+ - NCT05225792Recruiting
Fast rehab program for leg injuries and amputations
This trial tests a rapid rehabilitation approach for people with certain leg injuries, including amputations and limb salvage, while you are already in standard rehab. It may help improve walking and balance after trauma by using a structured training program.
Rochester, MinnesotaAges 18 years+ - NCT06473740RecruitingPhase 4
Gene therapy plus angioplasty for severe leg blockages
This study tests if adding gene therapy to a standard leg artery-opening procedure (angioplasty or stenting) helps people with severe leg pain or non-healing wounds due to blocked arteries. It may improve blood flow and save the leg from amputation.
Blagoveshchensk, Amur OblastAges 18 years+ - NCT06839885Recruiting
Water Therapy for Swelling in One Leg
This trial tests whether water-based therapy (hydrotherapy) can help reduce swelling in one leg caused by lymphedema. It's for people who have already tried standard lymphedema treatment.
IstanbulAges 18–75 - NCT03171012Recruiting
Exercise rehab with added movement retraining after stroke
This trial tests whether adding a specific movement-retraining method (proprioceptive neuromuscular facilitation) to heart-and-lung style exercise improves recovery after stroke. It focuses on people who still have one-sided weakness and can already walk a short distance.
Recife, PernambucoAges 21–65 - NCT06747117Recruiting
Removing blood clots in leg arteries with the Indigo system
This study tests a device that vacuums out blood clots from blocked leg arteries, potentially restoring blood flow without open surgery.
Scottsdale, ArizonaAges 18 years+ - NCT04658693Recruiting
Restore leg sensation in diabetic nerve damage with safe stimulation
This study tests a treatment that delivers mild stimulation to help bring back lower-limb feeling in people with diabetic nerve damage (or an insensate foot) and may also protect nerves. If you qualify and can safely take part in testing and follow-up, it could improve sensation and walking comfort.
Cleveland, OhioAges 18 years+ - NCT06737770Recruiting
Bone-anchored leg implant study
This study tests a bone-anchored implant (directly attached to the thighbone) for people with a single leg amputation above the knee. It aims to see if this implant helps with pain, movement, and skin issues caused by a traditional socket prosthetic.
BolognaAges 18–65 - NCT06519175Recruiting
Study of leg problems in children
This study gathers information on children with leg bone or muscle problems (from birth or later) to better understand their conditions. It may help improve future care for kids with similar issues.
BolognaAges Up to 18 years - NCT05124652Recruiting
Testing a prosthetic socket that adjusts automatically
This trial is testing a prosthetic socket that can automatically adjust to help fit better and feel more comfortable. It may help people with below-knee (transtibial) amputations who currently struggle with socket fit or comfort.
Seattle, WashingtonAges 18 years+ - NCT04063592Recruiting
Surgery plan for pain or skin problems in a healed leg stump
This study looks at a surgical approach for people who already had an above-knee or below-knee amputation and now have ongoing pain or skin/stump problems that haven’t improved. It aims to improve comfort and how well the stump area heals, assuming you’re healthy enough for surgery under standard anesthesia.
Bethesda, MarylandAges 18–65 - NCT06648798Recruiting
Comparing a new fast-fit prosthetic leg to your current one
This trial is testing a new quick-to-make, custom below-knee prosthetic leg (called the UniLeg). It compares how well it works for daily walking versus your current prosthetic. The goal is to see if the new leg can be made faster and fit better, helping you stay active.
La Jolla, CaliforniaAges 18–75 - NCT06667492Recruiting
Leg strength measurement in healthy kids
This study measures leg muscle strength in healthy children ages 5 to 16 to better understand normal development. If your child is developing typically and can follow instructions, they may be able to join.
Lamia, PhthiotisAges 5–16 - NCT07323147Enrolling by invitation
Robot-assisted walking therapy for hip fracture recovery
This study tests whether a robot suit can help older adults walk better after hip fracture surgery. If you are 65 or older and had surgery for a broken hip from a minor fall, you may be able to join.
Beijing, Beijing MunicipalityAges 65–100 - NCT05287646Recruiting
Track how your residual limb moves while walking with a prosthesis
This study uses a special X-ray and markers to measure how your leg and skin move inside your prosthetic socket while you walk. It may help researchers better understand fit and comfort for people with transtibial (below-knee) amputations.
New York, New YorkAges 18 years+
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Common questions
- Are there clinical trials for lower limb?
- Yes. Clin2 currently lists 194 recruiting lower limb studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a lower limb trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a lower limb trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.