Clinical trials
Lower Limb clinical trials
Below are recruiting lower limb clinical trials, each written for real people, not researchers. We’re tracking 205 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05287646Recruiting
Track how your residual limb moves while walking with a prosthesis
This study uses a special X-ray and markers to measure how your leg and skin move inside your prosthetic socket while you walk. It may help researchers better understand fit and comfort for people with transtibial (below-knee) amputations.
New York, New YorkAges 18 years+ - NCT07878767Recruiting
Sound waves for varicose veins in the legs
This study tests a new treatment that uses sound waves to close off varicose veins in the legs, without surgery. It may be an option for people with mild to moderate varicose veins who are looking for a less invasive treatment.
Câmpina, PrahovaAges 35–80 - NCT07872683Recruiting
Drinking carbohydrates before hip or leg surgery: maltodextrin vs sugar water
This study compares two drinks given before surgery—maltodextrin (a carbohydrate powder mixed with water) versus sugar water—to see which one keeps the stomach empty and reduces risks during surgery on the lower limbs. It may help older patients have a safer and more comfortable experience.
Denpasar, BaliAges 60 years+ - NCT07873424Recruiting
Recumbent cycling and electrical stimulation for leg rehab
This study tests whether combining recumbent cycling with electrical muscle stimulation can improve leg function. It may help people with leg weakness or injuries to recover strength and mobility.
Oro Verde, Entre Ríos ProvinceAges 18–60 - NCT06269354Recruiting
3D-printed implant for large lower-limb bone defects
This trial is testing a new way to treat large bone defects in the lower leg or thigh using a custom 3D-printed titanium implant. It may help people whose bone didn't heal after injury, infection, or tumor removal.
Beijing, HaidianAges 18–90 - NCT03035747Recruiting
Registry for treatment of varicose veins
This study collects information about people who have varicose veins with abnormal backflow in the leg veins. It’s meant to track how treatments for chronic venous problems are working over time, which can help improve care for others in the future.
Saint PetersburgAges 18 years+ - NCT07840781Recruiting
Building a performance model for amputee football players
This study aims to understand what makes amputee football players perform well, so it can help improve training and performance. If you play amputee football regularly, you may be able to join and contribute to this research.
AdanaAges Any age - NCT07811674Recruiting
Foot stimulation and vibration exercises for muscle strength in young adults
This study tests if foot stimulation, whole-body vibration, and a gentle exercise routine can improve muscle activation. It might help young adults strengthen their muscles safely.
Guangzhou, GuangdongAges 18–25 - NCT06538974Recruiting
Long-term use of an exoskeleton for leg weakness
This trial tests a walking device called an exoskeleton to help people with leg weakness or movement problems. It's designed to see if using the exoskeleton regularly over time can help improve walking or mobility.
ParisAges 18 years+ - NCT06543888Recruiting
Exoskeleton training for walking and daily tasks in older adults
This study tests whether a passive lower-limb exoskeleton can help older adults walk better and do daily activities more easily. You will wear the device during training sessions to see if it improves your movement and independence.
Taoyuan, GuishanAges 60 years+ - NCT07768761Recruiting
Electrical stimulation exercise for lower limb paralysis
This trial tests whether a muscle exercise program using electrical stimulation can help people with paralysis in their legs. It may improve muscle strength, blood flow, or other health benefits.
Cleveland, OhioAges 18 years+ - NCT07750808Recruiting
Walking rehabilitation with a robotic exoskeleton
This study tests a wearable robotic leg brace that helps people with leg weakness practice walking. It aims to see if using the robot improves strength and movement for people recovering from stroke, spinal cord injury, or joint replacement surgery.
DhakaAges 18–60 - NCT07742397Recruiting
Leg strength and balance in adults over 65
This study looks at how differences in strength and function between your left and right legs might affect your risk of falling. If you join, you'll help researchers understand why some older adults fall and others don't, which could lead to better fall prevention.
Milan, MilanAges 65 years+ - NCT07747727Recruiting
Ultrasound and walking tests for stress incontinence
This study looks at how the pelvic floor changes after menopause and whether simple tests like ultrasound and checking how you walk can help understand stress incontinence. It may help find better ways to diagnose this condition.
Banhā, QalyoubiaAges 50–65 - NCT07708662Recruiting
Boosted compression for long-term leg swelling
This trial tests a stronger compression method for people with long-lasting leg swelling (edema) that is not caused by another medical condition. The goal is to see if it works better than standard care.
Edegem, AntwerpAges 18 years+ - NCT06638723Recruiting
Better walking after leg amputation
This study tests a new training program to help improve walking and balance for people with one leg amputation. You'll visit UNLV six times for practice sessions.
Las Vegas, NevadaAges 18 years+ - NCT06596304Recruiting
How blood vessels respond to exercise with and without blood flow restriction
This study looks at how your blood vessels respond to resistance exercise (like weight lifting) with and without a technique called blood flow restriction. It compares younger and older adults to understand how aging affects these responses.
Almada, Monte Da CaparicaAges 18 years+ - NCT07685496Recruiting
How shoes affect walking for below-knee amputees
This study looks at how different types of footwear affect walking in people with a below-knee amputation. If you use a specific energy-returning prosthetic foot and can walk without aids, you may be able to join and help improve understanding of what shoes work best.
Manchester, Greate ManchesterAges 18–65 - NCT07673328Recruiting
Knee brace study for people with knee arthritis
This study tests a motorized knee brace for people with knee osteoarthritis. The brace helps support your knee as you walk, climb stairs, and go up and down ramps.
Ann Arbor, MichiganAges 18–85 - NCT07666828Recruiting
Electrical foot pad study for leg health in healthy adults
This trial tests three different electrical stimulation foot pad programs to see how they affect blood flow in the legs of healthy adults. It may help improve leg health by using mild electrical pulses on the feet.
Bracknell, BerkshireAges 18 years+ - NCT07663292Recruiting
Exercise program to improve walking after stroke
This study tests whether a 12-week exercise program can help people who have had a stroke walk better. It focuses on those with a slower walking speed and uses brain scans to see if exercise can trigger positive changes in the brain.
Atlanta, GeorgiaAges 18–80 - NCT07642778Recruiting
Measuring Leg Strength in Kidney Disease Patients on Dialysis
This study measures how strong your leg muscles are in patients with chronic kidney disease who receive dialysis treatment. Understanding normal strength patterns may help doctors better support kidney disease patients' physical health and quality of life.
MadridAges 18–85 - NCT07641621Recruiting
Chiropractic Ankle Treatment and Jump Performance Study
This study tests whether chiropractic ankle manipulation improves how high and powerfully you can jump. Researchers will work with recreationally active adults to see if this treatment affects athletic performance.
Seneca Falls, New YorkAges 18–35 - NCT06693245Recruiting
Pain during microwave treatment for varicose veins
This study looks at how much pain people feel during a microwave treatment for varicose veins in the leg. It aims to understand what factors affect pain, so the treatment can be more comfortable for future patients.
Chengdu, SichuanAges 18–90
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Common questions
- Are there clinical trials for lower limb?
- Yes. Clin2 currently lists 205 recruiting lower limb studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a lower limb trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a lower limb trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.