Clinical trials
Lower Limb clinical trials
Below are recruiting lower limb clinical trials, each written for real people, not researchers. We’re tracking 194 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07469020Recruiting
Cle-pad study: Checking leg artery health in spine surgery patients
This study is looking at how common blockages in leg arteries (peripheral artery disease, or PAD) are in people who are having surgery for lumbar spinal stenosis or had surgery less than 3 months ago. If you qualify, it may help doctors better understand and treat this condition.
LilleAges 18 years+ - NCT07135895Recruiting
Artix device for recent leg artery blockages
This study tests a device called Artix to remove blood clots from arteries in the leg that occurred within the last two weeks. It may help restore blood flow and avoid amputation.
San Francisco, CaliforniaAges 18 years+ - NCT07043101Recruiting
Virtual reality for leg rehab with Vector system
This study tests if using a virtual reality headset can help people who are already using a Vector walking system in the hospital. The virtual reality shows goals to aim for while walking, which may make rehab more engaging and effective.
Schenectady, New YorkAges 18 years+ - NCT06525532Recruiting
Tracking reabsorbable implant for flatfoot in kids
This study tracks how well a special reabsorbable implant works over time in children and teens who had subtalar surgery for flatfoot. You'll have an MRI to see how the implant has changed and if it helped your foot.
BolognaAges 8–15 - NCT04487314Recruiting
Study of chronic vein disease over time
This study follows people (and certain close family members) to document how chronic vein problems develop and change over time. You would get yearly checkups and ultrasound scans to track the natural course of the condition.
Saint PetersburgAges 10 years+ - NCT07134257Recruiting
Smart crutch tips for leg fracture recovery
This study tests a special crutch tip that helps guide how much weight you put on your leg after shinbone surgery. It may help you recover more safely by giving you feedback on your weight-bearing.
Kyiv, Kyiv OblastAges 18–80 - NCT07155967Enrolling by invitation
Blood flow restriction training for leg strength in older women
This trial tests whether a type of strength training that partly uses blood flow restriction can help older women build leg strength on one side, which may also benefit the other leg. It's for women who are generally healthy and have not had recent leg injuries or surgeries.
Presidente Prudente, São PauloAges 60 years+ - NCT07641621Recruiting
Chiropractic Ankle Treatment and Jump Performance Study
This study tests whether chiropractic ankle manipulation improves how high and powerfully you can jump. Researchers will work with recreationally active adults to see if this treatment affects athletic performance.
Seneca Falls, New YorkAges 18–35 - NCT06269354Recruiting
3D-printed implant for large lower-limb bone defects
This trial is testing a new way to treat large bone defects in the lower leg or thigh using a custom 3D-printed titanium implant. It may help people whose bone didn't heal after injury, infection, or tumor removal.
Beijing, HaidianAges 18–90 - NCT07629674Recruiting
Video Therapy to Help Leg Movement Recovery After Stroke
This study tests whether watching specially designed videos can help improve leg strength and walking ability in people recovering from stroke. You'll receive this video therapy alongside your regular rehabilitation care.
Saint-EtienneAges 18–80 - NCT06780943Recruiting
Study on how people with leg amputations adapt their walking
This study looks at how people with a leg amputation change the way they walk to make up for lost function. It may help improve rehabilitation and prosthetic care.
NîmesAges 18–80 - NCT06667739Recruiting
Promoting physical activity after leg amputation
This study tests a program to help people who have lost a leg due to diabetes or blood vessel disease become more active. It uses coaching and online modules to support your progress.
Toronto, OntarioAges 18 years+ - NCT07520487Recruiting
Ketamine Plus Spinal Anesthesia for Older Adults Undergoing Leg Surgery
This study tests whether adding ketamine (a type of anesthetic medication) to spinal anesthesia—numbing medication injected near the spine—can make the numbness last longer for older adults having leg surgery. The goal is to see if this combination improves pain control after surgery.
Cairo, Giza GovernorateAges 65 years+ - NCT06472518RecruitingPhase 4
Clot-busting treatment plus blood thinners for severe leg clots
This trial tests whether combining a clot-busting procedure (pharmaco-mechanical thrombolysis) with standard blood thinners works better than blood thinners alone for people with severe, recently formed deep vein clots in the upper leg.
NantesAges 18 years+ - NCT07561320RecruitingPhase 4
Two ways to treat enlarged veins in your leg
This study compares two minimally invasive procedures to treat enlarged great saphenous veins (a vein in your thigh that can cause swelling, pain, or skin changes). Both procedures seal off the problematic vein by either using heat and mechanical motion or injecting a foaming substance.
São Paulo, São PauloAges 18 years+ - NCT07592325Recruiting
Testing a New Flexible Prosthetic Socket for Below-Knee Amputees
This trial compares a new flexible prosthetic socket design to the rigid socket you currently wear. The goal is to see if the new socket is more comfortable, easier to put on, and improves how well your prosthetic leg works for daily activities.
ClamartAges 18 years+ - NCT07078201RecruitingPhase 4
Comparing two pain meds in spinal anesthesia for leg surgery
This study compares two medicines (dexmedetomidine and fentanyl) added to a spinal numbing shot for people having planned leg or knee surgery. The goal is to see which one works better to keep your blood pressure stable, and to make the numbing last while keeping you comfortable.
Port SaidAges 20–60 - NCT07124377Recruiting
Study of hereditary ATTR amyloidosis symptoms
This study looks at how a specific genetic change (Val50Met) affects people with hereditary ATTR amyloidosis. It may help doctors better understand the condition and its symptoms.
Charata, Chaco ProvinceAges 20 years+ - NCT07515144Enrolling by invitation
Nerve Stretching for Muscle Strength in Older Adults
This study tests whether a gentle nerve-stretching technique in the leg can help older adults with age-related muscle loss regain strength and muscle size. You'll attend sessions where a therapist guides your leg through specific movements designed to mobilize nerves and improve muscle function.
Seremban, Negeri SembilanAges 60 years+ - NCT07440615Recruiting
Leg muscle and heart performance in active adults
This study looks at how leg muscle size relates to heart and muscle performance in healthy men and women. It aims to understand normal differences between sexes.
EskişehirAges 18–30 - NCT06638723Recruiting
Better walking after leg amputation
This study tests a new training program to help improve walking and balance for people with one leg amputation. You'll visit UNLV six times for practice sessions.
Las Vegas, NevadaAges 18 years+ - NCT07384689Recruiting
Study of leg tissue in non-traumatic amputation patients
This study looks at the tissue environment in the legs of patients who need amputation due to non-traumatic causes, like poor blood flow or infection. Understanding the tissue better might help improve healing for future patients.
Aarhus NAges 18 years+ - NCT07175714Recruiting
Study of walking stumbles and slips
This study tests how well different methods can recreate stumbles and slips while walking. It may help people with and without prosthetic legs understand how to prevent falls.
ReykjavikAges 18 years+ - NCT06275282Recruiting
Nerve surgery for better leg prosthetic control
This trial tests a new nerve surgery technique to help people with above-knee leg amputations have better control of their prosthetic leg. The goal is to improve how well the prosthesis responds to your movements.
Ann Arbor, MichiganAges 18–75
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Common questions
- Are there clinical trials for lower limb?
- Yes. Clin2 currently lists 194 recruiting lower limb studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a lower limb trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a lower limb trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.