Clinical trials
Major Depression Severe clinical trials
Below are recruiting major depression severe clinical trials, each written for real people, not researchers. We’re tracking 282 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05703256Recruiting
Brain training with feedback to help depression
This trial tests a type of brain training called amygdala neurofeedback to reduce depression symptoms. It may help by teaching your brain patterns to become less “stuck” in depression-related activity.
Pittsburgh, PennsylvaniaAges 18–55 - NCT05142683Recruiting
Test an integrated care plan for teens with depression
This study tests whether a structured, coordinated care pathway helps teens (and their caregivers) manage depression better than usual care. It aims to see if targeted treatment and follow-up improve depression symptoms over time.
Toronto, OntarioAges 13–18 - NCT05437588Recruiting
Blood-based biomarkers for suicide risk in teens with depression
This study looks at tiny blood particles (exosomes) and specific microRNAs to see if they can signal suicide risk and predict treatment outcomes in adolescents. If you qualify, your blood may be used to help researchers find better ways to understand and track suicidality and depression treatment response.
Birmingham, AlabamaAges 10–24 - NCT05915013RecruitingPhase 1
Brain-targeting study of ketamine response in treatment-resistant depression
This early-stage study looks at how parts of brain cells respond to ketamine in people with depression who have not improved with usual antidepressants. It may help researchers find why ketamine works for some people and not others, and who might benefit.
New Haven, ConnecticutAges 18–60 - NCT07682207Recruiting
Accelerated brain stimulation for PTSD and depression
This study tests an accelerated form of brain stimulation called iTBS to see if it can help people with both PTSD and depression. It may be a good option if you have not found enough relief from your current treatments.
London, OntarioAges 18 years+ - NCT05423275Recruiting
Light treatment to help you stop antidepressants safely
This study tests whether a “light and ion” treatment can help people with major depression (MDD) who are doing well on antidepressants safely reduce or stop them. You must be in remission and be willing to discontinue for reasons like side effects or personal preference.
Vancouver, British ColumbiaAges 19–65 - NCT07217444Recruiting
Deep TMS for depression in teens
This trial tests whether a non-invasive brain stimulation technique called deep transcranial magnetic stimulation (dTMS) can help teens with moderate to severe depression feel better. It involves wearing a special magnetic coil on the head during several sessions.
Cincinnati, OhioAges 14–18 - NCT07015944Recruiting
Moving on after breast cancer: a depression trial for survivors in Pakistan
This study tests a program called "Moving on After Breast Cancer" for women in Pakistan who have finished breast cancer treatment and now have depression. The goal is to see if this program helps them feel better emotionally.
Karachi, SindhAges 18 years+ - NCT06983405Recruiting
Physical therapy for depression and quality of life pilot
This study is testing whether adding physical therapy to your usual depression care can improve your quality of life while you are in the hospital. If you are an adult admitted to the psychiatry unit with major depression, you may be able to join.
Zaragoza, AragonAges 18 years+ - NCT05570110RecruitingPhase 1/Phase 2
Enoxolone for depression, using body signals to track response
This study tests enoxolone, a medication related to licorice, in people with unipolar (non-bipolar) major depression. It also looks at your body “signals” (biomarkers) to see which ones match with whether treatment helps.
Marburg, HesseAges 18 years+ - NCT04581902Recruiting
Study blood and brain markers in moderate to severe depression
This study looks at changes in depression “markers” to understand what treatments help and why. You’ll have non-invasive brain stimulation and scans before and after treatment, over about 8 weeks.
San Francisco, CaliforniaAges 18–70 - NCT07554755Recruiting
Transcranial Stimulation for Teen Depression with Self-Injury
This trial tests a non-invasive brain stimulation treatment (TIS) for teenagers aged 12–22 with depression who injure themselves without wanting to die. The goal is to reduce depression symptoms and self-injury urges.
Hefei, AnhuiAges 12–22 - NCT06512324Enrolling by invitation
TMS with remote viewing for depression and anxiety
This trial tests whether adding 'remote viewing' (a technique where a person tries to perceive a distant target) to standard TMS brain stimulation can improve depression and anxiety symptoms. It is for people already getting TMS and who can attend weekly visits.
Encinitas, CaliforniaAges 12 years+ - NCT06402955RecruitingPhase 2
Imaging depression in Parkinson's disease
This study uses brain imaging (PET scans) to understand depression in people with Parkinson's disease. It may also test a depression treatment called ketamine, but the main goal is to see how the brain changes with depression.
New Haven, ConnecticutAges 40–80 - NCT06136546RecruitingPhase 2
Infliximab for depression with cognitive problems
This trial tests if a medicine called infliximab, given through an IV, can help improve thinking and memory problems in people with moderate to severe depression who also have high inflammation levels. It aims to see if lowering inflammation can ease both mood and cognitive symptoms.
Boston, MassachusettsAges 25–50 - NCT04124341Recruiting
Brain stimulation for treatment-resistant depression
This study tests a new brain stimulation treatment for people with severe depression that hasn't improved with standard treatments. You must have tried at least four different depression treatments without success, and either had or refused electroconvulsive therapy (ECT). You’ll need to be under a psychiatrist’s care and be enrolled in Medicare. The study involves brain scans and EEG sessions to tailor the treatment to you.
Minneapolis, MinnesotaAges 22–70 - NCT05866575Recruiting
Brain-modeling trial to predict depression treatment response
This trial uses computer modeling based on brain measurements to try to predict which depression treatment will work for you. It may help match you with the most effective option faster by understanding your motivation-related brain patterns.
La Tronche, IsèreAges 18 years+ - NCT07247968RecruitingEarly Phase 1
Esketamine with ECT for severe depression in teens
This study tests whether adding a low dose of esketamine (a type of anesthesia) to modified electroconvulsive therapy (ECT) helps treat severe depression in teenagers. It aims to see if this combination works better and is safer than ECT alone.
ChongqingAges 13–17 - NCT07127913Recruiting
Closed-loop brain stimulation for hard-to-treat bipolar depression
This trial tests a closed-loop deep brain stimulation system for people with bipolar II disorder whose depression has not responded to standard treatments. The device sends targeted electrical pulses to the brain based on real-time activity, aiming to reduce depression symptoms.
San Francisco, CaliforniaAges 22–70 - NCT06656416RecruitingPhase 2
Study of ALTO-100 for bipolar depression
This study tests an investigational drug called ALTO-100 for people with bipolar disorder who are currently experiencing depression. It aims to see if ALTO-100 can help improve depressive symptoms when added to your current mood stabilizer or antipsychotic medication.
Birmingham, AlabamaAges 18–70 - NCT04191811Recruiting
Using brain signals to predict CBT success for mood or sleep issues
This study tests whether brain measurements can help predict who will benefit from a type of talk therapy called CBT (cognitive behavioral therapy). If you have depression, social anxiety, or insomnia, your brain “response variability” may be used to personalize or improve treatment planning.
Huddinge, Stockholm CountyAges 18 years+ - NCT06376734RecruitingPhase 2
TMS for depression, anxiety, OCD, or schizophrenia
This study tests whether a brain stimulation technique called TMS can help people with depression, anxiety, OCD, or schizophrenia. It aims to find better ways to target the treatment for each person's specific needs.
Sunnyvale, CaliforniaAges 18–65 - NCT07216404RecruitingPhase 2
Psilocybin therapy for depression in lung cancer patients
This trial tests whether a psychedelic-assisted therapy can help treat major depression in people with non-small cell lung cancer. If you have moderate to severe depression and are receiving cancer treatment, you may be able to join.
Columbus, OhioAges 18 years+ - NCT07454070Recruiting
Testing ear nerve stimulation for depression after a heart attack
This trial tests if a gentle, non-invasive ear stimulation device can help relieve depression in people who have had a heart attack and a stent placed. It aims to offer a drug-free option for those who choose not to take antidepressants or see a therapist.
Xi'an, ShaanxiAges 18 years+
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Common questions
- Are there clinical trials for major depression severe?
- Yes. Clin2 currently lists 282 recruiting major depression severe studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a major depression severe trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a major depression severe trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.