Clinical trials
Major Depressive Disorder clinical trials
Below are recruiting major depressive disorder clinical trials, each written for real people, not researchers. We’re tracking 506 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05989412Enrolling by invitation
Mobile screening for depression in Rotterdam Zuid
This study uses a mobile app to screen for signs of major depression in adults from diverse backgrounds in Rotterdam Zuid. The goal is to find people who might have undiagnosed depression and guide them to care.
RotterdamAges 18 years+ - NCT05565352Enrolling by invitation
Ketamine safety study for people in inpatient psychiatric care
This trial looks at whether ketamine is safe and well-tolerated for certain mental health conditions when given in a hospital setting. It may help teams better understand side effects and comfort for people who may be offered ketamine.
GdanskAges 18–90 - NCT05487911Enrolling by invitation
Brain stimulation (rTMS) for depression symptoms
This trial tests whether a non-surgical brain stimulation technique (rTMS) can reduce depression symptoms in adults with major depression. You would likely have several study visits that include brain scans (MRI) and treatment sessions to see if symptoms improve.
Houston, TexasAges 18–64 - NCT04509102Enrolling by invitationEarly Phase 1
Test added stimulant medicine with rTMS for depression
This early study tests whether adding a stimulant medicine to repetitive TMS (a non-drug brain stimulation) can improve depression. It is aimed at people whose depression has not improved after at least two antidepressant tries.
Los Angeles, CaliforniaAges 18–65 - NCT03736538Enrolling by invitationPhase 1
Nitrous oxide for suicidal thoughts in depression
This Phase 1 study tests whether breathing nitrous oxide can safely reduce suicidal thoughts in adults with major depression. It may help people whose depression is causing moderate to severe suicidal thinking, by studying a fast-acting treatment approach.
St Louis, MissouriAges 18–65 - NCT07484217RecruitingPhase 3
Testing solriamfetol for depression with daytime sleepiness
This study tests if the drug solriamfetol can help people with major depression who also feel very tired during the day. It aims to improve both mood and daytime sleepiness.
Tucson, ArizonaAges 18–65 - NCT05423275Recruiting
Light treatment to help you stop antidepressants safely
This study tests whether a “light and ion” treatment can help people with major depression (MDD) who are doing well on antidepressants safely reduce or stop them. You must be in remission and be willing to discontinue for reasons like side effects or personal preference.
Vancouver, British ColumbiaAges 19–65 - NCT06136546RecruitingPhase 2
Infliximab for depression with cognitive problems
This trial tests if a medicine called infliximab, given through an IV, can help improve thinking and memory problems in people with moderate to severe depression who also have high inflammation levels. It aims to see if lowering inflammation can ease both mood and cognitive symptoms.
Boston, MassachusettsAges 25–50 - NCT07015944Recruiting
Moving on after breast cancer: a depression trial for survivors in Pakistan
This study tests a program called "Moving on After Breast Cancer" for women in Pakistan who have finished breast cancer treatment and now have depression. The goal is to see if this program helps them feel better emotionally.
Karachi, SindhAges 18 years+ - NCT07217444Recruiting
Deep TMS for depression in teens
This trial tests whether a non-invasive brain stimulation technique called deep transcranial magnetic stimulation (dTMS) can help teens with moderate to severe depression feel better. It involves wearing a special magnetic coil on the head during several sessions.
Cincinnati, OhioAges 14–18 - NCT06130371Recruiting
Stress, Inflammation & Brain in Depression vs. Severe PMS
This study looks at how stress and inflammation affect the brain in women with major depression compared to women with severe PMS (PMDD). It could help find better ways to understand and treat these mood disorders.
Tübingen, Baden-WurttembergAges 18–40 - NCT03665831Recruiting
Deep TMS for depression and memory problems in older adults
This study tests a type of brain stimulation called Deep TMS to help reduce depression and improve or stabilize memory-related symptoms in older adults with Alzheimer’s disease. It’s mainly for people whose depression did not improve or could not be tolerated with antidepressant medicine.
Toronto, OntarioAges 60 years+ - NCT06390462Recruiting
Counseling for teens in school-based primary care
This study tests a brief counseling approach called Interpersonal Counseling for Adolescents (IPC-A) in school settings. It aims to help teens with emotional or social challenges before they become more serious, and it's designed for those who aren't already in mental health treatment.
HämeenlinnaAges 13–16 - NCT06983405Recruiting
Physical therapy for depression and quality of life pilot
This study is testing whether adding physical therapy to your usual depression care can improve your quality of life while you are in the hospital. If you are an adult admitted to the psychiatry unit with major depression, you may be able to join.
Zaragoza, AragonAges 18 years+ - NCT07193901RecruitingPhase 2
Nasal spray for depression with suicidal thoughts
This trial tests an experimental nasal spray for people with major depression who are currently having suicidal thoughts. It aims to see if the spray can quickly reduce depression and suicidal feelings.
BeijingAges 18–64 - NCT07462013Recruiting
Lifestyle changes to prevent memory loss with depression
This study tests if healthy lifestyle changes can protect memory and thinking skills in people with depression who have no or mild memory problems.
Taichung, TaichungAges 50–80 - NCT07462637Recruiting
Light therapy for depression in unipolar and bipolar disorder
This study tests how well light therapy works for moderate to severe depression in people with or without bipolar disorder. It includes a possible MRI brain scan to understand how light affects the brain. You must not have certain eye conditions or high suicide risk.
ParisAges 18–65 - NCT06656416RecruitingPhase 2
ALTO-100 for bipolar depression
This trial tests an investigational drug called ALTO-100 in people with bipolar I or II who are currently experiencing depression. It looks at whether this new medicine can help improve depression symptoms when taken alongside your usual mood stabilizer or antipsychotic medication.
Chandler, ArizonaAges 18–70 - NCT06402955RecruitingPhase 2
Imaging depression in Parkinson's disease
This study uses brain imaging (PET scans) to understand depression in people with Parkinson's disease. It may also test a depression treatment called ketamine, but the main goal is to see how the brain changes with depression.
New Haven, ConnecticutAges 40–80 - NCT06537921Recruiting
Testing minocycline for depression with obesity
This trial tests whether adding the antibiotic minocycline to your current antidepressant helps people with both depression and obesity. It aims to see if reducing inflammation can improve mood.
LondonAges 18–65 - NCT07554755Recruiting
Transcranial Stimulation for Teen Depression with Self-Injury
This trial tests a non-invasive brain stimulation treatment (TIS) for teenagers aged 12–22 with depression who injure themselves without wanting to die. The goal is to reduce depression symptoms and self-injury urges.
Hefei, AnhuiAges 12–22 - NCT03646058RecruitingPhase 3
Add-on buprenorphine to ease suicidal thoughts in depression
This Phase 3 study tests whether adding buprenorphine to your usual pain-dose medicines can reduce severe suicidal thoughts during a major depressive episode. It may help people who are currently hospitalized or closely followed and have higher scores for both depression severity and suicidal thinking.
Bordeaux, FranceAges 18–65 - NCT07252427Recruiting
Gut bacteria in IBD with or without depression
This study looks at how the bacteria in your gut (gut microbiome) may differ between people with IBD who also have depression and those who don't. It aims to help understand the link between gut health and mood.
Jinan, ShandongAges 18 years+ - NCT05866575Recruiting
Brain-modeling trial to predict depression treatment response
This trial uses computer modeling based on brain measurements to try to predict which depression treatment will work for you. It may help match you with the most effective option faster by understanding your motivation-related brain patterns.
La Tronche, IsèreAges 18 years+
Hear when a new Major Depressive Disorder trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for major depressive disorder?
- Yes. Clin2 currently lists 506 recruiting major depressive disorder studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a major depressive disorder trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a major depressive disorder trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.