Clinical trials
Major Depressive Disorder clinical trials
Below are recruiting major depressive disorder clinical trials, each written for real people, not researchers. We’re tracking 504 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT03646058RecruitingPhase 3
Add-on buprenorphine to ease suicidal thoughts in depression
This Phase 3 study tests whether adding buprenorphine to your usual pain-dose medicines can reduce severe suicidal thoughts during a major depressive episode. It may help people who are currently hospitalized or closely followed and have higher scores for both depression severity and suicidal thinking.
Bordeaux, FranceAges 18–65 - NCT05866575Recruiting
Brain-modeling trial to predict depression treatment response
This trial uses computer modeling based on brain measurements to try to predict which depression treatment will work for you. It may help match you with the most effective option faster by understanding your motivation-related brain patterns.
La Tronche, IsèreAges 18 years+ - NCT06821646Enrolling by invitation
Brain responses in depression and autism with TMS and EEG
This study uses brain stimulation (TMS) and brain wave recording (EEG) to understand how the brain works in people with autism, depression, or both. It may help find better ways to treat these conditions.
TaipeiAges 20–50 - NCT07216404RecruitingPhase 2
Psilocybin therapy for depression in lung cancer patients
This trial tests whether a psychedelic-assisted therapy can help treat major depression in people with non-small cell lung cancer. If you have moderate to severe depression and are receiving cancer treatment, you may be able to join.
Columbus, OhioAges 18 years+ - NCT05366270Recruiting
Testing how mild heat affects depression symptoms and brain signals
This study tests whether controlled whole-body heat can change immune-related brain and body signals in people with major depressive disorder. It may help researchers understand why heat affects mood and who might benefit, while closely monitoring safety.
Boston, MassachusettsAges 18–65 - NCT07594483Recruiting
Brain Implant to Treat Hard-to-Treat Depression
This study tests a small implant placed under the scalp that delivers targeted electrical stimulation to the brain to help people with severe depression that hasn't improved with antidepressant medications. The implant is designed to rebalance brain activity and reduce depressive symptoms.
Atlanta, GeorgiaAges 22–85 - NCT07493317RecruitingPhase 2
Tocilizumab for depression with inflammation
This trial tests a medication called tocilizumab, which targets inflammation, to see if it can improve symptoms of major depression in people with signs of inflammation. You may be eligible if you have depression with a high monocyte count and significant loss of interest or pleasure.
New York, New YorkAges 18–70 - NCT07473648Recruiting
A trial of ECT and magnetic seizure therapy for mood disorders
This study compares two types of brain stimulation treatments—electroconvulsive therapy (ECT) and magnetic seizure therapy (MST)—to see which works better for people with certain mental health conditions. It may be an option if you have a mood disorder or vision problems that could be helped by these treatments.
Hefei, AnhuiAges 12–80 - NCT07402356Recruiting
Virtual reality eye test for thinking problems
This study uses virtual reality and eye-tracking (pupillometry) to measure thinking and memory problems in people with Alzheimer's, mild cognitive impairment, or depression. It aims to find better ways to detect and track cognitive changes using a simple, non-invasive procedure.
München, BavariaAges 18–80 - NCT07371065Enrolling by invitationPhase 1
Testing a new drug's safety in healthy adults
This trial tests a new medicine called LY03021 in healthy volunteers to see how safe it is, how the body processes it, and if food changes its effects. It's for people who are generally healthy and not taking other medications.
ShanghaiAges 18–45 - NCT07369180Enrolling by invitation
TMS for treatment-resistant depression in adults
This study tests a new type of transcranial magnetic stimulation (TMS) for adults whose depression hasn't gotten better with medication. It compares the real treatment to a sham (inactive) version to see how well it works.
Campbell, CaliforniaAges 22–85 - NCT07345377Enrolling by invitation
Personalized brain stimulation for irritable bowel syndrome
This study uses brain stimulation (TMS) customized for each person to treat IBS. It uses MRI scans to see how the brain responds, aiming to find better ways to predict who will benefit from this therapy.
Hangzhou, ZhejiangAges 18–75 - NCT07345858Enrolling by invitation
Saliva test for psychedelic depression treatment
This trial tests whether a simple saliva test can measure oxytocin levels during a psychedelic treatment for hard-to-treat depression. The goal is to find a biological marker that helps predict how well the therapy works.
GenevaAges 18 years+ - NCT07198100Recruiting
Ear stimulation, motivation, and insulin sensitivity in depression
This study explores how a gentle electrical stimulation of the ear might affect mood, motivation, and insulin sensitivity in people with and without depression. It aims to see if this non-invasive technique could offer new ways to help with depression.
BonnAges 18–60 - NCT07111169Recruiting
Brain stimulation and attention in depression study
This study tests whether a non-invasive brain stimulation technique (called iTBS) can improve attention problems in people with major depression. If you have depression and trouble focusing, this trial might help understand a new treatment option.
Chengdu, SichuanAges 18–55 - NCT07115628Recruiting
Accelerated TMS for treatment-resistant depression
This trial tests an accelerated form of transcranial magnetic stimulation (TMS) for people with treatment-resistant depression who have been referred for ECT. It aims to offer a non-invasive, less intensive alternative with fewer side effects.
Jette, Brussels CapitalAges 18–70 - NCT01980147Recruiting
Skills for Wellness program for youth coping with mental health risks
This trial tests a structured skills program to help children and teens (ages 9–21) cope with early mental health warning signs such as anxiety, mood swings, or unusual thoughts. It may help participants build practical coping tools and well-being.
Halifax, Nova ScotiaAges 9–21 - NCT07095205RecruitingPhase 4
Nicotine's effect on depression in brain imaging study
This trial uses a special brain scan to see how nicotine might help treat depression. It compares people with depression to healthy volunteers to understand how nicotine affects brain chemistry related to mood.
Stony Brook, New YorkAges 18–65 - NCT07076342RecruitingPhase 4
Glutamate receptors and cognitive behavioral therapy for insomnia
This study tests how a brain receptor called mGluR5 affects sleep and depression treatment. You may qualify if you have major depression with insomnia and are not currently on antidepressants.
Stony Brook, New YorkAges 18 years+ - NCT07059234Recruiting
Depression and Activity: The MASE Project
This study tests whether tracking your daily activity can help improve energy and mood in people with depression. You will wear a small device that measures your movement.
BernAges 18–60 - NCT06927076Recruiting
DMT with propofol for depression
This study tests whether a combination of DMT (a psychedelic) and propofol (a sedative) can help treat depression. You will receive both medicines in a hospital setting, and the team will monitor your response.
BaselAges 21 years+ - NCT06891300RecruitingPhase 2/Phase 3
Ketamine for Suicidal Thoughts in Depression
This study tests if ketamine can help reduce suicidal thoughts in people with major depression. You'll receive ketamine treatment and be monitored closely.
Ottawa, OntarioAges 18–65 - NCT06860724Recruiting
Stress and blood vessel health study for adults 18-55
This study looks at how daily stress affects blood vessel function in healthy adults and those with depression. It aims to find links between emotions and physical health.
Newark, DelawareAges 18–55 - NCT06854224RecruitingPhase 2
Testing a sleep drug for suicide risk in veterans with depression
This trial tests whether a medication called suvorexant (used for sleep) can help lower suicide risk in veterans who have major depression and have attempted suicide before. The study aims to see if blocking a brain chemical called orexin reduces suicidal thoughts.
The Bronx, New YorkAges 18–70
Hear when a new Major Depressive Disorder trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for major depressive disorder?
- Yes. Clin2 currently lists 504 recruiting major depressive disorder studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a major depressive disorder trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a major depressive disorder trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.