Clinical trials
Metastases clinical trials
Below are recruiting metastases clinical trials, each written for real people, not researchers. We’re tracking 453 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06367270RecruitingPhase 2
Chemotherapy spray into the belly for stomach, pancreas, or colon cancer
This trial tests a new way to give chemotherapy – as a fine mist sprayed directly into the belly during a short laparoscopy (keyhole surgery). It is for people whose stomach, pancreas, or colon cancer has spread to the lining of the belly, and who haven't had much chemotherapy before.
Hong KongAges 18 years+ - NCT06716294Recruiting
Radiofrequency ablation and stabilization for spine tumors
This trial tests a treatment that uses heat to destroy active spine tumors from cancer that has spread, followed by stabilizing the bone. It aims to see if the treatment works by using a special scan (PET-CT) to confirm the results.
Athens, AthensAges 18–90 - NCT07033364Recruiting
Liver function study after radiation treatment for metastases
This trial studies how well the liver works after stereotactic body radiation therapy (SBRT) for cancer that spread to the liver. If you had this specific type of radiation in three large doses, you may help researchers learn more about liver recovery.
AmsterdamAges 18 years+ - NCT07399236Recruiting
AI prediction of liver spread in colorectal cancer
This study looks at whether an AI tool can predict if colorectal cancer will spread to the liver. The researchers will review past medical records of patients who had surgery to remove their cancer and had no signs of spread at that time.
Wuhan, HubeiAges 18–75 - NCT07172282RecruitingEarly Phase 1
Immunotherapy for colorectal cancer liver metastases
This trial tests a new way to deliver immunotherapy directly into the liver for people with colorectal cancer that has spread only to the liver. The goal is to see if this approach can shrink tumors before surgery, and it may be an option if you've already had standard chemotherapy.
Lake Success, New YorkAges 18 years+ - NCT05863195RecruitingPhase 3
Pump chemotherapy plus standard chemo for liver-only colorectal spread
This study tests adding a chemotherapy “pump” directly into the liver along with standard chemotherapy, compared with standard chemotherapy alone. It’s for adults with colorectal cancer that has spread to the liver but cannot be surgically removed, and who are responding to first chemotherapy.
Birmingham, AlabamaAges 18 years+ - NCT05285358RecruitingPhase 1
Aerosol chemo plus standard drugs for bile duct and gallbladder cancer
This trial tests a new way to give the drug paclitaxel directly into your belly as a mist, along with two standard chemo drugs given through your veins, for bile duct or gallbladder cancer that has spread to the lining of the belly. The goal is to see if this approach can better control the cancer in the belly.
Duarte, CaliforniaAges 18 years+ - NCT03726359Recruiting
Targeted radiation for brain metastases using staged stereotactic treatment
This Phase 1 study tests a form of focused radiation given in stages to shrink larger brain metastases. It may help people whose tumors are in the brain but not suited to whole-brain radiation alone, while also checking safety and how well the treatment can be delivered.
The Bronx, New YorkAges 18 years+ - NCT00242723Recruiting
Looking at cell changes in lung, esophagus, and chest cancers
This study collects blood, urine, and tissue samples from people with lung, esophageal, or other chest cancers to look at cell changes. It does not test a new treatment—instead, it aims to better understand these cancers through research.
Bethesda, MarylandAges 2–120 - NCT03911388RecruitingPhase 1
HSV G207 for Children with Recurrent Cerebellar Brain Tumors
This trial is testing a virus called HSV G207, which is injected directly into the tumor, to treat children and young adults with a type of brain tumor in the cerebellum that has come back or not responded to standard treatments.
Birmingham, AlabamaAges 3–22 - NCT07281924RecruitingPhase 1/Phase 2
Combination Treatment for Melanoma Spread to Liver
This trial tests a combination of liver-directed chemotherapy (HEPZATO KIT) with a new immunotherapy called Opdualag for people whose melanoma has spread to the liver and who have not had many prior treatments.
Madison, WisconsinAges 18 years+ - NCT06519591RecruitingPhase 2
New drug combo for stomach cancer with abdominal spread
This trial tests a combination of three drugs (given through a vein and a pill) plus a chemotherapy infusion directly into your belly for stomach cancer that has spread to the lining of the abdomen. It specifically looks at a marker called Claudin 18.2 to see if this treatment works better for people with that marker.
Shanghai, Huangpu DistrictAges 18 years+ - NCT07328243Recruiting
New treatment for thyroid cancer that spread to neck lymph nodes
This study tests a minimally invasive treatment called irreversible electroporation for thyroid cancer that has come back or spread to lymph nodes in the neck. It may be an option for people who can't have another surgery or for whom radioactive iodine therapy hasn't worked.
Guangzhou, GuangdongAges 18 years+ - NCT06952803RecruitingPhase 3
Testing a new drug for men with BRCA-related prostate cancer
This trial tests whether adding a new drug (saruparib) to standard radiation and hormone therapy can help prevent prostate cancer from spreading to other parts of the body. It is for men with high-risk prostate cancer that has a BRCA gene mutation.
Phoenix, ArizonaAges 18 years+ - NCT04796818Recruiting
MRI scan to track response in colorectal liver metastases
This study uses a special MRI scan to see how colorectal cancer in the liver responds to planned chemotherapy before and after surgery. It may help doctors better measure treatment success and plan care.
Houston, TexasAges 18 years+ - NCT06047379RecruitingPhase 1/Phase 2
Testing NEO212 for brain tumors and metastases
This trial tests a new drug called NEO212 for people with certain brain tumors (like astrocytoma or glioblastoma) or cancer that has spread to the brain from other parts of the body. The goal is to see if it is safe and if it can help shrink or control the tumors.
Beverly Hills, CaliforniaAges 18 years+ - NCT03093909RecruitingPhase 1
Breathing treatment with gemcitabine for lung cancer spread
This early-stage trial studies an inhaled (aerosol) form of gemcitabine to treat solid tumors that have spread to the lungs. It aims to see whether this lung-focused treatment is safe and how well it might work when standard curative options are not available.
Houston, TexasAges 12–50 - NCT03280511RecruitingPhase 2
After surgery chemo sprayed into the abdomen for high-risk colon cancer
This Phase 2 study tests whether spraying chemotherapy into the abdomen (through a small procedure) after colon cancer surgery can lower the chance the cancer comes back. It is meant for people with high-risk tumor features but who have had surgery and have no proven relapse yet.
OdenseAges 18 years+ - NCT03324360RecruitingPhase 1
MRI scan test in people with brain metastases after SRS
This early-phase study tests a special MRI scan using a safe tracer to see how brain metastases and brain metabolism change after SRS (a focused radiation treatment). It may help researchers find better ways to monitor treatment response in the brain.
Toronto, OntarioAges 18 years+ - NCT03366051Recruiting
Check mapping of the first lymph node in high-risk uterine cancer
This trial studies how to find the “sentinel” (first) lymph node during surgery for high-risk endometrial (uterine) cancer. It may help surgeons better tell whether cancer has spread to nearby lymph nodes and guide the extent of lymph node removal.
Curitiba, ParanáAges 18–75 - NCT03392233RecruitingPhase 2
Targeted radiation for spinal metastases causing significant pain
This trial tests a focused form of radiation (stereotactic body radiation) to treat cancer spread to the spine, especially when it causes substantial pain. It may help shrink or control the spinal spots while limiting damage to surrounding tissues.
Shanghai, Shanghai MunicipalityAges 18–85 - NCT03416959Recruiting
Register study for surgery patients with long-bone bone metastases
This trial collects and follows information about people who had surgery to treat cancer that spread to their long bones (like the femur or humerus) to prevent or fix a broken bone. It may help doctors better understand outcomes after these surgeries and improve future care.
Bologna, BolognaAges Any age - NCT03494946Recruiting
Liver transplant vs chemotherapy for colon cancer liver spread
This trial compares liver transplantation to standard chemotherapy for people with colon or rectal cancer that has spread to the liver but cannot be removed surgically. It looks at whether transplant can help patients live longer or better than chemotherapy in the right patients.
OsloAges 18 years+ - NCT03563729RecruitingPhase 2
Melanoma in the brain: steroids plus targeted therapy
This Phase 2 trial studies how giving steroid medicine for brain swelling may help people with melanoma that has spread to the brain, and whether adding a targeted approach works for a specific genetic tumor type. It may help shrink brain tumors and improve symptoms, while comparing how patients respond.
Herlev, Capital RegionAges 18 years+
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Common questions
- Are there clinical trials for metastases?
- Yes. Clin2 currently lists 453 recruiting metastases studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a metastases trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a metastases trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.