Clinical trials
Metastases clinical trials
Below are recruiting metastases clinical trials, each written for real people, not researchers. We’re tracking 453 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04115254Recruiting
MRI-guided focused radiation for certain tumors
This study tests a type of high-precision radiation guided by MRI pictures to treat certain cancers. It may help doctors deliver radiation more accurately while avoiding nearby healthy tissue, but you must be able to safely complete an MRI scan and meet tumor-size and health requirements.
Boston, MassachusettsAges 18 years+ - NCT07132190RecruitingPhase 2
Radiation for growing brain tumors with same-day planning
This study tests whether a precise, one-day radiation treatment for brain tumors that are growing or in tricky spots can be effective with a smaller safety margin. It's designed for people whose brain tumors are changing quickly or sitting near areas of swelling or recent surgery.
Boston, MassachusettsAges 18 years+ - NCT07130786RecruitingPhase 2
Preventing seizures with medication for brain tumors in movement area
This study tests whether giving a seizure medication (levetiracetam) to people with brain tumors in the movement area can prevent seizures. It compares taking the medication to not taking it, starting before any seizure occurs.
Boston, MassachusettsAges 18 years+ - NCT07429422Recruiting
Precise Radiation for Spine Tumors
This trial is testing a very precise radiation technique called SBRT for tumors that have spread to the spine. It aims to see if this approach can treat the tumor effectively while reducing side effects.
LjubljanaAges 18 years+ - NCT07505173RecruitingPhase 2
Targeted radiation plus osimertinib for brain metastases from EGFR-mutant lung cancer
This trial tests adding a brain-sparing radiation technique to the targeted therapy drug osimertinib for people with EGFR-mutant lung adenocarcinoma that has spread to the brain and is causing symptoms. The goal is to see if this combination can better control the brain tumors while protecting the hippocampus, a key memory area.
TianjinAges 18–75 - NCT07511933Recruiting
New PET scan to detect tumor regrowth vs. scar tissue in brain
This study tests a new type of PET scan (a special imaging test) that uses a radioactive tracer to help doctors tell the difference between scar tissue from past radiation and cancer that has come back in the brain. This could help avoid unnecessary surgery or additional treatment.
AmsterdamAges Any age - NCT04109131Recruiting
Study platform for brain metastases in solid cancers
This trial studies people with solid tumors that have spread to the brain (including the brain lining) to help researchers learn what works and how best to treat it. You may be asked for blood/tissue samples and a procedure to collect spinal fluid when brain metastases are diagnosed.
AnderlechtAges 18 years+ - NCT07043608RecruitingPhase 2
Zanzalintinib for kidney cancer that spread to bone
This trial tests a new drug called zanzalintinib for people with advanced clear cell kidney cancer that has spread to the bones (at least 3 spots). The study wants to see if this drug can help slow down or shrink the cancer. It's for patients who have already had some prior treatments.
San Francisco, CaliforniaAges 18 years+ - NCT02896335RecruitingPhase 2
Palbociclib and pembrolizumab for brain metastases
This study tests two drugs, palbociclib and pembrolizumab, for people whose solid tumors (like breast cancer or melanoma) have spread to the brain. The goal is to see if this combination can shrink or slow the growth of brain tumors that are progressing despite prior treatment.
Boston, MassachusettsAges 18 years+ - NCT04689048RecruitingPhase 1
Testing a brain scan tracer for large, staged brain metastases
This Phase 1 study tests an injected radioactive tracer (18F-fluciclovine) to improve how doctors image and assess large brain metastases. It may help guide treatment when you’re receiving staged stereotactic radiosurgery (focused radiation in steps).
Miami, FloridaAges 18 years+ - NCT05050929RecruitingPhase 2
Targeted radiation for brain metastases using rapid imaging
This Phase 2 study tests a quicker, more targeted way to give radiation to brain metastases. It aims to treat tumors while using regular scans to check how well the treatment controls disease and how you feel.
Abbotsford British Columbia, British ColumbiaAges 18–100 - NCT05124912Recruiting
Laser treatment for recurrent brain metastases after prior SRS
This study tests whether repeating treatment with a laser (along with a small biopsy) can control brain metastases that have come back after earlier radiation called SRS. It may help people whose cancer is stable enough for surgery and who have a specific, reachable brain spot to target.
Los Angeles, CaliforniaAges 18 years+ - NCT05419518RecruitingPhase 2
Higher-dose radiation to ease pain from metastatic tumors
This Phase 2 study tests whether a stronger (higher-dose) radiation plan can better reduce pain from tumors that have spread to bone or other areas. It’s meant to help people live more comfortably by targeting painful spots while avoiding certain high-risk situations.
Hamilton, New JerseyAges 18 years+ - NCT05545007Recruiting
Pre-op vs post-op focused radiation for large brain metastases
This study compares giving focused, high-dose radiation before surgery versus after surgery for people with large brain metastases. The goal is to see which timing works best to control the tumors and help neurological outcomes.
Brescia, BresciaAges 18 years+ - NCT05755672Recruiting
Study biomarkers during curative-intent treatment for metastatic colon cancer
This study looks at biological markers (substances measured in the body) during treatment for metastatic colorectal cancer. It may help doctors better understand how treatment works, using patients who are treated with a goal of cure.
Lund, Skåne CountyAges 18–110 - NCT06253871RecruitingPhase 1
Study of IAM1363 for HER2 Cancers
This trial tests a new oral drug called IAM1363 for people with HER2-altered cancers that have stopped responding to previous treatments. The goal is to see if the drug is safe and how well it works against these cancers.
La Jolla, CaliforniaAges 18 years+ - NCT06620380RecruitingPhase 2
Testing tumor samples to find the best drug for brain metastases
This trial tests tumor samples from brain metastases to see which drug might work best for you. It aims to guide your next treatment when standard options are limited.
BaselAges 18 years+ - NCT06728865RecruitingPhase 2
Furmonertinib plus Avastin for EGFR+ lung cancer with brain mets
This trial tests a combination of two targeted drugs (Furmonertinib and Avastin) as the very first treatment for people with a specific type of lung cancer (EGFR-mutant non-small cell) that has spread to the brain. The goal is to see how well it works and how safe it is.
Guangzhou, GuangdongAges 15–75 - NCT06857006Recruiting
Comparing radiation margins for brain tumors
This trial tests two different radiation margins (how much healthy tissue is included around a brain tumor) during a single treatment session. It aims to see which margin is better at controlling brain metastases while reducing side effects.
Birmingham, AlabamaAges 19 years+ - NCT06974370RecruitingPhase 2
Avoiding brain radiation when chemo or other drugs work
This trial tests whether some people with brain metastases from solid tumors can safely skip radiation if their cancer drugs (like targeted therapy, immunotherapy, or certain chemotherapies) shrink the brain tumors. You will get MRI scans to see if the drugs are working.
Burlington, VermontAges 18 years+ - NCT07112989Recruiting
Building lab models for sarcoma and cancer spread
This study aims to create new laboratory models to better understand sarcomas and cancers that have spread to the bone or lungs. By using donated tumor tissue and blood, researchers hope to learn how these cancers grow and develop, which could lead to better treatments in the future.
BolognaAges Up to 85 years - NCT07764497RecruitingPhase 2
Chemotherapy through liver artery for colorectal cancer that spread to liver
This trial tests giving chemotherapy directly into the liver artery for people whose colorectal cancer has spread only to the liver and cannot be surgically removed. The goal is to shrink the tumors and make the liver healthy enough for surgery.
Toronto, OntarioAges 18 years+ - NCT06822543RecruitingPhase 2
A new treatment for lung cancer that has spread to the brain
This trial tests a combination of three drugs (datopotamab deruxtecan, carboplatin, and pembrolizumab) for people with a type of lung cancer called non-small cell lung cancer (NSCLC) that has spread to the brain and has not been treated before. The goal is to see if this combination can shrink tumors in the brain and elsewhere.
Fortaleza, CearáAges 18 years+ - NCT05477927RecruitingPhase 1
CAR-T therapy for cancers spread to lining of lungs, belly, or brain
This trial tests an experimental CAR-T cell treatment that targets proteins on cancer cells that have spread to the lining of the lungs, belly, or brain. It may help people whose cancer has not responded to standard treatments.
Chengdu, SichuanAges 18–80
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Common questions
- Are there clinical trials for metastases?
- Yes. Clin2 currently lists 453 recruiting metastases studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a metastases trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a metastases trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.