Clinical trials
Metformin clinical trials
Below are recruiting metformin clinical trials, each written for real people, not researchers. We’re tracking 148 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07771010RecruitingPhase 4
Comparing empagliflozin and metformin for muscle health in type 2 diabetes
This study tests two diabetes medications, empagliflozin and metformin, to see how they affect muscle energy use and blood flow in men with recently diagnosed type 2 diabetes. Participants will be followed at a diabetes clinic.
LjubljanaAges 18–75 - NCT02647827RecruitingPhase 2
Acupuncture or metformin for insulin resistance in PCOS
This study tests whether acupuncture or the diabetes medicine metformin can improve insulin resistance in women with PCOS. It may help with hormone-related symptoms and metabolic health, comparing the two approaches against usual care for non-PCOS controls.
BeijingAges 18–40 - NCT07696806Enrolling by invitationPhase 4
Needle-assisted treatment for melasma using common skin medications
This trial tests a microneedling technique combined with three topical medications (metformin, tranexamic acid, and a modified Kligman's formula) to treat melasma, a common skin condition causing dark patches. The goal is to see if this approach safely and effectively reduces melasma in eligible women.
TantaAges 18 years+ - NCT07693452RecruitingPhase 2
Testing metformin for recurrent appendix cancer
This trial tests whether the drug metformin (a common diabetes pill) can help control pseudomyxoma peritonei, a rare abdominal cancer. It is for people whose cancer has come back or cannot be surgically removed, and who aren't planning a major surgery with heated chemotherapy at this time.
Orange, CaliforniaAges 18 years+ - NCT07666698RecruitingPhase 1/Phase 2
Metformin to improve heart function after LVAD implant
This trial tests if metformin, a medicine commonly used for diabetes, can help improve heart function in people who have a mechanical heart pump (LVAD). You may be able to join if you are between 18 and 75, have a continuous-flow LVAD, and have a condition called insulin resistance (where your body doesn't use insulin well) but your blood sugar levels are well-controlled.
Nanjing, JiangsuAges 18–75 - NCT07654179Recruiting
Metformin for depression with obesity: a genetic study
This trial tests if adding metformin to antidepressants helps people who have both depression and obesity. It also looks at genetic factors that might affect treatment response.
Rawalpindi, Punjab ProvinceAges Any age - NCT06686043RecruitingPhase 2
HPV vaccine, imiquimod, and metformin for advanced cervical or vulvar cancer
This trial tests a combination of an HPV vaccine, an immune cream (imiquimod), and a diabetes drug (metformin) together with standard chemoradiation. The goal is to see if this mix helps treat advanced cervical, vaginal, or vulvar cancers better than standard care alone.
Houston, TexasAges 18–64 - NCT07645001Recruiting
Probiotics plus diabetes medicine for pregnancy blood sugar
This study tests whether adding probiotics (beneficial bacteria) to standard diabetes medication helps manage high blood sugar during pregnancy. Researchers hope this combination may improve health outcomes for both you and your baby.
Rawalpindi, Punjab ProvinceAges 18–45 - NCT04741945RecruitingPhase 2
Metformin to help prevent leukemia in certain blood disorders
This Phase 2 study tests whether metformin can lower the risk of leukemia developing in people with low-risk myelodysplastic syndrome (LR-MDS) or CCUS. You may be considered if your blood counts have stayed low and other causes have been ruled out.
Copenhagen, Copenhagen NAges 18 years+ - NCT07497568Recruiting
Metformin gel for dental implant stability
This study tests whether applying a metformin gel to the implant site can help the implant stay stable and improve bone density around it. It may be a good option if you need a dental implant and have healthy enough jawbone.
Baghdad, Baghdad GovernorateAges 18–70 - NCT06781775RecruitingPhase 4
Metformin vs insulin for gestational diabetes
This trial compares two medicines—metformin pills and insulin shots—to see which works better for controlling blood sugar in gestational diabetes. You may be able to join if you have gestational diabetes that needs treatment and are willing to take either medicine.
Charlottesville, VirginiaAges 18–50 - NCT07446400RecruitingPhase 1
Drug interaction study for repinatrabit
This trial tests how repinatrabit interacts with common medications like birth control, metformin, and others. It helps doctors understand safe dosing and potential side effects.
Melbourne, VictoriaAges 18–55 - NCT06826092RecruitingPhase 2
Metformin for advanced colorectal cancer with chemotherapy
This trial tests whether adding metformin (a diabetes drug) to standard chemotherapy (FOLFIRI) and targeted therapy can help people with metastatic colorectal cancer live longer or respond better to treatment.
Kaohsiung CityAges 20–90 - NCT07387900RecruitingPhase 2
Metformin for preventing cancer in oral leukoplakia
This study tests if metformin — a medication commonly used for diabetes — can prevent oral leukoplakia from turning into cancer when applied as a mouth rinse and taken as a pill. It is for people with non-severe white patches in the mouth.
CairoAges 21 years+ - NCT07372625RecruitingPhase 1
How rezatapopt affects common drugs in advanced solid tumors with TP53 Y220C mutation
This trial tests how rezatapopt changes the way your body processes four common medicines (metformin, rosuvastatin, repaglinide, and midazolam) in people with advanced solid tumors that have a specific TP53 Y220C gene change. It helps doctors understand the right dose for future patients.
Denver, ColoradoAges 18 years+ - NCT06845540RecruitingPhase 1/Phase 2
Metformin pills for melasma in Latin American women
This study tests if taking metformin pills can help treat melasma (dark patches on the skin) in Latin American women. It may be a new option for those whose melasma hasn't improved with other treatments.
San Juan, PRAges 21 years+ - NCT06367283RecruitingPhase 3
Metformin for treating hand osteoarthritis pain
This study tests whether metformin, a common diabetes medication, can reduce pain in hand osteoarthritis. You may be eligible if your hand pain is moderate to severe and you haven't taken metformin before.
Copenhagen, FrederiksbergAges 18 years+ - NCT05574387RecruitingPhase 2
Metformin added to treatment for ulcerative colitis
This Phase 2 study tests whether adding metformin to usual care can help people with mild to moderate ulcerative colitis. The goal is to see if it improves symptoms and disease control compared with standard therapy alone.
Al MansurahAges 18–75 - NCT07331389RecruitingPhase 1
How HDM1002 interacts with common drugs and diabetes medications
This study tests how a new drug called HDM1002 interacts with common diabetes medications (metformin, empagliflozin) and other drugs like warfarin and valsartan. If you are a generally healthy adult (age 18-45) with a higher BMI, this trial helps ensure the new drug is safe when taken with other medicines.
HefeiAges 18–45 - NCT07297290RecruitingPhase 3
Testing Metformin for Weight Loss in Obesity
This trial tests whether metformin, a common diabetes medicine, can help people with obesity lose weight. It is for people who do not have diabetes and have not used weight loss treatments in the past year.
Enugu, Enugu StateAges 20–59 - NCT07291297RecruitingPhase 2
Metformin plus standard therapy for soft tissue sarcoma
This trial tests adding metformin, a common diabetes drug, to the usual first cancer treatment for advanced soft tissue sarcoma. It may help the standard therapy work better.
Charlotte, North CarolinaAges 18 years+ - NCT07226453RecruitingPhase 2
Metformin for recurrent PFA ependymoma
This trial tests if metformin can help treat a certain type of brain tumor called PFA ependymoma that has come back after surgery and radiation. It's for people ages 1 to 39 who are healthy enough for surgery or have tumors that can be measured on scans.
Birmingham, AlabamaAges 1–39 - NCT07229651RecruitingPhase 2/Phase 3
Metformin for Parkinson's disease
This trial tests if metformin, a diabetes drug, can help people with Parkinson's disease. It may improve symptoms or slow progression.
TantaAges 50–70 - NCT06687265RecruitingPhase 2
Metformin for reducing liver pressure in cirrhosis
This trial tests if metformin can lower the pressure in the liver's blood vessels (portal hypertension) in people with cirrhosis. The goal is to see if it can help reduce complications like swelling or bleeding.
Clichy, FranceAges 18 years+
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Common questions
- Are there clinical trials for metformin?
- Yes. Clin2 currently lists 148 recruiting metformin studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a metformin trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a metformin trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.