Clinical trials
Microbiome clinical trials
Below are recruiting microbiome clinical trials, each written for real people, not researchers. We’re tracking 350 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05966649Recruiting
Synbiotics for preventing preterm birth in higher-risk pregnancies
This trial tests whether taking synbiotics (a mix of “good” probiotics and “food” for them) can help lower the chance of going into labor too early. It’s for pregnant people with certain risk factors for preterm birth, and it compares outcomes while you follow the study plan.
Edegem, AntwerpenAges 18 years+ - NCT05982795Recruiting
How CF modulators affect lung bacteria
This study looks at how highly effective CF modulator therapies change the bacteria living in the lungs of people with cystic fibrosis. Understanding these changes may help improve future treatments.
Lebanon, New HampshireAges 18–99 - NCT06221800Recruiting
Gut bacteria and lung cancer treatment side effects study
This study looks at how the bacteria in your gut (microbiome) might affect how well your lung cancer treatment works and what side effects you experience. The goal is to learn if certain gut bacteria can predict treatment response or side effects for people with advanced non-small cell lung cancer.
Orange, CaliforniaAges 18 years+ - NCT06279065Recruiting
Gut bacteria and giant cell arteritis study
This trial looks at how the bacteria in your gut might affect giant cell arteritis, a condition that causes inflammation in blood vessels. It aims to help doctors better understand the disease.
Bonn, North Rhine-WestphaliaAges 18 years+ - NCT06502704Recruiting
Bile acids and gut bacteria in early colorectal cancer
This trial studies how bile acids and gut bacteria are linked to early colorectal cancer. It may help identify patients at risk before cancer develops.
VilniusAges 18 years+ - NCT06649201Recruiting
Study of vaginal health after stem cell transplant
This study looks at how stem cell transplants affect the vagina, especially if you develop a condition called graft-versus-host disease (GVHD). Researchers will examine the vagina and test its natural germs (microbiome) to better understand and possibly improve treatment.
Cleveland, OhioAges 18–70 - NCT06734156Recruiting
Gut microbiome study in colorectal cancer patients
This study looks at how bacteria and other microbes in your gut are linked to colorectal cancer risk and outcomes. By collecting stool samples from people newly diagnosed with colorectal cancer, researchers hope to find patterns that could improve understanding and future treatments.
Lisbon, Lisbon DistrictAges 40–74 - NCT06738173Recruiting
Gut bacteria test to screen for colorectal cancer
This trial tests a new tool that looks at gut bacteria to help find colorectal cancer earlier. It's for people who already had a positive result on a standard stool test (FIT) as part of a national screening program.
Rome, RMAges 50–74 - NCT06741293Recruiting
Improving colorectal cancer early screening with stool tests
This study looks for markers in stool (poop) to detect colorectal cancer early. If you are between 40 and 74, live in the Lisbon area, and don't have certain digestive or cancer conditions, you may help improve screening by providing a stool sample.
Lisbon, Lisbon DistrictAges 40–74 - NCT06749483Recruiting
Gut bacteria and infection in intensive care patients
This study looks at how gut bacteria affect severe infections in the ICU. It tests whether the microbiome can be a source of sepsis and a target for treatment. If you are critically ill or a long-term sepsis survivor, you might help find new ways to prevent infections.
Jena, ThuringiaAges 18 years+ - NCT06903806Recruiting
Gut Microbiome Sampling During Endurance Exercise
This study looks at how endurance exercise affects the bacteria living in your gut. Researchers will collect samples before and after exercise to see what changes. It may help us understand how exercise keeps your gut healthy.
Stanford, CaliforniaAges 18–80 - NCT06992986Recruiting
Urine Bacteria in Bladder Cancer vs. Other Conditions
This study compares the bacteria in urine of men with bladder cancer to those with other urinary issues and healthy men. For bladder cancer patients, it looks at differences before a planned surgery to remove the bladder.
RomeAges 50–70 - NCT07066280RecruitingPhase 3
A cream to prevent skin irritation from radiation for breast cancer
This study tests a special cream that may prevent skin irritation (radiation dermatitis) caused by radiation therapy for breast cancer. The cream is made from natural weak acids and aims to protect the skin by keeping the skin's microbiome healthy.
Guangzhou, GuangdongAges 18–70 - NCT07071181Recruiting
Milk-based drinks for better sleep and health
This trial tests whether drinking a milk-based drink every day for four weeks can improve gut health, sleep quality, and heart health. It may be a good option if you have trouble sleeping and are overweight.
Leeds, West YorkshireAges 40–70 - NCT07264998Recruiting
Gut bacteria study in breast cancer patients on Abemaciclib
This study looks at how gut bacteria changes in people taking Abemaciclib (a breast cancer drug) and whether that relates to diarrhea. It may help find ways to prevent or manage this side effect.
Wuhan, HubeiAges 18–75 - NCT07532629Recruiting
How Gut Bacteria Affect IVF Success in Couples
This study examines how the bacteria in your gut and your partner's gut may affect the success of IVF (in vitro fertilization) treatment. Researchers will collect samples and health information from couples before IVF to see if certain bacterial patterns predict better pregnancy outcomes.
MalmöAges 18–40 - NCT07619638Recruiting
Microbiome Supplement for Mild-to-Moderate Ulcerative Colitis
This trial tests a specially designed supplement that aims to restore healthy gut bacteria in people with mild-to-moderate ulcerative colitis. The goal is to reduce inflammation and improve symptoms like rectal bleeding and bowel urgency.
IzmirAges 18–75 - NCT07651462Recruiting
Fasting Before Hip Surgery and Gut Health
This study tests whether fasting for 20 days before hip replacement surgery changes your gut bacteria in ways that might help your recovery. Researchers want to understand if this dietary approach affects how well you heal after the operation.
Berlin, State of BerlinAges 18–75 - NCT06657001Enrolling by invitation
Personalized nutrition study for gut health
This study uses information from your gut bacteria (microbiome) to create personalized nutrition advice. It is for people with gut conditions like IBD, IBS, or celiac disease, as well as healthy volunteers.
Rochester, MinnesotaAges 18 years+ - NCT05821309RecruitingPhase 4
Testing how a new enema routine changes gut bacteria
This study looks at how placing an antegrade (forward-flow) continence enema and starting a bowel flush routine may change your gut microbiome (your gut bacteria). It is meant for children who have long-lasting constipation that required a special surgical drainage channel.
Carmel, IndianaAges 2–18 - NCT07767981Recruiting
Gut bacteria and side effects of precise radiation therapy
This study looks at how the bacteria in your gut might affect side effects from a precise type of radiation therapy called stereotactic radiosurgery. By collecting samples, researchers hope to find ways to reduce side effects in the future.
Chicago, IllinoisAges 18 years+ - NCT06538415Recruiting
Can peas and beans improve your skin health?
This study tests whether adding more peas, beans, and lentils (polyphenol-rich pulses) to your daily diet can improve your skin health by changing the natural bacteria living on your skin.
Gainesville, FloridaAges 45–65 - NCT07456579Enrolling by invitation
Alcohol and cannabis use in pregnancy
This study looks at alcohol and cannabis use during pregnancy by asking new mothers about their habits and testing newborn stool samples (meconium). The goal is to understand how common these substances are among pregnant women in Slovenia and how they might affect babies.
LjubljanaAges Any age - NCT06681246Recruiting
How gut bacteria affect weight regain after weight loss
This study looks at how the natural bacteria in your gut (the microbiome) might be linked to regaining weight after losing it. It tests whether a short course of antibiotics or a placebo (a sugar pill) affects this process. The goal is to find new ways to help people keep weight off long-term.
RehovotAges 18–65
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Common questions
- Are there clinical trials for microbiome?
- Yes. Clin2 currently lists 350 recruiting microbiome studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a microbiome trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a microbiome trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.