Clinical trials
Microvascular Disease clinical trials
Below are recruiting microvascular disease clinical trials, each written for real people, not researchers. We’re tracking 47 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05178914Recruiting
Testing heart pain treatment guided by blood-flow measurements
This study looks at how to personalize treatment for people with angina (chest pain) by measuring how well blood flows through the heart’s small vessels and the main arteries during a procedure. It may help doctors choose the right approach after your coronary angiography (heart artery imaging).
La TroncheAges 18 years+ - NCT02301663Recruiting
Stress test study of heart blood-flow issues in adults
This study tests a new kind of stress test to understand how small blood-vessel heart problems relate to heart relaxation problems in people with angina (chest pain) but no blocked arteries. It may help doctors learn better ways to diagnose and guide treatment for these conditions.
Los Angeles, CaliforniaAges 18–60 - NCT04440761Recruiting
Registry for people with MINOCA heart-related chest pain
This is a research registry that collects information from people diagnosed with MINOCA (a specific type of heart-related injury). It may help researchers better understand causes and outcomes for this condition.
LondonAges 16 years+ - NCT05743140Recruiting
Eye scan to help identify heart artery disease
This trial tests whether a special eye imaging scan (fundus OCTA) can help identify “CMD,” a type of heart-related blood flow problem. You may be eligible if you already had coronary angiography and your coronary narrowing is less than 50%.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06529848Recruiting
Exercise for heart symptoms with clear arteries
This trial tests if exercise training can help people who have chest pain or shortness of breath even though their main heart arteries are not blocked. It focuses on those with small vessel disease in the heart, also known as INOCA.
CopenhagenAges 50 years+ - NCT04687215Recruiting
Spinal cord stimulation for painful diabetic nerve pain
This trial studies whether a spinal cord stimulator can reduce pain from diabetic nerve damage in the legs. It focuses on people with long-lasting type 2 diabetes and significant, treatment-resistant pain.
Chicago, IllinoisAges 18 years+ - NCT04827498Recruiting
Testing heart blood-flow problems without clogged arteries
This study looks at how well the heart’s blood vessels work in people who have symptoms of reduced blood flow but no major artery blockage. It uses special heart tests with medicines to check how the vessels respond and may help guide better diagnosis and treatment.
MadridAges 18 years+ - NCT06843902RecruitingPhase 2
Improving heart blood flow in women with HIV
This study is testing a medication that may help improve blood flow to the heart in women with HIV who also have diabetes, kidney disease, or protein in their urine. You would need to have a heart scan that shows low blood flow and not be taking certain diabetes drugs.
Boston, MassachusettsAges 45–75 - NCT06579677Recruiting
Watching small blood vessels in the brain over time
This study watches how small blood vessels in the brain change over time. It may help doctors understand brain health as people age.
Beijing, Beijing MunicipalityAges 50–75 - NCT06864234RecruitingPhase 4
Beta-blockers for chest pain without blocked arteries
This trial tests if beta-blocker medication improves blood flow and reduces resistance in the tiny blood vessels of the heart in people who have chest pain but no major blockages in their arteries.
Aalst, FlandersAges 18 years+ - NCT02582021Recruiting
Study of treatments and imaging in women with angina or HFpEF
This trial studies how heart disease affects the heart using heart imaging, and looks at people with chest pain/angina or heart failure with preserved pumping strength (HFpEF). It may help doctors better understand what’s driving symptoms and how best to evaluate these conditions.
Los Angeles, CaliforniaAges 18 years+ - NCT04674449Recruiting
Tests a targeted plan for people with chest pain from heart artery disease
This study aims to match people with angina (chest pain from heart artery problems) to the most helpful treatment plan based on their test results. It’s done around the time doctors are planning an invasive heart scan to look at the coronary arteries.
CorkAges 18 years+ - NCT06319339RecruitingEarly Phase 1
Studying a drug to improve walking in peripheral artery disease
This trial tests whether a drug called diroximel fumarate (Vumerity) can improve blood flow and walking ability in people with peripheral artery disease (PAD). It compares people with PAD to healthy volunteers of the same age.
Omaha, NebraskaAges 50–75 - NCT06613555Recruiting
Eye blood vessel scan study for systemic disease
This study uses an advanced eye scan (OCT-A) to look at tiny blood vessels in the back of the eye. It compares people with systemic blood vessel conditions (like high blood pressure or inflammatory disease) to healthy volunteers, to see if the eye scan can help predict or understand these diseases.
DijonAges 18 years+ - NCT05762952RecruitingPhase 1
Dapagliflozin study for heart micro-blood-flow symptoms in women
This early-phase study tests whether dapagliflozin can improve tiny blood-vessel function in women who have heart-ache-like symptoms but no major blockage on heart scans. If it works, it may help symptoms related to “microvascular” heart circulation problems.
Charlottesville, VirginiaAges 18–99 - NCT06089577RecruitingPhase 4
Cangrelor for heart blood flow during planned stent procedure
This trial tests if cangrelor, a fast-acting blood thinner, can prevent small vessel damage during a planned stent placement in patients with stable chest pain. It may help improve blood flow to the heart muscle.
FerraraAges 18 years+ - NCT07196397Recruiting
Polish Registry of Heart Nerve Procedures
This registry tracks people who have had or plan to have a procedure that changes the nerves controlling heart rate, such as cardioneuroablation. It aims to better understand and treat conditions like inappropriate tachycardia, POTS, and fainting spells.
RzeszówAges 18 years+ - NCT05634031Recruiting
Study of heart vessel dysfunction seen on heart imaging
This study looks at coronary microvascular dysfunction (small blood vessel problems in the heart) using heart imaging. It may help researchers understand causes of chest tightness with activity and shortness of breath when the main heart arteries are not blocked.
New York, New YorkAges 18 years+ - NCT07041307Recruiting
Study of blood flow in thyroid nodules before surgery
This trial uses a special imaging technique to look at the tiny blood vessels inside thyroid nodules before they are removed. It may help doctors understand which nodules are cancerous.
CopenhagenAges 18 years+ - NCT06969547Recruiting
Heart muscle coordination and microvessel function SPECT study
This study uses a special heart scan (SPECT) to look at how well the heart muscle is squeezing and how well the tiny blood vessels in the heart are working. It may help doctors understand why some people have chest pain even when their main arteries are not blocked.
TomskAges 18–75 - NCT03716401Recruiting
Imaging tests to predict kidney disease in type 2 diabetes
This study uses special kidney imaging to look for patterns that can predict how diabetic kidney disease may progress. It may help researchers find better ways to identify people at higher risk using noninvasive (and possibly biopsy-related) tests.
TurkuAges 18–80 - NCT07380919RecruitingPhase 2/Phase 3
Study of ranolazine to prevent heart muscle damage after a heart attack
This trial tests whether a medication called ranolazine can help prevent damage to tiny blood vessels in the heart after a certain type of heart attack (STEMI). You may be eligible if you recently had this kind of heart attack and had a successful procedure to open a blocked artery, but still have other blockages that can be treated with stents.
Catanzaro, ItalyAges 18–80 - NCT07498231Recruiting
Small heart vessel study for chest pain
This study looks at the tiny blood vessels in your heart (the microcirculation) that can cause chest pain even when the main arteries are open. It aims to better understand and treat this type of chest pain, called chronic coronary syndrome.
BialystokAges 18–75
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Common questions
- Are there clinical trials for microvascular disease?
- Yes. Clin2 currently lists 47 recruiting microvascular disease studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a microvascular disease trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a microvascular disease trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.