Clinical trials
Neoadjuvant Treatment clinical trials
Below are recruiting neoadjuvant treatment clinical trials, each written for real people, not researchers. We’re tracking 186 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05905315RecruitingPhase 2
Vulvar cancer treatment: chemoradiation vs chemotherapy then surgery
This Phase 2 trial compares two treatment approaches for some women with vulvar squamous cell cancer: chemoradiation first, or chemotherapy first followed by surgery. The goal is to see which strategy works better or is safer for tumors that are hard to remove without major pelvic surgery.
AmsterdamAges 18 years+ - NCT05241119Recruiting
Lymph node mapping to guide surgery after chemotherapy
This study tests using a special carbon-based tracing method to help doctors check which lymph nodes to treat during surgery after you finish chemotherapy. It may improve how accurately the surgical plan targets cancer in the armpit (axillary) lymph nodes.
Shenyang, LiaoningAges 18–70 - NCT05877573Recruiting
Toripalimab with chemo-radiation before surgery for rectal cancer
This trial studies whether adding toripalimab (an immunotherapy drug) to standard chemo-radiation before surgery can improve outcomes for people with higher-risk, locally advanced rectal cancer. It is meant for cancers that are mismatch-repair “MSS/pMMR,” and it checks safety plus effectiveness as a first treatment.
Guangzhou, GuangdongAges 18–75 - NCT07671885RecruitingPhase 3
Hormone therapy before surgery for premenopausal breast cancer
This trial tests if giving hormone-blocking pills before surgery can help guide which treatments you need after surgery. It is for premenopausal women with early-stage, hormone-sensitive breast cancer.
AkitaAges 18 years+ - NCT07542496Recruiting
Real-world study of breast cancer treatment with pertuzumab biosimilar
This study observes how a biosimilar version of pertuzumab (a targeted breast cancer drug) works in real-world patients. Researchers will track outcomes in patients receiving this drug either before surgery or as a first treatment for advanced breast cancer.
AlgiersAges 19 years+ - NCT07595874RecruitingPhase 2
New Immunotherapy Drugs Before Surgery for Advanced Colorectal Cancer
This trial tests two immunotherapy drugs (botensilimab and balstilimab) given before surgery to treat advanced colorectal cancer that can be removed. The goal is to help the immune system fight cancer cells and improve outcomes after surgery.
Goodyear, ArizonaAges 18 years+ - NCT06766578RecruitingPhase 2
Low-dose radiation plus immunotherapy and chemo before gastric cancer surgery
This trial tests a new combination of low-dose radiation, an immunotherapy drug (tirelizumab), and chemotherapy (SOX) given before surgery for locally advanced gastric or gastroesophageal junction cancer. The goal is to see if this approach can shrink tumors more effectively.
Jinan, ShandongAges 18–75 - NCT07702708Recruiting
AI predicts chemotherapy response in HR+/HER2- breast cancer
This trial uses AI to analyze your pre-treatment MRI and predict how well your tumor will respond to chemotherapy before surgery. It is for people with HR+/HER2- breast cancer who need chemo before their operation.
Fuzhou, FujianAges 18 years+ - NCT06783491RecruitingPhase 3
Chemotherapy with or without heated chemo for advanced colon cancer
This trial tests if adding heated chemotherapy directly into the abdomen during surgery improves outcomes for people with advanced colon cancer that hasn't spread to other organs. It compares standard chemotherapy before surgery alone versus chemotherapy before surgery plus heated chemo during surgery.
Córdoba, CórdobaAges 18–75 - NCT07248956RecruitingPhase 2
Chemo plus immunotherapy before surgery for throat cancer
This trial tests giving chemotherapy combined with an immunotherapy drug (finotonlimab) before surgery for locally advanced hypopharyngeal cancer. It aims to shrink the tumor enough to improve surgery outcomes.
Harbin, HeilongjiangAges 18–75 - NCT05563012RecruitingPhase 2
Short radiation plus chemo and PD-1 immunotherapy for stomach cancer
This Phase 2 trial tests whether giving a short course of radiation before surgery, along with chemotherapy and a PD-1 immunotherapy drug, can improve treatment outcomes for locally advanced stomach cancer. It may help shrink the tumor before surgery and strengthen the immune system’s attack on cancer.
Wuhan, HubeiAges 18–75 - NCT04192253RecruitingPhase 2
Carboplatin and paclitaxel before surgery for vulvar cancer
This trial tests giving chemotherapy (carboplatin and paclitaxel) before surgery for certain cases of squamous cell vulvar cancer. It may help shrink the tumor and make surgery more effective.
AmsterdamAges 18 years+ - NCT06534489Recruiting
Surgery for lung cancer after chemo or targeted therapy
This trial tests whether combining chemo or targeted therapy before surgery can help people with non-small cell lung cancer that may require removing a whole lung. We want to see if this approach makes the surgery safer and more effective.
ShanghaiAges 18–75 - NCT06904677Recruiting
Urine test to predict colorectal cancer treatment response
This study uses a special urine test to see if it can predict how well colorectal cancer responds to treatment. If you are about to start treatment before surgery, you may be able to join by giving urine samples before and during therapy.
Beijing, Chaoyang DistrictAges 18–75 - NCT06704945RecruitingPhase 3
Skipping armpit surgery after good chemo response
This trial tests whether it's safe to skip armpit surgery in people whose breast cancer has responded well to chemotherapy and whose lymph nodes appear cancer-free on ultrasound. It aims to reduce side effects like arm swelling while still controlling the cancer.
SeoulAges 19 years+ - NCT06537154RecruitingPhase 2/Phase 3
Neoadjuvant therapy for bladder cancer with active surveillance
This trial tests whether people with muscle-invasive bladder cancer can safely avoid immediate surgery or radiation after a short course of chemotherapy. Instead, they would be closely monitored and only treated if the cancer comes back.
Vancouver, British ColumbiaAges 19 years+ - NCT07104604RecruitingPhase 2
New combo before surgery for low rectal cancer
This trial tests a new combination of treatments (radiation, immunotherapy, and two chemotherapy drugs) given before surgery for people with a specific type of locally advanced rectal cancer that is close to the anus. The goal is to see if this approach is safe and effective.
Shantou, GuangdongAges 18–75 - NCT05861505RecruitingPhase 3
Treatment for new liver spread from colon cancer recurrence
This Phase 3 trial studies a treatment approach for people whose colorectal cancer has come back in the liver within 12 months and can be treated with local procedures. It aims to see whether the study treatment can improve outcomes compared with standard care for people with a limited number of liver tumors.
AmsterdamAges 18 years+ - NCT06719206Recruiting
Reducing sitting time during cancer treatment
This study looks at helping people with breast, prostate, or colorectal cancer who are starting or have recently started treatment (like chemo or radiation) to sit less and move more during their treatment. If you are treated at a hospital in Uppsala or Västerås, Sweden, you may be able to join.
UppsalaAges 18 years+ - NCT06830889RecruitingPhase 3
BL-M07D1 vs T-DM1 for HER2-positive breast cancer after neoadjuvant therapy
This trial tests whether a new drug called BL-M07D1 works better than an existing drug, T-DM1, for people with HER2-positive breast cancer who still have cancer cells after initial treatment (neoadjuvant therapy). The goal is to prevent the cancer from coming back.
Nanjing, JiangsuAges 18–75 - NCT04683315RecruitingPhase 2
Pancreatic cancer biopsy-guided chemo before surgery
This trial uses a special gene test on fluid taken from an endoscopic ultrasound (EUS) biopsy to help choose chemotherapy before surgery for pancreas cancer. It aims to see if this approach improves outcomes by matching treatment to the tumor’s RNA pattern.
Scottsdale, ArizonaAges 18 years+ - NCT03465982Recruiting
Timing surgery after chemotherapy and radiation for rectal cancer
This trial studies the best time to do surgery after you finish chemotherapy and radiation for rectal cancer. It may help improve how well minimally invasive surgery works and how safely it can be done.
Alessandria, ALAges 18 years+ - NCT04137653RecruitingPhase 3
New pre-surgery drug choice for triple-negative breast cancer
This trial tests which chemotherapy drug works better before surgery (neoadjuvant therapy) for triple-negative breast cancer that has spread to underarm lymph nodes. It compares two forms of paclitaxel given by random assignment to see which option may shrink the tumor more effectively and improve outcomes.
Shenyang, LiaoningAges 18–70 - NCT06017583RecruitingPhase 3
Chemo plus immunotherapy and targeted radiation for advanced rectal cancer
This trial tests whether combining chemotherapy, immunotherapy (PD-1 inhibitor), and a precise type of radiation can help shrink locally advanced rectal cancer before surgery. It aims to improve treatment success and reduce side effects.
Nanning, GuangxiAges 18–70
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Common questions
- Are there clinical trials for neoadjuvant treatment?
- Yes. Clin2 currently lists 186 recruiting neoadjuvant treatment studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a neoadjuvant treatment trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a neoadjuvant treatment trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.