Clinical trials
Neuromodulation clinical trials
Below are recruiting neuromodulation clinical trials, each written for real people, not researchers. We’re tracking 201 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT03877653Recruiting
Freedom-1 treatment for long-term knee pain in adults
This study tests a procedure called Freedom-1 to reduce long-term, limiting knee pain from knee arthritis. It may help if other non-surgical options didn’t work and you meet specific knee and health requirements.
Placentia, CaliforniaAges 18 years+ - NCT03953768Recruiting
Testing a new vagus nerve stimulator for gut and immune health
This study looks at what happens to your immune system and stomach/gut function after getting a vagus nerve stimulator (VNS) for the first time for epilepsy. It may help doctors understand whether the device benefits more than seizures.
Louisville, KentuckyAges birth–60 years - NCT03992378Recruiting
Nerve stimulation to calm inflammation in sepsis
This trial tests a form of nerve stimulation to help control the body’s overactive inflammation and “autonomic” nervous system imbalance during sepsis. It may help stabilize blood pressure and reduce complications, depending on the cause of your symptoms.
Oklahoma City, OklahomaAges 18 years+ - NCT05904132Recruiting
Brain stimulation therapy for early Alzheimer’s memory loss
This trial studies a “closed-loop” brain stimulation approach to improve symptoms in people with early Alzheimer’s-related memory problems. It may help by delivering stimulation based on your brain signals, if you meet the safety and diagnosis requirements.
Charlestown, MassachusettsAges 50–80 - NCT04197921Recruiting
Brain-focused ultrasound for opioid addiction-related substance use
This trial studies Exablate, a non-surgical brain treatment that aims to change activity in a specific brain area involved in cravings and substance use. It is meant for people in structured opioid or substance use treatment who are currently abstaining from opioids and other illicit drugs.
Tampa, FloridaAges 18–60 - NCT04296604Recruiting
tDCS brain stimulation to improve thinking and mood
This study tests whether a non-surgical brain stimulation called tDCS can improve “executive function,” which means skills like planning, focus, and decision-making. It is designed for people with several mental health and substance-use conditions, and it may help you if those skills are affected by your diagnosis.
Boston, MassachusettsAges 18–65 - NCT04527445Recruiting
Test to use less X-ray during sacral nerve lead placement
This trial studies whether doctors can place a sacral neuromodulation lead using fewer X-rays. If you’re getting this procedure for overactive bladder, it may help reduce radiation exposure while still guiding correct lead placement.
Loma Linda, CaliforniaAges 18–89 - NCT04547816RecruitingPhase 3
Non-surgical treatment for constipation-related prolapse in women
This study tests whether a non-surgical (“conservative”) approach can improve constipation-related bowel problems in women who have a mild-to-moderate rectal bulge from pelvic organ prolapse. It may help by addressing how the rectum and pelvic floor work during bowel movements.
MoscowAges 18–70 - NCT04783103Recruiting
Brain scan study of stimulation for depression in older adults
This is a pilot study that uses brain imaging to see how a brain “neuromodulation” approach may affect depression in people age 65 and older. You would be screened for depression severity, medication history, and safety limits, and then be asked to keep your depression medicines stable during the study.
Jette, Brussels CapitalAges 65 years+ - NCT04883463Recruiting
Brain and spinal stimulation to improve breathing after SCI
This trial tests a neuromodulation treatment to improve breathing in people living with a cervical spinal cord injury who have significant breathing problems. If you qualify, you would have regular weekly testing over many months to see whether breathing and breathing support needs improve.
Los Angeles, CaliforniaAges 18–75 - NCT04933370Recruiting
Testing a brain or nerve stimulator settings approach
This study is for people who are planning to get a device implanted that delivers stimulation to the brain or nerves. The trial tests whether different stimulation settings work better, which could improve symptom control for participants.
Calgary, AlbertaAges 18–100 - NCT05052736Recruiting
Noninvasive brain/nerve stimulation for early CRPS type I
This trial studies a noninvasive stimulation treatment to help people with early-stage complex regional pain syndrome (CRPS) type I. It may help calm nerve-related pain, especially soon after symptoms begin.
Las Palmas de Gran Canaria, Palmas, LasAges 18 years+ - NCT05095740Recruiting
Testing brain stimulation for laryngeal dystonia symptoms
This study tests whether a noninvasive brain stimulation treatment (referred to as neuromodulation, such as rTMS) can improve symptoms of laryngeal dystonia. It’s meant to see if stimulating certain brain areas can reduce how severely your voice/throat problem affects you.
Boston, MassachusettsAges 21–85 - NCT05141487Recruiting
Testing a nerve stimulation trigger for bladder control
This study tests whether a “triggered” nerve stimulation therapy can help people with nerve-related bladder problems hold urine better and empty their bladder more comfortably. It mainly looks at whether the approach is safe and workable for patients.
Cleveland, OhioAges 18 years+ - NCT05200923Recruiting
Testing a pelvic nerve device study for bladder and bowel leaks
This study checks how well an implanted pelvic nerve system works for people with bladder overactivity, non-obstructive urinary retention, or fecal incontinence. You may need to keep your current medications steady and track symptoms closely with diaries before and during evaluation.
Indianapolis, IndianaAges 18 years+ - NCT05303415Recruiting
Low-intensity ultrasound study during brain MRI
This study tests how low-power focused ultrasound changes brain signals measured during MRI. You may help researchers understand how ultrasound can affect brain activity, even if you don’t have a known brain condition.
Roanoke, VirginiaAges 18–65 - NCT05368987Recruiting
TMS for PTSD fear learning and safety memory
This study tests a brain-stimulation treatment called TMS to see if it improves how people with PTSD unlearn fear and form safer memories. It may help reduce fear responses by targeting specific fear-circuit areas in the brain.
Houston, TexasAges 18–70 - NCT05377216RecruitingEarly Phase 1
Testing nerve stimulation effects during heart ablation
This trial studies how a type of nerve stimulation affects the heart’s electrical signals during a procedure to treat a dangerous fast heart rhythm (ventricular tachycardia). It may help doctors better understand safety and effects during planned ablation.
Philadelphia, PennsylvaniaAges 18 years+ - NCT05580211Recruiting
Brain stimulation for schizophrenia with low insight
This trial tests a brain-stimulation approach for people with schizophrenia (or schizoaffective disorder) who don’t always recognize how their illness affects them. It may help improve symptoms and insight while you stay on stable medications during the study.
Toronto, OntarioAges 18 years+ - NCT05626608Recruiting
Directional brain stimulation for Parkinson’s tremor and movement control
This trial tests a continuous electrical brain stimulation device placed in a deep brain area to help Parkinson’s symptoms—especially tremor and trouble with movement. It may help improve daily function and reduce periods when medicine does not work well.
Montpellier, FranceAges 18–70 - NCT05682677Recruiting
Brain stimulation plus cognitive training for depression after mild head injury
This study tests whether a combination of brain stimulation and cognitive training can reduce depression symptoms in people who have ongoing mild traumatic brain injury (TBI). It may help by targeting both mood and thinking/processing skills affected after mTBI.
La Jolla, CaliforniaAges 18–65 - NCT05719454Recruiting
Pacemaker-based nerve therapy for high blood pressure
This study tests a new pacemaker programming method (nerve therapy) to help lower blood pressure. It may be an option if you need a dual-chamber pacemaker and your blood pressure stays high despite medicine.
PragueAges 18 years+ - NCT05762796Recruiting
Brain scan and stimulation study for kids with mild concussion
This study tests whether a brain “stimulation” approach, paired with brain imaging (MRI), can help children who still have symptoms after a mild concussion. There is also a comparison group of children without concussion history.
Buffalo, New YorkAges 10–15 - NCT05798143Recruiting
Testing brain-signal biomarkers in treatment-resistant depression
This trial studies signs in the brain (biomarkers) during an accelerated form of nerve stimulation to treat depression that hasn’t improved with usual antidepressants. It may help researchers learn who benefits and how to better personalize treatment.
ChietiAges 18–65
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Common questions
- Are there clinical trials for neuromodulation?
- Yes. Clin2 currently lists 201 recruiting neuromodulation studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a neuromodulation trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a neuromodulation trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.