Clinical trials
Obesity and Type 2 Diabetes clinical trials
Below are recruiting obesity and type 2 diabetes clinical trials, each written for real people, not researchers. We’re tracking 276 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06700538RecruitingPhase 1/Phase 2
Study of an experimental drug for obesity with or without type 2 diabetes
This study tests an experimental medication called ARO-INHBE in adults with obesity, including those who also have type 2 diabetes. The goal is to see if it helps with weight loss and is safe.
CamberwellAges 18–65 - NCT06682481Recruiting
Pancreas-Liver Communication in Teens with Obesity
This study looks at how the pancreas and liver talk to each other in teens with obesity. It may help understand why some teens develop diabetes or fatty liver.
Geneva, Canton of GenevaAges 12–16 - NCT06600555Recruiting
Metabolic surgery for diabetes control
This trial tests a type of weight-loss surgery (called metabolic surgery) to see if it helps people with type 2 diabetes achieve better blood sugar control. It's for people who have struggled to manage their diabetes with standard treatments and have a BMI between 30 and 35.
VilleurbanneAges 18–65 - NCT06572345Recruiting
Low energy diet for teens with obesity and type 2 diabetes
This trial tests whether a low-energy diet using meal replacements can help teenagers with type 2 diabetes improve their blood sugar control. It involves a period of following the diet, then weight management, and includes follow-up visits.
NottinghamAges 12–17 - NCT06571500Recruiting
Growth hormone and insulin cells in type 2 diabetes risk
This study looks at how growth hormone affects insulin-making cells in people at risk for type 2 diabetes. It may help explain why some people with a family history of diabetes develop the condition.
Columbia, MissouriAges 18–59 - NCT06562907RecruitingPhase 1
Study of an experimental drug for weight and diabetes
This study tests an investigational drug called GS-4571 in healthy people, people with obesity, and people with type 2 diabetes. It aims to see how the drug affects the body and whether it might help with weight and blood sugar control.
Miami, FloridaAges 18–65 - NCT06546085Recruiting
Extracellular vesicles, insulin, and exercise in type 2 diabetes
This study looks at how tiny particles called extracellular vesicles affect how your body uses insulin, and whether exercise can make a difference. It is for people with type 2 diabetes (or normal blood sugar) who are not very active and have been on diabetes medication for a long time.
New Brunswick, New JerseyAges 30–80 - NCT06526650Recruiting
Cooking demos for Native Hawaiian adults with diabetes or heart risks
This trial tests if cooking demonstrations can help Native Hawaiian adults with conditions like type 2 diabetes, pre-diabetes, high blood pressure, or high cholesterol improve their health. You'd learn healthy cooking and be encouraged to do moderate activity like brisk walking.
Honolulu, HawaiiAges 18 years+ - NCT06526273Recruiting
PILI 'Āina Household Program
This study is for Native Hawaiian adults living in homestead communities who are overweight or have health conditions like diabetes, high blood pressure, or high cholesterol. It looks at a household-based program to help you and your family make healthier lifestyle changes together.
Honolulu, HawaiiAges 18 years+ - NCT06525259Recruiting
Study on risk factors for type 2 diabetes in youth
This study looks for children and teens who are at high risk of developing type 2 diabetes to understand what factors lead to it. If your child is overweight, has slightly high blood sugar, and is in early to mid-puberty, they may be able to join.
Birmingham, AlabamaAges 8–15 - NCT06497595Recruiting
Lifestyle program to prevent muscle loss in older adults with diabetes on semaglutide
This trial tests whether a lifestyle program (diet and exercise) can help prevent muscle loss in people 65 and older with type 2 diabetes and obesity who are taking semaglutide. It may help you keep your strength and independence while losing weight.
Jerusalem, IsraelAges 65 years+ - NCT06411210RecruitingPhase 2
Weight loss medication for young adults with type 1 diabetes
This study tests whether a GLP-1 medication (a type of drug that helps with weight loss) can safely and effectively help young adults with type 1 diabetes who also have obesity. It aims to see if adding this treatment to insulin can improve weight and blood sugar control.
New Haven, ConnecticutAges 18–30 - NCT06335771Recruiting
Study on fat metabolism in obesity and diabetes
This study looks at how fat is processed in the body for people with different health conditions, including obesity and type 2 diabetes. It aims to find new ways to improve treatment by understanding these differences.
Columbia, MissouriAges 18–70 - NCT06329544Recruiting
Study of a high-fructose diet and gut health
This trial tests how a high-fructose diet affects your gut bacteria and overall metabolic health. It is for people who already know they don't absorb fructose well (fructose malabsorbers) and want to understand how this sugar impacts their body.
New York, New YorkAges 25–45 - NCT06291155RecruitingPhase 4
How SGLT2 inhibitors work in the kidneys for type 2 diabetes
This study tests how a drug called canagliflozin (an SGLT2 inhibitor) affects kidney function in people with type 2 diabetes. It involves two kidney biopsies to see how the drug works inside your kidneys, aiming to better protect kidney health.
Ann Arbor, MichiganAges 18–80 - NCT04187443RecruitingPhase 1
Drug MS-553 for diabetic eye swelling with reduced vision
This Phase 1 trial tests MS-553 to see how it works and how safely it can be given to people with diabetic retinopathy causing central macular swelling (macular edema). You may be considered if your vision and eye scan results match, and if you can follow frequent study visits.
Changsha, HunanAges 18 years+ - NCT06055036Recruiting
Stress reduction for heart health in Black men
This study looks at how reducing stress can improve cardiovascular health in Black men. It involves lifestyle changes and support to help lower your risk of heart disease.
Columbus, OhioAges 18 years+ - NCT06180837Recruiting
Can longer sleep improve heart health in overweight adults?
This study tests if getting more sleep (7+ hours) can lower certain fats in the blood called ceramides, which are linked to heart disease risk. It's for overweight adults who currently sleep less than 6.5 hours a night.
Salt Lake City, UtahAges 18–45 - NCT06138821Recruiting
Endoscopic sleeve gastroplasty for obesity and MASH
This study tests if a procedure called endoscopic sleeve gastroplasty helps people with obesity and a liver condition called MASH lose weight and improve their liver health. It might be an option if you have both obesity and MASH and haven't had weight-loss surgery before.
Boston, MassachusettsAges 18 years+ - NCT06115265Recruiting
Ketogenic diet study for prediabetes and weight loss
This trial tests whether a ketogenic diet can help people with prediabetes or high blood sugar improve their health and lose weight. You eat very low-carb, high-fat foods to see if it lowers your blood sugar and reduces your risk of developing diabetes.
Albuquerque, New MexicoAges 18 years+ - NCT06118931Recruiting
Time-Restricted Eating for Blood Sugar Control
This study tests whether eating only during a specific daily window helps control blood sugar in people with or at risk for type 2 diabetes. You'll follow a set eating schedule and use a phone app to track your meals.
Toronto, OntarioAges 40 years+ - NCT05000996Recruiting
Gut microbiome study for people having metabolic surgery
This study looks at your gut bacteria (your “microbiome”) around the time of metabolic surgery. It may help researchers understand how surgery affects gut health and related conditions like diabetes, blood pressure, and cholesterol.
Nashville, TennesseeAges 21–65 - NCT06043245Enrolling by invitation
Diabetes remission and weight loss surgery
This trial tests whether a specific type of weight loss surgery can help people with type 2 diabetes stop needing diabetes medication. It is for people with a very high body mass index (BMI over 45) who are currently on diabetes pills or insulin.
L'Hospitalet de Llobregat, BarcelonaAges 18–60 - NCT05987410Recruiting
Nordic walking for weight and heart health after a cardiac event
This trial tests if a nordic walking program helps people with diabetes who are overweight or obese recover after a heart attack or heart procedure. If you had a heart event or stent/bypass in the last 3 months, this program could help you get stronger and manage your weight.
MilanAges 18 years+
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Common questions
- Are there clinical trials for obesity and type 2 diabetes?
- Yes. Clin2 currently lists 276 recruiting obesity and type 2 diabetes studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a obesity and type 2 diabetes trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a obesity and type 2 diabetes trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.