Clinical trials
Obstructive Coronary Artery Disease clinical trials
Below are recruiting obstructive coronary artery disease clinical trials, each written for real people, not researchers. We’re tracking 114 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05762952RecruitingPhase 1
Dapagliflozin study for heart micro-blood-flow symptoms in women
This early-phase study tests whether dapagliflozin can improve tiny blood-vessel function in women who have heart-ache-like symptoms but no major blockage on heart scans. If it works, it may help symptoms related to “microvascular” heart circulation problems.
Charlottesville, VirginiaAges 18–99 - NCT06205810Recruiting
Complete study on heart artery blockages
This trial looks at people with a blockage in a heart artery of 50% or more. It tests a new way to check the blockage using a special CT scan. This could help decide the best treatment to prevent future heart problems.
Aalst, Oost-VlaanderenAges 18 years+ - NCT06445608Recruiting
Study of a heart pump for high-risk angioplasty
This trial tests a temporary heart pump (called the KARDION Cory P4) used during a high-risk angioplasty (stenting) procedure. The pump helps keep blood flowing in patients whose heart is weak or who have complex blockages, aiming to make the procedure safer.
Chandler, ArizonaAges 18–90 - NCT07048808RecruitingPhase 2
Gene therapy for chronic chest pain
This trial tests a new gene therapy (XC001) delivered through a thin tube into your heart's blood vessels. It aims to grow new blood vessels to relieve chest pain in people with chronic angina who have no other treatment options.
Cincinnati, OhioAges 18–85 - NCT07195968Enrolling by invitation
Comparing nitroglycerin and saline for heart artery testing
This trial compares two ways to test blood flow in the heart arteries: one uses a medicine called nitroglycerin, and the other uses salt water. It may help people with partial blockages (50-90%) in their heart arteries, especially if they have not had a recent serious heart attack.
Hsinchu, SelectAges 21 years+ - NCT06542575Enrolling by invitation
Home heart rehab with app after stent
This trial tests a home-based program that uses a smartphone app (digital therapy) to help people with high-risk heart conditions after a stent procedure. The goal is to improve recovery through exercise and lifestyle support, all from home.
Chengdu, SichuanAges 18–75 - NCT06986070RecruitingPhase 1
Stem cell therapy for mild to moderate COPD
This study tests whether a new type of stem cell (SMS cells) can help people with mild or moderate COPD caused by smoking or pollution. You will receive the treatment by inhalation and be followed to see if your breathing improves.
Melbourne, VictoriaAges 39–69 - NCT06283966RecruitingPhase 3
Triple inhaler for COPD with heart risk
This study tests a triple-combination inhaler (budesonide, glycopyrronium, and formoterol) to see if it can help protect the heart and lungs in people with COPD who also have heart problems or high risk for them.
Athens, AlabamaAges 40–80 - NCT07140328RecruitingPhase 2
Testing a new inhaler for COPD symptoms
This trial tests two forms of a new medication (HSK39004) in people with COPD. The goal is to see if they help improve breathing and are safe. Eligible participants must be between 40 and 80, have moderate to severe COPD, and be able to stop other COPD treatments during the study.
Nanchang, JiangsuAges 40–80 - NCT06249568Recruiting
Testing fluid response during heart bypass surgery
This study tests a method to see if your body needs more fluids during heart bypass surgery. After the surgeon opens your chest, they will use a special breathing maneuver to check how well your heart responds to extra fluid, which may help guide your care.
AnkaraAges 18–80 - NCT05714293Enrolling by invitation
CT measurements after surgical aortic valve replacement
This study uses a CT scan (with contrast dye) to measure the coronary artery openings after people have a new aortic valve placed surgically. It aims to see how to best plan or understand coronary blood flow after the surgery.
RomaAges 18–80 - NCT03890224Recruiting
Testing breathing support needs in COPD with high CO2
This trial studies how different breathing support strategies affect people with COPD who have high carbon dioxide (CO2) in their blood. It may help care teams choose safer respiratory support after a breathing machine is stopped.
Paris, Île-de-France RegionAges 18 years+ - NCT05844462RecruitingPhase 3
Tadalafil for severe lung blood-pressure problems from COPD
This study tests whether tadalafil can improve outcomes for people with severe pulmonary hypertension caused by COPD (chronic lung disease). It compares how you do with tadalafil versus standard care, focusing on breathing symptoms and how well your heart and lungs cope.
Le Kremlin-Bicêtre, FranceAges 18–85 - NCT02582021Recruiting
Study of treatments and imaging in women with angina or HFpEF
This trial studies how heart disease affects the heart using heart imaging, and looks at people with chest pain/angina or heart failure with preserved pumping strength (HFpEF). It may help doctors better understand what’s driving symptoms and how best to evaluate these conditions.
Los Angeles, CaliforniaAges 18 years+ - NCT06494163Recruiting
Exercise Training for Women With Heart Disease
This study compares two types of exercise training (high-intensity interval training vs. moderate-intensity continuous training) to see which is better for women with heart disease. You would be assigned randomly to one of the two exercise programs, and the study would last about 6 months.
Ottawa, OntarioAges 18 years+ - NCT06924593Recruiting
Shunt for carotid artery narrowing
This study tests a new device that is placed through the carotid artery in the neck to temporarily block blood flow during a procedure to open up a narrowed carotid artery. It might be an option for people who have high-risk features that make traditional surgery more challenging.
BeijingAges 18 years+ - NCT07748858Recruiting
Heart care support for older African American patients
This study aims to improve care for older African American patients with heart conditions and other health problems. It tests ways to provide more patient-centered support.
Birmingham, AlabamaAges 50–99 - NCT06179329Recruiting
Comparing two types of heart bypass grafts in women
This trial compares two types of grafts (the radial artery from the arm and a vein from the leg) used in women having heart bypass surgery for the first time. It aims to see which graft works better and stays open longer.
São Paulo, São PauloAges 18–75 - NCT04606459Recruiting
Device trial for hard-to-treat heart chest pain from small vessels
This trial tests whether a small pressure-reducing device placed in a heart vein (the coronary sinus) can reduce symptoms in people with ongoing chest pain from tiny blood vessel problems. It is for angina that has not improved despite standard heart medicines, and only if special heart tests show reversible reduced blood flow.
Mainz, Rhineland-PalatinateAges 18–85 - NCT06653387Recruiting
Testing a new carotid stent with blood-flow reversal for high-risk patients
This trial tests a new carotid stent system used with a special blood-flow reversal device to treat blocked carotid arteries. It is for people with high-risk conditions who might not be good candidates for traditional open surgery, and aims to see if the stent is safe and effective in preventing strokes.
Sacramento, CaliforniaAges 18–79 - NCT05426408Recruiting
Test study for heart attacks without blocked arteries
This study looks at people who may have MINOCA (heart attack symptoms with no major artery blockage) or takotsubo syndrome (a temporary stress-related heart condition). The goal is to better understand these causes and how they should be diagnosed and treated.
StockholmAges 35–79 - NCT06588244Recruiting
Registry for chest pain with open arteries
This study is looking at people who have chest pain or shortness of breath but whose heart arteries look fairly open on an angiogram. It aims to understand why they have symptoms and how to improve care. You may qualify if you're having a coronary angiogram and it shows no major blockages.
Naples, ItalyAges Any age - NCT06615492Recruiting
Lung transplant study: comparing two ECMO methods
This study compares two ways of using a heart-lung machine (ECMO) during lung transplant surgery. The goal is to see if using ECMO only when needed works as well as using it for everyone. This could help reduce risks and improve recovery.
Edmonton, AlbertaAges 18 years+ - NCT03667196Recruiting
Test opening blocked heart arteries using two different procedures
This trial studies whether two ways of threading a device to open a long-term blocked coronary artery are both safe and effective. You may qualify if you have a chronic total blockage and heart-related symptoms, and you can follow the study follow-up plan.
AnyangAges 19 years+
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Common questions
- Are there clinical trials for obstructive coronary artery disease?
- Yes. Clin2 currently lists 114 recruiting obstructive coronary artery disease studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a obstructive coronary artery disease trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a obstructive coronary artery disease trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Angina Patients With Non-obstructive Coronary Artery Disease
- Coronary Atherosclerosis of Native Coronary Artery
- Coronary Artery Bypass Grafting
- Multivessel Coronary Artery Disease
- Coronary Artery Bypass
- Coronary Artery Bypass Graft (CABG)
- Spontaneous Coronary Artery Dissection
- Coronary Artery Calcification
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.