Clinical trials
Osteoarthritis clinical trials
Below are recruiting osteoarthritis clinical trials, each written for real people, not researchers. We’re tracking 610 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT03383081RecruitingPhase 2
Stem cell injection for moderate knee osteoarthritis pain
This Phase 2 study tests whether injected umbilical-cord stem cells can improve safety and reduce symptoms in people with moderate knee osteoarthritis. It focuses on people with significant knee pain who have not gotten enough relief from standard, non-procedure treatments.
Changsha, HunanAges Up to 70 years - NCT03491761RecruitingPhase 2
PRP injection versus hyaluronic acid shots for knee arthritis
This trial tests whether a platelet-rich plasma (PRP) shot works better than a standard hyaluronic acid (“gel”) injection to reduce knee osteoarthritis pain. It may help people with ongoing knee pain choose the treatment that relieves symptoms more effectively.
Skokie, IllinoisAges 18–75 - NCT03949400Recruiting
Exercise therapy and a soft knee brace for knee arthritis
This study tests whether an exercise program plus education, along with a soft brace, helps improve symptoms and function in adults with knee osteoarthritis. It may help people who have knee pain by combining movement training with daily support.
Aalborg, NothernAges 18 years+ - NCT03984461RecruitingPhase 2
Platelet-rich treatment with joint fluid or bone cells for arthritis
This trial tests a joint treatment made from your own platelets (platelet-rich plasma, or PRP) combined with other biologic material (from fat tissue and/or bone marrow) to help osteoarthritis symptoms. It may be an option if you have early-to-moderate osteoarthritis in a major joint and meet safety requirements.
Kelowna, British ColumbiaAges 19–79 - NCT07701174Recruiting
Weighted exercise vs muscle stimulation for knee arthritis
This study compares two treatments for knee osteoarthritis: weighted dangling exercises and neuromuscular electrical stimulation of the knee muscle. It aims to see which one reduces pain and improves function better.
Lahore, Punjab ProvinceAges 40–60 - NCT04247672Recruiting
Study of knee replacement outcomes using a specific knee implant
This study follows people who need knee replacement for “end-stage” knee osteoarthritis and will receive a specific knee implant system as part of routine care. It aims to measure how well the knee replacement works for patients over time, which may help improve future care.
Hoofddorp, North HollandAges 21–90 - NCT04472702Recruiting
Ultrasound vs X-ray guidance for knee pain ablation
This trial compares two ways (ultrasound or X-ray guidance) to place a treatment for painful knee arthritis. It aims to see whether one guidance method works as well as the other for reducing knee pain.
Sacramento, CaliforniaAges 35–99 - NCT04688593Recruiting
Follow-up study of a hip implant cup and stem system
This study looks at how well a specific hip implant (the acetabular cup and femoral stem) works over short, mid, and long-term follow-up. It may help you and other patients by improving understanding of implant outcomes after surgery.
KielAges 18 years+ - NCT04901273Recruiting
PRP shot vs placebo for knee osteoarthritis in adults 65+
This trial compares an injection made from your own platelets (PRP) to a placebo shot to see if it helps knee osteoarthritis symptoms and function. It is designed for people over 65 with arthritis affecting only one knee.
BolognaAges 65 years+ - NCT04929951RecruitingPhase 1
Micro fat injection to treat shoulder arthritis
This Phase 1 study tests whether a micro-fragmented fat (MFAT) injection can reduce symptoms and improve shoulder function in people with shoulder osteoarthritis. It’s early research, so the goal is mainly to see if the treatment is safe and possibly helpful.
Stanford, CaliforniaAges 25–75 - NCT04937998Recruiting
PRP or hyaluronic acid injections for knee cartilage pain
This trial compares two injection treatments—platelet-rich plasma (PRP) and hyaluronic acid (HA)—for pain from osteoarthritis in the kneecap area. It looks to see which injection works better and for whom, using symptom follow-up and imaging.
BolognaAges 30–65 - NCT04960098Recruiting
Survey after hip or knee replacement surgery
This study asks people who have had a hip or knee replacement to share how they’re doing over time. It’s testing whether patient-reported survey answers can help measure recovery and outcomes.
MilanAges 18 years+ - NCT04998188Recruiting
Hydrolyzed collagen for one knee with osteoarthritis
This trial tests whether a hydrolyzed collagen drink or supplement can reduce knee pain and symptoms compared with a placebo (inactive treatment) in people with osteoarthritis. It may help if you’ve tried standard non-surgical treatments and still have ongoing knee trouble.
BolognaAges 18–75 - NCT05039463Recruiting
Platelet-Rich Plasma and Hyaluronic Acid for Knee Arthritis
This trial tests whether combining two types of injections—platelet-rich plasma (a concentration of healing cells from your own blood) and hyaluronic acid (a natural lubricant)—can reduce knee osteoarthritis pain and improve function over one year. You're eligible if you've already received or are about to receive these injections at Amiens University Hospital.
AmiensAges 18 years+ - NCT05100966Recruiting
Exercise program for people waiting for hip or knee replacement
This trial tests a “getting fit” program to help people who are somewhat frail before hip or knee replacement surgery. It aims to improve fitness while you wait for surgery, which may help you feel stronger for recovery.
Calgary, AlbertaAges 60 years+ - NCT05120492Recruiting
Program for severe knee arthritis and extreme weight
This feasibility study tests a practical approach to help people with very severe knee arthritis and very high body weight. It aims to find an effective and safe way to manage both conditions together in real-world care.
Halifax, Nova ScotiaAges 18–65 - NCT05254574RecruitingPhase 1
Acoustic therapy for ongoing joint pain from osteoarthritis
This Phase 1 study tests a sustained acoustic medicine device to help reduce pain from osteoarthritis (wear-and-tear arthritis) in joints like knees or hips. Because it’s early-stage research, you may be asked to follow strict rules about pain medicines and device use while the team monitors safety and comfort.
Tampa, FloridaAges 35–85 - NCT05278520Recruiting
Study of hip arthritis types during hip replacement surgery
This study looks at differences inside the hip joint and in body cells when people have hip arthritis or rheumatoid arthritis and receive a hip replacement. Researchers hope this can improve understanding and future treatments for these conditions.
Turku, Southwest FinlandAges 18–74 - NCT05378815Recruiting
Platelet injections for knee arthritis pain
This study tests whether platelet-rich plasma (a treatment made from your own blood) can reduce symptoms of knee osteoarthritis. It focuses on people with specific types of knee pain and X-ray findings, and compares against rules around current pain medicines and injections.
Créteil, Val-De-MarneAges 40–79 - NCT05423587Recruiting
Knee artery procedure for long-lasting knee arthritis pain
This study looks at whether blocking small blood vessels in the knee (genicular artery embolisation) can reduce pain from knee osteoarthritis when other non-surgical treatments haven't helped. It also checks safety and whether people can tolerate the imaging tests needed for the procedure.
ReadingAges 45 years+ - NCT05488093Recruiting
Testing knee movement in severe knee arthritis before replacement surgery
This study checks how well your knee moves and how that relates to pain and function in people with severe knee arthritis who are about to get total knee replacement. It may help doctors better plan and evaluate treatment before surgery.
MontpellierAges 60 years+ - NCT05497349Recruiting
PRP injections for one-sided hip osteoarthritis
This study compares two types of PRP (platelet-rich plasma)—with white blood cells or without—for pain from one-sided hip osteoarthritis. It may help you see which injection type works better and is safe for improving hip symptoms.
BolognaAges 35–70 - NCT05507099RecruitingPhase 2
Stem cell injections for knee or hip osteoarthritis pain
This Phase 2 study tests whether stem cell injections can reduce pain and improve symptoms in people with knee or hip osteoarthritis. You may be considered if you have moderate-to-severe pain despite trying standard treatments.
Brampton, OntarioAges 18–95 - NCT05543941Recruiting
Test advanced irrigation during knee, hip, or shoulder replacement
This trial studies a cleaning solution used during surgery to lower the risk of complications and improve outcomes after joint replacement. It may be an option if you’re having a planned knee, hip, or humerus (shoulder) replacement and meet the specific health and allergy requirements.
Vancouver, British ColumbiaAges 18 years+
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Common questions
- Are there clinical trials for osteoarthritis?
- Yes. Clin2 currently lists 610 recruiting osteoarthritis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a osteoarthritis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a osteoarthritis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.