Clinical trials
Osteoarthritis clinical trials
Below are recruiting osteoarthritis clinical trials, each written for real people, not researchers. We’re tracking 610 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05559463Recruiting
Anti-inflammatory diet for knee arthritis pain relief
This trial studies whether an anti-inflammatory eating plan (the “ITIS diet”) can improve symptoms in people with knee osteoarthritis. It is meant to see if changing what you eat can help reduce pain and improve function.
La Jolla, CaliforniaAges 18 years+ - NCT05700682Recruiting
MRI-guided artery blockage procedure for long-term joint pain
This study tests whether an MRI scan that looks at blood flow can help target a joint embolization procedure to reduce chronic shoulder, hip, or knee pain. It first uses MRI to find signs of increased blood flow, then may use the findings to guide treatment if you qualify.
Palo Alto, CaliforniaAges 25–80 - NCT05829733Recruiting
Synolis injection for 6 months in hip arthritis pain
This trial studies whether a treatment injection (Synolis VA 80/160) can safely reduce hip arthritis pain and improve function over 6 months. You may be eligible if you have confirmed hip osteoarthritis, ongoing pain despite common pain medicines, and no recent steroid or “visco-supplement” injections in that hip.
BelfortAges 18 years+ - NCT05848622Recruiting
Gait retraining after ACL surgery for fast knee recovery
This trial tests a walking (gait) rehabilitation program to improve how you move after ACL reconstruction. It may help if you are still having walking mechanics issues in the months to years after surgery.
Chapel Hill, North CarolinaAges 16–35 - NCT05887284Recruiting
Low-dose radiation study for osteoarthritis pain relief
This study tests whether giving a small amount of radiation to an osteoarthritis joint can improve symptoms. It’s designed for people who are newly starting this kind of treatment and can return for follow-up visits.
Erlangen, BavariaAges 39 years+ - NCT05906433RecruitingPhase 1
Best type of numbing medicine for knee steroid shots
This early (Phase 1) study looks at which anesthetic (numbing medicine) works best and is safest during steroid injections for knee osteoarthritis. It may help improve comfort and effectiveness of these common pain-relief shots.
Tampa, FloridaAges 18 years+ - NCT05917028Recruiting
Nonsurgical injections to reduce knee osteoarthritis pain
This study tests a procedure called transcatheter arterial micro-embolization (a targeted injection done through blood vessels) to lessen pain from knee osteoarthritis. It may help people who still have significant pain despite standard “non-surgical” treatments like therapy and joint injections.
Seoul, Seodaemun-guAges 50 years+ - NCT05923736Recruiting
Study of cardiovascular risk in people with digital osteoarthritis
This study looks at how heart-and-blood-vessel risk differs in people with digital osteoarthritis (arthritis affecting the fingers). It may help doctors understand whether finger osteoarthritis is linked with higher cardiovascular risk.
Clermont-FerrandAges 18 years+ - NCT05926622Recruiting
Testing a Medacta shoulder replacement system for pain relief
This trial studies how well a Medacta shoulder replacement works by looking at clinical results and X-ray/scan findings after surgery. It may help people with certain shoulder conditions who need shoulder replacement or revision surgery.
AnnecyAges 18 years+ - NCT05933434RecruitingPhase 1/Phase 2
Stem cell injection trial for chronic knee osteoarthritis
This early-phase study tests an injection of donor stem cells placed into the knee joint to help reduce symptoms of knee osteoarthritis. You may be eligible if you have long-lasting knee pain from mild-to-moderate arthritis and meet safety and imaging requirements.
Aarhus NAges 40–75 - NCT05946044Recruiting
Preventing Knee Arthritis in People at Higher Risk
This study looks at ways to help prevent knee osteoarthritis before it starts. It is designed for women with higher body weight who currently have no arthritis signs on scans and do not have much knee pain.
Boston, MassachusettsAges 50 years+ - NCT05962463Recruiting
Compare two pain injections for advanced knee arthritis
This trial compares pulsed radiofrequency therapy versus a targeted nerve pain block to help reduce knee pain from advanced osteoarthritis. You might join if you have knee osteoarthritis in the more severe range (Kellgren-Lawrence grade 3–4) and meet safety requirements.
LjubljanaAges 45–100 - NCT06034262RecruitingPhase 2
Umbilical cord tissue for finger joint arthritis
This trial tests a special, sterilized piece of umbilical cord tissue (amniotic membrane) that is placed in the finger joint during surgery to help reduce pain and improve function for people with arthritis in the middle joint of the finger. It's for patients who haven't gotten better with standard medical treatments and are considering surgery.
BesançonAges 18–75 - NCT06040957Recruiting
Bone marrow vs fat cells for knee osteoarthritis treatment
This trial compares using cells from your bone marrow or belly fat to treat knee osteoarthritis, aiming to reduce pain and improve function. It's for people who haven't gotten better with standard treatments like physical therapy or medications.
BolognaAges 40–75 - NCT06054633Recruiting
L-arginine for knee osteoarthritis pain
This study tests whether L-arginine, a natural amino acid, can help with knee pain from osteoarthritis. You might be eligible if you are 40–80 years old, have moderate osteoarthritis on X-ray, and have had knee pain for at least 3 months.
Changsha, HunanAges 40–80 - NCT06080347Recruiting
Anti-inflammatory diet for knee osteoarthritis
This study tests whether an anti-inflammatory diet can help with knee osteoarthritis. If you have OA in one knee and are open to changing your eating habits, you may be able to join.
San Diego, CaliforniaAges 18 years+ - NCT06084364RecruitingPhase 4
Steroid vs saline injection vs occupational therapy for thumb arthritis
This study compares a steroid injection (Kenacort), a saltwater (saline) injection, and occupational therapy to see which works best for thumb base osteoarthritis pain. It may help you if you have thumb pain with swelling and want to avoid surgery.
BodøAges 40–85 - NCT06084949Recruiting
Exercise for knee osteoarthritis relief
This trial tests if a structured exercise program can reduce pain and improve daily activities for people with knee osteoarthritis. If you have knee pain and trouble with daily tasks, this study may help you find a low-cost, non-drug way to feel better.
Kowloon City, KowloonAges 55 years+ - NCT06105788Recruiting
Exercise and pain relief for knee arthritis
This study looks at how moving your arms and legs might help reduce pain for people with knee osteoarthritis. If you join, you will do some light exercise so researchers can see if it helps your knee feel better.
El Paso, TexasAges 45–90 - NCT06145516Recruiting
Sleep program to ease pain after joint replacement
This study tests whether a sleep program can help with pain after knee or hip replacement. If you have insomnia and arthritis pain, you may be able to join before your surgery.
Uppsala, UpplandAges 18–100 - NCT06166628Recruiting
Comparing two procedures for knee osteoarthritis pain
This study compares two minimally invasive procedures—embolization (blocking blood flow) and nerve ablation (blocking pain signals)—to see which works better for knee osteoarthritis pain. If you have long-lasting knee pain and are considering knee replacement surgery, this trial may help find another option.
Kingston, OntarioAges 40 years+ - NCT06184451Recruiting
TENS with exercise for knee osteoarthritis
This study tests if adding TENS (a pain-relieving electrical stimulation) to a standard exercise program helps people with knee osteoarthritis feel better and move better.
São PauloAges 40–75 - NCT06196567Recruiting
Pulsed magnetic therapy for knee strength before replacement
This study tests whether pulsed electromagnetic field therapy (a non-invasive treatment using magnetic pulses) can improve muscle strength and function in people with severe knee osteoarthritis who are waiting for knee replacement surgery. It may help you feel stronger and move better before your operation.
Hong Kong, NEW TerritoriesAges 50–100 - NCT06208631Recruiting
Movement retraining for knee osteoarthritis pain
This study tests a movement retraining program to see if changing how you walk can reduce stress on your knee and ease osteoarthritis pain. It’s a good fit for people with mild knee pain who want a non-surgical option.
Stanford, CaliforniaAges 18 years+
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Common questions
- Are there clinical trials for osteoarthritis?
- Yes. Clin2 currently lists 610 recruiting osteoarthritis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a osteoarthritis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a osteoarthritis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.