Clinical trials
Pain, Chronic Disease clinical trials
Below are recruiting pain, chronic disease clinical trials, each written for real people, not researchers. We’re tracking 456 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05009459Recruiting
App-based program to help chronic pain and daily activity
This study tests an eVIS tool that combines information about physical activity and pain to help people with long-lasting pain improve how pain affects daily life. You may be a good fit if you have chronic pain and can complete the program in Swedish using your own device.
FalunAges 18–67 - NCT04706195Recruiting
Person-centered online rehab for chronic pain on sick leave
This trial tests an early, personalized (person-centered) rehabilitation program delivered through eHealth to help people living with long-term non-cancer pain. It may help reduce pain impact and improve function while you are on sick leave from work.
GothenburgAges 18–65 - NCT04512755Recruiting
AIMS medical outcomes study for new or established patients
This is an observational study where the AIMS team collects information from patients during a first visit or ongoing care. It helps the clinic understand patients’ experiences and outcomes, but it does not test a new medicine.
Seattle, WashingtonAges Any age - NCT04014829Recruiting
Study of pain processing after planned hysterectomy
This trial looks at how the nervous system and fear of pain may affect pain after a planned hysterectomy. If you qualify, you may be asked about pain levels and pain sensitivity to better understand who may have more pain recovery challenges.
SingaporeAges 21–80 - NCT07761936RecruitingPhase 3
Safinamide for Parkinson's disease pain
This study tests whether safinamide, an add-on medication for Parkinson's disease, can reduce chronic pain in people who also experience motor fluctuations (times when symptoms return between doses). It aims to see if this treatment can improve pain and quality of life.
Verona, VenetoAges 18 years+ - NCT07641504RecruitingPhase 2
Testing LY4065967 for chronic low back pain relief
This study tests whether a new medication called LY4065967 can reduce chronic low back pain. Researchers want to see if it works better than current treatments for people who have had lower back pain for at least 3 months.
Birmingham, AlabamaAges 18 years+ - NCT07127380Recruiting
Comparing two types of spine surgery for disc-related low back pain
This study compares two different surgery methods (Mini-TLIF and MIDLIF) for treating low back pain caused by worn-out discs in the lower back. The goal is to see which one offers better recovery, fewer complications, and lower costs.
Lodz, Łódź VoivodeshipAges 18 years+ - NCT07123233Recruiting
Cognitive behavioral treatment for chronic face and mouth pain
This trial tests a new cognitive-behavioral therapy (a type of talk therapy) for people with chronic orofacial pain – pain in the face, mouth, or jaw that has lasted for months. The goal is to learn skills to help manage pain and improve quality of life.
MilanAges 18–70 - NCT06973837Recruiting
Brain study on chronic back pain and insomnia
This study looks at how the brain works in people with chronic low back pain and/or chronic insomnia. It compares these groups to healthy volunteers using MRI and pain tests.
LeuvenAges 18–60 - NCT06963658Recruiting
Isometric Exercise and Pain Sensitivity in Chronic Low Back Pain
This study tests whether a simple, still (isometric) exercise can reduce how sensitive you are to pain. It is for adults with long-term low back pain who can safely do physical therapy exercises.
Bisha, 'Asir RegionAges 18 years+ - NCT06869668Recruiting
Chronic low back pain and quality of life study
This study looks at how long-term back pain affects your daily life, physical abilities, and how you feel about moving. It aims to find links between pain, fear of movement, and overall well-being.
Istanbul, BuyukcekmeceAges 18–50 - NCT06004804Recruiting
Psychological treatments for chronic pain in veterans
This study compares two group psychological treatments for chronic pain delivered over video conference. It aims to see if these treatments help reduce pain and improve quality of life for veterans.
West Los Angeles, CaliforniaAges 60–95 - NCT05986292RecruitingPhase 2
Study of new pain treatments for chronic pain
This study tests new treatments for people with chronic pain that has lasted at least 12 weeks. It aims to find better ways to reduce pain and improve quality of life.
Birmingham, AlabamaAges 18 years+ - NCT05700279Recruiting
PTSD treatment to help prevent future chronic pain
This study tests whether treating post-traumatic stress disorder (PTSD) right when you come to the emergency room for new, acute pain can lower the chance you develop long-term (chronic) pain. It may help people whose pain and trauma symptoms start around the same time.
Chicago, IllinoisAges 18–70 - NCT05069363Recruiting
Light therapy for widespread chronic pain
This trial tests whether using a whole-body light treatment (photobiomodulation) can reduce widespread chronic pain. It may help if you have long-lasting, widespread pain and can safely use the device for about 6 weeks.
BirminghamAges 18–100 - NCT07132762Recruiting
Shock wave therapy for chronic low back pain
This study tests whether adding a special sound wave therapy (called ESWT) to standard care (like exercise and education) can reduce pain and improve daily function in people with long-term low back pain. It is designed for people whose back pain does not have a specific known cause.
DenizliAges 18–65 - NCT06910475Enrolling by invitation
Exercise and biomarker study to reduce toxins in kidney disease
This study tests whether a supervised exercise program can help reduce toxins in the blood for people with chronic kidney disease and metabolic syndrome. Researchers will also look at blood markers to understand how exercise affects the body.
Taguatinga, Federal DistrictAges 18 years+ - NCT06861920RecruitingPhase 4
NSAID use for painful periods to prevent chronic pelvic pain
This study tests whether using NSAIDs (like naproxen) for painful periods can help prevent chronic pelvic pain later on. It's for people with regular, painful periods who are otherwise healthy.
Evanston, IllinoisAges 18–35 - NCT07212829Recruiting
Brain stimulation during exercise for chronic pain
This trial tests whether adding gentle brain stimulation (tDCS) to exercise can help people with chronic widespread pain (like fibromyalgia). It aims to see if this combination reduces pain better than exercise alone.
JetteAges 18–70 - NCT07338877Enrolling by invitation
Stem cell therapy for disc-related low back pain
This trial tests a new treatment that uses your own stem cells to help heal damaged discs in your lower back. The stem cells are injected into the disc during a minimally invasive procedure to reduce pain and improve function.
Košice, Košice RegionAges 18 years+ - NCT07334561Recruiting
Brain stimulation for depression and pain
This study tests a non-invasive brain stimulation treatment (transcranial electrical stimulation) for people who have both depression and chronic pain. It aims to see if this treatment can help improve mood and reduce pain.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT07272551Enrolling by invitation
Polyvagal therapy for chronic neck pain
This trial tests a new approach based on the polyvagal theory to help people with long-term neck pain. It uses gentle exercises and techniques to calm the nervous system and reduce pain.
Istanbul, MaltepeAges 18–50 - NCT07245121Recruiting
Sugar water injections for chronic knee arthritis pain
This trial tests whether injecting a sugar-water solution around the nerves of the knee can reduce chronic pain from osteoarthritis. It is for people with long-term knee pain, stiffness, and cracking who have not had recent knee treatments or surgery.
Athens, AtticaAges 38 years+ - NCT06994988Recruiting
Smart band-aid study for chronic pain in women
This trial tests a special band-aid that measures chronic pain. Women with chronic pain or healthy women may join to help researchers learn how this device works.
Chicago, IllinoisAges 18 years+
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Common questions
- Are there clinical trials for pain, chronic disease?
- Yes. Clin2 currently lists 456 recruiting pain, chronic disease studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a pain, chronic disease trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a pain, chronic disease trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.