Clinical trials
Pain clinical trials
Below are recruiting pain clinical trials, each written for real people, not researchers. We’re tracking 3,138 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07221786Recruiting
Opioid reduction before spine surgery
This trial tests whether slowly reducing opioid pain medications before spine surgery can lead to a better recovery afterward. It is for adults already taking daily opioids who have major spine surgery planned at least a month away.
Philadephia, PennsylvaniaAges 18 years+ - NCT07228377Recruiting
Virtual reality for cancer pain and opioid use
This study tests if using virtual reality can help manage chronic cancer pain and reduce the amount of opioid pain medicine needed. You would use a VR headset at home and report how you feel.
Washington D.C., District of ColumbiaAges 18 years+ - NCT07227077Recruiting
Physical activity study for older cancer survivors with chronic pain
This study uses a smartphone program to encourage physical activity in older adults who have survived cancer and have ongoing pain. It aims to learn how to best help you move more and feel better.
Milwaukee, WisconsinAges 65 years+ - NCT07224945Recruiting
Emergency room physical therapy for low back pain
This study tests whether physical therapy in the emergency room can help people with new or recent low back pain. If you have back pain that started in the last month, you may be able to join.
Chicago, IllinoisAges 18 years+ - NCT06912386Recruiting
Ear device for period pain relief study
This trial tests a device that gently stimulates a nerve in your ear to see if it eases menstrual cramps. It may offer a drug-free option for managing period pain.
Chengdu, SichuanAges 18–45 - NCT05287867Recruiting
Study for painful degenerative disc disease treatment
This trial is testing a treatment approach for people with long-lasting, painful worn-out discs in the lower back (and sometimes leg pain). It looks for people who tried common non-surgical options without enough relief and who may be headed toward a lumbar procedure.
Broomfield, ColoradoAges 25–65 - NCT06913868Recruiting
Comparing two types of physical therapy for fibromyalgia pain
This study compares a standard physical therapy approach with one based on group consensus to see which works better for fibromyalgia pain. It may help find a more personalized treatment for your condition.
CairoAges 18–65 - NCT06913920Recruiting
Comparing therapies for hand swelling and pain after wrist fracture surgery
This trial tests whether using mechanical devices (like compression or massage) reduces swelling and pain better than standard care after wrist fracture surgery. It may help you recover hand function more comfortably.
CairoAges 18–65 - NCT07212920Recruiting
Video physiotherapy for recent knee injuries
This study tests whether a video-based physiotherapy assessment works as well as an in-person exam for people with recent knee injuries. If you have a knee injury that started 1 to 12 weeks ago and haven't been treated yet, you may be able to participate from home using your phone or computer.
AlingsåsAges 18 years+ - NCT05898035Recruiting
Testing symptoms after root-end dental surgery
This study looks at what symptoms you feel after endodontic microsurgery (a type of root-end tooth procedure). It will help doctors understand what to expect after surgery in properly selected patients.
IrbidAges 18–65 - NCT07215546Enrolling by invitation
Stopping pain after heart surgery with a special chest closure
This trial tests a new device to close the breastbone after open-heart surgery to see if it helps reduce the need for prescription pain medicine. The device is designed to hold the bone together more securely, which may lead to less pain and faster recovery.
Naples, FloridaAges 19–80 - NCT06796309Recruiting
Testing a rural health app for seniors and shoulder pain
This study tests a digital tool (called TRAK) to improve healthcare quality and access in rural areas. It is for healthcare workers or patients who are seniors or have long-term shoulder pain.
MadridAges 18 years+ - NCT06915558Recruiting
Reducing inflammation in weight loss surgery
This trial tests a method to control inflammation during bariatric surgery. It may help patients recover better and have fewer complications.
Barcelona, BarcelonaAges 18–65 - NCT06861582Recruiting
Faster troponin test for chest pain in the ER
This study tests a faster way to measure a heart-muscle protein (troponin) in the emergency room, to see if it can help doctors decide sooner whether your chest pain is from a heart attack. If you are having chest pain that started a few hours ago, you may be able to join.
São PauloAges 18 years+ - NCT07218133Recruiting
Ear Stimulation to Reduce Pain After Spine Surgery
This trial tests whether a gentle electrical stimulation delivered through the ear can reduce inflammation and pain after major spinal fusion surgery. If you are having a long spinal fusion, you might be able to join.
St Louis, MissouriAges 18 years+ - NCT07217821Recruiting
Music and imagery for chronic pain
This study tests a step-by-step approach using music and guided imagery to help people with long-term muscle or joint pain. It's done from home using a device, so you don't need to travel.
Indianapolis, IndianaAges 18 years+ - NCT07213375RecruitingPhase 2/Phase 3
High-dose steroid to reduce pain after lung surgery
This trial tests if a high dose of dexamethasone (a steroid) can lower pain after keyhole lung surgery. If you are having planned keyhole lung surgery for a lobe or segment, you may be eligible.
Copenhagen, CopenhagenAges 18 years+ - NCT07219888Enrolling by invitationPhase 4
Comparing suzetrigine and oxycodone for knee replacement pain
This study compares a new pain medicine called suzetrigine with a commonly used opioid, oxycodone, for pain after a knee replacement. The goal is to see which works better and has fewer side effects.
Louisville, KentuckyAges 21–89 - NCT06916676Recruiting
Laser therapy for knee osteoarthritis pain
This study tests a type of laser treatment called HILT to see if it can help reduce knee pain from osteoarthritis. You would attend 3 sessions each week for 4 weeks.
CairoAges 18–65 - NCT06088420Recruiting
Pain relief after cesarean section with nerve blocks
This study compares different nerve blocks for pain control after a planned cesarean delivery. The goal is to find which block provides the best pain relief with fewer side effects.
Asyut, ManfaloutAges 18–40 - NCT06583122Recruiting
Nerve block study for occipital pain or migraine
This trial tests if using ultrasound-guided heat (radiofrequency ablation) on the occipital nerve can reduce headache pain. It is for people with occipital neuralgia or migraine pain at the back of the head who haven't had enough relief from oral medications.
Kansas City, KansasAges 18–80 - NCT06914557RecruitingPhase 2
Scrambler therapy plus duloxetine for chemo nerve pain
This study tests whether adding a non-invasive device called Scrambler Therapy to the usual nerve pain medicine (duloxetine) can better relieve chemotherapy-induced nerve pain. It is for people with cancer who still have significant nerve pain despite taking duloxetine.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06888804Recruiting
Nerve block for chronic heel fracture pain
This study tests a non-surgical treatment (pulsed radiofrequency, or PRF) applied to a nerve in the ankle to see if it can reduce long-term pain after a heel bone (calcaneus) fracture. It may be an option if you have had pain for more than 3 months and other treatments haven't worked.
AnkaraAges 18–80 - NCT07203222Recruiting
Laser vs electric stimulation for shoulder pain after stroke
This study compares two non-invasive treatments—low-level laser therapy and electrical nerve stimulation—to see which works better for relieving moderate to severe shoulder pain in people who have had a stroke. If you have had a stroke in the last 2 weeks to 6 months and have shoulder pain, this trial may be an option for you.
Ankara, YenimahalleAges 18–75
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Common questions
- Are there clinical trials for pain?
- Yes. Clin2 currently lists 3,138 recruiting pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.