Clinical trials
Pain clinical trials
Below are recruiting pain clinical trials, each written for real people, not researchers. We’re tracking 3,136 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05787470Recruiting
How hormone levels affect pain signals
This study looks at how hormone treatment and hormone levels may change how the body produces pain signals. It may help researchers better understand pain differences between people with different hormone levels and treatment histories.
Birmingham, AlabamaAges 18–65 - NCT05746143RecruitingPhase 4
Zolpidem during recovery after lower-back fusion surgery
This trial studies whether taking zolpidem around the time of recovery from lower-back (lumbar) fusion surgery affects outcomes. It may help doctors understand how sleep medicine can (or can’t) support recovery in certain people.
Los Angeles, CaliforniaAges 18–75 - NCT05747937Recruiting
Tracking nerve changes in people with ALS
This study follows people with ALS over time to learn how the body’s automatic nerves and nerve sensing (how you feel touch and pain) change. It may help researchers understand ALS better and guide future care.
Telese Terme, BeneventoAges 18 years+ - NCT05761015RecruitingPhase 4
Test of an NSAID to help osteoarthritis pain when walking
This trial studies whether taking an anti-inflammatory pain medicine (an NSAID) can reduce hip or knee osteoarthritis pain during walking. It may help people who have had walking pain for at least 3 months and don’t already take NSAIDs.
Clermont-FerrandAges 50–70 - NCT05750992Recruiting
Ultrasound vs surgery guidance for numbing during C-section
This trial compares two ways of placing numbing medicine (with bupivacaine) during a planned C-section: an ultrasound-guided approach versus a surgical approach. It aims to find which method provides better pain control and comfort with fewer problems.
CairoAges 21–35 - NCT05773482Recruiting
Breathing and attention training for fibromyalgia pain
This study tests whether breathing and attention exercises can change how your body controls pain in people with fibromyalgia. It may help you learn non-medication ways to influence pain signals and improve comfort.
Gainesville, FloridaAges 18–70 - NCT05748015Recruiting
Checking how the nervous system is affected in multiple sclerosis
This study looks at signs of how your automatic “control” nerves (the autonomic nervous system) may be affected in people with multiple sclerosis. It may help researchers better understand different types of MS and how to recognize nervous-system involvement.
Telese Terme, BeneventoAges 18 years+ - NCT05748028Recruiting
Testing treatment for pain and nerve symptoms in Parkinson’s
This study looks at pain and “autonomic” (automatic body) symptoms in people with Parkinson’s disease or a related condition called multiple system atrophy. It aims to understand what helps and to learn more about these symptoms in different types of Parkinson-like illnesses.
Telese Terme, BeneventoAges 18 years+ - NCT05753046Enrolling by invitationPhase 4
Nerve-block during robotic prostate surgery to reduce pain
This trial studies whether a laparoscopic nerve block (called a TAP block) given during robotic prostate surgery can reduce postoperative pain. It compares comfort after surgery and looks for side effects or issues that could affect results.
Royal Oak, MichiganAges 18 years+ - NCT05774002Recruiting
Psychological check-in for teens getting back surgery for scoliosis
This study asks teens with idiopathic scoliosis to complete psychological assessments while planning for elective back surgery. It may help doctors better understand patients’ mental and emotional needs around surgery.
The Bronx, New YorkAges 10–19 - NCT03265379Recruiting
Registry study for breast cancer invading the chest wall
This study follows people with breast cancer that has spread into the chest wall who are planning full-thickness chest wall surgery. It aims to improve quality of life by collecting real-world information during and after treatment.
Toronto, OntarioAges 18 years+ - NCT05737121RecruitingPhase 2
Study drug for bladder pain compared with lidocaine, heparin, or placebo
This Phase 2 trial tests VNX001 to see if it helps people with interstitial cystitis/bladder pain syndrome (IC/BPS) compared with its separate ingredients (lidocaine and heparin) or a placebo (inactive treatment). You may be eligible if you have had IC/BPS for months and recently had a moderate-to-severe bladder pain flare.
Escondido, CaliforniaAges 18 years+ - NCT05730491Recruiting
Online parenting program for kids with IBS-related belly pain
This trial tests an online social learning program to help parents support their child when the parent has irritable bowel syndrome (IBS) or related belly pain. It may help families build coping skills and resilience through guided parent sessions.
Seattle, WashingtonAges 18 years+ - NCT05726786RecruitingPhase 3
Immunonutrition before bladder removal surgery
This study tests whether a special nutrition drink given before open bladder surgery can reduce complications and improve the body’s immune response after surgery. It’s for adults having bladder removal and is compared against standard care.
Lausanne, Canton of VaudAges 18 years+ - NCT05744024Enrolling by invitation
VR-based comfort care during complex wound procedures
This trial studies a non-medicine way to reduce pain during complex wound care, possibly using VR or similar distraction tools. You may be able to join if you have painful wound procedures and can safely use the VR setup.
Amsterdam, North HollandAges 18 years+ - NCT05720065RecruitingPhase 2
Testing botulinum toxin A for jaw muscle pain
This trial studies whether botulinum toxin A (a type of muscle-relaxing medicine) can reduce jaw muscle pain and help explain why it happens. It focuses on people with specific jaw muscle pain patterns and tests outcomes after injection/biopsy.
Huddinge, Stockholm CountyAges 20–45 - NCT05722002RecruitingPhase 4
Compare pain-med plans after low-risk surgery
This study tests which pain-medication plan works best and has the fewest side effects after certain low-risk surgeries. You may be assigned to receive opioid-based, NSAID-based, or acetaminophen-based pain control depending on your situation.
Ann Arbor, MichiganAges 18 years+ - NCT05712395Recruiting
Pain-free exercise program for people with leg artery disease
This trial tests a new kind of exercise that is meant to be non-ischemic (not reduce blood flow) and pain-free, to see if it helps people with peripheral artery disease (PAD) who get leg pain when walking. You may be eligible if you have PAD confirmed by specific treadmill and blood-pressure measurements and meet the exercise and health safety requirements.
Oklahoma City, OklahomaAges 40 years+ - NCT05725967Enrolling by invitation
Endoscopic and bariatric procedures for obesity
This study looks at people who are having obesity-related procedures, including options done with a scope (endoscopic) and revision after prior bariatric surgery. It may help doctors understand outcomes and improve care for people undergoing these treatments.
Boston, MassachusettsAges 18–80 - NCT05585229RecruitingPhase 2
Psilocybin therapy to help you taper opioid pain medicine
This Phase 2 study tests a structured, therapist-led treatment using standardized natural psilocybin to help people reduce or stop long-term opioid use for chronic (non-cancer) pain. It’s mainly for those who have tried tapering before but couldn’t, and who are motivated to try again.
Kelowna, British ColumbiaAges 19–75 - NCT05688904RecruitingPhase 1
Topical imipramine with light treatment for skin pain relief
This Phase 1 study tests whether applying imipramine cream to the skin affects pain and effectiveness when combined with a light-based skin treatment (photodynamic therapy). It’s mainly looking at safety and early signs of benefit for people with certain sun-damaged skin areas.
Fairborn, OhioAges 18 years+ - NCT05705128Enrolling by invitationPhase 2/Phase 3
Dexmedetomidine to help pain after shoulder surgery
This trial studies whether dexmedetomidine can reduce pain after elective shoulder arthroscopy surgery done under general anesthesia. If you’re eligible, it may help improve postoperative comfort and reduce the need for additional pain treatment.
AsyutAges 18–60 - NCT05674357Recruiting
Training therapists to help people with cancer distress
This trial trains therapists in evidence-based treatments to reduce distress related to cancer and cancer care. You may be able to join if you’re being treated or followed at MGH Cancer Center and your distress level is high.
Boston, MassachusettsAges 18 years+ - NCT03230565RecruitingPhase 4
Continuous vs bolus pain medication through nerve catheter
This study compares two ways of delivering numbing pain medicine through a nerve catheter after surgery: a steady infusion versus scheduled bolus doses. It aims to see which method works better and is easier to use for post-operative pain control.
Stanford, CaliforniaAges 18 years+
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Common questions
- Are there clinical trials for pain?
- Yes. Clin2 currently lists 3,136 recruiting pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.