Clinical trials
Pain clinical trials
Below are recruiting pain clinical trials, each written for real people, not researchers. We’re tracking 3,263 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04880707RecruitingPhase 2
Pain medication options for lower wisdom tooth removal
This study compares pain-medication approaches during and after removing at least one lower impacted wisdom tooth (a tooth that’s stuck). It may help find a safer or more effective way to control dental pain after surgery.
Newark, New JerseyAges 18 years+ - NCT04912531Recruiting
Virtual reality and smell tools to ease surgery pain
This trial tests whether a combination of virtual reality and guided smells can reduce pain and anxiety around major heart and chest surgeries. If you’re scheduled for one of the listed operations, the study may help make recovery feel more comfortable by using sensory-based distraction.
Boston, MassachusettsAges 18 years+ - NCT04930887RecruitingPhase 2
Numbing injection in the face to ease craniofacial pain
This trial tests whether an injection of a numbing medicine (bupivacaine) guided by an endoscope can reduce craniofacial pain. It may help people with certain headache or facial pain conditions by targeting the pain area more precisely.
Stanford, CaliforniaAges 18–80 - NCT05579496Recruiting
Rebooting infant pain care using skin-to-skin contact
This trial tests how skin-to-skin contact affects pain and brain activity in premature babies during a routine heel prick. It may help find better ways to manage pain for infants in the NICU.
Toronto, OntarioAges 6 months–8 months - NCT07511959Enrolling by invitation
Blood-derived treatment for chronic jaw pain
This trial tests whether a treatment made from your own blood (platelet-rich plasma exosomes) can help relieve long-term jaw joint pain and improve function. If you qualify, you would receive injections directly into your jaw area.
WroclawAges 18 years+ - NCT03912519Enrolling by invitation
Testing two ways to numb lumbar back pain with radiofrequency
This study compares two needle-based techniques to treat long-lasting low back pain by stopping overactive pain signals from specific back joints. If you’ve already tried physical therapy and pain medicines without enough relief, this trial may test which technique works better for pain reduction.
Nashville, TennesseeAges 40 years+ - NCT04970121RecruitingPhase 2
Duloxetine for chemotherapy nerve pain in solid tumor patients
This Phase 2 trial tests duloxetine to see if it safely reduces painful nerve damage caused by chemotherapy (especially taxanes) in people with solid tumors. If you have moderate-to-severe nerve pain and meet lab and heart-safety checks, this study may be an option.
Bengbu, AnhuiAges 18–75 - NCT04996628Recruiting
Testing nerve pain signals to guide treatment for chronic pancreatitis pain
This study checks how your nerves respond to controlled touch and temperature tests, to help predict how well you’ll respond to procedures that relieve blockage in the main pancreatic duct. It may help doctors choose the most effective treatment for chronic pancreatitis pain.
Indianapolis, IndianaAges 18 years+ - NCT05005026Recruiting
Online walking program to ease nerve pain after spinal cord injury
This study tests a virtual, at-home walking exercise program to reduce long-lasting nerve pain after spinal cord injury. It may help if your pain has been present for months and you can safely use the online walking sessions without significant side effects.
Birmingham, AlabamaAges 18 years+ - NCT05009433Recruiting
Exercise plans in pregnancy and afterward for mom and baby health
This study compares two types of exercise—short, intense intervals versus moderate steady activity—during pregnancy and looks at effects on mothers and children. It also checks how participants do on health, fitness, and well-being tests before, during, and after pregnancy.
Gdansk, Pomeranian VoivodeshipAges 18–45 - NCT05009771Recruiting
Testing a pain-control method after C-section
This study looks at how to better manage pain after a C-section using spinal anesthesia and either a patient-controlled IV pain pump or a specific pain medicine (naldebaein). You may be able to join if you’re scheduled for a C-section at 37–40 weeks and can take the usual pain medicines.
New Taipei City, TaiwanAges 20–40 - NCT05010148RecruitingPhase 3
IV lidocaine after spinal fusion to reduce delirium and pain
This trial tests whether giving lidocaine through a vein after elective spinal fusion surgery can help prevent confusion (delirium) and reduce pain. It may help people recover more comfortably and think more clearly after surgery.
San Francisco, CaliforniaAges 60 years+ - NCT05023005Recruiting
Strain-Counterstrain therapy for piriformis muscle pain
This trial tests a hands-on physical therapy technique called “strain-counterstrain” to reduce pain from the piriformis muscle. It may help people whose pain is coming from that specific muscle rather than the low back.
Loma Linda, CaliforniaAges 18–65 - NCT05052736Recruiting
Noninvasive brain/nerve stimulation for early CRPS type I
This trial studies a noninvasive stimulation treatment to help people with early-stage complex regional pain syndrome (CRPS) type I. It may help calm nerve-related pain, especially soon after symptoms begin.
Las Palmas de Gran Canaria, Palmas, LasAges 18 years+ - NCT05058287RecruitingPhase 3
Steroid shot during low-back surgery
This trial tests whether using a steroid medicine (a steroid shot) around the time of low-back decompression surgery improves pain and recovery. It is for adults having a limited-area laminectomy, and it compares steroid use versus not using it.
New York, New YorkAges 18–85 - NCT05069363Recruiting
Light therapy for widespread chronic pain
This trial tests whether using a whole-body light treatment (photobiomodulation) can reduce widespread chronic pain. It may help if you have long-lasting, widespread pain and can safely use the device for about 6 weeks.
BirminghamAges 18–100 - NCT05094297Recruiting
Study of muscle contraction training for veteran tiredness and pain
This study tests whether a guided exercise approach using focused muscle contractions can improve pain, fatigue, or low energy in U.S. Veterans. If you’re having trouble doing everyday activities, this program may help you feel better and function more easily.
Chicago, IllinoisAges 18 years+ - NCT05100381Recruiting
Dry needling for long-lasting lower back muscle pain
This study tests whether dry needling (thin needles placed into specific muscles) can reduce moderate, long-lasting lower back pain. It focuses on people who have pain from trigger points in a specific back muscle, rather than pain caused by other medical problems.
Tehran, Tehran ProvinceAges 18–45 - NCT05120076RecruitingPhase 3
Dexamethasone during surgery to reduce hip surgery pain and nausea
This trial tests whether a single steroid medicine called dexamethasone given around the time of surgery can reduce pain and nausea after a periacetabular osteotomy. It may help you feel more comfortable in the first days after surgery, depending on your medical history.
ZurichAges 18–99 - NCT05122403Recruiting
MRI-guided brain procedure for stubborn nerve pain
This trial tests a brain treatment guided by MRI to treat chronic nerve (neuropathic) pain that hasn’t improved with many prior treatments. It may help reduce pain intensity when standard pain medicines and procedures have not worked.
Beijing, Beijing MunicipalityAges 18–75 - NCT05131178Recruiting
Study for pain control after C-section
This trial looks at how to reduce pain after a C-section (cesarean delivery). You may be able to join if you’re having a scheduled or urgent C-section and can use the planned pain-control method.
Aurora, ColoradoAges 18–50 - NCT05152264Recruiting
TENS device study for endometriosis-related chronic pain
This study tests whether a skin-applied electrical nerve pain-relief device (TENS) can help with long-lasting pain from endometriosis. It mainly looks at people who have confirmed endometriosis and are on stable hormone treatment.
GothenburgAges 18–100 - NCT05172739RecruitingPhase 4
Opioid-free anesthesia during lung surgery for early lung cancer
This study tests whether an opioid-free pain/anesthesia plan during elective lung surgery can reduce surgical “stress” on the body and affect the immune system. You may be eligible if you have early-stage non-small cell lung cancer and are scheduled for a specific type of surgery (VATS lobectomy).
Heraklion, CreteAges 18–80 - NCT05174247Recruiting
Using FFRct to guide tests for stable chest pain
This study checks whether adding FFRct analysis (a special computer-based estimate of blood flow from a CT scan) improves the diagnostic pathway for people with stable chest pain. It may help doctors decide what to do next by clarifying how much a narrowed heart artery is truly limiting blood flow.
Rotterdam, South HollandAges 18 years+
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Common questions
- Are there clinical trials for pain?
- Yes. Clin2 currently lists 3,263 recruiting pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.