Clinical trials
Pain clinical trials
Below are recruiting pain clinical trials, each written for real people, not researchers. We’re tracking 3,142 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07008703RecruitingPhase 1/Phase 2
Study of sss40 for cancer bone pain
This trial tests a new injection called sss40 to treat moderate-to-severe pain caused by cancer that has spread to the bones. The goal is to see if it is safe and effective for people whose pain is not being controlled by current treatments.
Zhengzhou, HenanAges 18 years+ - NCT07009158RecruitingPhase 1/Phase 2
Ketamine plus therapy for pain and PTSD
This trial tests if ketamine combined with talk therapy helps people with both chronic pain and PTSD. Participants receive ketamine through an IV in group therapy sessions over several weeks, with the goal of reducing pain and PTSD symptoms.
Kingston, OntarioAges 18–64 - NCT07006675RecruitingPhase 3
NSAIDs for Tibia Fracture Pain and Healing Study
This study tests whether NSAID pain relievers (like ibuprofen) affect bone healing after a broken tibia and if they can help reduce the need for stronger painkillers. If you qualify, you could help doctors learn the safest way to manage pain after this common injury.
Indianapolis, IndianaAges 18–80 - NCT07008261Recruiting
Robot-assisted bladder removal surgery study
This study is for people who are scheduled to have their bladder removed (radical cystectomy). It looks at whether using a robot helps with blood loss, pain, and the need for blood transfusions during and after surgery.
Frankfurt am MainAges 18 years+ - NCT07005375Enrolling by invitation
Hot mineral water baths for rowers' pain and performance
This trial tests whether bathing in thermal mineral water can reduce pain and improve performance in rowers. It is open to competitive and recreational rowers who train regularly.
Budapest, BudapestAges 14–75 - NCT07009028Recruiting
Storigami to reduce pain and fear from IV insertion in kids
This study tests a fun storytelling-and-paper-folding method called 'storigami' to see if it helps children feel less pain, fear, and worry when they get an IV. It's for children who need an IV for the first time during this hospital visit.
Izmir, BornovaAges 6–9 - NCT06806514Recruiting
Exercise and muscle strength in chronic low back pain
This trial measures how well you can use your arms and how strong your breathing and other muscles are if you have chronic low back pain. It aims to understand the links between these factors to improve future treatments.
KırşehirAges 18–65 - NCT06908486Recruiting
Cognitive training for pain in type 2 diabetes
This study tests a computer-based training program that may help people with type 2 diabetes and ongoing pain think about pain in a less negative way. You can do it from home on your computer over 3 months.
Camperdown, New South WalesAges 18 years+ - NCT06587399Recruiting
Manual Therapy vs. Shock Waves for Shoulder Pain
This study compares two non-surgical treatments—manual therapy (hands-on techniques) and radial shock wave therapy (sound wave pulses)—to see which works better for long-lasting shoulder pain. It may be a good fit if your pain is from a common cause called impingement syndrome.
Alcalá de Henares, MadridAges 18–80 - NCT07002541Recruiting
Nerve block comparison for breast surgery pain
This study tests two different nerve-block methods (PECS-II and ESP) to see which better reduces painkiller use during breast surgery. A special monitor guides how much pain medicine you need. The goal is to help you recover with less opioid side effects.
IstanbulAges 18–80 - NCT06999772Recruiting
Combining brain stimulation with physiotherapy for chronic back pain
This study tests if adding a non-invasive brain stimulation technique to physiotherapy can help veterans with chronic low back pain. It aims to improve pain and function by targeting both the brain and the body.
Québec, QuebecAges 18–65 - NCT06995287RecruitingPhase 3
Botulinum toxin injection for severe period pain
This trial tests whether injecting botulinum toxin into the uterine muscle during a hysteroscopy can reduce severe period pain or chronic pelvic pain that hasn't improved with standard treatments. It may be an option for women who have tried hormonal therapy and pain relievers without success.
Aix-en-ProvenceAges 18 years+ - NCT07003113Recruiting
Blood flow therapy for knee and back pain
This study tests a treatment called ischemic preconditioning, which uses a blood pressure cuff to temporarily restrict blood flow to your leg. It may help reduce pain from osteoarthritis in the knee or chronic back pain.
Chicago, IllinoisAges 50 years+ - NCT07002944Recruiting
Testing nerve treatment for shoulder pain after mastectomy
This study compares two types of pulsed radiofrequency (a minimally invasive treatment using radio waves) to see which better relieves shoulder pain in women who have had a mastectomy. It's for women who still have pain despite taking a high dose of tramadol.
CairoAges 18–65 - NCT06996561RecruitingPhase 2/Phase 3
How your genes affect pain relief after surgery
This study looks at how your genes might affect pain relief from a medication called nalbuphine after abdominal or pelvic surgery. It aims to personalize pain management based on your genetic makeup.
Karachi, SindhAges 18–70 - NCT07002853Recruiting
Nature walks for chronic back pain in older adults
This trial tests whether spending time in nature can help older adults with long-term low back pain feel better and move more easily. If you are 65 or older and have had back pain for at least three months, you may be able to join.
Saguenay, QuebecAges 65 years+ - NCT06984939Recruiting
Handheld distraction tool for kids during needle procedures
This study tests a small handheld tool that may help distract children and teenagers during painful procedures like getting an IV, a blood draw, a dental needle, or if you have just been diagnosed with type 1 diabetes and need frequent blood checks and insulin shots. The tool is meant to make the experience less stressful.
Bergen, VestlandAges 8–15 - NCT06983678Recruiting
Quitting smoking and pain sensitivity study
This study looks at how quitting smoking affects pain sensitivity in people who smoke, especially those with chronic low back pain. Researchers will use brain scans and daily surveys to understand these changes.
Durham, North CarolinaAges 21–65 - NCT06984796Enrolling by invitation
Light therapy for pain during IUD insertion
This study tests if light therapy (photobiomodulation) can reduce pain when an IUD is inserted. It might help women who are anxious about pain during the procedure.
São PauloAges 18–50 - NCT06991075Recruiting
TENS for pain relief during IUD placement
This study tests if a small device called TENS (which uses mild electrical pulses) can reduce pain when getting an IUD placed. If you are coming to MUSC Women's Health for an IUD insertion and choose a specific type, you may be able to join.
Charleston, South CarolinaAges 18 years+ - NCT06991205Recruiting
Web mind-body program for pain and substance use
This trial tests a web-based mind-body program to help people who have ongoing arm or hand pain and also use substances like alcohol or cannabis. It aims to improve resilience and reduce pain without requiring in-person visits.
Boston, MassachusettsAges 18 years+ - NCT06988319RecruitingPhase 1
Psilocybin for chronic pelvic pain in women: a pilot study
This trial tests whether psilocybin (a psychedelic drug) can help women with long-term pelvic pain that hasn't gotten better with standard treatments. The goal is to see if it's possible and safe to use this approach in a future larger study.
Portland, OregonAges 18–45 - NCT05816798RecruitingPhase 2/Phase 3
Laser treatment to reduce chronic knee pain before weight-surgery
This trial tests whether photobiomodulation (a type of laser/light therapy) can reduce chronic pain in both knees for people preparing for bariatric (weight-loss) surgery. If you have knee pain that limits daily life, the treatment may help you feel better while you’re in the pre-surgery rehabilitation period.
Goiânia, GoiásAges 18–70 - NCT06980948RecruitingPhase 1/Phase 2
Gene therapy study for nerve pain from small fiber neuropathy
This trial tests a new gene therapy called ST-503 for people with long-lasting nerve pain from small fiber neuropathy that hasn't improved with standard treatments. The study will check if the treatment is safe and tolerable.
Scottsdale, ArizonaAges 18 years+
Hear when a new Pain trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for pain?
- Yes. Clin2 currently lists 3,142 recruiting pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.