Clinical trials
Pain clinical trials
Below are recruiting pain clinical trials, each written for real people, not researchers. We’re tracking 3,263 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04526093Recruiting
Study of medical cannabis using patient symptom reports
This study looks at how medical cannabis affects symptoms like pain, epilepsy, sleep, and anxiety or depression, based on what patients report over time. It may help researchers understand what works in real life when people use verified medical cannabis products.
Toronto, OntarioAges 19 years+ - NCT07188779RecruitingPhase 2
Impact of a special gel on tonsillectomy recovery in children
This trial tests whether applying a special gel called RADA16 to the surgical site after tonsillectomy (removal of tonsils) can help children heal better and with less pain. It may offer a new way to improve recovery after this common surgery.
Livingston, New JerseyAges 3–17 - NCT07603934RecruitingEarly Phase 1
Testing Medications Inside Root Canals to Reduce Pain
This study tests different medications placed inside a tooth's root canal during treatment to see which one best reduces pain afterward. If you have a tooth with a dead nerve (necrotic pulp), this trial might help determine the best way to manage your pain during the healing process.
Cairo, Cairo GovernorateAges 18–40 - NCT07715591Recruiting
Relaxing breathing during awake cataract surgery
This study tests a special breathing and pain education program to help you stay calm and comfortable during cataract surgery while you are awake. It may reduce pain and anxiety without extra medicine.
Los Angeles, CaliforniaAges Any age - NCT07517679RecruitingPhase 4
Methadone for Pain After Spine Surgery
This study tests whether methadone, an opioid medication, can safely manage pain after elective spine surgery. Researchers want to see if it works well and is safe for patients staying overnight in the hospital after their procedure.
Lexington, KentuckyAges 18–120 - NCT07712419Recruiting
Predicting response to knee nerve block with ultrasound
This study is testing if a type of ultrasound can help predict how well a nerve block injection will work for people with severe knee osteoarthritis. It may help doctors choose the best treatment for your pain.
IstanbulAges 45 years+ - NCT07709975Recruiting
Pain relief and early movement for older ICU patients
This study tests different ways to manage pain and help older patients get moving again sooner after major surgery. If you are 65 or older and in the ICU, this trial may help you recover more comfortably and quickly.
Istanbul, IstanbulAges 65 years+ - NCT07712354Recruiting
Acupuncture and magnetic therapy for neck pain that travels to the arm
This study tests if high-frequency electroacupuncture (needles with mild electric current) at specific points on the neck, combined with electromagnetic field therapy, can help relieve pain from cervical spondylotic radiculopathy. It may be an option if you have neck pain that travels to your shoulder or arm and are not using strong painkillers.
Ho Chi Minh CityAges 30 years+ - NCT07506018Recruiting
MucoLock for mouth pain caused by stomatitis
This study tests a new mouth rinse, MucoLock, to see if it can help people with severe mouth pain (stomatitis). If you have burning or painful mouth sores that rate very high on a pain scale, this trial may offer a new treatment option.
Miami, FloridaAges 18 years+ - NCT03952299RecruitingPhase 3
Oxybutynin patch after bladder surgery for children’s urgency pain
This study tests whether an oxybutynin skin patch after bladder surgery can reduce bladder pain and urgent, frequent urination in children. It compares symptoms after surgery to see if the patch helps more than the control plan.
Sacramento, CaliforniaAges 4–8 - NCT07707401Recruiting
WeChat neck exercises for recovery after thyroid surgery
This study tests whether simple neck exercises, guided through the WeChat app, can help you recover more quickly after thyroid surgery. If you have no serious complications and don't have neck problems, you may be able to join.
Shanghai, Shanghai MunicipalityAges 18–60 - NCT07709598RecruitingPhase 2/Phase 3
HL-1186 for pain after abdominal surgery
This study tests a new painkiller called HL-1186 for people having abdominal surgery. If you qualify and enroll, you will receive the drug after surgery to see if it safely helps reduce your pain better than a placebo (a pill with no medicine).
Chengdu, SichuanAges 18–75 - NCT05906511RecruitingEarly Phase 1
Study how THC levels change in older adults
This early study measures how a THC dose (by mouth or vaporized form) moves through the body and how it affects the body’s responses. It mainly looks at safety and how THC behaves in older adults, including people who have used cannabis before.
West Haven, ConnecticutAges 65 years+ - NCT04025359RecruitingEarly Phase 1
Test dronabinol for pain responses in people on opioid treatment
This early-stage study tests whether dronabinol (a form of THC) changes pain perception in people with opioid use disorder who are already stable on methadone or buprenorphine. It may help researchers understand whether this treatment affects pain and drug-related outcomes in a safer, controlled way.
West Haven, ConnecticutAges 18–70 - NCT07688044Recruiting
How food and bacteria cause belly pain in IBS
This study looks at how certain foods and gut bacteria might trigger abdominal pain in people with Irritable Bowel Syndrome (IBS). If you have IBS and frequent belly pain, you may help researchers understand the link between diet, bacteria, and pain.
Kingston, OntarioAges 18–70 - NCT07704554Recruiting
Dural puncture epidural for labor pain relief
This study compares a modified epidural technique (dural puncture epidural) to the standard method for managing labor pain. It aims to see if the new approach is safer or works better for women in labor.
Columbus, OhioAges 18 years+ - NCT07519109RecruitingPhase 1
SYH9089 for pain after abdominal surgery
This study tests an injected medicine (SYH9089) to see if it safely controls pain after abdominal surgery. It may help you recover with less discomfort.
Changsha, HunanAges 18–75 - NCT07481864Recruiting
Early mental exercise after shoulder tendon repair
This study tests if a gentle, early mental exercise program helps improve shoulder recovery after a specific type of rotator cuff repair. It might be a good fit if you had surgery on two front shoulder tendons and are otherwise healthy.
Istanbul, TurkeyAges 30–65 - NCT03037684Recruiting
Electrical skin stimulation for nerve and chronic pain
This trial tests whether painless electrical stimulation through the skin can reduce neuropathic pain or long-lasting pain after surgery. It may help some people by changing how pain signals travel in the nervous system.
NottwilAges 18–65 - NCT03230565RecruitingPhase 4
Continuous vs bolus pain medication through nerve catheter
This study compares two ways of delivering numbing pain medicine through a nerve catheter after surgery: a steady infusion versus scheduled bolus doses. It aims to see which method works better and is easier to use for post-operative pain control.
Stanford, CaliforniaAges 18 years+ - NCT03265379Recruiting
Registry study for breast cancer invading the chest wall
This study follows people with breast cancer that has spread into the chest wall who are planning full-thickness chest wall surgery. It aims to improve quality of life by collecting real-world information during and after treatment.
Toronto, OntarioAges 18 years+ - NCT03353584Recruiting
Virtual reality for pain relief during sickle cell pain crises
This trial tests whether a virtual reality (VR) experience can help reduce pain during a sickle cell “vaso-occlusive crisis,” which is an episode of sudden, severe pain. It’s offered alongside the care team’s usual pain management to see if VR makes pain feel better.
Memphis, TennesseeAges 6–25 - NCT03371121Recruiting
AMIC cartilage repair for ankle cartilage damage in adults
This trial studies outcomes after a specific ankle cartilage repair surgery called AMIC. It looks at clinical results and imaging (pictures) after surgery to see how well the treatment works.
MilanAges 18–65 - NCT03427736Recruiting
Studying pain and numbing medicines in children
This trial looks at how well different numbing and pain-relief medicines work in children during routine care. It may help doctors choose safer, better pain control for kids who need these medicines.
Stanford, CaliforniaAges birth–17 years
Hear when a new Pain trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for pain?
- Yes. Clin2 currently lists 3,263 recruiting pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.