Clinical trials
Pain clinical trials
Below are recruiting pain clinical trials, each written for real people, not researchers. We’re tracking 3,263 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04918329Recruiting
Digestive symptom check-in study for adults
This study follows adults with long-lasting “functional” digestive symptoms as part of routine care. It may help researchers better understand these conditions and improve how they are managed.
RouenAges 18 years+ - NCT04929951RecruitingPhase 1
Micro fat injection to treat shoulder arthritis
This Phase 1 study tests whether a micro-fragmented fat (MFAT) injection can reduce symptoms and improve shoulder function in people with shoulder osteoarthritis. It’s early research, so the goal is mainly to see if the treatment is safe and possibly helpful.
Stanford, CaliforniaAges 25–75 - NCT04933370Recruiting
Testing a brain or nerve stimulator settings approach
This study is for people who are planning to get a device implanted that delivers stimulation to the brain or nerves. The trial tests whether different stimulation settings work better, which could improve symptom control for participants.
Calgary, AlbertaAges 18–100 - NCT07699601RecruitingPhase 2/Phase 3
Testing a pain tablet after orthopedic surgery
This trial tests an investigational tablet called HL-1186 for controlling pain after orthopedic surgery. It explores whether the drug can safely reduce moderate to severe pain when given after the procedure.
Changsha, HunanAges 18–75 - NCT07698665Recruiting
Ketamine vs dexmedetomidine in scalp block for brain tumor surgery
This trial compares two medicines, ketamine and dexmedetomidine, added to a scalp nerve block during brain tumor removal surgery. The goal is to see which provides better pain control and recovery after surgery.
Cairo, GovernorateAges 20–60 - NCT05543694RecruitingPhase 4
Testing epidural pain relief for labor
This study is testing how well a combination of two medicines (bupivacaine and lidocaine) works for epidural pain relief during early labor. The goal is to find the best dose to help manage labor pain.
Boston, MassachusettsAges 18–50 - NCT06146842RecruitingPhase 4
Pain relief study for labor epidurals
This study tests two different epidural techniques to find the best dose of pain medicine for labor. It aims to improve comfort during childbirth.
Boston, MassachusettsAges Any age - NCT07672236RecruitingPhase 3
Comparing two mouth pain treatments for head and neck cancer patients
This trial tests a new mouthwash (BupiZenge) against a standard numbing medicine (lidocaine) for pain caused by mouth sores from radiation therapy. It may help you if you are about to start radiation for certain head and neck cancers.
CopenhagenAges 18–80 - NCT07274254RecruitingPhase 3
Lidocaine to reduce opioid use for sickle cell pain crisis
This trial tests if adding lidocaine to standard pain treatment can reduce the amount of morphine or oxycodone needed for a severe pain crisis or acute chest syndrome in sickle cell disease. It is for adults in the ICU who have already started opioid treatment within the last 72 hours.
BordeauxAges 18 years+ - NCT04938245Recruiting
Testing improvements to spinal cord stimulation with ECAPS
This study looks at a method (ECAPS) to improve how spinal cord stimulation works. It may help people who are already scheduled to have a spinal cord stimulator trial started.
Minneapolis, MinnesotaAges 22 years+ - NCT04939623RecruitingPhase 2
Probenecid to ease opioid withdrawal symptoms while tapering
This Phase 2 study tests whether probenecid can lessen discomfort from opioid withdrawal in adults who are gradually lowering their opioid pain medicine. If it works, it may make tapering feel more tolerable and safer.
Calgary, AlbertaAges 18–80 - NCT04964206Recruiting
Epidural pain relief in labor and baby brain development
This trial studies how epidural pain relief during vaginal labor may affect a child’s early brain and development. It’s for first-time, term pregnancies where you plan a vaginal birth.
Beijing, Beijing MunicipalityAges 18–35 - NCT04979338RecruitingPhase 3
Opioid-sparing pain control for gender-affirming surgery
This Phase 3 study tests ways to manage pain during and after gender-affirming surgery while using less opioid medicine. It may help improve comfort after surgery and reduce opioid-related side effects.
Los Angeles, CaliforniaAges 18 years+ - NCT04984291Recruiting
Study of shoulder replacement implants for eligible adults
This trial looks at a specific shoulder replacement implant and follow-up care for people who need a shoulder arthroplasty (shoulder replacement) for certain joint problems or fractures. You may be a candidate if you can take part in required visits and your shoulder muscles and bone are suitable.
Irvine, CaliforniaAges 20 years+ - NCT04988724Recruiting
Hospital staff exercise program trial
This trial tests whether a hospital-based exercise program is feasible and beneficial for hospital employees at Nordsjællands Hospital. It may help staff feel better and potentially improve wellbeing at work.
Hillerød, Capital RegionAges 18 years+ - NCT04990713Recruiting
Compare two pain-blocking methods during lung surgery
This study tests two different ways of numbing the chest to reduce pain during video-assisted lung surgery (VATS). It may help some people have less pain after surgery while still allowing the surgeon to do the operation safely.
London, OntairoAges 18 years+ - NCT04992624RecruitingPhase 2
Cannabinoid treatment effects on knee pain and nerve signals
This Phase 2 study tests whether a cannabinoid-related treatment changes how pain works in people with knee osteoarthritis. It uses questionnaires, MRI, and gentle nerve testing to understand if treatment helps pain and pain-related signals.
Ann Arbor, MichiganAges 21–75 - NCT04995224Recruiting
Study what causes long-term pain in new Crohn’s or colitis
This study looks at why some people develop long-term pain after being newly diagnosed with ulcerative colitis or Crohn’s disease. It may help researchers understand the pain process and improve future treatments.
LondonAges 18 years+ - NCT05008185Recruiting
Nerve interface surgery to reduce hand pain nerve tumors
This trial tests a regenerative nerve device/surgery approach to reduce painful nerve growths (neuromas) after a finger or partial hand amputation. You may qualify if you’re an adult with confirmed, localized neuroma pain and have already tried a 6-week desensitization therapy plan.
Baltimore, MarylandAges 18 years+ - NCT05023369RecruitingPhase 4
Hip replacement patients may get an added steroid injection
This trial tests whether a steroid injection placed around the hip after hip replacement can reduce pain and shorten hospital stay. It is meant for older adults who are having hip replacement due to a broken femoral neck bone.
LuganoAges 50–90 - NCT05066334RecruitingPhase 2
Back pain trial using your own stem cells in discs
This Phase 2 trial tests whether injecting your own stem cells into a few back discs can reduce chronic low back pain that has not improved with standard treatments. It may help by targeting disc-related (degenerative) wear seen on MRI, but it requires detailed MRI and blood test screening.
Roma, ItalyAges 18–65 - NCT05066308RecruitingPhase 2
Cannabidiol to reduce inflammation in chronic low back pain
This Phase 2 study tests cannabidiol (CBD) to calm inflammation in the brain that may be linked to chronic low back pain. If you qualify, you’ll take study CBD and undergo brain imaging to see whether inflammation changes.
Boston, MassachusettsAges 18–75 - NCT05068791RecruitingEarly Phase 1
Psilocybin-assisted treatment for long-term body pain
This early trial studies whether psilocybin, given in a supported setting, can reduce long-term widespread musculoskeletal pain (including fibromyalgia-like symptoms). You would be monitored closely and need someone to take you home after the medicine session.
Birmingham, AlabamaAges 25–65 - NCT05067998Recruiting
Natural medicine and vitamin IV study for overall health
This study looks at whether natural medicine, vitamin IV fluids, and supplements can help people maintain good health. There don’t appear to be specific eligibility limits listed, so many people may be able to join, but you’d still need screening by the study team.
Dover, DelawareAges 21–80
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Common questions
- Are there clinical trials for pain?
- Yes. Clin2 currently lists 3,263 recruiting pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.