Clinical trials
Pain clinical trials
Below are recruiting pain clinical trials, each written for real people, not researchers. We’re tracking 3,263 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05068011Recruiting
Tested spinal cord stimulation for long-term severe back pain
This trial studies a targeted spinal cord stimulation therapy to reduce severe, long-lasting pain. It may help people whose pain is due to failed back surgery and who can safely use the implanted system.
Jette, Brussels CapitalAges 18 years+ - NCT05110989Recruiting
Registry study of pain relief after freezing intercostal nerves
This study collects real-world information about how well freezing (cryoablation) of the intercostal nerves helps with pain after a procedure. It may help doctors understand outcomes and improve care for future patients.
Jacksonville, FloridaAges 12 years+ - NCT05127265Recruiting
AI and sensors to monitor patients in the ICU
This study uses AI and sensor data to better monitor people while they are in an intensive care unit (ICU). It may help teams notice changes sooner and improve care for ICU patients.
Gainesville, FloridaAges 18 years+ - NCT05141591Recruiting
Anxiety before ENT surgery and opioid use after surgery
This trial looks at whether people’s anxiety before ear, nose, and throat (ENT) surgery affects how much pain medicine (opioids) they need after surgery. It may help doctors better plan pain control based on anxiety level and possibly gender-related patterns.
Vienna, State of ViennaAges 18 years+ - NCT05142267Recruiting
Study stress and opioid-risk factors in chronic low back pain
This study looks at how stress and the body’s natural opioid/cannabinoid systems may relate to risk of opioid misuse. It tests people with long-lasting low back pain to see what biological or psychological factors might increase or lower that risk.
Nashville, TennesseeAges 18 years+ - NCT05149573Recruiting
PEMF therapy for women with painful bladder symptoms
This trial studies whether a device that uses gentle pulsed electromagnetic waves (PEMF) can reduce symptoms in women with interstitial cystitis/bladder pain syndrome (IC/BPS). It may help if your symptoms are currently fairly severe and ongoing.
Winston-Salem, North CarolinaAges 18–80 - NCT05150795RecruitingEarly Phase 1
Testing pregabalin before surgery versus fentanyl during surgery
This trial compares two medicines used around the time of surgery—pregabalin given by mouth before surgery versus fentanyl given during surgery—to see which better controls pain after the operation. You might join if you’re a generally healthy surgical patient and aren’t using certain related medicines.
CairoAges 21–45 - NCT05156060RecruitingPhase 1/Phase 2
Gabapentin and ketamine to treat head and neck cancer pain
This early-phase study tests whether gabapentin and a ketamine nasal spray can help prevent or lessen short-term and long-term pain from locally advanced head and neck cancer. It may help by changing how the nervous system responds to pain during and after radiation and chemoradiation.
Nashville, TennesseeAges 21 years+ - NCT05179928Recruiting
Numbing injections for less pain after belly surgery
This trial compares two different numbing injection techniques to help control pain after surgery above the belly button. It may help people who qualify have better or longer-lasting pain relief with fewer side effects.
Damanhūr, El-BeheiraAges 21–60 - NCT05217160RecruitingPhase 4
KeraStat gel with morphine for non-healing painful open wounds
This study tests whether KeraStat® gel that delivers morphine through the skin can reduce pain and help manage non-healing ulcers or open wounds. You may be eligible if your wound fits specific size and depth limits and you can track pain every day.
San Antonio, TexasAges 18 years+ - NCT05224726Recruiting
Platelet-rich plasma for healing after C-section
This study tests whether a treatment made from your own platelets (platelet-rich plasma) can help the uterus heal after an elective C-section. You may be considered if you are full-term and having a planned C-section.
Ramat Gan, CenterAges 18–52 - NCT05228262Recruiting
Testing blood-vessel function and muscle strength in osteoporosis
This study looks at how well your blood vessels work and how strong your muscles are, in women after menopause with osteoporosis. You may be asked to start standard osteoporosis treatment, and the researchers will study pain and changes related to vascular function and sarcopenia (loss of muscle and strength).
Clermont-FerrandAges 50 years+ - NCT05241197Recruiting
Low-load leg training with blood flow restriction for Achilles pain
This study tests whether gentle resistance exercises plus a blood-flow restriction wrap can reduce long-lasting Achilles tendon pain. You may be asked to train in the clinic several times a week for 12 weeks.
Rosario, Santa Fe ProvinceAges 18–50 - NCT05245695Recruiting
Endometriosis test using deep computer learning during surgery
This trial studies whether a computer (deep neural network) can better identify endometriosis in people with long-lasting pelvic pain using information from surgery. It may help doctors sort who has endometriosis more accurately when surgery is already planned.
Chandler, ArizonaAges 14–50 - NCT05253326Recruiting
Relaxing muscle exercises after spine surgery
This trial tests whether a structured “progressive muscle relaxation” routine can reduce pain and help recovery after spine surgery. You may be asked to learn and practice the relaxation steps even if you’ve never done them before.
Istanbul, ÜsküdarAges 18 years+ - NCT05254574RecruitingPhase 1
Acoustic therapy for ongoing joint pain from osteoarthritis
This Phase 1 study tests a sustained acoustic medicine device to help reduce pain from osteoarthritis (wear-and-tear arthritis) in joints like knees or hips. Because it’s early-stage research, you may be asked to follow strict rules about pain medicines and device use while the team monitors safety and comfort.
Tampa, FloridaAges 35–85 - NCT05260320Recruiting
Testing the best anesthesia plan for teens having jaw surgery
This study looks at whether a standardized anesthesia plan works best for kids and teens having Le Fort jaw surgery at Johns Hopkins. If you qualify, the team may use or adjust anesthesia to improve safety and comfort during surgery.
Baltimore, MarylandAges 14 years+ - NCT05263297Recruiting
Testing two ways to reduce anxiety during blood draws
This study compares two combined programs to help children feel less stressed during a blood draw. It uses simple, child-friendly activities to see which approach works better for coping during the procedure.
KaramanAges 8–10 - NCT05269212Recruiting
Help people with ongoing back pain return to work
This study looks at how to help people with long-lasting spinal pain (PSPS-Type II) get back to work. It may help by testing a plan for managing persistent pain so work becomes more doable.
GhentAges 18–60 - NCT05271331Recruiting
Numbing injection options for back surgery pain
This trial compares two ways of numbing tissue during a planned back surgery called a laminectomy: an “ESPB block” versus numbing the wound directly. It aims to see which method works better for pain control and comfort after surgery.
Padova, VenetoAges 18 years+ - NCT05272280Recruiting
Ultrasound nerve blocks for pain after gallbladder surgery
This trial compares two ultrasound-guided nerve block techniques to control pain after laparoscopic gallbladder (cholecystectomy) surgery. It may help by finding which method gives better pain relief with fewer side effects.
Asyut, Assiut, Asyut Governorate, Egypt,Ages 18–65 - NCT05272488Recruiting
Manual therapy plus vagus nerve stimulation for jaw muscle pain
This trial tests whether combining hands-on jaw treatment with a vagus nerve stimulator can reduce jaw muscle pain and improve jaw movement. It may help people whose jaw pain has been present recently and who have not had recent physiotherapy.
Alcalá de Henares, MadridAges 18 years+ - NCT05279963Recruiting
Study for bladder pain using a nerve-based treatment (EA)
This trial tests whether a nerve-based therapy called EA can reduce bladder pain. It also aims to understand why the treatment may help by looking at underlying mechanisms.
Hangzhou, ZhejiangAges 18–70 - NCT05287867Recruiting
Study for painful degenerative disc disease treatment
This trial is testing a treatment approach for people with long-lasting, painful worn-out discs in the lower back (and sometimes leg pain). It looks for people who tried common non-surgical options without enough relief and who may be headed toward a lumbar procedure.
Broomfield, ColoradoAges 25–65
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Common questions
- Are there clinical trials for pain?
- Yes. Clin2 currently lists 3,263 recruiting pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.