Clinical trials
Paroxysmal Atrial Fibrillation clinical trials
Below are recruiting paroxysmal atrial fibrillation clinical trials, each written for real people, not researchers. We’re tracking 179 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05144503Recruiting
Test of a new catheter procedure for irregular heart rhythm
This study checks how safe and effective a special catheter procedure (SpherePVI) is for treating paroxysmal (comes and goes) or persistent atrial fibrillation. You may be considered if your atrial fibrillation keeps returning and you’ve already tried at least one medication but it didn’t work or you couldn’t tolerate it.
VilniusAges 18–75 - NCT05115214Recruiting
Device test for treating irregular heartbeat with AF ablation
This trial studies a heart procedure using the Affera SpherePVI system to treat paroxysmal (comes and goes) or persistent atrial fibrillation. It’s for people who still have symptoms despite at least one anti-arrhythmia medicine, and who are good candidates for catheter ablation.
PragueAges 18–75 - NCT04823299Recruiting
Atrial fibrillation ablation using two different energy types
This trial tests whether one ablation approach works better than another for paroxysmal (intermittent) atrial fibrillation by targeting the heart’s “triggers” and “substrate” (where the rhythm problem is). If you qualify, you’ll be randomly assigned to one of two ablation energy methods during a pulmonary vein isolation procedure.
Ottawa, OntarioAges 18 years+ - NCT04529785Recruiting
Tested added ethanol vein treatment during repeat atrial fibrillation ablation
This trial compares two ways to help stop atrial fibrillation during a repeat procedure: standard vein isolation only versus standard isolation plus an added medicine (ethanol) into the vein of Marshall. It aims to see whether the added step improves results when atrial fibrillation returns after a previous successful treatment.
Bruges, Please SelectAges 18 years+ - NCT04148625Enrolling by invitation
Sub-xiphoid hybrid maze for persistent atrial fibrillation after failed ablation
This trial studies a hybrid heart procedure to treat persistent atrial fibrillation in people whose previous catheter ablation did not work. It aims to improve heart rhythm and reduce ongoing symptoms by using a planned combination of techniques and careful follow-up.
Ages 18–80 - NCT04088071Recruiting
Ablation for heart rhythm problems using a specific technology
This study looks at how well catheter ablation works for treating certain heart rhythm disorders (like atrial fibrillation or ventricular arrhythmias) using a specific brand of catheters. The aim is to gather real-world data to better understand the procedure's outcomes.
Birmingham, AlabamaAges 18 years+ - NCT07630857Recruiting
Heart Mapping to Personalize Atrial Fibrillation Treatment
This trial tests a new way to map the heart's electrical signals to help doctors better target and treat atrial fibrillation (an irregular heartbeat). If you're having a procedure to treat AF, this study may help improve the success of your treatment.
Beijing, Beijing MunicipalityAges 18–80 - NCT07301190Recruiting
Study of PFLotus for persistent atrial fibrillation
This study tests a new device called PFLotus for people with persistent atrial fibrillation (AF), a type of irregular heartbeat. The goal is to see if it can help restore a normal heart rhythm in people who haven't gotten better with medicine.
ChengduAges 18–75 - NCT07122336Recruiting
A better way to treat persistent atrial fibrillation
This trial tests a new method to treat persistent atrial fibrillation (a long-lasting irregular heartbeat) to see if it helps patients who haven't been helped by medication. It focuses on cleaning up the back wall of the heart to restore a normal rhythm.
ShanghaiAges 18–80 - NCT07064616Recruiting
Pulsed field vs. cryoballoon ablation for persistent atrial fibrillation
This trial compares two techniques—pulsed field ablation and cryoballoon ablation—to treat persistent atrial fibrillation (a type of irregular heartbeat that lasts less than a year). The goal is to see which method works better and is safer for patients.
Sagamihara, KanagawaAges 18–85 - NCT06995391Recruiting
Alcohol reduction app for atrial fibrillation
This trial tests if a smartphone app can help people with atrial fibrillation reduce or stop drinking alcohol. The goal is to see if cutting down on alcohol makes AF symptoms less severe or occur less often.
San Francisco, CaliforniaAges 21 years+ - NCT05427435Recruiting
Testing alcohol treatment of a heart vein during atrial fibrillation ablation
This study tests whether applying a small amount of alcohol to a specific heart vein (“vein of Marshall”) is safe and feasible during a standard atrial fibrillation (AF) ablation. It may help improve AF treatment, but the goal here is mainly to see if the approach can be done safely in the right patients.
PessacAges 18 years+ - NCT06883864Recruiting
Ablation for leaky valve with constant atrial fibrillation
This study tests whether a catheter ablation procedure (a way to fix abnormal heart rhythms) can help people who have both constant atrial fibrillation and severe mitral regurgitation (a leaky heart valve). It is for people whose heart valve leak is caused by the rhythm problem, not by valve damage.
Hefei, AnhuiAges 18–80 - NCT05976685Recruiting
Close the left atrial appendage after stroke despite blood thinners
This study tests whether closing a heart pouch called the left atrial appendage can prevent future strokes in people with atrial fibrillation who had an ischemic stroke even while taking blood thinners. It may help reduce stroke risk by blocking a common place where clotting can start.
BrugesAges 18 years+ - NCT05292209RecruitingPhase 2
RiLuzole pill to reduce atrial fibrillation on heart monitoring
This Phase 2 study tests whether riLuzole can reduce episodes of atrial fibrillation (an irregular heart rhythm) around the time of planned cardioversion. Doctors will monitor your heart using a Holter monitor to count and compare rhythm episodes.
Salt Lake City, UtahAges 18 years+ - NCT06212674RecruitingPhase 4
Stroke prevention: combined heart procedure for atrial fibrillation
This study tests a combined approach — a catheter ablation to fix the irregular heartbeat (atrial fibrillation) and a device to close the left atrial appendage — in people who recently had a stroke caused by a clot. The goal is to prevent future strokes and reduce the need for long-term blood thinners.
Katowice, Upper SilesiaAges 18–75 - NCT06647251Recruiting
Comparing different radiofrequency modes for atrial fibrillation ablation
This trial tests three different ways of delivering radiofrequency energy using a specific catheter (QDOT) during a first-time procedure to treat atrial fibrillation (AF), a type of irregular heartbeat. It aims to find which method works best for patients with recent or short-lasting AF episodes.
Paris, ParisAges 18 years+ - NCT07139301Recruiting
Timing of blood thinners after stroke clot removal in atrial fibrillation
This study aims to find the best time to start blood thinners after emergency clot removal in people with atrial fibrillation who had a stroke. It may help reduce the risk of another stroke or bleeding.
Ma’anshan, AnhuiAges 18 years+ - NCT06954610Recruiting
Heart Check for Stroke Risk in Atrial Fibrillation
This trial uses heart imaging to better understand stroke risk in people with atrial fibrillation (an irregular heartbeat). It may help doctors decide on the best treatment to prevent another stroke.
BernAges 18 years+ - NCT06716021RecruitingPhase 3
Etripamil for rapid heart rate in atrial fibrillation
This trial tests a medication called etripamil to see if it can quickly slow down a rapid heart rate during episodes of atrial fibrillation. It may help people who have frequent, long-lasting episodes with a fast heartbeat.
West Hills, CaliforniaAges 18 years+ - NCT04685317Recruiting
Sentinel brain-protection device during atrial fibrillation ablation
This trial tests whether a specialized “brain protection” device can improve safety during atrial fibrillation (AF) catheter ablation. It may help reduce the risk of stroke or related complications while treating AF.
Rochester, MinnesotaAges 18 years+ - NCT04045665RecruitingPhase 3
Blood thinner vs usual care for new heart rhythm after bypass surgery
This trial tests whether using a blood thinner in people with new, temporary atrial fibrillation after CABG (heart bypass surgery) can reduce harmful outcomes compared with standard treatment. It may help prevent stroke or other complications if your rhythm problem fits the trial’s timing and risk profile.
Little Rock, ArkansasAges 18 years+ - NCT03862859RecruitingPhase 4
Warfarin safety for people with atrial fibrillation on dialysis
This trial studies whether the blood thinner warfarin is safe and effective for preventing stroke and blood clots in people who have atrial fibrillation and need long-term dialysis. It may help your care team better balance clot prevention against bleeding risk.
Herlev, HerlevAges 18 years+ - NCT03546374Recruiting
Stop a common heart rhythm with surgery add-on therapy
This study looks at whether an added heart device approach around the time of planned open-heart surgery can help treat non-paroxysmal atrial fibrillation (AF), a long-lasting irregular heartbeat. It may help lower ongoing AF burden in people who also need non-emergency heart surgery.
Palo Alto, CaliforniaAges 18 years+
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Common questions
- Are there clinical trials for paroxysmal atrial fibrillation?
- Yes. Clin2 currently lists 179 recruiting paroxysmal atrial fibrillation studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a paroxysmal atrial fibrillation trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a paroxysmal atrial fibrillation trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.