Clinical trials
Peripheral Nerve Block clinical trials
Below are recruiting peripheral nerve block clinical trials, each written for real people, not researchers. We’re tracking 53 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04699734Recruiting
Nerve block for nerve pain from diabetes
This trial studies whether a numbing “nerve block” can reduce long-lasting nerve pain caused by diabetic neuropathy. You may keep your usual pain medicines, and the study will mainly check whether you fit the safety and diagnosis criteria.
Aarhus N, JutlandAges 18 years+ - NCT07302997Recruiting
Watching injection pressure during arm nerve block
This study monitors the pressure used while giving a nerve block (numbing shot) in the armpit area for hand, wrist, or forearm surgery. The goal is to see if real-time pressure monitoring can help make the block safer and more comfortable.
BellinzonaAges 18 years+ - NCT07217626RecruitingPhase 4
Nerve blocks before leg fracture surgery in older adults
This trial tests whether giving a nerve block (medicine to numb the leg) before surgery helps older adults recover better from a broken leg bone. If you are 50 or older and need surgery for a specific type of leg fracture, you may be eligible.
Baltimore, MarylandAges 50 years+ - NCT07709975Recruiting
Pain relief and early movement for older ICU patients
This study tests different ways to manage pain and help older patients get moving again sooner after major surgery. If you are 65 or older and in the ICU, this trial may help you recover more comfortably and quickly.
Istanbul, IstanbulAges 65 years+ - NCT07640516Recruiting
Pain Relief Comparison for Amputation Surgery in High-Risk Patients
This study compares two medications (dexmedetomidine and fentanyl) mixed with a numbing agent to see which works better for blocking pain during above-knee amputation surgery in patients with serious heart or lung disease. Both drugs are already used in anesthesia, and this trial tests which combination is safest and most effective for you.
CairoAges 18 years+ - NCT06182059Recruiting
Pain after knee replacement study
This study looks at long-term pain after total knee replacement surgery. It may help understand why some people have persistent pain and find ways to prevent it.
Monza, Monza BrianzaAges 18–85 - NCT06886815Recruiting
Nerve block for Achilles tendon repair surgery
This trial tests if a nerve block in the back of the knee improves pain control after surgery to repair a torn Achilles tendon. It may help you recover more comfortably as a day surgery patient.
Toronto, OntarioAges 18–65 - NCT06566664Enrolling by invitation
Nerve stimulation to help with arm surgery nerve blocks
This study tests if using a small electrical stimulator on the skin can make a nerve block work better for arm surgery. If you are having planned arm surgery and getting a nerve block, you may be able to join.
Stanford, CaliforniaAges 18 years+ - NCT06741579RecruitingPhase 3
Pain relief study for nerve injury pain
This trial tests how well two types of peripheral nerve stimulation (PNS) devices relieve chronic pain caused by a single nerve injury. It looks for people who already have a referral for PNS therapy as part of their usual care and who have gotten at least 50% relief from a diagnostic nerve block.
Palo Alto, CaliforniaAges 18 years+ - NCT05008185Recruiting
Nerve interface surgery to reduce hand pain nerve tumors
This trial tests a regenerative nerve device/surgery approach to reduce painful nerve growths (neuromas) after a finger or partial hand amputation. You may qualify if you’re an adult with confirmed, localized neuroma pain and have already tried a 6-week desensitization therapy plan.
Baltimore, MarylandAges 18 years+ - NCT05372393Recruiting
Carpal tunnel surgery with local anesthesia, with or without nerve block
This study compares two ways of giving pain control during carpal tunnel release surgery: local anesthesia alone versus local anesthesia plus a targeted nerve block. It may help find the safest and most comfortable option for people having carpal tunnel surgery.
Kuopio, Northern SavoniaAges 18 years+ - NCT06221280Enrolling by invitation
Nerve blocks for pain after cesarean and depression
This study tests whether a nerve block (extra numbing medicine) given during a cesarean section can help with pain after delivery and may reduce the risk of postpartum depression. The trial compares the nerve block to standard care.
Kahramanmaraş, KahramanmaraşAges 18 years+ - NCT07574385RecruitingPhase 2
Nerve Block Pain Relief After Bunion Surgery
This study tests a new nerve-blocking medication (ALX006) injected near the sciatic nerve to reduce pain after bunion surgery. The goal is to see if it provides better pain relief compared to standard care.
Millcreek, UtahAges 18 years+ - NCT06568770RecruitingPhase 2/Phase 3
Comparing two nerve blocks for femur fracture surgery pain
This trial tests if one type of nerve block (PENG block) works better than another (S-FICB) for controlling pain during and after femur fracture surgery. Both blocks are guided by ultrasound to help with your recovery.
Sahiwal, Punjab ProvinceAges 20–70 - NCT07153263Recruiting
Testing a new numbing shot for lung nodule localization
This study tests a new type of numbing injection (called a retro-superior costotransverse ligament space block) to see how well it spreads and numbs the area during CT-guided lung nodule localization. The goal is to find better ways to keep you comfortable during the procedure.
Nanjing, JiangsuAges 18–80 - NCT07301476Recruiting
Testing numbing medicine spread in a knee block
This trial checks how a numbing medicine moves during a common knee block for surgery. It may help doctors improve pain control after knee operations.
Boulogne-BillancourtAges 18 years+ - NCT06486246Recruiting
Nerve block options for ACL surgery recovery
This trial compares two types of nerve blocks for pain relief after ACL reconstruction. It aims to find which approach provides better comfort and faster recovery.
BarcelonaAges 18–50 - NCT07730216Recruiting
Ultrasound-Guided Knee Block Study for Knee Replacement
This study looks at whether using ultrasound to guide a numbing injection around the knee can improve pain control after knee replacement surgery. It aims to make recovery more comfortable.
Konya, KonyaAges 18 years+ - NCT07745881Recruiting
Pain relief after lung cancer surgery
This trial tests a nerve block that may reduce pain after surgery for lung cancer. It's a technique that numbs a specific area in the back to help you feel more comfortable during recovery.
Nanjing, JiangsuAges 18–80 - NCT05868330RecruitingPhase 4
Compare two nerve-block methods for shoulder replacement
This trial compares two different ways of giving numbing medicine around the shoulder nerve before reverse shoulder replacement surgery. It may help find which method works better for pain control and comfort after surgery.
Iowa City, IowaAges 18–90 - NCT07263295Recruiting
Diaphragm function after shoulder block with long-lasting numbing medication
This study checks how a nerve block for upper arm surgery affects the diaphragm, the muscle that helps you breathe. It uses a long-lasting numbing medicine to see if breathing is affected.
Hangzhou, ZhejiangAges 18 years+ - NCT05672784Recruiting
Knee numbing injections during knee replacement surgery
This trial compares two ways of numbing a knee area during planned knee replacement surgery: a nerve block alone versus a nerve block plus additional numbing medicine near the back of the knee. It may help doctors find which approach improves pain control and recovery while keeping side effects low.
ZagazigAges 21–60 - NCT07050277RecruitingPhase 3
Morphine for bladder issues after knee replacement
This study tests whether adding morphine to spinal anesthesia can reduce trouble urinating after a second knee replacement surgery. It may help you avoid needing a catheter after surgery.
Toronto, OntarioAges 21 years+ - NCT05734625RecruitingPhase 2
Nerve block injections for episodic migraine pain relief
This Phase 2 trial tests whether nerve block injections can reduce pain from episodic migraines. It may help some people who get frequent migraine attacks but are not also using certain migraine preventions or strong pain medicines.
Rochester, MinnesotaAges 18 years+
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Common questions
- Are there clinical trials for peripheral nerve block?
- Yes. Clin2 currently lists 53 recruiting peripheral nerve block studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a peripheral nerve block trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a peripheral nerve block trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.