Clinical trials
Persistent Atrial Fibrillation clinical trials
Below are recruiting persistent atrial fibrillation clinical trials, each written for real people, not researchers. We’re tracking 215 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07064616Recruiting
Pulsed field vs. cryoballoon ablation for persistent atrial fibrillation
This trial compares two techniques—pulsed field ablation and cryoballoon ablation—to treat persistent atrial fibrillation (a type of irregular heartbeat that lasts less than a year). The goal is to see which method works better and is safer for patients.
Sagamihara, KanagawaAges 18–85 - NCT07095959Recruiting
Ethanol vein infusion plus pulsed field ablation for paroxysmal AF
This study compares two treatments for paroxysmal atrial fibrillation (AF that comes and goes): using pulsed electric field ablation alone versus combining it with ethanol infusion into a specific vein. The goal is to see which approach works better for first-time ablation patients.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07118488Recruiting
New ablation approach for persistent atrial fibrillation with heart issues
This study tests a new way to treat long-lasting atrial fibrillation using focused energy (pulse field ablation) guided by special heart mapping. It may help people who have not improved with medications or have other heart problems like heart failure.
Madrid, MadridAges 18–80 - NCT07122336Recruiting
A better way to treat persistent atrial fibrillation
This trial tests a new method to treat persistent atrial fibrillation (a long-lasting irregular heartbeat) to see if it helps patients who haven't been helped by medication. It focuses on cleaning up the back wall of the heart to restore a normal rhythm.
ShanghaiAges 18–80 - NCT07156877Recruiting
Balloon Catheter Ablation for Atrial Fibrillation
This study tests a new balloon catheter that uses pulsed electric fields to isolate the veins that carry blood from your lungs to your heart. It may be a treatment option for people with atrial fibrillation who are scheduled for an ablation procedure.
BrugesAges 18 years+ - NCT07171463Recruiting
New ablation for paroxysmal atrial fibrillation
This trial tests a new treatment that uses two types of energy (pulsed field and radiofrequency) to fix the heart's electrical signals in people with paroxysmal atrial fibrillation (AFib that comes and goes). It aims to be more effective and safer than standard ablation alone.
Rzeszów, Podkarpackie VoivodeshipAges 18 years+ - NCT07181590Recruiting
Balloon-based ablation for atrial fibrillation: post-approval study
This trial tests a balloon catheter that uses pulsed field energy to treat atrial fibrillation (AF) in people who have tried medication without success. It aims to see how well it works in real-world use.
LinzAges 18 years+ - NCT07267949RecruitingPhase 2
Study of AP31969 for atrial fibrillation rhythm control
This study tests a new medication, AP31969, to control heart rhythm in people with atrial fibrillation. It compares the drug to a placebo to see if it can reduce how often AF episodes happen over time.
Plovdiv, PDAges 18 years+ - NCT07273994RecruitingPhase 4
Comparing two amiodarone doses after heart shock treatment for atrial fibrillation
This trial tests two different ways of taking amiodarone (a heart rhythm medicine) to keep your heart in a normal rhythm after a procedure called electrical cardioversion. It's designed for people with persistent atrial fibrillation (a fast, irregular heartbeat lasting at least 7 days).
BarcelonaAges 18 years+ - NCT07298473Recruiting
Redo ablation for recurrent atrial fibrillation with Sphere-9 catheter
This trial tests a new catheter and system for people who have had one previous ablation for atrial fibrillation but still have symptoms. It aims to see if a repeat procedure can safely and effectively treat recurrent episodes.
Birmingham, AlabamaAges 18 years+ - NCT07301190Recruiting
Study of PFLotus for persistent atrial fibrillation
This study tests a new device called PFLotus for people with persistent atrial fibrillation (AF), a type of irregular heartbeat. The goal is to see if it can help restore a normal heart rhythm in people who haven't gotten better with medicine.
ChengduAges 18–75 - NCT02741349Recruiting
Checking stroke and bleeding risks in atrial fibrillation
This study looks at how to better predict both stroke risk and bleeding risk in people with atrial fibrillation. It may help doctors choose safer blood-thinner treatment and follow-up plans.
ParisAges 18 years+ - NCT02932007RecruitingPhase 2
Chloroquine to treat ongoing atrial fibrillation symptoms
This trial tests whether chloroquine can reduce symptoms in people with persistent atrial fibrillation (AF), an irregular heartbeat that lasts longer than a week. It will also closely monitor heart rhythm and safety, since the medicine can affect the heart and other organs.
Tampa, FloridaAges 18 years+ - NCT03355456Recruiting
Catheter ablation for atrial fibrillation with low-voltage mapping
This trial studies a catheter procedure that targets areas in the heart that show low electrical voltage to treat atrial fibrillation (an irregular heartbeat). You may be eligible if you have non-paroxysmal atrial fibrillation, have tried heart rhythm medicines, and your scan shows low-voltage areas in the left atrium.
Cleveland, OhioAges 18–85 - NCT06735534Recruiting
Repeat ablation for persistent atrial fibrillation with pulsed field
This trial tests a newer type of ablation (pulsed field ablation) for people with persistent atrial fibrillation who have already had one ablation. The goal is to see if it can fix the heart rhythm problem again.
Mobile, AlabamaAges 18 years+ - NCT07441382Recruiting
Comparing treatments for frail older adults with atrial fibrillation
This study tests whether combining a heart procedure (catheter ablation) with a device to close the left atrial appendage (LAAO) is safer or better than blood thinners alone for frail patients 75 years or older with atrial fibrillation and high stroke risk. It aims to find a treatment that reduces stroke while lowering bleeding risks.
Guangzhou, GuangdongAges 75 years+ - NCT07444320Recruiting
Testing new energy pulses for atrial fibrillation treatment
This trial tests a new way to deliver energy (FARAPULSE PFA system) to treat atrial fibrillation (AF), a type of irregular heartbeat. It aims to see if these new waveforms can safely and effectively stop AF symptoms and improve quality of life.
SplitAges 18 years+ - NCT07508618RecruitingPhase 4
Qidong Yixin Granule for preventing atrial fibrillation after ablation
This trial tests whether a traditional Chinese medicine granule, Qidong Yixin, can help prevent atrial fibrillation from coming back after a heart ablation procedure. It is for people with persistent atrial fibrillation who have not had good results from other heart rhythm medications.
HangzhouAges 18–80 - NCT07535268Recruiting
Heart rhythm ablation outcomes in minority patients
This registry tracks outcomes for racial and ethnic minority patients undergoing a specific type of heart rhythm treatment (ablation) for atrial fibrillation. The goal is to understand how well this treatment works across different populations.
New York, New YorkAges 18 years+ - NCT07563257Recruiting
Comparing Two Mapping Catheters for Heart Rhythm Ablation
This trial compares two types of specialized catheters used during heart rhythm ablation procedures to help doctors confirm they've created the right burn patterns. If you're having ablation for persistent atrial fibrillation or flutter with complex burn lines planned, this trial may help improve how your procedure is done.
Be’er Ya‘aqovAges 18 years+ - NCT07446244Enrolling by invitation
Catheter ablation for advanced atrial fibrillation
This trial tests a special type of catheter ablation (using electric pulses called electroporation) to treat people with long-lasting atrial fibrillation and a very enlarged left atrium. It may offer a new treatment option when standard approaches are limited.
Ljubljana, OsrednjaslovenskaAges Up to 80 years - NCT07100483Enrolling by invitation
Comparing surgery methods for atrial fibrillation
This trial studies different surgical techniques for treating atrial fibrillation during heart surgery. It may help people with a history of AFib who are already scheduled for open-heart surgery.
Grand Rapids, MichiganAges 18–85 - NCT07077811Enrolling by invitation
Pulsed field ablation for heart failure with preserved pumping strength
This trial tests a new procedure called pulsed field ablation for people who have both persistent atrial fibrillation and a type of heart failure (HFpEF). It aims to see if this ablation safely helps control the heart rhythm.
Nantong, JiangsuAges 18–80 - NCT06988202Enrolling by invitation
Comparing repeat ablation methods for atrial fibrillation
This trial compares different techniques for a second heart ablation procedure in people with atrial fibrillation (AFib) who have already had one ablation. It aims to find the best approach to stop AFib from coming back.
Rochester, New YorkAges 18 years+
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Common questions
- Are there clinical trials for persistent atrial fibrillation?
- Yes. Clin2 currently lists 215 recruiting persistent atrial fibrillation studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a persistent atrial fibrillation trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a persistent atrial fibrillation trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.