Clinical trials
Placebo clinical trials
Below are recruiting placebo clinical trials, each written for real people, not researchers. We’re tracking 5,154 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05018481RecruitingEarly Phase 1
Study for moderate alcoholic hepatitis after heavy drinking
This early-phase study is testing a treatment approach for people with alcoholic hepatitis (liver inflammation caused by heavy alcohol use). It may help by improving liver function and outcomes in people who meet specific lab and health criteria.
Cleveland, OhioAges 21–65 - NCT05052541RecruitingPhase 3
Oral cannabis for long-term spine pain
This trial studies whether taking cannabis by mouth can safely reduce chronic spine pain and improve daily comfort. You may be eligible if you have long-lasting spine pain and can follow study rules about stopping or limiting other cannabis and certain other treatments.
Aurora, ColoradoAges 21–84 - NCT05052853RecruitingPhase 2
Early treatment trial for early schizophrenia warning signs
This Phase 2 study tests an NMDA-enhancer medicine to see if it can help people who are in the early “prodromal” stage—when symptoms are starting but full schizophrenia is not diagnosed yet. It aims to reduce or prevent worsening symptoms over the study period.
TaichungAges 13–45 - NCT05011266RecruitingPhase 2/Phase 3
Buprenorphine plus naltrexone shot to prevent opioid relapse
This trial tests whether a combination of buprenorphine (through your care plan) and a monthly extended-release naltrexone (XR-NTX) shot can help prevent opioid relapse. It may help people who are ready to move toward a naltrexone-based relapse-prevention treatment after detox.
Rockville, MarylandAges 18–65 - NCT05063149RecruitingPhase 3
Bacterial lysate for preventing breathing infections in preterm infants
This study tests a medicine called a bacterial lysate, which might help prevent respiratory infections and wheezing in babies born early. It could reduce sickness and breathing problems in the first year of life.
Rotterdam, South HollandAges 1 month–2 months - NCT05061368RecruitingPhase 2
Sildenafil by mouth to improve breathing in COPD
This Phase 2 trial tests whether sildenafil tablets can improve exercise ability, shortness of breath, and heart-lung function in people with COPD. It also compares against people without COPD to better understand how sildenafil affects breathing tests.
Edmonton, AlbertaAges 40–80 - NCT05004727RecruitingPhase 4
Study for a psoriasis medicine in adults
This trial studies how guselkumab works for people with long-lasting, more severe psoriasis and signs that may affect joints. It may help by improving psoriasis symptoms and possibly reducing related inflammation, while researchers track safety and outcomes.
Boston, MassachusettsAges 18 years+ - NCT05058287RecruitingPhase 3
Steroid shot during low-back surgery
This trial tests whether using a steroid medicine (a steroid shot) around the time of low-back decompression surgery improves pain and recovery. It is for adults having a limited-area laminectomy, and it compares steroid use versus not using it.
New York, New YorkAges 18–85 - NCT05004987RecruitingPhase 4
Study brain and blood changes in older adults with depression
This study looks at how a brain protein linked to Alzheimer’s disease changes over time in older adults who have major depression but no major memory problems. It involves brain scans, blood and urine tests, and a spinal fluid sample to better understand the connection between depression and brain aging.
New York, New YorkAges 60 years+ - NCT05040204RecruitingPhase 1
Test supplements to change how sugars attach to blood proteins
This early (Phase 1) study tests how adding specific dietary supplements affects “protein glycosylation,” which means how sugar molecules attach to proteins in your blood. It’s meant to see how the supplements change these blood measurements and whether the approach is tolerable in generally healthy adults.
Sacramento, CaliforniaAges 18–45 - NCT05028062RecruitingPhase 4
Naltrexone injections for people who want to cut alcohol drinking
This Phase 4 study tests whether naltrexone injections can help people with alcohol use disorder (AUD) reduce or stop heavy drinking. You may get two injections over 8 weeks, and you can join if you meet specific drinking pattern and eligibility rules.
Philadelphia, PennsylvaniaAges 18–65 - NCT04939051RecruitingPhase 2
Obeticholic acid to prevent Barrett’s esophagus worsening
This Phase 2 trial tests whether obeticholic acid (a medicine) can help stop Barrett’s esophagus from getting worse. You must already be taking acid-suppressing medicine and have non-cancer Barrett’s changes, and the study checks safety and whether the lining improves or stays stable.
Kansas City, KansasAges 18 years+ - NCT04976153RecruitingPhase 3
Stem cell implant to treat fecal urge incontinence
This Phase 3 study tests an implant made from a person’s own muscle-related cells to improve fecal “urge” leakage. It’s for adults whose symptoms haven’t improved enough with usual conservative treatments.
GrazAges 18 years+ - NCT04957719Enrolling by invitationPhase 3
Testing selatogrel to prevent problems after a recent heart attack
This trial tests selatogrel to see if it can better prevent harmful heart and blood-clot outcomes after a recent heart attack. You may be considered if you had a heart attack in the past 4 weeks and have higher-risk heart artery disease.
Alexander City, AlabamaAges 18 years+ - NCT04951622RecruitingPhase 3
Testing nipocalimab for adults with generalized myasthenia gravis
This Phase 3 study tests nipocalimab, a medication given by infusion (and in some groups by injections under the skin), to improve symptoms in adults with generalized myasthenia gravis (MG). It may help reduce weakness in daily activities, especially if you meet specific symptom and safety criteria.
Paradise Valley, ArizonaAges 18 years+ - NCT04984512RecruitingPhase 2/Phase 3
Testing mitizodone tablets for major depression symptoms
This trial studies whether mitizodone phosphate tablets can improve symptoms of major depressive disorder (MDD). It also checks the treatment’s safety, including mood and physical health effects.
Dongguan, GuangdongAges 18–65 - NCT04941599RecruitingPhase 2
2-HOBA to improve “good cholesterol” function in FH
This Phase 2 trial tests whether 2-HOBA can improve how “good cholesterol” (HDL) works in people with familial hypercholesterolemia (FH). If HDL works better, it may help lower heart risk markers. You would need to meet several heart, health, and medication-related safety checks.
Nashville, TennesseeAges 18–69 - NCT04976036RecruitingPhase 2
Nintedanib to reduce nosebleeds in adults with HHT
This trial tests whether nintedanib can reduce how often and how severe nosebleeds are in adults with hereditary hemorrhagic telangiectasia (HHT). It may help by calming blood-vessel problems that cause bleeding.
BronAges 18 years+ - NCT04963777Recruiting
Prebiotics for gut health in young people with type 1 diabetes
This trial studies whether taking prebiotics can change gut bacteria (gut microbiome) in people with type 1 diabetes. The goal is to see if these gut changes are linked to better health or diabetes-related outcomes.
Calgary, AlbertaAges 7 years+ - NCT04981821Recruiting
Mobile exercise coaching for older adults with blood cancers
This study tests whether a mobile (phone-based) exercise program can help older adults with myeloid blood cancers stay active and function better while they receive outpatient cancer treatment. You may be asked to follow an exercise plan and participate in assessments during the trial.
Rochester, New YorkAges 60 years+ - NCT04962776RecruitingPhase 4
Carb plus nitrate drinks before gynecologic surgery
This trial compares two pre-surgery drink plans: a low-sugar/low-concentration carbohydrate drink plus nitrates versus a carbohydrate drink alone. It aims to see which plan works better for patients having open gynecologic surgery.
CairoAges 18–60 - NCT04984226RecruitingPhase 2
Sodium bicarbonate for kidney disease energy and acidity
This trial studies whether taking sodium bicarbonate changes “energy” in cells and improves metabolic acidosis (an acid build-up) in people with moderate-to-severe chronic kidney disease. You may be able to join if your kidney function and blood bicarbonate levels fit their targets and you meet safety rules.
Sacramento, CaliforniaAges 21–85 - NCT04972760RecruitingPhase 3
Baricitinib for active dermatomyositis in adults
This trial studies whether baricitinib can improve symptoms and test results in adults with active dermatomyositis (a muscle and skin inflammation disease). It’s for people whose disease is still active despite prior treatment or who have been recently diagnosed.
ParisAges 18–64 - NCT04971954Recruiting
Nicotine test to improve age-related hearing processing
This study tests whether nicotine can improve how your brain processes sounds, which can get worse with age. It’s designed for non-smokers without significant hearing or medical/medication issues.
Irvine, CaliforniaAges 18–85
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Common questions
- Are there clinical trials for placebo?
- Yes. Clin2 currently lists 5,154 recruiting placebo studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a placebo trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a placebo trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.