Clinical trials
Portal Hypertension clinical trials
Below are recruiting portal hypertension clinical trials, each written for real people, not researchers. We’re tracking 63 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06669806Recruiting
TIPS Stent Graft for Cirrhosis Complications
This study tests a TIPS stent graft (a tiny mesh tube placed in the liver to relieve pressure) for people with cirrhosis and complications like bleeding or fluid buildup. It aims to see how well it works and if it's safe.
Changsha, HunanAges 18–75 - NCT05782556Recruiting
Freiburg TIPS Registry for portal hypertension patients
This is a registry study that collects information from people who need a procedure called TIPS for portal hypertension. It may help doctors better understand outcomes and care for both cirrhotic and non-cirrhotic causes of portal hypertension.
Freiburg im BreisgauAges 18–100 - NCT06117735Recruiting
Covered stent for portal hypertension
This trial tests a special stent to treat high blood pressure in the liver caused by cirrhosis. It may help patients who need a procedure called TIPS to improve blood flow.
Fuzhou, FujianAges 18–85 - NCT06797193Recruiting
Ultrasound technique to find liver blood pressure
This trial tests a new ultrasound technique called SHAPE to see if it can detect high blood pressure in the liver (portal hypertension) without needing an invasive procedure. It may help people who are already scheduled for a standard liver pressure measurement.
Scottsdale, ArizonaAges 18 years+ - NCT07473375Recruiting
Factors affecting portal vein clot reopening in cirrhosis
This study looks at factors that help open up blood clots in the main vein to the liver (portal vein) in people with cirrhosis and varices. It might help guide treatment to improve blood flow.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT06687265RecruitingPhase 2
Metformin for reducing liver pressure in cirrhosis
This trial tests if metformin can lower the pressure in the liver's blood vessels (portal hypertension) in people with cirrhosis. The goal is to see if it can help reduce complications like swelling or bleeding.
Clichy, FranceAges 18 years+ - NCT06205992Recruiting
Comparing 2D and 3D MRI scans for liver scarring and pressure
This study compares two types of MRI scans (2D and 3D) to see which is better at measuring liver scarring and high blood pressure in the liver's main vein. It is for people with cirrhosis who are already scheduled to have their liver vein pressure measured.
Shenyang, LiaoningAges 18–75 - NCT04720456RecruitingPhase 2
Ultrasound test study for high pressure in liver veins in kids
This Phase 2 trial looks at a special ultrasound approach to better understand and measure portal hypertension—high pressure in the liver’s vein system—in children with long-term (chronic) liver disease. The results may help doctors track this condition more accurately and safely.
Philadelphia, PennsylvaniaAges 6–21 - NCT05475015Recruiting
3D MRI scan to assess liver scarring and pressure
This study tests whether a special 3D MRI scan (3D-MRE) can measure liver scarring and the high pressure in the liver called portal hypertension. It may help your team use imaging to understand how severe your liver disease is, especially when a pressure test (HVPG) is being considered.
Shenyang, LiaoningAges 18–75 - NCT06970509Recruiting
Improving treatment for stomach bleeding from liver disease
This trial studies better ways to use endoscopy and other treatments to stop bleeding in the stomach or esophagus caused by high blood pressure in the liver (portal hypertension). It may help if you have been diagnosed with portal hypertension and have varices (enlarged veins) in your esophagus or stomach.
Guangzhou, GuangdongAges 18 years+ - NCT07280390Recruiting
Microplastics in people with cirrhosis
This trial checks whether tiny plastic particles (microplastics) are present in the liver and body of people with cirrhosis who are having planned surgery or a liver transplant. It aims to understand if microplastics might make liver disease worse.
Chandigarh, ChandigarhAges 18–70 - NCT07424963Recruiting
Comparing two ways to measure liver pressure
This study compares a newer, less invasive method using an endoscope (EUS-PPG) with a standard catheter method (HVPG) to measure liver pressure in people with advanced liver disease. The goal is to see if the newer method is equally accurate and safer.
Prague, BohemiaAges 18–75 - NCT05470205RecruitingPhase 3
Noninvasive blood-pressure measurement to estimate liver portal pressure
This Phase 3 study tests a noninvasive ultrasound-based method to estimate portal hypertension, which is high blood pressure in the liver’s blood vessels. It aims to help doctors measure how severe the liver circulation problem is without needing invasive pressure testing.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07080697Recruiting
Spleen removal during pancreas surgery for severe pancreatitis
This trial tests whether removing the spleen during open surgery for infected dead pancreas tissue helps people with a specific type of high blood pressure around the spleen caused by severe pancreatitis. It may lower bleeding risk and improve recovery.
Hangzhou, ZhejiangAges 18–75 - NCT07419724Recruiting
Portal hypertension biobank study
This study collects medical data and images from people with portal hypertension who have enlarged veins in the esophagus or stomach. It aims to build a database for future research.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT05508633Enrolling by invitationPhase 2
Alverine test to lower high pressure in the liver
This trial studies alverine to lower portal hypertension, which is high blood pressure in the liver that can happen with cirrhosis. If it works safely, it may reduce pressure-related complications in people with confirmed liver scarring.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT07521332RecruitingPhase 4
Testing Apixaban to Prevent Bleeding Complications in Cirrhosis
This study tests whether a blood thinner called apixaban can safely prevent dangerous bleeding in people with cirrhosis (liver scarring) who have portal hypertension (high blood pressure in veins leading to the liver). The goal is to see if it reduces bleeding risk without causing excessive bleeding.
Hyderābād, SindhAges 18 years+ - NCT07122622Recruiting
Spleen stiffness test to check for dangerous veins in the liver
This trial uses a non-invasive ultrasound test to measure spleen stiffness, which may help find problems with blood pressure in the liver and identify enlarged veins that can bleed. It could help avoid more invasive tests.
Roma, ItaliaAges 18 years+ - NCT07358663Recruiting
Portal hypertension esophageal gastric varices treatment study
This study looks at how well treatments work for people with enlarged veins in the esophagus and stomach caused by a condition called portal hypertension. If you have this condition and have had a CT scan and an upper endoscopy (camera down the throat), you may be able to take part to help doctors understand which treatments work best.
ShanghaiAges 18 years+ - NCT07163689Recruiting
TIPS for liver disease with portal hypertension
This trial compares patients who have a rare liver condition (porto-sinusoidal vascular disease) with those who have cirrhosis, to see how a procedure called TIPS (a shunt placed in the liver to reduce blood pressure) works for complications like bleeding, fluid buildup, or blood clots.
Amiens, PicardieAges 18 years+ - NCT04578301Recruiting
Predicting who develops serious liver worsening after surgery
This study looks at your liver health before and after surgery to predict the risk of “acute-on-chronic liver failure,” which means a sudden worsening of liver function on top of an existing liver condition. If you qualify, your doctors may use study data to better identify who needs closer monitoring after surgery.
BonnAges 18 years+ - NCT07058155RecruitingPhase 4
TIPS and weight-loss surgery for liver disease with high blood pressure
This trial tests if doing a TIPS procedure (to lower blood pressure in the liver) before weight-loss surgery (sleeve gastrectomy) helps people with advanced liver disease. It's for those who have cirrhosis and very high blood pressure in the liver, and who qualify for sleeve gastrectomy.
Cleveland, OhioAges 18–70 - NCT04633356RecruitingPhase 1/Phase 2
Measuring pressure in the liver using an endoscopy device
This early-phase study tests a technique to measure blood pressure changes in people with cirrhosis (scarring of the liver). It may help doctors better understand liver circulation problems and guide safer treatment decisions.
Hong Kong, Hong KongAges 18–75 - NCT02417740Recruiting
Study of the natural course of noncirrhotic portal hypertension
This study follows people with noncirrhotic portal hypertension (NCPH) or people at risk for it to better understand how the condition progresses over time. It does not sound like a medication trial—more like careful monitoring to learn what happens in different people.
Bethesda, MarylandAges 12–100
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Common questions
- Are there clinical trials for portal hypertension?
- Yes. Clin2 currently lists 63 recruiting portal hypertension studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a portal hypertension trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a portal hypertension trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.