Clinical trials
Portal Hypertension clinical trials
Below are recruiting portal hypertension clinical trials, each written for real people, not researchers. We’re tracking 64 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT02417740Recruiting
Study of the natural course of noncirrhotic portal hypertension
This study follows people with noncirrhotic portal hypertension (NCPH) or people at risk for it to better understand how the condition progresses over time. It does not sound like a medication trial—more like careful monitoring to learn what happens in different people.
Bethesda, MarylandAges 12–100 - NCT07461545Recruiting
Apixaban for late portal vein clot after spleen surgery
This trial tests if apixaban, a blood thinner, is more effective than aspirin at treating blood clots in the portal vein that form more than a year after laparoscopic spleen removal in people with cirrhosis and an enlarged spleen.
Yangzhou, JiangsuAges 18 years+ - NCT07461532Recruiting
Apixaban for late portal vein clot after spleen surgery
This trial is testing whether a blood thinner called apixaban can treat a blood clot in the main vein to the liver (portal vein) that appeared more than a year after spleen surgery in people with cirrhosis. It compares apixaban to a low-dose aspirin to see if one works better with fewer side effects.
Yangzhou, JiangsuAges 18 years+ - NCT06210178Recruiting
New way to measure liver pressure without needles
This study tests a new, non-invasive method (using an MRI) to estimate pressure in the veins of the liver. If successful, it could replace the need for a catheter procedure for patients being evaluated for a liver transplant.
Leiden, South HollandAges 18–75 - NCT06513195Recruiting
EUS-guided tool to check how well beta-blockers work for cirrhosis
This study tests a new way to measure if a type of blood pressure medicine called non-selective beta-blockers (NSBBs) is helping patients with cirrhosis. It uses a thin, flexible tube with a camera (endoscope) to measure pressures in the liver and a nearby vein. If you have cirrhosis with high pressure in the portal vein but haven't started NSBBs yet, this study may help your doctor decide if the medicine is working for you.
Leuven, Vlaams-BrabantAges 18–80 - NCT06863012Recruiting
Measuring liver pressure with endoscopy: a new method
This trial compares a newer, less invasive method (using an endoscope) to measure pressure in the liver's blood vessels with the standard technique. It may help people with liver disease or suspected cirrhosis better understand their condition.
BarcelonaAges 18–85 - NCT07116096Recruiting
Handgrip strength and blood flow in liver cirrhosis
This study measures how handgrip strength relates to blood flow in the portal vein (the main vein to the liver) in people with liver cirrhosis. It aims to find simple ways to check liver health.
Luoyang, HenanAges 18 years+ - NCT07304466Recruiting
Terlipressin and somatostatin for portal pressure in liver transplant
This study tests two medicines (terlipressin and somatostatin) to see how they affect pressure in the portal vein during liver transplant. It may help people with high portal pressure who are getting a right lobe living donor liver transplant.
Istanbul, BagcilarAges 18–70 - NCT07439939Recruiting
Blood Clotting Study in Cirrhosis Patients Getting a TIPS
This study looks at blood clotting in patients with cirrhosis who are getting a TIPS—a tube placed in the liver to help blood flow. The study aims to understand how the procedure affects bleeding and clotting, which could help make it safer for people with liver disease.
VillejuifAges 18 years+ - NCT06266260Recruiting
Measuring liver pressure with ultrasound for advanced liver disease
This trial uses a minimally invasive ultrasound technique to directly measure blood pressure in the liver's main vein. It may help doctors decide if patients with severe scarred livers need medication to prevent variceal bleeding.
RomaAges 18–99 - NCT07111221Recruiting
Reducing bleeding risk before liver transplant
This trial tests a procedure to lower blood loss during liver transplant for patients with high blood pressure in the liver. It may help those who have had a previous transplant, abdominal surgery, or certain complications of liver disease.
WarsawAges 18 years+ - NCT04393519Recruiting
Program to monitor you after TIPS with noninvasive checks
This trial looks at a follow-up and monitoring program after TIPS (a procedure to improve blood flow in the liver). It is meant to make sure the TIPS is working and to guide follow-up without relying on invasive testing when possible.
BonnAges 18–100 - NCT05502198Recruiting
How muscle loss matters in advanced liver disease
This study looks at how loss of muscle strength or mass (sarcopenia) relates to advanced liver disease. It may help doctors understand which patients are at higher risk and could guide future care choices.
EksjöAges 18 years+ - NCT06500403Recruiting
Non-invasive tools for liver injury after chemotherapy
This study tests non-invasive methods to diagnose a liver condition called PSVD in people who have received platinum chemotherapy. It may help find liver problems early without a biopsy.
Guangzhou, GuangdongAges 18–80 - NCT07799948Recruiting
Stent adjustment for repeated confusion after liver shunt
This study tests a procedure to narrow a stent in the liver to reduce episodes of confusion caused by toxins reaching the brain. It may help people who still have frequent confusion despite standard treatments.
Xi'an, ShaanxiAges 18 years+ - NCT05882370RecruitingPhase 2
Immunotherapy plus TIPS for liver cancer with blocked portal vein
This study tests whether adding the immunotherapy drug cadonilimab (and a related treatment plan) plus TIPS can help people with advanced liver cancer that has a tumor clot causing portal vein pressure problems. It aims to improve disease control while managing the circulation pressure in the liver.
Guangzhou, GuangdongAges 18–75 - NCT06646198RecruitingPhase 2
TIPS with half-dose Donafenib for liver cancer with portal hypertension
This trial tests a treatment that combines a procedure called TIPS with a targeted therapy drug (Donafenib) at half strength. It is for people with advanced liver cancer that has spread into the portal vein and caused high blood pressure in the liver (portal hypertension). The goal is to see if this combination can help control the cancer and reduce complications.
Guangzhou, GuangdongAges 18–75 - NCT03409263Recruiting
Registry for people with TIPS for high portal pressure
This study is a registry, meaning it collects health information to better understand people who have a TIPS procedure for high pressure in the liver’s blood vessels. It may help doctors improve how TIPS is used and monitored over time.
Vienna, State of ViennaAges 18–99 - NCT07598669Recruiting
Austrian Primary Biliary Cholangitis Registry Study
This is a registry study that collects health information from people with primary biliary cholangitis (PBC), a rare liver disease where the immune system damages bile ducts. By joining, you help researchers better understand PBC and improve care for patients with this condition.
Klagenfurt, CarinthiaAges 18 years+ - NCT04073290RecruitingPhase 4
Rifaximin and lactulose to prevent confusion after TIPS
This trial studies whether taking rifaximin plus lactulose can prevent a brain problem called hepatic encephalopathy (confusion) after TIPS, a procedure to reduce pressure in the liver. It may help people who are having TIPS planned and are at risk of this complication.
LeuvenAges 18–80 - NCT07462091Recruiting
Nerve-guided surgery for enlarged spleen and bleeding risk
This study tests a special surgery using a nerve-guided technique to remove the enlarged spleen and reduce bleeding risk in people with cirrhosis and portal hypertension. It may help if you have an enlarged spleen and have had bleeding related to liver disease.
Yangzhou, JiangsuAges 18 years+ - NCT07390344Recruiting
Study of VIATORR TIPS device for liver pressure
This study tests a new version of a device (VIATORR TIPS) that helps lower high blood pressure in the liver for people with cirrhosis. The device is placed to create a small channel that reroutes blood flow and reduces pressure.
Atlanta, GeorgiaAges 18 years+ - NCT07352228Enrolling by invitationPhase 4
Comparing carvedilol and propranolol to prevent variceal rebleeding
This trial tests whether carvedilol or propranolol works better to prevent another bleeding episode from enlarged veins in the stomach or esophagus (varices) after they have been treated with endoscopy. If you have cirrhosis and had a variceal bleed 6 to 30 days ago, this study may help find the most effective medicine for you.
Xi'anAges 18–75 - NCT07291141Recruiting
MRI vs. Ultrasound for Liver Cancer Detection in Cirrhosis
This study compares MRI and ultrasound to see which is better at finding liver cancer early in people with liver cirrhosis. It also looks at body composition and other factors that could lead to worsening liver function.
Linköping, Select A State Or ProvinceAges 18 years+
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Common questions
- Are there clinical trials for portal hypertension?
- Yes. Clin2 currently lists 64 recruiting portal hypertension studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a portal hypertension trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a portal hypertension trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.